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Conserved domains on  [gi|295789059|ref|NP_001171423|]
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X-linked retinitis pigmentosa GTPase regulator isoform 4 [Mus musculus]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-303 3.45e-58

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 199.43  E-value: 3.45e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789059   3 GSNNWGQLGLGSKAAIIKPTCIKALkpEKVKLAACGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPA 82
Cdd:COG5184   23 GDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTGV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789059  83 dtiKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVTVG-KPISWISCGYYHSAFVTMDGELYTFGEPE 161
Cdd:COG5184  101 ---VAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGlSGVVAIAAGGYHTCALKSDGTVWCWGANS 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789059 162 NGKLGLPNELlmNHRSPQRVLGIpERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFLFETSePKIIERIKDqkI 240
Cdd:COG5184  178 YGQLGDGTTT--DRPTPVQVGGL-SGVVAVAAGGDHSCALKSDgTVWCWGSNSSGQLGDGTTTDRAT-PVQVAGLTG--V 251

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295789059 241 CHISCGENHT-ALMTElGLLYTFGDGRHGKLGLGmeNFTNQFFPTLCSNFLRfaVQLIACGGCH 303
Cdd:COG5184  252 VAIAAGGSHTcALKSD-GTVWCWGDNSYGQLGDG--TTTDRSTPVKVPGLSG--VVAVAAGSSH 310
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-303 3.45e-58

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 199.43  E-value: 3.45e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789059   3 GSNNWGQLGLGSKAAIIKPTCIKALkpEKVKLAACGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPA 82
Cdd:COG5184   23 GDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTGV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789059  83 dtiKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVTVG-KPISWISCGYYHSAFVTMDGELYTFGEPE 161
Cdd:COG5184  101 ---VAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGlSGVVAIAAGGYHTCALKSDGTVWCWGANS 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789059 162 NGKLGLPNELlmNHRSPQRVLGIpERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFLFETSePKIIERIKDqkI 240
Cdd:COG5184  178 YGQLGDGTTT--DRPTPVQVGGL-SGVVAVAAGGDHSCALKSDgTVWCWGSNSSGQLGDGTTTDRAT-PVQVAGLTG--V 251

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295789059 241 CHISCGENHT-ALMTElGLLYTFGDGRHGKLGLGmeNFTNQFFPTLCSNFLRfaVQLIACGGCH 303
Cdd:COG5184  252 VAIAAGGSHTcALKSD-GTVWCWGDNSYGQLGDG--TTTDRSTPVKVPGLSG--VVAVAAGSSH 310
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
151-201 7.11e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 60.61  E-value: 7.11e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 295789059  151 DGELYTFGEPENGKLGLPNELlmNHRSPQRVLGIPE-RVIQVACGGGHTVVL 201
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTE--NVLVPQKVEGLSGnKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-303 3.45e-58

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 199.43  E-value: 3.45e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789059   3 GSNNWGQLGLGSKAAIIKPTCIKALkpEKVKLAACGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPA 82
Cdd:COG5184   23 GDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTGV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789059  83 dtiKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVTVG-KPISWISCGYYHSAFVTMDGELYTFGEPE 161
Cdd:COG5184  101 ---VAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGlSGVVAIAAGGYHTCALKSDGTVWCWGANS 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789059 162 NGKLGLPNELlmNHRSPQRVLGIpERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFLFETSePKIIERIKDqkI 240
Cdd:COG5184  178 YGQLGDGTTT--DRPTPVQVGGL-SGVVAVAAGGDHSCALKSDgTVWCWGSNSSGQLGDGTTTDRAT-PVQVAGLTG--V 251

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295789059 241 CHISCGENHT-ALMTElGLLYTFGDGRHGKLGLGmeNFTNQFFPTLCSNFLRfaVQLIACGGCH 303
Cdd:COG5184  252 VAIAAGGSHTcALKSD-GTVWCWGDNSYGQLGDG--TTTDRSTPVKVPGLSG--VVAVAAGSSH 310
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 1-284 3.31e-57

