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Conserved domains on  [gi|258679524|ref|NP_001158310|]
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leucine-rich repeat flightless-interacting protein 2 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LRRFIP pfam09738
LRRFIP family; LRRFIP1 is a transcriptional repressor which preferentially binds to the ...
47-340 6.52e-121

LRRFIP family; LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin.


:

Pssm-ID: 462869 [Multi-domain]  Cd Length: 303  Bit Score: 353.23  E-value: 6.52e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   47 DIRMRELERQQREgvedtlslrslgshrLDEKSDKQYAENYT---------RPSSRNSASATTPLSGNSSRRGSGDTSSL 117
Cdd:pfam09738  17 EIRMRELERQQKE---------------VEENADRVFDMSSSsgadtasgsPTASTTSAGTLNSLGGTSSRRSSEDSSIS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524  118 IDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVL 197
Cdd:pfam09738  82 LEDEGSLRDIKHELKEVEEKYRKAMISNAQLDNEKSNLMYQVDLLKDKLEEMEESLAELQRELREKNKELERLKRNLRRL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524  198 QHKMDELKEGLRQRDELIEKHGLVIIPDSTPNGDVHHEPVVGAITAVSQEAAQVLESAGEGPLDVRLRKLAGEKDELLSQ 277
Cdd:pfam09738 162 QFQLAELKEQLKQRDELIEKHGLVIVPDENTNGEEENSPADAKRALVSVEAAEVLESAGEGSLDVRLKKLADEKEELLDE 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 258679524  278 IRKLKLQLEEERQ-KCSRNDGMSGDLAGLQNGSDLqfIEMQRDANRQISEYKFKLSKAEQDIAT 340
Cdd:pfam09738 242 VRKLKLQLEEEKSkRNSTRSSQSPDGFGLENGSHV--IEVQREANKQISDYKFKLQKAEQEITT 303
COG2433 super family cl43687
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
318-406 1.61e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


The actual alignment was detected with superfamily member COG2433:

Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 40.61  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524 318 RDANRQISEYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELkaerRKLQRELRTAQDKIEEMEMTNSHL 397
Cdd:COG2433  416 RRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEERREIRKDREI----SRLDREIERLERELEEERERIEEL 491

                 ....*....
gi 258679524 398 AKRLEKMKA 406
Cdd:COG2433  492 KRKLERLKE 500
 
Name Accession Description Interval E-value
LRRFIP pfam09738
LRRFIP family; LRRFIP1 is a transcriptional repressor which preferentially binds to the ...
47-340 6.52e-121

LRRFIP family; LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin.


