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Conserved domains on  [gi|254939613|ref|NP_001157164|]
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ubiquitin-associated protein 1-like [Homo sapiens]

Protein Classification

ubiquitin-associated protein 1-like( domain architecture ID 10198575)

ubiquitin-associated protein 1-like (UBAP1L)

Gene Ontology:  GO:0043162|GO:0043130|GO:0000813
PubMed:  19468686

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UBA2_UBAP1_like cd14316
UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, ...
 341-377 1.71e-14

UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, also called nasopharyngeal carcinoma-associated gene 20 protein, is a ubiquitously expressed protein that may play an important role in the ubiquitin pathway and cell progression. It co-localizes with TDP-43 proteins in neuronal cytoplasmic inclusions and acts as a genetic risk factor for frontotemporal lobar degeneration (FTLD). Moreover, UBAP-1, together with VPS37A, forms an endosome-specific endosomal sorting complexes I required for transport (ESCRT-I) complex that displays a restricted cellular function, ubiquitin-dependent endosomal sorting and multivesicular body (MVB) biogenesis. UBAP-1 contains an N-terminal UBAP-1-MVB12-associated (UMA) domain, and two tandem ubiquitin-associated (UBA) domains that may be responsible for the binding of ubiquitin-conjugating enzymes. This model corresponds to UBA2 domain.


:

Pssm-ID: 270501  Cd Length: 37  Bit Score: 66.78  E-value: 1.71e-14
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 254939613 341 FLRLWEQFSDMGFQQDRIKEVLLVHGNRREQALEELV 377
Cdd:cd14316    1 FLKLLNQLHELGFPEDKIKEALLKHNNDRDKALDELV 37
 
Name Accession Description Interval E-value
UBA2_UBAP1_like cd14316
UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, ...
 341-377 1.71e-14

UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, also called nasopharyngeal carcinoma-associated gene 20 protein, is a ubiquitously expressed protein that may play an important role in the ubiquitin pathway and cell progression. It co-localizes with TDP-43 proteins in neuronal cytoplasmic inclusions and acts as a genetic risk factor for frontotemporal lobar degeneration (FTLD). Moreover, UBAP-1, together with VPS37A, forms an endosome-specific endosomal sorting complexes I required for transport (ESCRT-I) complex that displays a restricted cellular function, ubiquitin-dependent endosomal sorting and multivesicular body (MVB) biogenesis. UBAP-1 contains an N-terminal UBAP-1-MVB12-associated (UMA) domain, and two tandem ubiquitin-associated (UBA) domains that may be responsible for the binding of ubiquitin-conjugating enzymes. This model corresponds to UBA2 domain.


Pssm-ID: 270501  Cd Length: 37  Bit Score: 66.78  E-value: 1.71e-14
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 254939613 341 FLRLWEQFSDMGFQQDRIKEVLLVHGNRREQALEELV 377
Cdd:cd14316    1 FLKLLNQLHELGFPEDKIKEALLKHNNDRDKALDELV 37
 
Name Accession Description Interval E-value
UBA2_UBAP1_like cd14316
UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, ...
 341-377 1.71e-14

UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, also called nasopharyngeal carcinoma-associated gene 20 protein, is a ubiquitously expressed protein that may play an important role in the ubiquitin pathway and cell progression. It co-localizes with TDP-43 proteins in neuronal cytoplasmic inclusions and acts as a genetic risk factor for frontotemporal lobar degeneration (FTLD). Moreover, UBAP-1, together with VPS37A, forms an endosome-specific endosomal sorting complexes I required for transport (ESCRT-I) complex that displays a restricted cellular function, ubiquitin-dependent endosomal sorting and multivesicular body (MVB) biogenesis. UBAP-1 contains an N-terminal UBAP-1-MVB12-associated (UMA) domain, and two tandem ubiquitin-associated (UBA) domains that may be responsible for the binding of ubiquitin-conjugating enzymes. This model corresponds to UBA2 domain.


Pssm-ID: 270501  Cd Length: 37  Bit Score: 66.78  E-value: 1.71e-14
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 254939613 341 FLRLWEQFSDMGFQQDRIKEVLLVHGNRREQALEELV 377
Cdd:cd14316    1 FLKLLNQLHELGFPEDKIKEALLKHNNDRDKALDELV 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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