NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|295148163|ref|NP_001171189|]
View 

Krueppel-like factor 11 isoform b [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 23-377 1.45e-105

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


:

Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 313.85  E-value: 1.45e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163  23 LEQTDMEAVEALVCMSSWGQRSQKGDLLRIRPLTPVSDSGDVTttvHMDAATPELPKDFHSLSTLCITPPQSPDLVEPST 102
Cdd:cd21584    1 LEQNDLEAVEALVCMSSWGQRSQKGDLLKIRPLTPASDSCDSL---TLHPAAPELPKDFHSLSSLCMTPPHSPSFAEPST 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 103 RTPvspqvtdskactatdvlqssavvaralsggaergllglepvpSSPCRAKGTSVIRHTGESPAacfptiqtpdcrlsd 182
Cdd:cd21584   78 TAP------------------------------------------PPPCRAMATSVIRHTADSSP--------------- 100

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 183 sregeeqllghfetlqdthltdsllstnlvscqpclhksggllltdkgqqagwpgavqtcspknyendlprkttpliSVS 262
Cdd:cd21584  101 -----------------------------------------------------------------------------PVP 103

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 263 VPAPPVLCQMIPVTGQSSMLPAFLKPPPqLSVGTVRPILAQAAPAPQPVFVGPAVPQGAVMLVLPQGALPPPAPCAANVM 342
Cdd:cd21584  104 VPSPPVLCQMIPVSGQSGMISAFLQPPA-LSAGTVKPILPQTAPASQPLLVGSPVPQGTVMLVLPQASVPQPPQCPQTVM 182

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 295148163 343 AAGNTKLLPLAPAPVFITSSQNCVPQVDFSRRRNY 377
Cdd:cd21584  183 TLGNTKLLPLAPAPVFIPSGQSCAPQVDFSRRRNY 217
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
376-432 5.18e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 5.18e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 295148163 376 NYVCSFPGCRKTYFKSSHLKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRTHT 432
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 437-459 8.08e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 8.08e-05
                          10        20
                  ....*....|....*....|...
gi 295148163  437 FVCPVCDRRFMRSDHLTKHARRH 459
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 23-377 1.45e-105

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 313.85  E-value: 1.45e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163  23 LEQTDMEAVEALVCMSSWGQRSQKGDLLRIRPLTPVSDSGDVTttvHMDAATPELPKDFHSLSTLCITPPQSPDLVEPST 102
Cdd:cd21584    1 LEQNDLEAVEALVCMSSWGQRSQKGDLLKIRPLTPASDSCDSL---TLHPAAPELPKDFHSLSSLCMTPPHSPSFAEPST 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 103 RTPvspqvtdskactatdvlqssavvaralsggaergllglepvpSSPCRAKGTSVIRHTGESPAacfptiqtpdcrlsd 182
Cdd:cd21584   78 TAP------------------------------------------PPPCRAMATSVIRHTADSSP--------------- 100

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 183 sregeeqllghfetlqdthltdsllstnlvscqpclhksggllltdkgqqagwpgavqtcspknyendlprkttpliSVS 262
Cdd:cd21584  101 -----------------------------------------------------------------------------PVP 103

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 263 VPAPPVLCQMIPVTGQSSMLPAFLKPPPqLSVGTVRPILAQAAPAPQPVFVGPAVPQGAVMLVLPQGALPPPAPCAANVM 342
Cdd:cd21584  104 VPSPPVLCQMIPVSGQSGMISAFLQPPA-LSAGTVKPILPQTAPASQPLLVGSPVPQGTVMLVLPQASVPQPPQCPQTVM 182

