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Conserved domains on  [gi|1733582503|ref|NP_001156945|]
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UPF0450 protein C17orf58 homolog isoform 1 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NTR_like super family cl02512
NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in ...
 154-284 6.59e-27

NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the domain plays a role in controlling axon branching in neural development, while the common function of these modules in TIMPs appears to be binding to metzincins. A subset of this family is also known as the C345C domain because it occurs as a C-terminal domain in complement C3, C4 and C5. In C5, the domain interacts with various partners during the formation of the membrane attack complex.


The actual alignment was detected with superfamily member cd03576:

Pssm-ID: 470599  Cd Length: 124  Bit Score: 102.08  E-value: 6.59e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503 154 PETQSCARACSADADEWEAYCASEFAaVNGIVHDVDVLGAGMRLVTLLvdpDGLYKMSRLYITPDGFFFRVHILALDsss 233
Cdd:cd03576     1 PTAALCQQKCRRTGTLESNYCSSEFV-ITGTVISMTRGPGSLHATVSI---IKLYKEGRLAITQAGKTMSVKITVVC--- 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1733582503 234 chKPCPEFKPGSRYIVMGHIYH-KRRQLPSAllQVLRGRLRPGDGLIRGSSS 284
Cdd:cd03576    74 --KQCPLLRRGLNYILMGQVDEeGRGVIPPE--SFVMLYKTKHQKLLAALSN 121
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 27-167 2.87e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503   27 PPPHRKPDSRETPGPRAQPLPEfSRRPRAAYAGPRAWPDPRRRKTAPPADNRA---GFRDAVHAPAALPGPRLAQAENRA 103
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPPPTVPP-PERPRDDPAPGRVSRPRRARRLGRAAQASSppqRPRRRAARPTVGSLTSLADPPPPP 2705

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1733582503  104 SPPEDSPRRALSRAVRPPG---ARAASPAHPNRPRAAAQPSG--TPQALSPEDREPETQSCARACSADA 167
Cdd:PHA03247  2706 PTPEPAPHALVSATPLPPGpaaARQASPALPAAPAPPAVPAGpaTPGGPARPARPPTTAGPPAPAPPAA 2774
 
Name Accession Description Interval E-value
NTR_PCOLCE cd03576
NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are ...
 154-284 6.59e-27

NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which have been suggested to possess inhibitory functions towards specific serine proteases but not towards metzincins, which are inhibited by the related TIMPs.


Pssm-ID: 239631  Cd Length: 124  Bit Score: 102.08  E-value: 6.59e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503 154 PETQSCARACSADADEWEAYCASEFAaVNGIVHDVDVLGAGMRLVTLLvdpDGLYKMSRLYITPDGFFFRVHILALDsss 233
Cdd:cd03576     1 PTAALCQQKCRRTGTLESNYCSSEFV-ITGTVISMTRGPGSLHATVSI---IKLYKEGRLAITQAGKTMSVKITVVC--- 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1733582503 234 chKPCPEFKPGSRYIVMGHIYH-KRRQLPSAllQVLRGRLRPGDGLIRGSSS 284
Cdd:cd03576    74 --KQCPLLRRGLNYILMGQVDEeGRGVIPPE--SFVMLYKTKHQKLLAALSN 121
PHA03247 PHA03247
large tegument protein UL36; Provisional
 27-167 2.87e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503   27 PPPHRKPDSRETPGPRAQPLPEfSRRPRAAYAGPRAWPDPRRRKTAPPADNRA---GFRDAVHAPAALPGPRLAQAENRA 103
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPPPTVPP-PERPRDDPAPGRVSRPRRARRLGRAAQASSppqRPRRRAARPTVGSLTSLADPPPPP 2705

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1733582503  104 SPPEDSPRRALSRAVRPPG---ARAASPAHPNRPRAAAQPSG--TPQALSPEDREPETQSCARACSADA 167
Cdd:PHA03247  2706 PTPEPAPHALVSATPLPPGpaaARQASPALPAAPAPPAVPAGpaTPGGPARPARPPTTAGPPAPAPPAA 2774
 
Name Accession Description Interval E-value
NTR_PCOLCE cd03576
NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are ...
 154-284 6.59e-27

NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which have been suggested to possess inhibitory functions towards specific serine proteases but not towards metzincins, which are inhibited by the related TIMPs.