Pssm-ID: 462869 [Multi-domain]  Cd Length: 303  Bit Score: 353.23  E-value: 6.52e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   47 DIRMRELERQQREgvedtlslrslgshrLDEKSDKQYAENYT---------RPSSRNSASATTPLSGNSSRRGSGDTSSL 117
Cdd:pfam09738  17 EIRMRELERQQKE---------------VEENADRVFDMSSSsgadtasgsPTASTTSAGTLNSLGGTSSRRSSEDSSIS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524  118 IDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVL 197
Cdd:pfam09738  82 LEDEGSLRDIKHELKEVEEKYRKAMISNAQLDNEKSNLMYQVDLLKDKLEEMEESLAELQRELREKNKELERLKRNLRRL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524  198 QHKMDELKEGLRQRDELIEKHGLVIIPDSTPNGDVHHEPVVGAITAVSQEAAQVLESAGEGPLDVRLRKLAGEKDELLSQ 277
Cdd:pfam09738 162 QFQLAELKEQLKQRDELIEKHGLVIVPDENTNGEEENSPADAKRALVSVEAAEVLESAGEGSLDVRLKKLADEKEELLDE 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 258679524  278 IRKLKLQLEEERQ-KCSRNDGMSGDLAGLQNGSDLqfIEMQRDANRQISEYKFKLSKAEQDIAT 340
Cdd:pfam09738 242 VRKLKLQLEEEKSkRNSTRSSQSPDGFGLENGSHV--IEVQREANKQISDYKFKLQKAEQEITT 303
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
162-415 8.46e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.01  E-value: 8.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524 162 LKDVIEEQEEQM---------AEFYRENEEKSKELERQkhmcsVLQHKMDELKEGLRQRDELIEKHglviipdstpngdv 232
Cdd:COG1196  191 LEDILGELERQLeplerqaekAERYRELKEELKELEAE-----LLLLKLRELEAELEELEAELEEL-------------- 251
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524 233 hhepvvgAITAVSQEAAQVLESAGEGPLDVRLRKLAGEKDELLSQIRKLKLQLEEERQKCSRNDGMSGDLAGLQNGSDLQ 312
Cdd:COG1196  252 -------EAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEE 324
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524 313 FIEMQR---DANRQISEYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEE 389
Cdd:COG1196  325 LAELEEeleELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEE 404
                        250       260
                 ....*....|....*....|....*.
gi 258679524 390 MEMTNSHLAKRLEKMKANRTALLAQQ 415
Cdd:COG1196  405 LEEAEEALLERLERLEEELEELEEAL 430
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
117-390 1.12e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.74  E-value: 1.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   117 LIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSV 196
Cdd:TIGR02168  721 LEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKA 800
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   197 LQHKMDELKEGLRQRDELIekhglviipDSTPNGDVHHEPVVGAITAVSQEAAQVLESAGEgpldvRLRKLAGEKDELLS 276
Cdd:TIGR02168  801 LREALDELRAELTLLNEEA---------ANLRERLESLERRIAATERRLEDLEEQIEELSE-----DIESLAAEIEELEE 866
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   277 QIRKLKLQLEE-ERQKCSRNDGMSGDLAGLQN-GSDLQFIEMQR-DANRQISEYKFKLSKAEQDIATLEQSISRLEGQVL 353
Cdd:TIGR02168  867 LIEELESELEAlLNERASLEEALALLRSELEElSEELRELESKRsELRRELEELREKLAQLELRLEGLEVRIDNLQERLS 946
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 258679524   354 -RYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEM 390
Cdd:TIGR02168  947 eEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL 984
mukB PRK04863
chromosome partition protein MukB;
124-388 3.66e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 43.02  E-value: 3.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524  124 LSELRESLSEVEEKYKKA-----MVSNAQLDNEK--------NNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQ 190
Cdd:PRK04863  316 LAELNEAESDLEQDYQAAsdhlnLVQTALRQQEKieryqadlEELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDEL 395
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524  191 KHMCSVLQHKMDELKE---GLRQRDELIEK-HGLVIIPDSTPNG--DVHHEpvvgaITAVSQEAAQVLESAgEGPLDVR- 263
Cdd:PRK04863  396 KSQLADYQQALDVQQTraiQYQQAVQALERaKQLCGLPDLTADNaeDWLEE-----FQAKEQEATEELLSL-EQKLSVAq 469
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524  264 ------------LRKLAGEKD--ELLSQIRKLKLQLEEERQKCSRNDGMSGDLAGLQngsdlQFIEMQRDANRQISEYKF 329
Cdd:PRK04863  470 aahsqfeqayqlVRKIAGEVSrsEAWDVARELLRRLREQRHLAEQLQQLRMRLSELE-----QRLRQQQRAERLLAEFCK 544
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 258679524  330 KLSKAEQDIATLEQSISRLEGQVLRYKTAAENA-------EKIEDELKAERRKLQR---ELRTAQDKIE 388
Cdd:PRK04863  545 RLGKNLDDEDELEQLQEELEARLESLSESVSEArerrmalRQQLEQLQARIQRLAArapAWLAAQDALA 613
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
318-406 1.61e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 40.61  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524 318 RDANRQISEYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELkaerRKLQRELRTAQDKIEEMEMTNSHL 397
Cdd:COG2433  416 RRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEERREIRKDREI----SRLDREIERLERELEEERERIEEL 491

                 ....*....
gi 258679524 398 AKRLEKMKA 406
Cdd:COG2433  492 KRKLERLKE 500
 
Name Accession Description Interval E-value
LRRFIP pfam09738
LRRFIP family; LRRFIP1 is a transcriptional repressor which preferentially binds to the ...
47-340 6.52e-121

LRRFIP family; LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin.