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 196.74  E-value: 3.31e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789059   1 MFGSNNWGQLGLGSKAAIIKPTCIKALKPekVKLAACGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVffT 80
Cdd:COG5184   71 CWGNNSYGQLGDGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVD--A 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789059  81 PADTIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVTVGKPISWISCGYYHSAFVTMDGELYTFGEP 160
Cdd:COG5184  147 GLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSGVVAVAAGGDHSCALKSDGTVWCWGSN 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789059 161 ENGKLGLPNELlmNHRSPQRVLGiPERVIQVACGGGHT-VVLTEKVVYAFGLGQFGQLGLGTFLFETSePKIIERIKDqk 239
Cdd:COG5184  227 SSGQLGDGTTT--DRATPVQVAG-LTGVVAIAAGGSHTcALKSDGTVWCWGDNSYGQLGDGTTTDRST-PVKVPGLSG-- 300

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 295789059 240 ICHISCGENHT-ALMTElGLLYTFGDGRHGKLGLGmeNFTNQFFPT 284
Cdd:COG5184  301 VVAVAAGSSHTcALLTD-GTVWCWGDNAYGQLGDG--TTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 32-306 1.33e-50

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 179.02  E-value: 1.33e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789059  32 VKLAAcGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIvffTPADTIKQLSAGANTSAALTEDGKLFMWGDNS 111
Cdd:COG5184    1 TQVAA-GGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRV---PGLSNVVAVAAGGDHTCALKADGTVWCWGNNS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789059 112 EGQIGLEDKSNVCIPHEVTVGKPISWISCGYYHSAFVTMDGELYTFGEPENGKLGLPNEllMNHRSPQRVLGIPERVIQV 191
Cdd:COG5184   77 YGQLGDGTTTDRTTPVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTT--TNRLTPVQVDAGLSGVVAI 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295789059 192 ACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTFLfETSEPKIIERIKDqkICHISCGENHTALMTELGLLYTFGDGRHGKL 270
Cdd:COG5184  155 AAGGYHTCALKSDgTVWCWGANSYGQLGDGTTT-DRPTPVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQL 231

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 295789059 271 GLGmeNFTNQFFPTLCSNfLRFAVQlIACGGCHMLV 306
Cdd:COG5184  232 GDG--TTTDRATPVQVAG-LTGVVA-IAAGGSHTCA 263
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
151-201 7.11e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 60.61  E-value: 7.11e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 295789059  151 DGELYTFGEPENGKLGLPNELlmNHRSPQRVLGIPE-RVIQVACGGGHTVVL 201
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTE--NVLVPQKVEGLSGnKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
101-148 2.12e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 59.07  E-value: 2.12e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 295789059  101 DGKLFMWGDNSEGQIGLEDKSNVCIPHEVT--VGKPISWISCGYYHSAFV 148
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEglSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
206-253 6.35e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 57.91  E-value: 6.35e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 295789059  206 VYAFGLGQFGQLGLGTFlFETSEPKIIERIKDQKICHISCGENHTALM 253
Cdd:pfam00415   4 VYTWGRNDYGQLGLGTT-ENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
2-44 2.54e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 55.99  E-value: 2.54e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 295789059    2 FGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHTLV 44
Cdd:pfam00415   7 WGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
85-114 2.65e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 52.81  E-value: 2.65e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 295789059   85 IKQLSAGANTSAALTEDGKLFMWGDNSEGQ 114
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
257-303 4.30e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 46.74  E-value: 4.30e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 295789059  257 GLLYTFGDGRHGKLGLGmeNFTNQFFPTLCSNFLRFAVQLIACGGCH 303
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLG--TTENVLVPQKVEGLSGNKVVQVACGGDH 46
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
49-98 2.83e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 44.43  E-value: 2.83e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 295789059   49 GGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFtPADTIKQLSAGANTSAAL 98
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGL-SGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
32-61 3.23e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 43.95  E-value: 3.23e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 295789059   32 VKLAACGRNHTLVSTDTGGVYAAGGNNEGQ 61
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
188-216 2.23e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 41.64  E-value: 2.23e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 295789059  188 VIQVACGGGHTVVLTE-KVVYAFGLGQFGQ 216
Cdd:pfam13540   1 VVSVAAGDNHTLALTSdGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
240-268 1.97e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 38.94  E-value: 1.97e-04
                          10        20
                  ....*....|....*....|....*....
gi 295789059  240 ICHISCGENHTALMTELGLLYTFGDGRHG 268
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYG 29
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
138-163 2.83e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 38.56  E-value: 2.83e-04
                          10        20
                  ....*....|....*....|....*.
gi 295789059  138 ISCGYYHSAFVTMDGELYTFGEPENG 163
Cdd:pfam13540   4 VAAGDNHTLALTSDGRVYCWGDNSYG 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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