Pssm-ID: 239631  Cd Length: 124  Bit Score: 102.08  E-value: 6.59e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503 154 PETQSCARACSADADEWEAYCASEFAaVNGIVHDVDVLGAGMRLVTLLvdpDGLYKMSRLYITPDGFFFRVHILALDsss 233
Cdd:cd03576     1 PTAALCQQKCRRTGTLESNYCSSEFV-ITGTVISMTRGPGSLHATVSI---IKLYKEGRLAITQAGKTMSVKITVVC--- 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1733582503 234 chKPCPEFKPGSRYIVMGHIYH-KRRQLPSAllQVLRGRLRPGDGLIRGSSS 284
Cdd:cd03576    74 --KQCPLLRRGLNYILMGQVDEeGRGVIPPE--SFVMLYKTKHQKLLAALSN 121
PHA03247 PHA03247
large tegument protein UL36; Provisional
 27-167 2.87e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503   27 PPPHRKPDSRETPGPRAQPLPEfSRRPRAAYAGPRAWPDPRRRKTAPPADNRA---GFRDAVHAPAALPGPRLAQAENRA 103
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPPPTVPP-PERPRDDPAPGRVSRPRRARRLGRAAQASSppqRPRRRAARPTVGSLTSLADPPPPP 2705

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1733582503  104 SPPEDSPRRALSRAVRPPG---ARAASPAHPNRPRAAAQPSG--TPQALSPEDREPETQSCARACSADA 167
Cdd:PHA03247  2706 PTPEPAPHALVSATPLPPGpaaARQASPALPAAPAPPAVPAGpaTPGGPARPARPPTTAGPPAPAPPAA 2774
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
53-171 3.36e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 48.33  E-value: 3.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  53 PRAAYAGPRAWPDPRRR--KTAPPADNRAGFRDAVHAPAALPGPRLAQAENRASPP-------EDSPRRALSRAVRPPGA 123
Cdd:PRK12323  374 PATAAAAPVAQPAPAAAapAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPApealaaaRQASARGPGGAPAPAPA 453

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1733582503 124 RAASPAhPNRPRAAAQPSGTPQALSPEDREPETQSCARACSADADEWE 171
Cdd:PRK12323  454 PAAAPA-AAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWE 500
PHA03247 PHA03247
large tegument protein UL36; Provisional
 27-149 7.01e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 7.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503   27 PPPHRKPDSRETPGPRAQPLPEFSRRPRAAYAGPRAWPDPRRRKTA---PPADNRAGFRDAVHAPAALPGPR--LAQAEN 101
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpatPGGPARPARPPTTAGPPAPAPPAapAAGPPR 2781

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1733582503  102 RASPPEDSPRRALSRAVRPPGARAASPAHPNRPRAAAQPSGTPQALSP 149
Cdd:PHA03247  2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLP 2829
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 14-172 2.02e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 2.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  14 GWSPEAPVAERKAPPPHRKPDSRETPGPRAQPLPEFSRRPRAAYAGPRAWPDPrrrkTAPPADNRAGFRDAVHAPAALPG 93
Cdd:PRK07764  635 APAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAP----AAPAAPAGAAPAQPAPAPAATPP 710

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  94 PRLAQAENRASPP----EDSPRRALSRAVRPPGARAASPAHPNRPRAAAQPSGTPQALSPEDREPETQSCARACSADADE 169
Cdd:PRK07764  711 AGQADDPAAQPPQaaqgASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDA 790