Pssm-ID: 462869 [Multi-domain]  Cd Length: 303  Bit Score: 353.23  E-value: 6.52e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   47 DIRMRELERQQREgvedtlslrslgshrLDEKSDKQYAENYT---------RPSSRNSASATTPLSGNSSRRGSGDTSSL 117
Cdd:pfam09738  17 EIRMRELERQQKE---------------VEENADRVFDMSSSsgadtasgsPTASTTSAGTLNSLGGTSSRRSSEDSSIS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524  118 IDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVL 197
Cdd:pfam09738  82 LEDEGSLRDIKHELKEVEEKYRKAMISNAQLDNEKSNLMYQVDLLKDKLEEMEESLAELQRELREKNKELERLKRNLRRL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524  198 QHKMDELKEGLRQRDELIEKHGLVIIPDSTPNGDVHHEPVVGAITAVSQEAAQVLESAGEGPLDVRLRKLAGEKDELLSQ 277
Cdd:pfam09738 162 QFQLAELKEQLKQRDELIEKHGLVIVPDENTNGEEENSPADAKRALVSVEAAEVLESAGEGSLDVRLKKLADEKEELLDE 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 258679524  278 IRKLKLQLEEERQ-KCSRNDGMSGDLAGLQNGSDLqfIEMQRDANRQISEYKFKLSKAEQDIAT 340
Cdd:pfam09738 242 VRKLKLQLEEEKSkRNSTRSSQSPDGFGLENGSHV--IEVQREANKQISDYKFKLQKAEQEITT 303
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
162-415 8.46e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.01  E-value: 8.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524 162 LKDVIEEQEEQM---------AEFYRENEEKSKELERQkhmcsVLQHKMDELKEGLRQRDELIEKHglviipdstpngdv 232
Cdd:COG1196  191 LEDILGELERQLeplerqaekAERYRELKEELKELEAE-----LLLLKLRELEAELEELEAELEEL-------------- 251
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524 233 hhepvvgAITAVSQEAAQVLESAGEGPLDVRLRKLAGEKDELLSQIRKLKLQLEEERQKCSRNDGMSGDLAGLQNGSDLQ 312
Cdd:COG1196  252 -------EAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEE 324
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524 313 FIEMQR---DANRQISEYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEE 389
Cdd:COG1196  325 LAELEEeleELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEE 404
                        250       260
                 ....*....|....*....|....*.
gi 258679524 390 MEMTNSHLAKRLEKMKANRTALLAQQ 415
Cdd:COG1196  405 LEEAEEALLERLERLEEELEELEEAL 430
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
117-390 1.12e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.74  E-value: 1.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   117 LIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSV 196
Cdd:TIGR02168  721 LEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKA 800
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   197 LQHKMDELKEGLRQRDELIekhglviipDSTPNGDVHHEPVVGAITAVSQEAAQVLESAGEgpldvRLRKLAGEKDELLS 276
Cdd:TIGR02168  801 LREALDELRAELTLLNEEA---------ANLRERLESLERRIAATERRLEDLEEQIEELSE-----DIESLAAEIEELEE 866
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   277 QIRKLKLQLEE-ERQKCSRNDGMSGDLAGLQN-GSDLQFIEMQR-DANRQISEYKFKLSKAEQDIATLEQSISRLEGQVL 353
Cdd:TIGR02168  867 LIEELESELEAlLNERASLEEALALLRSELEElSEELRELESKRsELRRELEELREKLAQLELRLEGLEVRIDNLQERLS 946
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 258679524   354 -RYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEM 390
Cdd:TIGR02168  947 eEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL 984
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
103-414 3.45e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 3.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   103 SGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 182
Cdd:TIGR02168  658 GGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLAR 737
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   183 KSKELERQKHMCSVLQHKMDELKEGLRQRDELIEKHGLVIIPDSTpngdvhhepvvgAITAVSQEAAQVLESAGEgpLDV 262
Cdd:TIGR02168  738 LEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEA------------EIEELEAQIEQLKEELKA--LRE 803
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   263 RLRKLAGEKDELLSQIRKLKLQLEEERQKCSRNDGMSGDLAglQNGSDLQfiEMQRDANRQISEYKFKLSKAEQDIATLE 342
Cdd:TIGR02168  804 ALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLE--EQIEELS--EDIESLAAEIEELEELIEELESELEALL 879
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 258679524   343 QSISRLEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEMEMtnshlakRLEKMKANRTALLAQ 414
Cdd:TIGR02168  880 NERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLEL-------RLEGLEVRIDNLQER 944
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
123-414 3.72e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.21  E-value: 3.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   123 SLSELRESLSEVEEKYKKAMVSN--AQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHK 200
Cdd:TIGR02169  659 SRAPRGGILFSRSEPAELQRLRErlEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKER 738