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 295148163 343 AAGNTKLLPLAPAPVFITSSQNCVPQVDFSRRRNY 377
Cdd:cd21584  183 TLGNTKLLPLAPAPVFIPSGQSCAPQVDFSRRRNY 217
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
376-432 5.18e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 5.18e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 295148163 376 NYVCSFPGCRKTYFKSSHLKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRTHT 432
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
393-420 4.03e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.03e-05
                          10        20
                  ....*....|....*....|....*...
gi 295148163  393 HLKAHLRTHTGEKPFNCswDGCDKKFAR 420
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 437-459 8.08e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 8.08e-05
                          10        20
                  ....*....|....*....|...
gi 295148163  437 FVCPVCDRRFMRSDHLTKHARRH 459
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
437-459 6.43e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 6.43e-03
                           10        20
                   ....*....|....*....|...
gi 295148163   437 FVCPVCDRRFMRSDHLTKHARRH 459
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 23-377 1.45e-105

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 313.85  E-value: 1.45e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163  23 LEQTDMEAVEALVCMSSWGQRSQKGDLLRIRPLTPVSDSGDVTttvHMDAATPELPKDFHSLSTLCITPPQSPDLVEPST 102
Cdd:cd21584    1 LEQNDLEAVEALVCMSSWGQRSQKGDLLKIRPLTPASDSCDSL---TLHPAAPELPKDFHSLSSLCMTPPHSPSFAEPST 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 103 RTPvspqvtdskactatdvlqssavvaralsggaergllglepvpSSPCRAKGTSVIRHTGESPAacfptiqtpdcrlsd 182
Cdd:cd21584   78 TAP------------------------------------------PPPCRAMATSVIRHTADSSP--------------- 100

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 183 sregeeqllghfetlqdthltdsllstnlvscqpclhksggllltdkgqqagwpgavqtcspknyendlprkttpliSVS 262
Cdd:cd21584  101 -----------------------------------------------------------------------------PVP 103

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 263 VPAPPVLCQMIPVTGQSSMLPAFLKPPPqLSVGTVRPILAQAAPAPQPVFVGPAVPQGAVMLVLPQGALPPPAPCAANVM 342
Cdd:cd21584  104 VPSPPVLCQMIPVSGQSGMISAFLQPPA-LSAGTVKPILPQTAPASQPLLVGSPVPQGTVMLVLPQASVPQPPQCPQTVM 182

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 295148163 343 AAGNTKLLPLAPAPVFITSSQNCVPQVDFSRRRNY 377
Cdd:cd21584  183 TLGNTKLLPLAPAPVFIPSGQSCAPQVDFSRRRNY 217
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 24-377 1.22e-79

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 247.54  E-value: 1.22e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163  24 EQTDMEAVEALVCMSSWGQRSQKgDLLRIRPLTPVSDSGDvtttvhmDAATPELPKDFHSLSTLCITPPQSPDLVEPSTR 103
Cdd:cd21974    1 EQGDLEAVEALVSMSSWWKRRQK-RLRKPRPLTPSSDSSD-------EDDAPESPKDFHSLSSLCMTPPYSPPFFEASHS 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 104 TPVSPQVTDSKACTATDVLQSSAvvaralsggaergllglEPVPSSPCRAKGTSVIRHTGESPaacfptiqtpdcrlsds 183
Cdd:cd21974   73 PSVASLHPPSAASSQPPPEPESS-----------------EPPAASPQRAQATSVIRHTADPV----------------- 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 184 regeeqllghfetlqdthltdsllstnlvscqpclhksggllltdkgqqagwpgavqtcspknyendlprkttplisvSV 263
Cdd:cd21974  119 ------------------------------------------------------------------------------PV 120

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 264 PAPPVLCQMIPVTGQSSMLPAFLKPPPQLSVGTVRPILaqaaPAPQPVFVGPAVPQGAVMLVLPQGALPPPAPCAaNVMA 343
Cdd:cd21974  121 SPPPVLCQMLPVSSSSGVIVAFLKAPQQPSPQPQKPAL----PQPQVVLVGGQVPQGPVMLVVPQPAVPQPYVQP-TVVT 195

                        330       340       350
                 ....*....|....*....|....*....|....
gi 295148163 344 AGNTKLLPLAPAPVFITSSQNCVPQVDFSRRRNY 377
Cdd:cd21974  196 PGGTKLLPIAPAPGFIPSGQSSAPQPDFSRRRNH 229
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 23-376 1.42e-26

