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Conserved domains on  [gi|289547680|ref|NP_001166139|]
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zinc finger protein 668 isoform a [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
80-414 1.44e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 1.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680  80 KPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGR--RFMQPVCLRVHLASHAGELPFRCAH-CPKAYGALSKLK 156
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 157 IHQRGHTGERPYACADCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELK----------------------DLRNH 214
Cdd:COG5048  110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 215 ERSHTGERPFLCSECGKSFSR-------------SSSLTCHQRIHA---------------------AQKPYRCPACGKG 260
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSipssssdqnlensSSSLPLTTNSQLspksllsqspsslsssdssssASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 261 FTQLSSYQSHERTHSG-EKPFLCPRCGRMFSDPSSFRRHQRAH----EGVKPYHC--EKCGKDFRQPADLAMHRRVHTGD 333
Cdd:COG5048  270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 334 RPFKC--LQCDKTFVASWDLKRHALVH-----SGQRPFRCE--ECGRAFAERASLTKHSRVHSGERP--FHCNACGKSFV 402
Cdd:COG5048  350 SPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFN 429

                        410
                 ....*....|..
gi 289547680 403 VSSSLRKHERTH 414
Cdd:COG5048  430 RHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
248-595 8.37e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 8.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 248 AQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGR--MFSDPSSFRRHQRAHEGVKPYHCEKCGKDFRQPADLAM 325
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 326 HRRVHTGdrPFKCLQCDKtfvaswdlkrHALVHSGQRPFRCEEcgrafaerasltkHSRVHSGERPFH-CNACGKSFVVS 404
Cdd:COG5048  110 LSSSSSN--SNDNNLLSS----------HSLPPSSRDPQLPDL-------------LSISNLRNNPLPgNNSSSVNTPQS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 405 SSLR-----KHERTHRSSEAAGVPPAQELVVGLALPVGVAGESSA--APAAGAGLGDPPAGLLGLPPESGGV--MATQWQ 475
Cdd:COG5048  165 NSLHpplpaNSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYsiPSSSSDQNLENSSSSLPLTTNSQLSpkSLLSQS 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 476 VVG--MTVEHVECQDagVREAPGPLEGAGEAGGEEADEKPPQ-----FVCRECKETFSTMTLLRRHERSH----PELRPF 544
Cdd:COG5048  245 PSSlsSSDSSSSASE--SPRSSLPTASSQSSSPNESDSSSEKgfslpIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPF 322

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 289547680 545 PCT--QCGKSFSDRAGLRKHSRTHSSVRPYTCP--HCPKAFLSASDLRKHERTHP 595
Cdd:COG5048  323 SCPysLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQ 377
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
80-414 1.44e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 1.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680  80 KPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGR--RFMQPVCLRVHLASHAGELPFRCAH-CPKAYGALSKLK 156
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 157 IHQRGHTGERPYACADCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELK----------------------DLRNH 214
Cdd:COG5048  110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 215 ERSHTGERPFLCSECGKSFSR-------------SSSLTCHQRIHA---------------------AQKPYRCPACGKG 260
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSipssssdqnlensSSSLPLTTNSQLspksllsqspsslsssdssssASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 261 FTQLSSYQSHERTHSG-EKPFLCPRCGRMFSDPSSFRRHQRAH----EGVKPYHC--EKCGKDFRQPADLAMHRRVHTGD 333
Cdd:COG5048  270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 334 RPFKC--LQCDKTFVASWDLKRHALVH-----SGQRPFRCE--ECGRAFAERASLTKHSRVHSGERP--FHCNACGKSFV 402
Cdd:COG5048  350 SPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFN 429

                        410
                 ....*....|..
gi 289547680 403 VSSSLRKHERTH 414
Cdd:COG5048  430 RHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
248-595 8.37e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 8.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 248 AQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGR--MFSDPSSFRRHQRAHEGVKPYHCEKCGKDFRQPADLAM 325
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 326 HRRVHTGdrPFKCLQCDKtfvaswdlkrHALVHSGQRPFRCEEcgrafaerasltkHSRVHSGERPFH-CNACGKSFVVS 404
Cdd:COG5048  110 LSSSSSN--SNDNNLLSS----------HSLPPSSRDPQLPDL-------------LSISNLRNNPLPgNNSSSVNTPQS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 405 SSLR-----KHERTHRSSEAAGVPPAQELVVGLALPVGVAGESSA--APAAGAGLGDPPAGLLGLPPESGGV--MATQWQ 475
Cdd:COG5048  165 NSLHpplpaNSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYsiPSSSSDQNLENSSSSLPLTTNSQLSpkSLLSQS 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 476 VVG--MTVEHVECQDagVREAPGPLEGAGEAGGEEADEKPPQ-----FVCRECKETFSTMTLLRRHERSH----PELRPF 544
Cdd:COG5048  245 PSSlsSSDSSSSASE--SPRSSLPTASSQSSSPNESDSSSEKgfslpIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPF 322

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 289547680 545 PCT--QCGKSFSDRAGLRKHSRTHSSVRPYTCP--HCPKAFLSASDLRKHERTHP 595
Cdd:COG5048  323 SCPysLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQ 377
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-235 1.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.79e-04
                          10        20
                  ....*....|....*....|....*.
gi 289547680  210 DLRNHERSHTGERPFLCSECGKSFSR 235
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
559-583 3.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.09e-03
                          10        20
                  ....*....|....*....|....*
gi 289547680  559 LRKHSRTHSSVRPYTCPHCPKAFLS 583
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
80-414 1.44e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 1.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680  80 KPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGR--RFMQPVCLRVHLASHAGELPFRCAH-CPKAYGALSKLK 156
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 157 IHQRGHTGERPYACADCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELK----------------------DLRNH 214
Cdd:COG5048  110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 215 ERSHTGERPFLCSECGKSFSR-------------SSSLTCHQRIHA---------------------AQKPYRCPACGKG 260
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSipssssdqnlensSSSLPLTTNSQLspksllsqspsslsssdssssASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 261 FTQLSSYQSHERTHSG-EKPFLCPRCGRMFSDPSSFRRHQRAH----EGVKPYHC--EKCGKDFRQPADLAMHRRVHTGD 333
Cdd:COG5048  270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 334 RPFKC--LQCDKTFVASWDLKRHALVH-----SGQRPFRCE--ECGRAFAERASLTKHSRVHSGERP--FHCNACGKSFV 402
Cdd:COG5048  350 SPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFN 429