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   201 MDELKEGLRQRDELIEKHGLVIipdstpngdVHHEPVVGAITAVSQEAAQVLESAGEGPLDVRLRKLAGEKDELLSQIRK 280
Cdd:TIGR02169  739 LEELEEDLSSLEQEIENVKSEL---------KELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSR 809
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   281 LKLQLEEERQKCSRNDgmsgdlaglqngSDLQFIEMQR-DANRQISEYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAA 359
Cdd:TIGR02169  810 IEARLREIEQKLNRLT------------LEKEYLEKEIqELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAAL 877
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 258679524   360 ENAEKIEDELKAERRKLQRELRTAQDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 414
Cdd:TIGR02169  878 RDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEE 932
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
260-406 4.35e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 4.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524  260 LDVRLRKLAGEKDELLSQIRKLKLQLEEERQKCsrnDGMSGDLAGlQNGSDLQFIEMQ-RDANRQISEYKFKLSKAEQDI 338
Cdd:COG4913   293 LEAELEELRAELARLEAELERLEARLDALREEL---DELEAQIRG-NGGDRLEQLEREiERLERELEERERRRARLEALL 368
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 258679524  339 ATLEQSI-----------SRLEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEMEMTNSHLAKRLEKMKA 406
Cdd:COG4913   369 AALGLPLpasaeefaalrAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRD 447
mukB PRK04863
chromosome partition protein MukB;
124-388 3.66e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 43.02  E-value: 3.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524  124 LSELRESLSEVEEKYKKA-----MVSNAQLDNEK--------NNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQ 190
Cdd:PRK04863  316 LAELNEAESDLEQDYQAAsdhlnLVQTALRQQEKieryqadlEELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDEL 395
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524  191 KHMCSVLQHKMDELKE---GLRQRDELIEK-HGLVIIPDSTPNG--DVHHEpvvgaITAVSQEAAQVLESAgEGPLDVR- 263
Cdd:PRK04863  396 KSQLADYQQALDVQQTraiQYQQAVQALERaKQLCGLPDLTADNaeDWLEE-----FQAKEQEATEELLSL-EQKLSVAq 469
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524  264 ------------LRKLAGEKD--ELLSQIRKLKLQLEEERQKCSRNDGMSGDLAGLQngsdlQFIEMQRDANRQISEYKF 329
Cdd:PRK04863  470 aahsqfeqayqlVRKIAGEVSrsEAWDVARELLRRLREQRHLAEQLQQLRMRLSELE-----QRLRQQQRAERLLAEFCK 544
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 258679524  330 KLSKAEQDIATLEQSISRLEGQVLRYKTAAENA-------EKIEDELKAERRKLQR---ELRTAQDKIE 388
Cdd:PRK04863  545 RLGKNLDDEDELEQLQEELEARLESLSESVSEArerrmalRQQLEQLQARIQRLAArapAWLAAQDALA 613
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
260-414 4.91e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.06  E-value: 4.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524 260 LDVRLRKLAGEKDELLSQIRKLKLQLEEERQKCSRNdGMSGDLAGLQNGSDLQFIEMQRDANRQISEYKfklskaEQDIA 339
Cdd:COG4942   81 LEAELAELEKEIAELRAELEAQKEELAELLRALYRL-GRQPPLALLLSPEDFLDAVRRLQYLKYLAPAR------REQAE 153
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 258679524 340 TLEQSISRLEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 414
Cdd:COG4942  154 ELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
260-415 7.66e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 7.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   260 LDVRLRKLAGEKDELLSQIRKLKLQLEEERQKCSRndgMSGDLAGLQnGSDLQFIEMQRDANRQISEYKFKLSKAEQDIA 339
Cdd:TIGR02168  244 LQEELKEAEEELEELTAELQELEEKLEELRLEVSE---LEEEIEELQ-KELYALANEISRLEQQKQILRERLANLERQLE 319
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 258679524   340 TLEQSISRLEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 415
Cdd:TIGR02168  320 ELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQI 395
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
123-362 1.10e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524 123 SLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMD 202
Cdd:COG4942   21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELE 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524 203 ELKEGLRQRDELIEKHG-----LVIIPDSTPNGDVHHEPVVGAITAVSQEAAQVLESAGEgpldvRLRKLAGEKDELLSQ 277
Cdd:COG4942  101 AQKEELAELLRALYRLGrqpplALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLA-----ELAALRAELEAERAE 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524 278 IRKLKLQLEEERQKcsrndgmsgdLAGLQNGSDlqfiEMQRDANRQISEYKFKLSKAEQDIATLEQSISRLEGQVLRYKT 357
Cdd:COG4942  176 LEALLAELEEERAA----------LEALKAERQ----KLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241

