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Conserved domains on  [gi|262231791|ref|NP_001160096|]
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complement factor H-related protein 3 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 69-268 4.27e-16

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 75.84  E-value: 4.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262231791  69 YIHCTQNGWSPAVPCL-RKCYFPY-LENGYNQNYGRKFvqGNSTEVACHPGY---GLPKAQTTVTCT-EKGWSP-TPRCi 141
Cdd:PHA02927  67 YAKCTGTGWTLFNQCIkRRCPSPRdIDNGQLDIGGVDF--GSSITYSCNSGYqliGESKSYCELGSTgSMVWNPeAPIC- 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262231791 142 rvnSSEKCGPPPPISNGDTTSFLlKVYVPQSRVEYQCQPYYELQGSNYVTCSNGEWSEPP-----RCIHPCIiteenmnk 216
Cdd:PHA02927 144 ---ESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTI-------- 211

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 262231791 217 NNIKLKGRSDRKYyaKTGDTIEFMCKLGYNANTSILSFQAVCREGIVEYPRC 268
Cdd:PHA02927 212 SNGYLSSGFKRSY--SYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKC 261
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 69-268 4.27e-16

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 75.84  E-value: 4.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262231791  69 YIHCTQNGWSPAVPCL-RKCYFPY-LENGYNQNYGRKFvqGNSTEVACHPGY---GLPKAQTTVTCT-EKGWSP-TPRCi 141
Cdd:PHA02927  67 YAKCTGTGWTLFNQCIkRRCPSPRdIDNGQLDIGGVDF--GSSITYSCNSGYqliGESKSYCELGSTgSMVWNPeAPIC- 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262231791 142 rvnSSEKCGPPPPISNGDTTSFLlKVYVPQSRVEYQCQPYYELQGSNYVTCSNGEWSEPP-----RCIHPCIiteenmnk 216
Cdd:PHA02927 144 ---ESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTI-------- 211

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 262231791 217 NNIKLKGRSDRKYyaKTGDTIEFMCKLGYNANTSILSFQAVCREGIVEYPRC 268
Cdd:PHA02927 212 SNGYLSSGFKRSY--SYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKC 261
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 149-204 7.98e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 56.32  E-value: 7.98e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 262231791 149 CGPPPPISNGDTTSFLlKVYVPQSRVEYQCQPYYELQGSNYVTC-SNGEWS-EPPRCI 204
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCtENGGWSpPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
149-203 7.59e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.88  E-value: 7.59e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 262231791  149 CGPPPPISNGDTTSfLLKVYVPQSRVEYQCQPYYELQGSNYVTCS-NGEWS-EPPRC 203
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 149-203 1.29e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.52  E-value: 1.29e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 262231791   149 CGPPPPISNGDTTSFLlKVYVPQSRVEYQCQPYYELQGSNYVTC-SNGEWS-EPPRC 203
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITClENGTWSpPPPTC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 69-268 4.27e-16

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 75.84  E-value: 4.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262231791  69 YIHCTQNGWSPAVPCL-RKCYFPY-LENGYNQNYGRKFvqGNSTEVACHPGY---GLPKAQTTVTCT-EKGWSP-TPRCi 141
Cdd:PHA02927  67 YAKCTGTGWTLFNQCIkRRCPSPRdIDNGQLDIGGVDF--GSSITYSCNSGYqliGESKSYCELGSTgSMVWNPeAPIC- 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262231791 142 rvnSSEKCGPPPPISNGDTTSFLlKVYVPQSRVEYQCQPYYELQGSNYVTCSNGEWSEPP-----RCIHPCIiteenmnk 216
Cdd:PHA02927 144 ---ESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTI-------- 211

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 262231791 217 NNIKLKGRSDRKYyaKTGDTIEFMCKLGYNANTSILSFQAVCREGIVEYPRC 268
Cdd:PHA02927 212 SNGYLSSGFKRSY--SYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKC 261
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 149-204 7.98e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 56.32  E-value: 7.98e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 262231791 149 CGPPPPISNGDTTSFLlKVYVPQSRVEYQCQPYYELQGSNYVTC-SNGEWS-EPPRCI 204
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCtENGGWSpPPPTCE 57
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 13-144 7.43e-08

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 52.40  E-value: 7.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262231791  13 VSCANGQVKPCDfpdIKHGGLfhENMRRPYfpvAVGKYYSYYCDEHFETPSGSYwdyIHCTQNGWSPAVPCLRKCYFPYL 92
Cdd:PHA02954 123 VTCPNAECQPLQ---LEHGSC--QPVKEKY---SFGEHITINCDVGYEVIGASY---ISCTANSWNVIPSCQQKCDIPSL 191