                  ...
gi 1733582503 170 WEA 172
Cdd:PRK07764  791 PSM 793
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
16-183 3.35e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.25  E-value: 3.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  16 SPEAPVAERKAPPphRKPDSRETPGPRAQPLPEFSRRPRAAYAGPRAWPDPRRRKTAPPADNRAGFRDAV----HAPAAL 91
Cdd:PRK12323  429 APEALAAARQASA--RGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPppweELPPEF 506

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  92 PGPRLAQAEN--RASPPEDSPRRALSRAVRPPGARAASPAHPNRPRAAAQPSGTPQALSPEdrepetQSCARACSADADE 169
Cdd:PRK12323  507 ASPAPAQPDAapAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPR------ASASGLPDMFDGD 580

                         170       180
                  ....*....|....*....|....*...
gi 1733582503 170 WEAYCA--------------SEFAAVNG 183
Cdd:PRK12323  581 WPALAArlpvrglaqqlarqSELAGVEG 608
PHA03247 PHA03247
large tegument protein UL36; Provisional
 17-164 3.91e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 3.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503   17 PEAPVAERKAPPPHRKP-------DSRETPgPRAQPLPEFSRRPRAAYAGPRAWPDPRRRKTA-----PPADNRAGFRDA 84
Cdd:PHA03247  2559 APPAAPDRSVPPPRPAPrpsepavTSRARR-PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDthapdPPPPSPSPAANE 2637

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503   85 VHAPAALPGPRLAQAENRASPPEDSPRRALSRAVRPPgaRAASPAHPNRPRAAAQPSGTPQALS-PEDREPETQSCARAC 163
Cdd:PHA03247  2638 PDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAA--QASSPPQRPRRRAARPTVGSLTSLAdPPPPPPTPEPAPHAL 2715


                   .
gi 1733582503  164 S 164
Cdd:PHA03247  2716 V 2716
PHA03247 PHA03247
large tegument protein UL36; Provisional
 16-164 4.50e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 4.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503   16 SPEAPVAERkAPPPHRKPDSRETPGPRAQPLPEFSRRPRAAYAG----PRAWPDPRRRKTAppadnragfrdavhAPAAL 91
Cdd:PHA03247  2597 RPRAPVDDR-GDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDphppPTVPPPERPRDDP--------------APGRV 2661

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1733582503   92 PGPRLAQAENRASPPEDSPRRALSRAVRPPGARAASPAHPNRPRAAAQPSgtPQALSPEDREPETQSCARACS 164
Cdd:PHA03247  2662 SRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA--PHALVSATPLPPGPAAARQAS 2732
PHA03247 PHA03247
large tegument protein UL36; Provisional
 19-142 6.52e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 6.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503   19 APVAERKAPPPhrkPDSRETPGPRAQPLPEFSRRP--RAAYAGPRAWPDPRRRKTAPPADNRAGFRDAVhAPAALPGPRL 96
Cdd:PHA03247  2835 QPTAPPPPPGP---PPPSLPLGGSVAPGGDVRRRPpsRSPAAKPAAPARPPVRRLARPAVSRSTESFAL-PPDQPERPPQ 2910

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1733582503   97 AQAENRASPPEDSPRRALSRAVRPPGARAASPAHPN-RPRAAAQPSG 142
Cdd:PHA03247  2911 PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTtDPAGAGEPSG 2957
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
19-172 1.30e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.68  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  19 APVAERKAPPPHRKPDSRETPGPRAQPLPEFSRRPRAAYAGPRAWP------DPRRRKTAPPADNRAGFRDAVHAPAALP 92
Cdd:PRK07003  367 APGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPkaaaaaAATRAEAPPAAPAPPATADRGDDAADGD 446

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  93 GPRLAQAENRASPPEdsprRALSRAVRPPGARA--ASPAHPNRPRAAAQPSGTPQALSPEDREPETQSCARACSADADEW 170
Cdd:PRK07003  447 APVPAKANARASADS----RCDERDAQPPADSGsaSAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAP 522