                 ....*
gi 258679524 358 AAENA 362
Cdd:COG4942  242 RTPAA 246
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
147-415 1.35e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 1.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   147 QLDNEKNNLiyqvDTLKDVIEEQEEQM---------AEFYRENEEKSKELERqkhmcSVLQHKMDELKEGLRQRDELIEK 217
Cdd:TIGR02168  180 KLERTRENL----DRLEDILNELERQLkslerqaekAERYKELKAELRELEL-----ALLVLRLEELREELEELQEELKE 250
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   218 hglviipdstpNGDVHHEPVVGAitAVSQEAAQVLESAgEGPLDVRLRKLAGEKDELLSQIRKLKLQLEEERQKcsrndg 297
Cdd:TIGR02168  251 -----------AEEELEELTAEL--QELEEKLEELRLE-VSELEEEIEELQKELYALANEISRLEQQKQILRER------ 310
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   298 msgdLAGLQNgsDLQFIEMQRDAN-RQISEYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDEL------- 369
Cdd:TIGR02168  311 ----LANLER--QLEELEAQLEELeSKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELeeqletl 384
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 258679524   370 KAERRKLQRELRTAQDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 415
Cdd:TIGR02168  385 RSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKL 430
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
124-390 1.44e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   124 LSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLkdviEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDE 203
Cdd:TIGR02168  770 LEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDEL----RAELTLLNEEAANLRERLESLERRIAATERRLEDLEE 845
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   204 LKEGLRQRDELIEKHglviIPDSTPNGDVHHEPVVGA--ITAVSQEAAQVLESAGEGpLDVRLRKLAGEKDELLSQIRKL 281
Cdd:TIGR02168  846 QIEELSEDIESLAAE----IEELEELIEELESELEALlnERASLEEALALLRSELEE-LSEELRELESKRSELRRELEEL 920
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   282 KLQLEEERQKCSrndGMSGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAEN 361
Cdd:TIGR02168  921 REKLAQLELRLE---GLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGPVNLAAIEEYEE 997
                          250       260
                   ....*....|....*....|....*....
gi 258679524   362 AEKIEDELKAERRKLQRELRTAQDKIEEM 390
Cdd:TIGR02168  998 LKERYDFLTAQKEDLTEAKETLEEAIEEI 1026
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
318-406 1.61e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 40.61  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524 318 RDANRQISEYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELkaerRKLQRELRTAQDKIEEMEMTNSHL 397
Cdd:COG2433  416 RRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEERREIRKDREI----SRLDREIERLERELEEERERIEEL 491

