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Conserved domains on  [gi|269846910|ref|NP_001161337|]
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non-structural maintenance of chromosomes element 4 homolog A isoform 2 [Homo sapiens]

Protein Classification

non-structural maintenance of chromosomes element 4 family protein( domain architecture ID 10634160)

non-structural maintenance of chromosomes (non-SMC) element 4 (NSE4) family protein has key roles in the maintenance of chromosome integrity during mitotic proliferation, meiosis, and DNA repair and is critical for genome stability

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nse4_C pfam08743
Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges ...
 285-373 5.23e-33

Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges the heads of Smc5 and Smc6. This is the C-terminal domain of Nse4 that interacts with the head domain of Smc5.


:

Pssm-ID: 462585  Cd Length: 89  Bit Score: 118.40  E-value: 5.23e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269846910  285 PMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIEPVSINEENEGFEHNTQvRNQGIIALSYRDWE-IV 363
Cdd:pfam08743   1 PINLFKFVINPKSFAQTVENLFYLSFLVKDGRVGIELDEDGLPVLEPVAPPEEEEAKEGGVS-RNQAVFSLDMKTWKeLI 79

                          90
                  ....*....|
gi 269846910  364 KTFEISEPVI 373
Cdd:pfam08743  80 EAFDITEPMI 89
Nse4-Nse3_bdg pfam15412
Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that ...
 133-187 1.96e-11

Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that bind over this region to the Nse3 pocket, in MAGE family pfam01454.


:

Pssm-ID: 464708  Cd Length: 56  Bit Score: 58.76  E-value: 1.96e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 269846910  133 DAHFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEELIRDEDS 187
Cdd:pfam15412   1 DSRLLVLASDLGAEKARNLKSGGGGFDVDEFVSKLKTFMGGNRLEGAGEEDDDDD 55
 
Name Accession Description Interval E-value
Nse4_C pfam08743
Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges ...
 285-373 5.23e-33

Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges the heads of Smc5 and Smc6. This is the C-terminal domain of Nse4 that interacts with the head domain of Smc5.


Pssm-ID: 462585  Cd Length: 89  Bit Score: 118.40  E-value: 5.23e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269846910  285 PMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIEPVSINEENEGFEHNTQvRNQGIIALSYRDWE-IV 363
Cdd:pfam08743   1 PINLFKFVINPKSFAQTVENLFYLSFLVKDGRVGIELDEDGLPVLEPVAPPEEEEAKEGGVS-RNQAVFSLDMKTWKeLI 79

                          90
                  ....*....|
gi 269846910  364 KTFEISEPVI 373
Cdd:pfam08743  80 EAFDITEPMI 89
COG5125 COG5125
Uncharacterized conserved protein [Function unknown];
231-373 3.57e-12

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227454 [Multi-domain]  Cd Length: 259  Bit Score: 65.79  E-value: 3.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269846910 231 PRVDRPRKVPVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQtyfredPDTPMSFFDFVVDPHSFPRTVENIFHVSF 310
Cdd:COG5125  130 PSRRRAQSQRSRQTLPETEVPTNITRQEDSVEEPKILAQISRLLA------EKGRTNYFKFIIDPRSFSKTIENLFYLSF 203

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 269846910 311 IIRDGFARIRLDQDRLPVIEPVSIneenegFEHNTqvrNQGIIALSYRDW-EIVKTFEISEPVI 373
Cdd:COG5125  204 LLKEGKAFLEFDEDGTLYVVSEGS------EGAST---GHLVVEMTYDEYlRIVERMGISKAMI 258
Nse4-Nse3_bdg pfam15412
Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that ...
 133-187 1.96e-11

Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that bind over this region to the Nse3 pocket, in MAGE family pfam01454.


Pssm-ID: 464708  Cd Length: 56  Bit Score: 58.76  E-value: 1.96e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 269846910  133 DAHFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEELIRDEDS 187
Cdd:pfam15412   1 DSRLLVLASDLGAEKARNLKSGGGGFDVDEFVSKLKTFMGGNRLEGAGEEDDDDD 55
 
Name Accession Description Interval E-value
Nse4_C pfam08743
Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges ...
 285-373 5.23e-33

Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges the heads of Smc5 and Smc6. This is the C-terminal domain of Nse4 that interacts with the head domain of Smc5.


Pssm-ID: 462585  Cd Length: 89  Bit Score: 118.40  E-value: 5.23e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269846910  285 PMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIEPVSINEENEGFEHNTQvRNQGIIALSYRDWE-IV 363
Cdd:pfam08743   1 PINLFKFVINPKSFAQTVENLFYLSFLVKDGRVGIELDEDGLPVLEPVAPPEEEEAKEGGVS-RNQAVFSLDMKTWKeLI 79

                          90
                  ....*....|
gi 269846910  364 KTFEISEPVI 373
Cdd:pfam08743  80 EAFDITEPMI 89
COG5125 COG5125
Uncharacterized conserved protein [Function unknown];
231-373 3.57e-12

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227454 [Multi-domain]  Cd Length: 259  Bit Score: 65.79  E-value: 3.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269846910 231 PRVDRPRKVPVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQtyfredPDTPMSFFDFVVDPHSFPRTVENIFHVSF 310
Cdd:COG5125  130 PSRRRAQSQRSRQTLPETEVPTNITRQEDSVEEPKILAQISRLLA------EKGRTNYFKFIIDPRSFSKTIENLFYLSF 203

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 269846910 311 IIRDGFARIRLDQDRLPVIEPVSIneenegFEHNTqvrNQGIIALSYRDW-EIVKTFEISEPVI 373
Cdd:COG5125  204 LLKEGKAFLEFDEDGTLYVVSEGS------EGAST---GHLVVEMTYDEYlRIVERMGISKAMI 258
Nse4-Nse3_bdg pfam15412
Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that ...
 133-187 1.96e-11

Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that bind over this region to the Nse3 pocket, in MAGE family pfam01454.


Pssm-ID: 464708  Cd Length: 56  Bit Score: 58.76  E-value: 1.96e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 269846910  133 DAHFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEELIRDEDS 187
Cdd:pfam15412   1 DSRLLVLASDLGAEKARNLKSGGGGFDVDEFVSKLKTFMGGNRLEGAGEEDDDDD 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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