                        410
                 ....*....|..
gi 289547680 403 VSSSLRKHERTH 414
Cdd:COG5048  430 RHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-385 2.87e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 2.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 223 PFLCSECGKSFSRSSSLTCHQR--IH--AAQKPYRCPA--CGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDPSSF- 295
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLn 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 296 -RRHQRAH-----EGVKPYHCE--KCGKDFRQPADLAMHRRVHTGDRP--FKCLQCDKTFVASWDLKRHALVHSGQRPFR 365
Cdd:COG5048  369 nEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        170       180
                 ....*....|....*....|
gi 289547680 366 CEECGRaFAERASLTKHSRV 385
Cdd:COG5048  449 CSILKS-FRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
248-595 8.37e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 8.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 248 AQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGR--MFSDPSSFRRHQRAHEGVKPYHCEKCGKDFRQPADLAM 325
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 326 HRRVHTGdrPFKCLQCDKtfvaswdlkrHALVHSGQRPFRCEEcgrafaerasltkHSRVHSGERPFH-CNACGKSFVVS 404
Cdd:COG5048  110 LSSSSSN--SNDNNLLSS----------HSLPPSSRDPQLPDL-------------LSISNLRNNPLPgNNSSSVNTPQS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 405 SSLR-----KHERTHRSSEAAGVPPAQELVVGLALPVGVAGESSA--APAAGAGLGDPPAGLLGLPPESGGV--MATQWQ 475
Cdd:COG5048  165 NSLHpplpaNSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYsiPSSSSDQNLENSSSSLPLTTNSQLSpkSLLSQS 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 476 VVG--MTVEHVECQDagVREAPGPLEGAGEAGGEEADEKPPQ-----FVCRECKETFSTMTLLRRHERSH----PELRPF 544
Cdd:COG5048  245 PSSlsSSDSSSSASE--SPRSSLPTASSQSSSPNESDSSSEKgfslpIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPF 322

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 289547680 545 PCT--QCGKSFSDRAGLRKHSRTHSSVRPYTCP--HCPKAFLSASDLRKHERTHP 595
Cdd:COG5048  323 SCPysLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQ 377
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-299 1.02e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 138 LPFRCAHCPKAYGALSKLKIHQRG--HTGE--RPYAC--ADCGKSFADPSVFRKHRRTHAGLRPYSC--ERCGKAYAELK 209
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 210 DLRNHERSH-----TGERPFLC--SECGKSFSRSSSLTCHQRIHAAQKP--YRCPACGKGFTQLSSYQSHERTHSGEKPF 280
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*....
gi 289547680 281 LCPRCGRMFSDPSSFRRHQ 299
Cdd:COG5048  448 LCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 192-275 5.27e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 5.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 192 GLRPYSCE--RCGKAYAELKDLRNHErshtgerpfLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQS 269
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 289547680 270 HeRTHS 275
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-235 1.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.79e-04
                          10        20
                  ....*....|....*....|....*.
gi 289547680  210 DLRNHERSHTGERPFLCSECGKSFSR 235
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
98-121 1.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.24e-03
                          10        20
                  ....*....|....*....|....
gi 289547680   98 ELRSHGRSHTGEKPFPCPECGRRF 121
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 321-414 2.86e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547680 321 ADLAMHRRVHTGDRPFKC--LQCDKTFVASWDLKRHALvHSGQRPfrceecgrAFAERASLTKHSRVHSGERPFHCNACG 398
Cdd:COG5189  335 IDTPSRMLKVKDGKPYKCpvEGCNKKYKNQNGLKYHML-HGHQNQ--------KLHENPSPEKMNIFSAKDKPYRCEVCD 405

                         90
                 ....*....|....*.
gi 289547680 399 KSFVVSSSLRKHeRTH 414
Cdd:COG5189  406 KRYKNLNGLKYH-RKH 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
559-583 3.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.09e-03
                          10        20
                  ....*....|....*....|....*
gi 289547680  559 LRKHSRTHSSVRPYTCPHCPKAFLS 583
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
322-346 3.45e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.45e-03
                          10        20
                  ....*....|....*....|....*
gi 289547680  322 DLAMHRRVHTGDRPFKCLQCDKTFV 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
155-178 3.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.62e-03
                          10        20
                  ....*....|....*....|....
gi 289547680  155 LKIHQRGHTGERPYACADCGKSFA 178
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
531-554 3.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.80e-03
                          10        20
                  ....*....|....*....|....
gi 289547680  531 LRRHERSHPELRPFPCTQCGKSFS 554
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-402 3.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.91e-03
                          10        20
                  ....*....|....*....|....*
gi 289547680  378 SLTKHSRVHSGERPFHCNACGKSFV 402
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 544-566 6.55e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.55e-03
                          10        20
                  ....*....|....*....|...
gi 289547680  544 FPCTQCGKSFSDRAGLRKHSRTH 566
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-374 7.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.20e-03
                          10        20
                  ....*....|....*....|....*
gi 289547680  350 DLKRHALVHSGQRPFRCEECGRAFA 374
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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