                  ..
gi 1733582503 171 EA 172
Cdd:PRK07003  523 AA 524
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 14-172 1.59e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  14 GWSPEAPVAERKAPP-PHRKPDSRETPGPRAQPLPEFSRRPRAAYAG--PRAWPDPRRRKTAPPADNRAGfRDAVHAPAA 90
Cdd:PRK07764  605 SSGPPEEAARPAAPAaPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEhhPKHVAVPDASDGGDGWPAKAG-GAAPAAPPP 683

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  91 LPGPRLAQAENRASPPEDSPRRALSRAVRPPGARAASPAHPNRPRAAAQPSGTPQALSPEDREPETQSCARACSADADEW 170
Cdd:PRK07764  684 APAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPA 763


                  ..
gi 1733582503 171 EA 172
Cdd:PRK07764  764 PA 765
PHA03247 PHA03247
large tegument protein UL36; Provisional
 17-154 1.65e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 1.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503   17 PEAPVAERkaPPPHRKPDS-RETPGPRAQPLPEFSRRPRAAYAGPRAWPDPRRRKTAPP-------ADNRAGFRDAVHAP 88
Cdd:PHA03247  2475 PGAPVYRR--PAEARFPFAaGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPVHPrmltwirGLEELASDDAGDPP 2552

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1733582503   89 AALPGPRLAQAENRASPPEDSPRRALSRAVRPPGARAASPAHPNRPRAAAQPSGTPQALSPEDREP 154
Cdd:PHA03247  2553 PPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLP 2618
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
17-156 1.85e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  17 PEAPVAERKAPPPHRKPDSRETPGPRAQPLPEfsrrprAAYAGPRAWPDPRRRKTAPPADNRAGFRDAVHAPAALPGPRL 96
Cdd:PRK12323  375 ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAP------AAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  97 AQAENRASPPEDSPRRALSRAVRPPgarAASPAHPNRPRAAAQPSGTPQALSPEDREPET 156
Cdd:PRK12323  449 APAPAPAAAPAAAARPAAAGPRPVA---AAAAAAPARAAPAAAPAPADDDPPPWEELPPE 505
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 17-150 2.58e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 2.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  17 PEAPVAERKAPpphrkpdsreTPGPRAQPLPefSRRPRAAYAGPRAWPDPRRRKTAPPADNRAGFRDAVHAPAALPGPRL 96
Cdd:PRK14951  371 EAAAPAEKKTP----------ARPEAAAPAA--APVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAP 438

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1733582503  97 AQAENRASPPEDSPRRALSRAVRPPGARAASPAHPNRPRA-AAQPSGTPQALSPE 150
Cdd:PRK14951  439 AAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPApAAAPAAARLTPTEE 493
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 20-151 5.98e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.60  E-value: 5.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  20 PVAERKAPPPHRKPDSRET------PGP----RAQPLPEFSRRPraayAGPRAWPDPRRRKTaPPADNRAgfrDAVHAPA 89
Cdd:PTZ00449  536 DSKESDEPKEGGKPGETKEgevgkkPGPakehKPSKIPTLSKKP----EFPKDPKHPKDPEE-PKKPKRP---RSAQRPT 607

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1733582503  90 ALPGPRLAQAENRASPPED-----SPRRAlsravrPPGARAASPAHPNRPRAAAQPSGTPQALSPED 151
Cdd:PTZ00449  608 RPKSPKLPELLDIPKSPKRpespkSPKRP------PPPQRPSSPERPEGPKIIKSPKPPKSPKPPFD 668
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
16-147 6.09e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 6.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  16 SPEAPVAERKAPPPHRKP----DSRETPGPRAQPLPefSRRPRAAYAGPRAWPDPR--------RRKTAPPADNRAGFRD 83
Cdd:PRK07003  413 KAAAAAAATRAEAPPAAPappaTADRGDDAADGDAP--VPAKANARASADSRCDERdaqppadsGSASAPASDAPPDAAF 490

