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Conserved domains on  [gi|511093995|ref|NP_001165411|]
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fibronectin type III domain-containing protein 5 isoform 3 preproprotein [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein with an immunoglobulin-like (Ig-like) fold similar to mammalian interleukin-9 and interleukin-21 receptors, and to immunoglobulin I-set domains (antibody intermediate domain-like) such as myomesin, contactin, neural cell adhesion molecule 1, roundabout homologs, and cell adhesion molecules, among others

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  9541533|7833045|8981327|7932691

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 34-124 1.04e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.37  E-value: 1.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511093995  34 PSAPVNVTVRHLKANSAVVSWDVLEDE--VVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQ 111
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|...
gi 511093995 112 GQSPASEPVLFKT 124
Cdd:cd00063   81 GESPPSESVTVTT 93
DUF4808 super family cl24589
Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. ...
 151-172 8.64e-04

Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 106 and 135 amino acids in length.


The actual alignment was detected with superfamily member pfam16066:

Pssm-ID: 374343  Cd Length: 121  Bit Score: 37.46  E-value: 8.64e-04
                          10        20
                  ....*....|....*....|..
gi 511093995  151 RTGEVLIIVVVLFMWAGVIALF 172
Cdd:pfam16066   3 RGEEILIVVLVLIVWVAAIALF 24
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 34-124 1.04e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.37  E-value: 1.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511093995  34 PSAPVNVTVRHLKANSAVVSWDVLEDE--VVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQ 111
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|...
gi 511093995 112 GQSPASEPVLFKT 124
Cdd:cd00063   81 GESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 34-114 1.26e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.32  E-value: 1.26e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511093995    34 PSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAIS--QQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQ 111
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGyrVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 511093995   112 GQS 114
Cdd:smart00060  81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
35-117 1.05e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 1.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511093995   35 SAPVNVTVRHLKANSAVVSWDVLED--EVVIGFAIsqQKKDVRMLRFIQEVNT--TTRSCALWDLEEDTEYIVHVQAISI 110
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDgnGPITGYEV--EYRPKNSGEPWNEITVpgTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  ....*..
gi 511093995  111 QGQSPAS 117
Cdd:pfam00041  79 GGEGPPS 85
DUF4808 pfam16066
Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. ...
 151-172 8.64e-04

Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 106 and 135 amino acids in length.


Pssm-ID: 374343  Cd Length: 121  Bit Score: 37.46  E-value: 8.64e-04
                          10        20
                  ....*....|....*....|..
gi 511093995  151 RTGEVLIIVVVLFMWAGVIALF 172
Cdd:pfam16066   3 RGEEILIVVLVLIVWVAAIALF 24
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
34-120 9.22e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.22  E-value: 9.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511093995  34 PSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQKKDVRMLRFIQEVNTT----TrscalwDLEEDTEYIVHVQAIS 109
Cdd:COG3401  233 PSAPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTKVATVTTTsytdT------GLTNGTTYYYRVTAVD 306

                         90
                 ....*....|..
gi 511093995 110 IQG-QSPASEPV 120
Cdd:COG3401  307 AAGnESAPSNVV 318
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 34-124 1.04e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.37  E-value: 1.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511093995  34 PSAPVNVTVRHLKANSAVVSWDVLEDE--VVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQ 111
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|...
gi 511093995 112 GQSPASEPVLFKT 124
Cdd:cd00063   81 GESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 34-114 1.26e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.32  E-value: 1.26e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511093995    34 PSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAIS--QQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQ 111
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGyrVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 511093995   112 GQS 114
Cdd:smart00060  81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
35-117 1.05e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 1.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511093995   35 SAPVNVTVRHLKANSAVVSWDVLED--EVVIGFAIsqQKKDVRMLRFIQEVNT--TTRSCALWDLEEDTEYIVHVQAISI 110
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDgnGPITGYEV--EYRPKNSGEPWNEITVpgTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  ....*..
gi 511093995  111 QGQSPAS 117
Cdd:pfam00041  79 GGEGPPS 85
DUF4808 pfam16066
Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. ...
 151-172 8.64e-04

Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 106 and 135 amino acids in length.


Pssm-ID: 374343  Cd Length: 121  Bit Score: 37.46  E-value: 8.64e-04
                          10        20
                  ....*....|....*....|..
gi 511093995  151 RTGEVLIIVVVLFMWAGVIALF 172
Cdd:pfam16066   3 RGEEILIVVLVLIVWVAAIALF 24
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
34-120 9.22e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.22  E-value: 9.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511093995  34 PSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQKKDVRMLRFIQEVNTT----TrscalwDLEEDTEYIVHVQAIS 109
Cdd:COG3401  233 PSAPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTKVATVTTTsytdT------GLTNGTTYYYRVTAVD 306

                         90
                 ....*....|..
gi 511093995 110 IQG-QSPASEPV 120
Cdd:COG3401  307 AAGnESAPSNVV 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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