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 107.77  E-value: 1.42e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163  23 LEQTDMEAVEALVCMSS-WGQRSQKgdLLRIRPLTPVSDSGDvtttvhmDAATPeLPKDFHSLSTLCITPPQSPDLVEPS 101
Cdd:cd21572    1 MGAGDMEAVEALMSMTKhWKTRSFR--LRHFRPLTPSSDSSE-------DDDLP-SPADFHDSPPFCMTPPYSPPHFEAT 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 102 TRTPVSPQVTDSKACTATDVLQSsavvaralsggaergllglePVPSSPCRAKGTSVIRHTgespaacfptiqtpdcrlS 181
Cdd:cd21572   71 HPPSAATLHPPAAQPPEEQHLSA--------------------ETAASQQRFQCTSVIRHT------------------A 112

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 182 DsregeeqllghfetlqdthltdsllstnlvsCQPClhksggllltdkgqqagwpgavqTCSPKNyENDLPRKTTPLISV 261
Cdd:cd21572  113 D-------------------------------AQPC-----------------------SCSSCP-SSPSVVPSVPAGVA 137

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 262 SVPAPPVLCQMIPVTGQSSMLPAFLKPPPQLSvgtvrpilAQAAPAPQPVFVGPAVPQGAVMLVLPQGALPPPAPCAANV 341
Cdd:cd21572  138 GVSPVPVYCQILPVSSSSTTVVAAQAPLPQPQ--------QQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLV 209

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 295148163 342 MAAGnTKLLPLAPAPVFITSSQNCVP-QVDFSRRRN 376
Cdd:cd21572  210 TPGG-TKLAAIAPAPGHTPSEQRKSPpQPEVSRVRS 244
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
376-432 5.18e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 5.18e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 295148163 376 NYVCSFPGCRKTYFKSSHLKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRTHT 432
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
393-420 4.03e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.03e-05
                          10        20
                  ....*....|....*....|....*...
gi 295148163  393 HLKAHLRTHTGEKPFNCswDGCDKKFAR 420
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
361-455 8.01e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 8.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 361 SSQNCVPQVDFSRRRNYVCSFPGCRKTYFKSSHLKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRTHTgEKKFVCP 440
Cdd:COG5048  371 PPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLC 449

                         90
                 ....*....|....*
gi 295148163 441 VCDRRFMRSDHLTKH 455
Cdd:COG5048  450 SILKSFRRDLDLSNH 464
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 437-459 8.08e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 8.08e-05
                          10        20
                  ....*....|....*....|...
gi 295148163  437 FVCPVCDRRFMRSDHLTKHARRH 459
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
354-433 1.21e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163 354 PAPVFITSSQNCVPQVDfSRRRNYVCSFPGCRKTYFKSSHLKAHLRT--HTGE--KPFNCSWDGCDKKFARSDELSRHRR 429
Cdd:COG5048  266 PTASSQSSSPNESDSSS-EKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHIL 344


                 ....
gi 295148163 430 THTG 433
Cdd:COG5048  345 LHTS 348
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 403-461 2.86e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 2.86e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 295148163 403 GEKPFNCSWDGCDKKFARSDELSRHR-------RTH------------TGEKKFVCPVCDRRFMRSDHLTKHaRRHMT 461
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH-RKHSH 422
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 379-455 1.14e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.55  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148163  379 CSFPGCRKTYFKSSHLKAHLRTHTGE------KPFNCSWDGCDKKFARSDELSRHRRTHTGEKK-FVCPVCDRRFMRSDH 451
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHYKPNRyFKCENCLLRFRTHRS 81


                  ....
gi 295148163  452 LTKH 455
Cdd:pfam15909  82 LFKH 85
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 407-431 3.56e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.56e-03
                          10        20
                  ....*....|....*....|....*
gi 295148163  407 FNCswDGCDKKFARSDELSRHRRTH 431
Cdd:pfam00096   1 YKC--PDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
437-459 6.43e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 6.43e-03
                           10        20
                   ....*....|....*....|...
gi 295148163   437 FVCPVCDRRFMRSDHLTKHARRH 459
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH