NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|260166543|ref|NP_001159431|]
View 

gasdermin-B isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Gasdermin super family cl20270
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
5-233 1.34e-26

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


The actual alignment was detected with superfamily member pfam04598:

Pssm-ID: 398339  Cd Length: 240  Bit Score: 106.67  E-value: 1.34e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166543    5 FEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRTFFGC---RHYTTGLTLMDILDTDGDKwLDELDSGlqgqk 81
Cdd:pfam04598   2 FEKATRNLVKELDSGGDLIPVDSLNDSTKFQPFCLVTKKKRSSWFwqpRYVPVDFTLLDVLEPDSPV-PEPVESG----- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166543   82 aEFQILDNVDST--GELIVRLPKEITISGSFQGFHHQ--KIKISENRISQQYLATLENRKLKRELP-FSFRSINTRENLY 156
Cdd:pfam04598  76 -FFKFKDKMDGKvqGDVEVAAGGELKIGGGAAVSQSSfgSLEVQELSVQPLTLESLQERKLLDPEPsFLQQCRERGENLY 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166543  157 LVTETLETVKEETLKSDRQYKF-------WSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKETMNIHF--RGK 227
Cdd:pfam04598 155 VVTEVIETTQEVVLTEHSQVEGsgkgmlpGTKTVQGSGQGHKDKKVAVTIPKGTVLAYRVIQLVIKSDGQWEILLldDDK 234

                  ....*.
gi 260166543  228 TKSFPE 233
Cdd:pfam04598 235 QGTFEP 240
Gasdermin_C super family cl39239
Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion ...
239-365 5.96e-15

Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


The actual alignment was detected with superfamily member pfam17708:

Pssm-ID: 407590  Cd Length: 174  Bit Score: 72.39  E-value: 5.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166543  239 SEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGEL-HMEDPDKPLLSSLFNAAGVL 317
Cdd:pfam17708   1 HGDFSVLKKEVERQFQPLAKLPKDLQRALFSSLLALLRDEEALQALEDMLEDLCGGGELgPLDGPDGAILLELVGDSGLL 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 260166543  318 VEARAKAILDFLDALLELSEEQQFV-AEALEKGTLPLLKDQVKSVMEQN 365
Cdd:pfam17708  81 SQELADAILYLLSALAELSDTQLVLlATCCELQILPAQLELVESILEQN 129
 
Name Accession Description Interval E-value
Gasdermin pfam04598
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
5-233 1.34e-26

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 398339  Cd Length: 240  Bit Score: 106.67  E-value: 1.34e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166543    5 FEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRTFFGC---RHYTTGLTLMDILDTDGDKwLDELDSGlqgqk 81
Cdd:pfam04598   2 FEKATRNLVKELDSGGDLIPVDSLNDSTKFQPFCLVTKKKRSSWFwqpRYVPVDFTLLDVLEPDSPV-PEPVESG----- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166543   82 aEFQILDNVDST--GELIVRLPKEITISGSFQGFHHQ--KIKISENRISQQYLATLENRKLKRELP-FSFRSINTRENLY 156
Cdd:pfam04598  76 -FFKFKDKMDGKvqGDVEVAAGGELKIGGGAAVSQSSfgSLEVQELSVQPLTLESLQERKLLDPEPsFLQQCRERGENLY 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166543  157 LVTETLETVKEETLKSDRQYKF-------WSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKETMNIHF--RGK 227
Cdd:pfam04598 155 VVTEVIETTQEVVLTEHSQVEGsgkgmlpGTKTVQGSGQGHKDKKVAVTIPKGTVLAYRVIQLVIKSDGQWEILLldDDK 234

                  ....*.
gi 260166543  228 TKSFPE 233
Cdd:pfam04598 235 QGTFEP 240
Gasdermin_C pfam17708
Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion ...
239-365 5.96e-15

Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 407590  Cd Length: 174  Bit Score: 72.39  E-value: 5.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166543  239 SEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGEL-HMEDPDKPLLSSLFNAAGVL 317
Cdd:pfam17708   1 HGDFSVLKKEVERQFQPLAKLPKDLQRALFSSLLALLRDEEALQALEDMLEDLCGGGELgPLDGPDGAILLELVGDSGLL 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 260166543  318 VEARAKAILDFLDALLELSEEQQFV-AEALEKGTLPLLKDQVKSVMEQN 365
Cdd:pfam17708  81 SQELADAILYLLSALAELSDTQLVLlATCCELQILPAQLELVESILEQN 129
 
Name Accession Description Interval E-value
Gasdermin pfam04598
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
5-233 1.34e-26

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 398339  Cd Length: 240  Bit Score: 106.67  E-value: 1.34e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166543    5 FEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRTFFGC---RHYTTGLTLMDILDTDGDKwLDELDSGlqgqk 81
Cdd:pfam04598   2 FEKATRNLVKELDSGGDLIPVDSLNDSTKFQPFCLVTKKKRSSWFwqpRYVPVDFTLLDVLEPDSPV-PEPVESG----- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166543   82 aEFQILDNVDST--GELIVRLPKEITISGSFQGFHHQ--KIKISENRISQQYLATLENRKLKRELP-FSFRSINTRENLY 156
Cdd:pfam04598  76 -FFKFKDKMDGKvqGDVEVAAGGELKIGGGAAVSQSSfgSLEVQELSVQPLTLESLQERKLLDPEPsFLQQCRERGENLY 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166543  157 LVTETLETVKEETLKSDRQYKF-------WSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKETMNIHF--RGK 227
Cdd:pfam04598 155 VVTEVIETTQEVVLTEHSQVEGsgkgmlpGTKTVQGSGQGHKDKKVAVTIPKGTVLAYRVIQLVIKSDGQWEILLldDDK 234

                  ....*.
gi 260166543  228 TKSFPE 233
Cdd:pfam04598 235 QGTFEP 240
Gasdermin_C pfam17708
Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion ...
239-365 5.96e-15

Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 407590  Cd Length: 174  Bit Score: 72.39  E-value: 5.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166543  239 SEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGEL-HMEDPDKPLLSSLFNAAGVL 317
Cdd:pfam17708   1 HGDFSVLKKEVERQFQPLAKLPKDLQRALFSSLLALLRDEEALQALEDMLEDLCGGGELgPLDGPDGAILLELVGDSGLL 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 260166543  318 VEARAKAILDFLDALLELSEEQQFV-AEALEKGTLPLLKDQVKSVMEQN 365
Cdd:pfam17708  81 SQELADAILYLLSALAELSDTQLVLlATCCELQILPAQLELVESILEQN 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH