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Conserved domains on  [gi|289666734|ref|NP_001166238|]
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forkhead box protein P2 isoform VI [Homo sapiens]

Protein Classification

FOXP family forkhead box protein( domain architecture ID 11241229)

FOXP family forkhead box protein, similar to forkhead box protein P1 which is necessary for the proper development of the brain, heart, and lung in mammals

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FOXP-CC pfam16159
FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found ...
 367-434 4.54e-42

FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found in Forkhead box proteins in various Mammalia species. It is a coiled-coil domain, which modulates the dimeric associations of FOXP transcription factors. Several key disease mutations, for instance those found in the IPEX syndrome are located in this domain


:

Pssm-ID: 465036  Cd Length: 68  Bit Score: 143.21  E-value: 4.54e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 289666734  367 LYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHL 434
Cdd:pfam16159   1 LFGHGVCRWPGCETVCEDFGSFLKHLNSEHALDDRSTAQCRVQMQVVQQLEIQLTKEKERLQAMMAHL 68
 
Name Accession Description Interval E-value
FOXP-CC pfam16159
FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found ...
 367-434 4.54e-42

FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found in Forkhead box proteins in various Mammalia species. It is a coiled-coil domain, which modulates the dimeric associations of FOXP transcription factors. Several key disease mutations, for instance those found in the IPEX syndrome are located in this domain


Pssm-ID: 465036  Cd Length: 68  Bit Score: 143.21  E-value: 4.54e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 289666734  367 LYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHL 434
Cdd:pfam16159   1 LFGHGVCRWPGCETVCEDFGSFLKHLNSEHALDDRSTAQCRVQMQVVQQLEIQLTKEKERLQAMMAHL 68
 
Name Accession Description Interval E-value
FOXP-CC pfam16159
FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found ...
 367-434 4.54e-42

FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found in Forkhead box proteins in various Mammalia species. It is a coiled-coil domain, which modulates the dimeric associations of FOXP transcription factors. Several key disease mutations, for instance those found in the IPEX syndrome are located in this domain


Pssm-ID: 465036  Cd Length: 68  Bit Score: 143.21  E-value: 4.54e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 289666734  367 LYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHL 434
Cdd:pfam16159   1 LFGHGVCRWPGCETVCEDFGSFLKHLNSEHALDDRSTAQCRVQMQVVQQLEIQLTKEKERLQAMMAHL 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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