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Conserved domains on  [gi|288541323|ref|NP_001165359|]
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FGFR1 oncogene partner 2 isoform 3 [Homo sapiens]

Protein Classification

SIKE family protein( domain architecture ID 10530487)

SIKE family protein is a DUF837 domain-containing protein; similar to Homo sapiens suppressor of IKBKE 1 and FGFR1 oncogene partner 2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SIKE pfam05769
SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) ...
 2-133 6.41e-60

SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) is a physiological suppressor of IKK-epsilon and TBK1, which are two IKK-related kinases involved in virus- and TLR3-triggered activation of interferon regulatory factor 3 (IRF-3). Other members of this family are circulating cathodic antigen (CCA), found in Schistosoma mansoni (Blood fluke), and FGFR1 oncogene partner 2, which may be involved in wound healing pathway.


:

Pssm-ID: 461735 [Multi-domain]  Cd Length: 180  Bit Score: 184.01  E-value: 6.41e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541323    2 SCTIEKALADAKALVERLRDHDDAAESLIEQTTALNKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQ 81
Cdd:pfam05769   1 SLTIEQILADAKRLVGRLKEHDTAADSLIEQAQALNKKIEAMKQYQEELKELNEAAKHRPHSLLIAGIQQENRQIRELQQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 288541323   82 ENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDDPGIIMKLkeQHSKI 133
Cdd:pfam05769  81 ENRELRASLEEHQSALELIMSKYREQVLQLLLASKFNFTDAYLSL--QLSEE 130
 
Name Accession Description Interval E-value
SIKE pfam05769
SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) ...
 2-133 6.41e-60

SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) is a physiological suppressor of IKK-epsilon and TBK1, which are two IKK-related kinases involved in virus- and TLR3-triggered activation of interferon regulatory factor 3 (IRF-3). Other members of this family are circulating cathodic antigen (CCA), found in Schistosoma mansoni (Blood fluke), and FGFR1 oncogene partner 2, which may be involved in wound healing pathway.


Pssm-ID: 461735 [Multi-domain]  Cd Length: 180  Bit Score: 184.01  E-value: 6.41e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541323    2 SCTIEKALADAKALVERLRDHDDAAESLIEQTTALNKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQ 81
Cdd:pfam05769   1 SLTIEQILADAKRLVGRLKEHDTAADSLIEQAQALNKKIEAMKQYQEELKELNEAAKHRPHSLLIAGIQQENRQIRELQQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 288541323   82 ENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDDPGIIMKLkeQHSKI 133
Cdd:pfam05769  81 ENRELRASLEEHQSALELIMSKYREQVLQLLLASKFNFTDAYLSL--QLSEE 130
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
12-107 3.07e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 37.20  E-value: 3.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541323   12 AKALVERLRDHDDAAESLIEQTTALNKRVEAMKQYQEEIQELNEVARHRPRSTL----------VMGIQQENRQIRELQQ 81
Cdd:COG4913   694 LEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELralleerfaaALGDAVERELRENLEE 773

                          90       100
                  ....*....|....*....|....*.
gi 288541323   82 ENKELRTSLEEHQSALELIMSKYREQ 107
Cdd:COG4913   774 RIDALRARLNRAEEELERAMRAFNRE 799
 
Name Accession Description Interval E-value
SIKE pfam05769
SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) ...
 2-133 6.41e-60

SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) is a physiological suppressor of IKK-epsilon and TBK1, which are two IKK-related kinases involved in virus- and TLR3-triggered activation of interferon regulatory factor 3 (IRF-3). Other members of this family are circulating cathodic antigen (CCA), found in Schistosoma mansoni (Blood fluke), and FGFR1 oncogene partner 2, which may be involved in wound healing pathway.


Pssm-ID: 461735 [Multi-domain]  Cd Length: 180  Bit Score: 184.01  E-value: 6.41e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541323    2 SCTIEKALADAKALVERLRDHDDAAESLIEQTTALNKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQ 81
Cdd:pfam05769   1 SLTIEQILADAKRLVGRLKEHDTAADSLIEQAQALNKKIEAMKQYQEELKELNEAAKHRPHSLLIAGIQQENRQIRELQQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 288541323   82 ENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDDPGIIMKLkeQHSKI 133
Cdd:pfam05769  81 ENRELRASLEEHQSALELIMSKYREQVLQLLLASKFNFTDAYLSL--QLSEE 130
Tho2 pfam11262
Transcription factor/nuclear export subunit protein 2; THO and TREX form a eukaryotic complex ...
 43-144 1.01e-03

Transcription factor/nuclear export subunit protein 2; THO and TREX form a eukaryotic complex which functions in messenger ribonucleoprotein metabolism and plays a role in preventing the transcription-associated genetic instability. Tho2, along with four other subunits forms THO


Pssm-ID: 463251  Cd Length: 304  Bit Score: 38.37  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541323   43 MKQYQEEIQELNEVAR---HRPRSTLVMGIQQENRQIRELQQENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDD 119
Cdd:pfam11262  23 TESYEAEIERLKKQIRelsRDRSDMSRAGASKKKKEKKRLEALIDKLKEELKEHIEHVEKTRKRLQKEKDSWFPGSKAKK 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 288541323  120 PGIIMKLKEQ-------HSKID---------MVHRNKSEGF 144
Cdd:pfam11262 103 NALIDAFLQHcilpralLSPADalycakfikLLHELGTPNF 143
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
12-107 3.07e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 37.20  E-value: 3.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541323   12 AKALVERLRDHDDAAESLIEQTTALNKRVEAMKQYQEEIQELNEVARHRPRSTL----------VMGIQQENRQIRELQQ 81
Cdd:COG4913   694 LEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELralleerfaaALGDAVERELRENLEE 773

                          90       100
                  ....*....|....*....|....*.
gi 288541323   82 ENKELRTSLEEHQSALELIMSKYREQ 107
Cdd:COG4913   774 RIDALRARLNRAEEELERAMRAFNRE 799
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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