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Conserved domains on  [gi|294489328|ref|NP_001170939|]
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protein myomixer isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Minion cd20278
Microprotein INducer of fusION (Minion); Microprotein INducer of fusION (Minion), also called ...
20-64 6.84e-10

Microprotein INducer of fusION (Minion); Microprotein INducer of fusION (Minion), also called protein myomixer or protein myomerger, is encoded by the MYMX gene. Along with Myomaker, it allows cells to fuse and form multinucleated fibers that are capable of contracting. A lack of Minion disables skeletal muscles, including the diaphragm, resulting in perinatal death in mice. This insight into the Minion-Myomaker system may one day be exploited for targeted drug delivery involving fusing cells in cancer or other contexts. The production of Minion peaks three to four days after injury, similar to the expression profile of Myomaker.


:

Pssm-ID: 380748  Cd Length: 57  Bit Score: 49.61  E-value: 6.84e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 294489328 20 PVARLARQHLLPLLRRLARRLSSQDMREALLSCLLFVLSQQQPPD 64
Cdd:cd20278  13 PAARLARQHLLPLLRRLARRLGSQDSREALLGCLLFILSQRHPPD 57
 
Name Accession Description Interval E-value
Minion cd20278
Microprotein INducer of fusION (Minion); Microprotein INducer of fusION (Minion), also called ...
20-64 6.84e-10

Microprotein INducer of fusION (Minion); Microprotein INducer of fusION (Minion), also called protein myomixer or protein myomerger, is encoded by the MYMX gene. Along with Myomaker, it allows cells to fuse and form multinucleated fibers that are capable of contracting. A lack of Minion disables skeletal muscles, including the diaphragm, resulting in perinatal death in mice. This insight into the Minion-Myomaker system may one day be exploited for targeted drug delivery involving fusing cells in cancer or other contexts. The production of Minion peaks three to four days after injury, similar to the expression profile of Myomaker.


Pssm-ID: 380748  Cd Length: 57  Bit Score: 49.61  E-value: 6.84e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 294489328 20 PVARLARQHLLPLLRRLARRLSSQDMREALLSCLLFVLSQQQPPD 64
Cdd:cd20278  13 PAARLARQHLLPLLRRLARRLGSQDSREALLGCLLFILSQRHPPD 57
 
Name Accession Description Interval E-value
Minion cd20278
Microprotein INducer of fusION (Minion); Microprotein INducer of fusION (Minion), also called ...
20-64 6.84e-10

Microprotein INducer of fusION (Minion); Microprotein INducer of fusION (Minion), also called protein myomixer or protein myomerger, is encoded by the MYMX gene. Along with Myomaker, it allows cells to fuse and form multinucleated fibers that are capable of contracting. A lack of Minion disables skeletal muscles, including the diaphragm, resulting in perinatal death in mice. This insight into the Minion-Myomaker system may one day be exploited for targeted drug delivery involving fusing cells in cancer or other contexts. The production of Minion peaks three to four days after injury, similar to the expression profile of Myomaker.


Pssm-ID: 380748  Cd Length: 57  Bit Score: 49.61  E-value: 6.84e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 294489328 20 PVARLARQHLLPLLRRLARRLSSQDMREALLSCLLFVLSQQQPPD 64
Cdd:cd20278  13 PAARLARQHLLPLLRRLARRLGSQDSREALLGCLLFILSQRHPPD 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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