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1733582503  84 AVHAPAALPGPRLAQAENRASPPEDSPRRALSRAVRPPGARAASPAhPNRPRAAAQPSGTPQAL 147
Cdd:PRK07003  491 EPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPT-PAAAAPAARAGGAAAAL 553
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 16-142 6.24e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.24  E-value: 6.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  16 SPEAPVAERKAPPPHRKPDSRETPGPRAQPLPEFSRRPRAAYAGPRAWPDPRRRKTAPPADNRAGFRDAVHAPAALPGPr 95
Cdd:PRK14951  376 AEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQ- 454

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1733582503  96 lAQAENRASPPEDSPRRAlsravrPPGARAASPAHPNRPRAAAQPSG 142
Cdd:PRK14951  455 -AAPETVAIPVRVAPEPA------VASAAPAPAAAPAAARLTPTEEG 494
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 16-155 6.33e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 6.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  16 SPEAPVAERKAPPPhrkpdsretPGPRAQPLPEFSRRPRAAYAGPRAWPDPRRRKTAPPADNRAGFRDAVHAPAALPGPR 95
Cdd:PRK07764  399 PSAAAAAPAAAPAP---------AAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPA 469

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  96 LAQAENRASPPEDSprralsravrpPGARAASPAHPNRPRAAAQPSGTPQALSPEDREPE 155
Cdd:PRK07764  470 PAAAPEPTAAPAPA-----------PPAAPAPAAAPAAPAAPAAPAGADDAATLRERWPE 518
PHA03247 PHA03247
large tegument protein UL36; Provisional
 26-157 6.73e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 6.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503   26 APPPHRKPDSRETPGPRAQPLPEFSRRPRAAYAGPRAWpDPRRRKTAPPADNRAGFRDAVHAPAALPGPRLAQAENRASP 105
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPW-DPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP 2843

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1733582503  106 PEDSPRRALSRAVRP---------PGARAASPAHPNRPRA------AAQPSGTPQALSPEDREPETQ 157
Cdd:PHA03247  2844 GPPPPSLPLGGSVAPggdvrrrppSRSPAAKPAAPARPPVrrlarpAVSRSTESFALPPDQPERPPQ 2910
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
16-181 7.12e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 7.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  16 SPEAPVAERKAPPPHRKPDSRETPGPRAQPLPEFSRRPRAAYAGPRAWPDPRRRKTAPPAdnragfrdAVHAPAALPGPR 95
Cdd:PRK12323  390 AAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPA--------PAPAPAAAPAAA 461

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  96 LAQAenrASPPEDSPRRALSRAVRPPGARAASPAHPNRPRAAAQPsGTPQALSPEDREPETQSCARACSADADEWEAYCA 175
Cdd:PRK12323  462 ARPA---AAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELP-PEFASPAPAQPDAAPAGWVAESIPDPATADPDDA 537


                  ....*.
gi 1733582503 176 SEFAAV 181
Cdd:PRK12323  538 FETLAP 543
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 19-168 7.55e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 7.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  19 APVAERKAPPPHRKPDSRETPGPRAQPLPEFSRRPRAAYAGPRAWPDPRRRKTAPPADNRAGFRDAVHAPAALPGPRLAQ 98
Cdd:PRK07764  591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP 670

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  99 AENRASPPEDSPRRALSRAVRPPGARAASPAHPnrpRAAAQPSGTPQALSPEDREPETQSCARACSADAD 168
Cdd:PRK07764  671 AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAP---APAATPPAGQADDPAAQPPQAAQGASAPSPAADD 737
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 16-169 9.00e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 9.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  16 SPEAPVAERKAPPPHRKPDSRETPGPRAQPLPEFSRRPRAAYAGPRAWPDPRR-RKTAPPADNRAGFRDAVHAPAALPGP 94
Cdd:PRK07764  620 APAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKaGGAAPAAPPPAPAPAAPAAPAGAAPA 699

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  95 RLAQ-------AENRASPPEDSPRRALSRAVRPPGARAASPAHP---NRPRAAAQPSGTPQALSPEDREPETQSCARACS 164
Cdd:PRK07764  700 QPAPapaatppAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPepdDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPP 779


                  ....*
gi 1733582503 165 ADADE 169
Cdd:PRK07764  780 SEEEE 784
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 17-172 9.16e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 9.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  17 PEAPVAERKAPPPHRKPDSRETPGPRAQPlPEFSRrPRAAYAGPRAWPDPRR-RKTAPPADNRAGFRDAVHAPAALPGPR 95
Cdd:PRK07764  365 PSASDDERGLLARLERLERRLGVAGGAGA-PAAAA-PSAAAAAPAAAPAPAAaAPAAAAAPAPAAAPQPAPAPAPAPAPP 442

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1733582503  96 LAQAENRASPPEdSPRRALSRAVRPPGARAASPAHPNRPRAAAQPSGTPQALSPEDREPETQSCARACSADADEWEA 172
Cdd:PRK07764  443 SPAGNAPAGGAP-SPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERWPE 518
PHA03378 PHA03378
EBNA-3B; Provisional
 26-147 1.08e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  26 APPPHRKPDSRETPGPRAQPLPEFSRRPRAAYA---GPRAWPDPRRRKTAPPADNR--AGFRDAVHAPAALPGPrlaqae 100
Cdd:PHA03378  690 APGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGrarPPAAAPGRARPPAAAPGRARppAAAPGRARPPAAAPGR------ 763

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1733582503 101 nrASPPEDSPRRAlsravRPPGARAASPAHPNRPRAAAQPSGTPQAL 147
Cdd:PHA03378  764 --ARPPAAAPGAP-----TPQPPPQAPPAPQQRPRGAPTPQPPPQAG 803
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 14-151 1.57e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  14 GWSPEAPVAERKAPPPHRKPDSRETPGPRAQPLPEFSRRPRAAyagPRAWPDPRRRKTAPPADNRAGFRDAVHAPAALPG 93
Cdd:PRK07764  668 GWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPP---AGQADDPAAQPPQAAQGASAPSPAADDPVPLPPE 744

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1733582503  94 PRLAQAENRASPPEDSPRRAlsrAVRPPGARAASPAHPN----RPRAAAQPSGTPQALSPED 151
Cdd:PRK07764  745 PDDPPDPAGAPAQPPPPPAP---APAAAPAAAPPPSPPSeeeeMAEDDAPSMDDEDRRDAEE 803
dnaA PRK14086
chromosomal replication initiator protein DnaA;
20-171 1.66e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 39.81  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  20 PVAERKAPPPhrkPDSRETPGPRaqpLPEFSRRPRAAYAGPRAWPdprRRKTAPPADNRagfrdavhaPAALPGprlAQA 99
Cdd:PRK14086   90 PSAGEPAPPP---PHARRTSEPE---LPRPGRRPYEGYGGPRADD---RPPGLPRQDQL---------PTARPA---YPA 148

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1733582503 100 ENRASPPEDSPRRALSRAVRPPGArAASPAHPNRPRAAAQPSGTPQALSPEDREPETQSCARACSADADEWE 171
Cdd:PRK14086  149 YQQRPEPGAWPRAADDYGWQQQRL-GFPPRAPYASPASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWD 219
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
17-167 1.69e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.83  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  17 PEAPVAERKAPPPHRKPDSRETPGPRAQPLPEFSRrprAAYAGPRAWPDPRRRKTAPPADNRAGFRDAVHAPAALPGPRL 96
Cdd:PRK07003  402 VTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATA---DRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSAS 478

