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Conserved domains on  [gi|257153474|ref|NP_001158017|]
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disrupted in schizophrenia 1 protein isoform h [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG4913 super family cl25907
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
329-488 1.56e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


The actual alignment was detected with superfamily member COG4913:

Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.91  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153474  329 LLRKWEPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVE----NDDYDKAETLQQRLEDLEQEK--------------ISL 390
Cdd:COG4913   292 LLEAELEELRAELARLEAELERLEARLDALREELDELEaqirGNGGDRLEQLEREIERLERELeererrrarleallAAL 371
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153474  391 HFQLPSRQPALSSflghLAAQVQAALRRGATQQASGDDthtplrmeprlleptAQDSLHVSITRrdwLLQEKQQLQKEIE 470
Cdd:COG4913   372 GLPLPASAEEFAA----LRAEAAALLEALEEELEALEE---------------ALAEAEAALRD---LRRELRELEAEIA 429
                         170
                  ....*....|....*...
gi 257153474  471 ALQARMFVLEAKDQQLRR 488
Cdd:COG4913   430 SLERRKSNIPARLLALRD 447
 
Name Accession Description Interval E-value
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
329-488 1.56e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.91  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153474  329 LLRKWEPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVE----NDDYDKAETLQQRLEDLEQEK--------------ISL 390
Cdd:COG4913   292 LLEAELEELRAELARLEAELERLEARLDALREELDELEaqirGNGGDRLEQLEREIERLERELeererrrarleallAAL 371
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153474  391 HFQLPSRQPALSSflghLAAQVQAALRRGATQQASGDDthtplrmeprlleptAQDSLHVSITRrdwLLQEKQQLQKEIE 470
Cdd:COG4913   372 GLPLPASAEEFAA----LRAEAAALLEALEEELEALEE---------------ALAEAEAALRD---LRRELRELEAEIA 429
                         170
                  ....*....|....*...
gi 257153474  471 ALQARMFVLEAKDQQLRR 488
Cdd:COG4913   430 SLERRKSNIPARLLALRD 447
DUF4515 pfam14988
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and ...
336-488 6.64e-03

Domain of unknown function (DUF4515); This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.


Pssm-ID: 405647 [Multi-domain]  Cd Length: 206  Bit Score: 38.21  E-value: 6.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153474  336 VLRDCLLRNRRqmEVISLRLKLQKLQEDAVENDDYDkaetlqQRLEDLEQEKISLHFQLPSR-QPALSSFLghlaaQVQA 414
Cdd:pfam14988  51 ELQTQLLQKEK--EQASLKKELQALRPFAKLKESQE------REIQDLEEEKEKVRAETAEKdREAHLQFL-----KEKA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153474  415 ALRRGATQQ---ASGDDTHTPLRMEPRLLEPTAQDSLH---VSITRRDWLLQEK-QQLQKEIEALQARMFVLEAKDQQLR 487
Cdd:pfam14988 118 LLEKQLQELrilELGERATRELKRKAQALKLAAKQALSefcRSIKRENRQLQKElLQLIQETQALEAIKSKLENRKQRLK 197

                  .
gi 257153474  488 R 488
Cdd:pfam14988 198 E 198
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
347-560 6.92e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 6.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153474   347 QMEVISLRLKLQKLQEDAveNDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSF---LGHLAAQVQAALRRGATQQ 423
Cdd:TIGR02168  809 RAELTLLNEEAANLRERL--ESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELeelIEELESELEALLNERASLE 886
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153474   424 AsgddthtpLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLrreieeqeqqlqwqgcd 503
Cdd:TIGR02168  887 E--------ALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNL----------------- 941
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 257153474   504 ltplvgqlslgqLQEVSKALQDTLASAgqIPFHAEPPETIRSLQERIKSLNLSLKEI 560
Cdd:TIGR02168  942 ------------QERLSEEYSLTLEEA--EALENKIEDDEEEARRRLKRLENKIKEL 984
 
Name Accession Description Interval E-value
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
329-488 1.56e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.91  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153474  329 LLRKWEPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVE----NDDYDKAETLQQRLEDLEQEK--------------ISL 390
Cdd:COG4913   292 LLEAELEELRAELARLEAELERLEARLDALREELDELEaqirGNGGDRLEQLEREIERLERELeererrrarleallAAL 371
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153474  391 HFQLPSRQPALSSflghLAAQVQAALRRGATQQASGDDthtplrmeprlleptAQDSLHVSITRrdwLLQEKQQLQKEIE 470
Cdd:COG4913   372 GLPLPASAEEFAA----LRAEAAALLEALEEELEALEE---------------ALAEAEAALRD---LRRELRELEAEIA 429
                         170
                  ....*....|....*...
gi 257153474  471 ALQARMFVLEAKDQQLRR 488
Cdd:COG4913   430 SLERRKSNIPARLLALRD 447
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
337-488 4.03e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.14  E-value: 4.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153474 337 LRDCLLRNRRQMEviSLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKIslhfQLPSRQPALSSFLghlaAQVQAAL 416
Cdd:COG4717   93 LQEELEELEEELE--ELEAELEELREELEKLEKLLQLLPLYQELEALEAELA----ELPERLEELEERL----EELRELE 162
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 257153474 417 RRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARmfvLEAKDQQLRR 488
Cdd:COG4717  163 EELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEE---LEELEEELEQ 231
DUF4515 pfam14988
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and ...
336-488 6.64e-03

Domain of unknown function (DUF4515); This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.


Pssm-ID: 405647 [Multi-domain]  Cd Length: 206  Bit Score: 38.21  E-value: 6.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153474  336 VLRDCLLRNRRqmEVISLRLKLQKLQEDAVENDDYDkaetlqQRLEDLEQEKISLHFQLPSR-QPALSSFLghlaaQVQA 414
Cdd:pfam14988  51 ELQTQLLQKEK--EQASLKKELQALRPFAKLKESQE------REIQDLEEEKEKVRAETAEKdREAHLQFL-----KEKA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153474  415 ALRRGATQQ---ASGDDTHTPLRMEPRLLEPTAQDSLH---VSITRRDWLLQEK-QQLQKEIEALQARMFVLEAKDQQLR 487
Cdd:pfam14988 118 LLEKQLQELrilELGERATRELKRKAQALKLAAKQALSefcRSIKRENRQLQKElLQLIQETQALEAIKSKLENRKQRLK 197

                  .
gi 257153474  488 R 488
Cdd:pfam14988 198 E 198
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
347-560 6.92e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 6.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153474   347 QMEVISLRLKLQKLQEDAveNDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSF---LGHLAAQVQAALRRGATQQ 423
Cdd:TIGR02168  809 RAELTLLNEEAANLRERL--ESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELeelIEELESELEALLNERASLE 886
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153474   424 AsgddthtpLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLrreieeqeqqlqwqgcd 503
Cdd:TIGR02168  887 E--------ALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNL----------------- 941
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 257153474   504 ltplvgqlslgqLQEVSKALQDTLASAgqIPFHAEPPETIRSLQERIKSLNLSLKEI 560
Cdd:TIGR02168  942 ------------QERLSEEYSLTLEEA--EALENKIEDDEEEARRRLKRLENKIKEL 984
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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