                 ....*....
gi 258679524 398 AKRLEKMKA 406
Cdd:COG2433  492 KRKLERLKE 500
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
260-414 2.83e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.14  E-value: 2.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524 260 LDVRLRKLAGEKDELLSQIRKLKLQLEEERQKCSRNDGMSGDLAglqngSDLQFIEMQ-RDANRQISEYKFKLSKA---- 334
Cdd:COG1579   15 LDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLE-----KEIKRLELEiEEVEARIKKYEEQLGNVrnnk 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524 335 -----EQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEMEmtnSHLAKRLEKMKANRT 409
Cdd:COG1579   90 eyealQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEEL---AELEAELEELEAERE 166

                 ....*
gi 258679524 410 ALLAQ 414
Cdd:COG1579  167 ELAAK 171
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
122-415 3.66e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 39.64  E-value: 3.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   122 TSLSELRESLSEVEEKYKKAMvsnAQLDNEKNNLIYQvdTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKM 201
Cdd:TIGR00606  792 TIMERFQMELKDVERKIAQQA---AKLQGSDLDRTVQ--QVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKT 866
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   202 DELKEGLRQRDELIEKHGLVIIPDSTPNGDVHHepvvgAITAVSQEAAQVLesagegPLDVRLRKLAGEKDELLSQI--- 278
Cdd:TIGR00606  867 NELKSEKLQIGTNLQRRQQFEEQLVELSTEVQS-----LIREIKDAKEQDS------PLETFLEKDQQEKEELISSKets 935
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   279 -RKLKLQLEEERQKCSRNDGMSGDLAG-LQNGSDLQFIEMQRDANR---QISEYKFKLSKAEQDIATLEQSISRlEGQVL 353
Cdd:TIGR00606  936 nKKAQDKVNDIKEKVKNIHGYMKDIENkIQDGKDDYLKQKETELNTvnaQLEECEKHQEKINEDMRLMRQDIDT-QKIQE 1014
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 258679524   354 RYKTAAENAEKIEDELKAERRKLQRELR-TAQDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 415
Cdd:TIGR00606 1015 RWLQDNLTLRKRENELKEVEEELKQHLKeMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQ 1077
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
260-414 5.48e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.13  E-value: 5.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524  260 LDVRLRKLAGEKDELLSQIRKLKLQLEEERQkcsrndgmsgdlaglqngsdlqfiemQRDANRQISEYKFklskAEQDIA 339
Cdd:COG4913   615 LEAELAELEEELAEAEERLEALEAELDALQE--------------------------RREALQRLAEYSW----DEIDVA 664
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 258679524  340 TLEQSISRLEGQvlryKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 414
Cdd:COG4913   665 SAEREIAELEAE----LERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDR 735
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
268-414 5.62e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.13  E-value: 5.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524  268 AGEKDELLSQIRKLKLQLEEERQKCSRNDGmsgdlagLQNGSDLQFIEMQRDANRQiseykfKLSKAEQDIATLEQSISR 347
Cdd:COG4913   247 AREQIELLEPIRELAERYAAARERLAELEY-------LRAALRLWFAQRRLELLEA------ELEELRAELARLEAELER 313
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 258679524  348 LEGQvlryktaaenaekiEDELKAERRKLQRELRTAQ-DKIEEMEMTNSHLAKRLEKMKANRTALLAQ 414
Cdd:COG4913   314 LEAR--------------LDALREELDELEAQIRGNGgDRLEQLEREIERLERELEERERRRARLEAL 367
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
320-415 6.91e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.21  E-value: 6.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524 320 ANRQISEYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEMEMTNSHLAK 399
Cdd:COG4942   18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97
                         90
                 ....*....|....*.
gi 258679524 400 RLEKMKAnrtaLLAQQ 415
Cdd:COG4942   98 ELEAQKE----ELAEL 109
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
124-391 8.48e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 38.51  E-value: 8.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   124 LSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYREN-----EEKSKELERQKHMCSVLQ 198
Cdd:TIGR02169  732 EEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLshsriPEIQAELSKLEEEVSRIE 811
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   199 HKMDELKEGLRQRDELIE-----KHGLVIIPDSTPNGDVHHEPVVGAITAVSQEAAQVLE--SAGEGPLDVRLRKLAGEK 271
Cdd:TIGR02169  812 ARLREIEQKLNRLTLEKEylekeIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEelEAALRDLESRLGDLKKER 891
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258679524   272 DELLSQIRKLKL---QLEEERQKcsRNDGMSGDLAGLQNGSD-LQFIEMQRDANRQISEYKFKLSKAEQDIATLEQSISR 347
Cdd:TIGR02169  892 DELEAQLRELERkieELEAQIEK--KRKRLSELKAKLEALEEeLSEIEDPKGEDEEIPEEELSLEDVQAELQRVEEEIRA 969
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 258679524   348 LEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEME 391
Cdd:TIGR02169  970 LEPVNMLAIQEYEEVLKRLDELKEKRAKLEEERKAILERIEEYE 1013
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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