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Conserved domains on  [gi|295821198|ref|NP_001171478|]
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Bardet-Biedl syndrome 12 protein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Cpn60_TCP1 super family cl28953
TCP-1/cpn60 chaperonin family; This family includes members from the HSP60 chaperone family ...
284-543 5.07e-06

TCP-1/cpn60 chaperonin family; This family includes members from the HSP60 chaperone family and the TCP-1 (T-complex protein) family.


The actual alignment was detected with superfamily member pfam00118:

Pssm-ID: 395068 [Multi-domain]  Cd Length: 489  Bit Score: 49.51  E-value: 5.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295821198  284 KLVEEAVQLQYQNAcvqqgnctkpFMFDISRIFTCCLPG-LPETSSCVcPGYITVVSVSNNPVIKELQNqpVRIVLIEGD 362
Cdd:pfam00118 143 KLVVDAVLAIPKND----------GSFDLGNIGVVKILGgSLEDSELV-DGVVLDKGPLHPDMPKRLEN--AKVLLLNCS 209
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295821198  363 LteNYRHLGFNKSANIKTVLDSMRLQEDssEELWANHVLQVLIQFKVNLVLVQGNVSERLIEKCINSKRLVIGSVNGSVM 442
Cdd:pfam00118 210 L--EYEKTETKATVVLSDAEQLERFLKA--EEEQILEIVEKIIDSGVNVVVCQKGIDDLALHFLAKNGIMALRRVKKRDL 285
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295821198  443 QAFAEAAGAVQVAYITQVNEDCVG--DGVCVtfwrsspldVVDRNNRIAILLKTEGINLVTAVLTNPVTAQMQIKEDRFW 520
Cdd:pfam00118 286 ERLAKATGARAVSSLDDLTPDDLGtaGKVEE---------EKIGDEKYTFIEGCKSPKAATILLRGATDHVLDEIERSIH 356
                         250       260
                  ....*....|....*....|....*
gi 295821198  521 T--CAYRLyyALKEEKVFLGGGAVE 543
Cdd:pfam00118 357 DalCVVKN--AIEDPRVVPGGGAVE 379
 
Name Accession Description Interval E-value
Cpn60_TCP1 pfam00118
TCP-1/cpn60 chaperonin family; This family includes members from the HSP60 chaperone family ...
284-543 5.07e-06

TCP-1/cpn60 chaperonin family; This family includes members from the HSP60 chaperone family and the TCP-1 (T-complex protein) family.


Pssm-ID: 395068 [Multi-domain]  Cd Length: 489  Bit Score: 49.51  E-value: 5.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295821198  284 KLVEEAVQLQYQNAcvqqgnctkpFMFDISRIFTCCLPG-LPETSSCVcPGYITVVSVSNNPVIKELQNqpVRIVLIEGD 362
Cdd:pfam00118 143 KLVVDAVLAIPKND----------GSFDLGNIGVVKILGgSLEDSELV-DGVVLDKGPLHPDMPKRLEN--AKVLLLNCS 209
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295821198  363 LteNYRHLGFNKSANIKTVLDSMRLQEDssEELWANHVLQVLIQFKVNLVLVQGNVSERLIEKCINSKRLVIGSVNGSVM 442
Cdd:pfam00118 210 L--EYEKTETKATVVLSDAEQLERFLKA--EEEQILEIVEKIIDSGVNVVVCQKGIDDLALHFLAKNGIMALRRVKKRDL 285
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295821198  443 QAFAEAAGAVQVAYITQVNEDCVG--DGVCVtfwrsspldVVDRNNRIAILLKTEGINLVTAVLTNPVTAQMQIKEDRFW 520
Cdd:pfam00118 286 ERLAKATGARAVSSLDDLTPDDLGtaGKVEE---------EKIGDEKYTFIEGCKSPKAATILLRGATDHVLDEIERSIH 356
                         250       260
                  ....*....|....*....|....*
gi 295821198  521 T--CAYRLyyALKEEKVFLGGGAVE 543
Cdd:pfam00118 357 DalCVVKN--AIEDPRVVPGGGAVE 379
 
Name Accession Description Interval E-value
Cpn60_TCP1 pfam00118
TCP-1/cpn60 chaperonin family; This family includes members from the HSP60 chaperone family ...
284-543 5.07e-06

TCP-1/cpn60 chaperonin family; This family includes members from the HSP60 chaperone family and the TCP-1 (T-complex protein) family.


Pssm-ID: 395068 [Multi-domain]  Cd Length: 489  Bit Score: 49.51  E-value: 5.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295821198  284 KLVEEAVQLQYQNAcvqqgnctkpFMFDISRIFTCCLPG-LPETSSCVcPGYITVVSVSNNPVIKELQNqpVRIVLIEGD 362
Cdd:pfam00118 143 KLVVDAVLAIPKND----------GSFDLGNIGVVKILGgSLEDSELV-DGVVLDKGPLHPDMPKRLEN--AKVLLLNCS 209
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295821198  363 LteNYRHLGFNKSANIKTVLDSMRLQEDssEELWANHVLQVLIQFKVNLVLVQGNVSERLIEKCINSKRLVIGSVNGSVM 442
Cdd:pfam00118 210 L--EYEKTETKATVVLSDAEQLERFLKA--EEEQILEIVEKIIDSGVNVVVCQKGIDDLALHFLAKNGIMALRRVKKRDL 285
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295821198  443 QAFAEAAGAVQVAYITQVNEDCVG--DGVCVtfwrsspldVVDRNNRIAILLKTEGINLVTAVLTNPVTAQMQIKEDRFW 520
Cdd:pfam00118 286 ERLAKATGARAVSSLDDLTPDDLGtaGKVEE---------EKIGDEKYTFIEGCKSPKAATILLRGATDHVLDEIERSIH 356
                         250       260
                  ....*....|....*....|....*
gi 295821198  521 T--CAYRLyyALKEEKVFLGGGAVE 543
Cdd:pfam00118 357 DalCVVKN--AIEDPRVVPGGGAVE 379
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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