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Conserved domains on  [gi|260166700|ref|NP_001159453|]
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DDB1- and CUL4-associated factor 17 isoform a [Mus musculus]

Protein Classification

DCAF17 domain-containing protein( domain architecture ID 11239316)

DCAF17 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DCAF17 pfam15802
DDB1- and CUL4-associated factor 17; DCAF17, DDB1- and CUL4-associated factor 17, is a family ...
31-504 0e+00

DDB1- and CUL4-associated factor 17; DCAF17, DDB1- and CUL4-associated factor 17, is a family of proteins found in eukaryotes. It may function as a substrate-receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Mutations in the human protein, otherwise known as C2orf37, are responsible for Woodhouse-Sakati Syndrome. Woodhouse-Sakati Syndrome is a rare autosomal recessive multi-systemic disorder characterized by hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome.


:

Pssm-ID: 464881  Cd Length: 474  Bit Score: 868.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166700   31 TNLGILRALVCQESTKFKNVWTTHSKSPIAYERGRIYFDNYRCCVSSVASEPRKLYEMPKCSKSEKIEDALLWECPVGDI 110
Cdd:pfam15802   1 KNLKILRFLLLQDSTVFRNVWTKHSKSPIMYESGRIYFDNYRNCFSCVNGEPKILYKMPKCSKSEKIEDALLCQCPLEDV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166700  111 LPDPSDYKSSLIALTAHNWLLRISATTGEVLEKIYLASYCKFRYLSWDTPQEVIAVKSAQNKGSAAARQAGTSPPVLLYL 190
Cdd:pfam15802  81 LPSPSDYKPSLLALTANNWLLRISADTGEVLQKVYLSPLCKFRYLGWDVPQETLYVKSVQNKQTPLARQAGITQNVLMHL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166700  191 AVFRVLPFSLVGILEINKKVFEN-VTDATLSHGILIVMYSSGLVRLYSFQAIIEQFMQQKLDLGCACSQGGTTGTVGEAP 269
Cdd:pfam15802 161 AVFSVFPLQFVGILEINKKVFGNtVTDALLSQGILAVSHSSGLVRLYSFEHIVEKFMTQKLDLGQQCELNGGTGTVGDAP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166700  270 FGIPCNVKITDSPPPLFEVSSLENAFQIGGHPWHYIITPNKKKQKGVFHICALKDNSLAKNGIQEMECCSLESDWIYFHP 349
Cdd:pfam15802 241 FGIPVNIQITDCPPLLFEVSCLENGFQIGGFPWHYIYTPNKKKHKGTFHVCSLKDGTLAKNGIQDMKCCSLEPDWIFFHP 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166700  350 DASGRIIHVGPNQVKVLKLSEVENDSSQHQISEDFVIWAKREDRKENLITVTASGRVVKRNVSLLDDDPEQETFKIVDYE 429
Cdd:pfam15802 321 DDSGRIIHVGPNSINVLKLKEELNNDLGYEVLEDFSILASRENNPTSQVTVTSSGRTVKKRFQQLDDDPEQETFQMVDYE 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 260166700  430 DELDLLSVVaVTQIDAEGKAHLDFHCNEYGTLLKSIPLVESWDVTYSHEVYFDRDLVLHIEQKPNRVFSCYVYQM 504
Cdd:pfam15802 401 DELDLLAVV-VTQTESEGRAHIDLYDNQTGTLLKKIPLVESWDVTYSHEVFFDRDTIVHIEQKPNSKFCCYVYKM 474
 
Name Accession Description Interval E-value
DCAF17 pfam15802
DDB1- and CUL4-associated factor 17; DCAF17, DDB1- and CUL4-associated factor 17, is a family ...
31-504 0e+00

DDB1- and CUL4-associated factor 17; DCAF17, DDB1- and CUL4-associated factor 17, is a family of proteins found in eukaryotes. It may function as a substrate-receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Mutations in the human protein, otherwise known as C2orf37, are responsible for Woodhouse-Sakati Syndrome. Woodhouse-Sakati Syndrome is a rare autosomal recessive multi-systemic disorder characterized by hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome.