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1733582503  97 AQAE-------NRASPPEDSPRRALSRAVRPPGARAASPAHPNRPRAAAQPSGTPQALSPEDREPetqscARACSADA 167
Cdd:PRK07003  479 APASdappdaaFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPA-----ARAGGAAA 551
flhF PRK06995
flagellar biosynthesis protein FlhF;
53-162 2.09e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 235904 [Multi-domain]  Cd Length: 484  Bit Score: 39.56  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  53 PRAAYAGPRAWPDPRrrkTAPPADNRAGfrdavhAPAALPGPRLAQAENRASPPEDSPRRALSRAVRPPGARAASPAHPN 132
Cdd:PRK06995   53 PPAAAAPAAAQPPPA---AAPAAVSRPA------APAAEPAPWLVEHAKRLTAQREQLVARAAAPAAPEAQAPAAPAERA 123

                          90       100       110
                  ....*....|....*....|....*....|
gi 1733582503 133 RPRAAAQPSGTPQALSPEDREPETQSCARA 162
Cdd:PRK06995  124 AAENAARRLARAAAAAPRPRVPADAAAAVA 153
flhF PRK06995
flagellar biosynthesis protein FlhF;
16-122 2.34e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 235904 [Multi-domain]  Cd Length: 484  Bit Score: 39.18  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  16 SPEAPVAERKAPPPHRKPDSRETPGPRAQPLPEFSRRPRAAyAGPRAwpDPRRRKTAPPADNRAGFRDAVHAPAALPGPR 95
Cdd:PRK06995   54 PAAAAPAAAQPPPAAAPAAVSRPAAPAAEPAPWLVEHAKRL-TAQRE--QLVARAAAPAAPEAQAPAAPAERAAAENAAR 130

                          90       100
                  ....*....|....*....|....*..
gi 1733582503  96 LAQAENRASPPEDSPRRAlSRAVRPPG 122
Cdd:PRK06995  131 RLARAAAAAPRPRVPADA-AAAVADAV 156
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 15-142 4.20e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.00  E-value: 4.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503   15 WSPEAPVAERKAPPPHRKPDSRETPGPRAQPLPEFSRRPRAAYAGPRAWPDPRRRKTAPPADNRAGFRDAVHAPAALPGP 94
Cdd:PHA03307   270 WEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSR 349

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1733582503   95 RLAQAENRASPPEDSPRRAlSRAVRPPGARAASPAHPNRPRAAAQPSG 142
Cdd:PHA03307   350 SPSPSRPPPPADPSSPRKR-PRPSRAPSSPAASAGRPTRRRARAAVAG 396
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 91-175 5.74e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 38.18  E-value: 5.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  91 LPGPRLAQAENRASPPEDSPRRAlsrAVRPPGARAASPAHPNRPRAAAQPsgtPQALSPedrePETQSCARACSADADEW 170
Cdd:PRK14965  381 APAPPSAAWGAPTPAAPAAPPPA---AAPPVPPAAPARPAAARPAPAPAP---PAAAAP----PARSADPAAAASAGDRW 450


                  ....*
gi 1733582503 171 EAYCA 175
Cdd:PRK14965  451 RAFVA 455
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
16-150 6.03e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 38.29  E-value: 6.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733582503  16 SPEAPVAERKAPPPHRKPDSRETPGPRAQPLPEFSRRP-----------RAAYAGPRAWPDPRRRKTAPPADNRAgfRDA 84
Cdd:PRK07003  469 QPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAvpdarapaaasREDAPAAAAPPAPEARPPTPAAAAPA--ARA 546

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1733582503  85 VHAPAAL-----PGPRLAQAENRASPPEDSPRRALSRAVRPPGARAASPA-HPNRPRAAAQPSGTPQALSPE 150
Cdd:PRK07003  547 GGAAAALdvlrnAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVpTPRARAATGDAPPNGAARAEQ 618
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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