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 262231791  93 ENGYNQnyGRKFVQGNSTEVACHPGYGLPKAQTTvTCTEKGWSPT-PRCIRVN 144
Cdd:PHA02954 192 SNGLIS--GSTFSIGGVIHLSCKSGFTLTGSPSS-TCIDGKWNPVlPICVRSN 241
Sushi pfam00084
Sushi repeat (SCR repeat);
149-203 7.59e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.88  E-value: 7.59e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 262231791  149 CGPPPPISNGDTTSfLLKVYVPQSRVEYQCQPYYELQGSNYVTCS-NGEWS-EPPRC 203
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 149-203 1.29e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.52  E-value: 1.29e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 262231791   149 CGPPPPISNGDTTSFLlKVYVPQSRVEYQCQPYYELQGSNYVTC-SNGEWS-EPPRC 203
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITClENGTWSpPPPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 23-204 4.04e-04

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 41.19  E-value: 4.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262231791  23 CDFPDIKHGGLFHENMRRpyfpVAVGKYYSYYCDEHFETPSGSYWDYIHCTQNG-WSPAVP--CLRKCYFP-YLENGYNQ 98
Cdd:PHA02639  22 CDKPDDISNGFITELMEK----YEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAiWSNKAPfcMLKECNDPpSIINGKIY 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262231791  99 NYGRKFVQGNSTEVACHPGYGLPKA---QTTVTCTE-KGWSPTPR-CIRVNSSEkcgppPPISNGDTTSFLL-KVYVPQS 172
Cdd:PHA02639  98 NKREMYKVGDEIYYVCNEHKGVQYSlvgNEKITCIQdKSWKPDPPiCKMINCRF-----PALQNGYINGIPSnKKFYYKT 172

                        170       180       190
                 ....*....|....*....|....*....|....
gi 262231791 173 RVEYQCQPYYELQGSNYVTCS-NGEW-SEPPRCI 204
Cdd:PHA02639 173 RVGFSCKSGFDLVGEKYSTCNiNATWfPSIPTCV 206
PHA02817 PHA02817
EEV Host range protein; Provisional
 1-146 6.34e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 39.92  E-value: 6.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262231791   1 MLLLINVILtlwvsCANGQVKPCDFPDIKHGGLFheNMRRPYfpvAVGKYYSYYCDEHFETPSGSYW--DYIHCTQNG-W 77
Cdd:PHA02817   8 LILLCNKVY-----SLCDLNKCCYPPSIKNGYIY--NKKTEY---NIGSNVTFFCGNNTRGVRYTLVgeKNIICEKDGkW 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 262231791  78 SPAVPCLR--KCYFPYLENGYNQNY--GRKFVQGNSTEVACHPGYGLPKAQTTVTCTEKGWSP-TPRCIRVNSS 146
Cdd:PHA02817  78 NKEFPVCKiiRCRFPALQNGFVNGIpdSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPkVPICSRDNIT 151
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 69-204 9.87e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 40.07  E-value: 9.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262231791  69 YIHCTQ-NG---WSPAVPCLR-KCYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGLPKAqTTVTCTEKGWSPTPRCirv 143
Cdd:PHA02954 107 YFRCEEkNGntsWNDTVTCPNaECQPLQLEHGSCQPVKEKYSFGEHITINCDVGYEVIGA-SYISCTANSWNVIPSC--- 182

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 262231791 144 nsSEKCGPPPpISNGDTTSFLLKVyvpQSRVEYQCQPYYELQGSNYVTCSNGEWSEP-PRCI 204
Cdd:PHA02954 183 --QQKCDIPS-LSNGLISGSTFSI---GGVIHLSCKSGFTLTGSPSSTCIDGKWNPVlPICV 238
PHA02831 PHA02831
EEV host range protein; Provisional
 70-142 1.41e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 39.21  E-value: 1.41e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 262231791  70 IHCTQNGWSPAVPC--LRKCYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGLPKAQTTVTCTEKGWSPT-PRCIR 142
Cdd:PHA02831 122 VKCINKQWVPKYPVckLIRCKYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGiPKCVK 197
PHA02831 PHA02831
EEV host range protein; Provisional
 162-269 1.85e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 38.82  E-value: 1.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262231791 162 SFLLKVYVPQSRVEYQCQPYYElqgSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNiKLKGRSDRKYYaktGDTIEFMC 241
Cdd:PHA02831  34 SYENKVYEENENLEYKCNNNFD---KVFVTCNNGSWSTKNMCIGKRNCKDPVTILNG-YIKNKKDQYSF---GDSVTYAC 106

                         90       100       110
                 ....*....|....*....|....*....|.
gi 262231791 242 KLGYNANTSILSFQAV-CREG--IVEYPRCE 269
Cdd:PHA02831 107 KVNKLEKYSIVGNETVkCINKqwVPKYPVCK 137
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 87-141 2.64e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 35.52  E-value: 2.64e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 262231791  87 CYFPY-LENGYNQNYGRKFVQGNSTEVACHPGYGLpKAQTTVTCTEKG-WSPT-PRCI 141
Cdd:cd00033    1 CPPPPvPENGTVTGSKGSYSYGSTVTYSCNEGYTL-VGSSTITCTENGgWSPPpPTCE 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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