Pssm-ID: 464881  Cd Length: 474  Bit Score: 868.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166700   31 TNLGILRALVCQESTKFKNVWTTHSKSPIAYERGRIYFDNYRCCVSSVASEPRKLYEMPKCSKSEKIEDALLWECPVGDI 110
Cdd:pfam15802   1 KNLKILRFLLLQDSTVFRNVWTKHSKSPIMYESGRIYFDNYRNCFSCVNGEPKILYKMPKCSKSEKIEDALLCQCPLEDV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166700  111 LPDPSDYKSSLIALTAHNWLLRISATTGEVLEKIYLASYCKFRYLSWDTPQEVIAVKSAQNKGSAAARQAGTSPPVLLYL 190
Cdd:pfam15802  81 LPSPSDYKPSLLALTANNWLLRISADTGEVLQKVYLSPLCKFRYLGWDVPQETLYVKSVQNKQTPLARQAGITQNVLMHL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166700  191 AVFRVLPFSLVGILEINKKVFEN-VTDATLSHGILIVMYSSGLVRLYSFQAIIEQFMQQKLDLGCACSQGGTTGTVGEAP 269
Cdd:pfam15802 161 AVFSVFPLQFVGILEINKKVFGNtVTDALLSQGILAVSHSSGLVRLYSFEHIVEKFMTQKLDLGQQCELNGGTGTVGDAP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166700  270 FGIPCNVKITDSPPPLFEVSSLENAFQIGGHPWHYIITPNKKKQKGVFHICALKDNSLAKNGIQEMECCSLESDWIYFHP 349
Cdd:pfam15802 241 FGIPVNIQITDCPPLLFEVSCLENGFQIGGFPWHYIYTPNKKKHKGTFHVCSLKDGTLAKNGIQDMKCCSLEPDWIFFHP 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166700  350 DASGRIIHVGPNQVKVLKLSEVENDSSQHQISEDFVIWAKREDRKENLITVTASGRVVKRNVSLLDDDPEQETFKIVDYE 429
Cdd:pfam15802 321 DDSGRIIHVGPNSINVLKLKEELNNDLGYEVLEDFSILASRENNPTSQVTVTSSGRTVKKRFQQLDDDPEQETFQMVDYE 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 260166700  430 DELDLLSVVaVTQIDAEGKAHLDFHCNEYGTLLKSIPLVESWDVTYSHEVYFDRDLVLHIEQKPNRVFSCYVYQM 504
Cdd:pfam15802 401 DELDLLAVV-VTQTESEGRAHIDLYDNQTGTLLKKIPLVESWDVTYSHEVFFDRDTIVHIEQKPNSKFCCYVYKM 474
 
Name Accession Description Interval E-value
DCAF17 pfam15802
DDB1- and CUL4-associated factor 17; DCAF17, DDB1- and CUL4-associated factor 17, is a family ...
31-504 0e+00

DDB1- and CUL4-associated factor 17; DCAF17, DDB1- and CUL4-associated factor 17, is a family of proteins found in eukaryotes. It may function as a substrate-receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Mutations in the human protein, otherwise known as C2orf37, are responsible for Woodhouse-Sakati Syndrome. Woodhouse-Sakati Syndrome is a rare autosomal recessive multi-systemic disorder characterized by hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome.


Pssm-ID: 464881  Cd Length: 474  Bit Score: 868.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166700   31 TNLGILRALVCQESTKFKNVWTTHSKSPIAYERGRIYFDNYRCCVSSVASEPRKLYEMPKCSKSEKIEDALLWECPVGDI 110
Cdd:pfam15802   1 KNLKILRFLLLQDSTVFRNVWTKHSKSPIMYESGRIYFDNYRNCFSCVNGEPKILYKMPKCSKSEKIEDALLCQCPLEDV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166700  111 LPDPSDYKSSLIALTAHNWLLRISATTGEVLEKIYLASYCKFRYLSWDTPQEVIAVKSAQNKGSAAARQAGTSPPVLLYL 190
Cdd:pfam15802  81 LPSPSDYKPSLLALTANNWLLRISADTGEVLQKVYLSPLCKFRYLGWDVPQETLYVKSVQNKQTPLARQAGITQNVLMHL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166700  191 AVFRVLPFSLVGILEINKKVFEN-VTDATLSHGILIVMYSSGLVRLYSFQAIIEQFMQQKLDLGCACSQGGTTGTVGEAP 269
Cdd:pfam15802 161 AVFSVFPLQFVGILEINKKVFGNtVTDALLSQGILAVSHSSGLVRLYSFEHIVEKFMTQKLDLGQQCELNGGTGTVGDAP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166700  270 FGIPCNVKITDSPPPLFEVSSLENAFQIGGHPWHYIITPNKKKQKGVFHICALKDNSLAKNGIQEMECCSLESDWIYFHP 349
Cdd:pfam15802 241 FGIPVNIQITDCPPLLFEVSCLENGFQIGGFPWHYIYTPNKKKHKGTFHVCSLKDGTLAKNGIQDMKCCSLEPDWIFFHP 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166700  350 DASGRIIHVGPNQVKVLKLSEVENDSSQHQISEDFVIWAKREDRKENLITVTASGRVVKRNVSLLDDDPEQETFKIVDYE 429
Cdd:pfam15802 321 DDSGRIIHVGPNSINVLKLKEELNNDLGYEVLEDFSILASRENNPTSQVTVTSSGRTVKKRFQQLDDDPEQETFQMVDYE 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 260166700  430 DELDLLSVVaVTQIDAEGKAHLDFHCNEYGTLLKSIPLVESWDVTYSHEVYFDRDLVLHIEQKPNRVFSCYVYQM 504
Cdd:pfam15802 401 DELDLLAVV-VTQTESEGRAHIDLYDNQTGTLLKKIPLVESWDVTYSHEVFFDRDTIVHIEQKPNSKFCCYVYKM 474
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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