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Conserved domains on  [gi|295842342|ref|NP_001171504|]
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zinc finger C4H2 domain-containing protein isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C4H2 super family cl24228
Zinc finger-containing protein; This is a family of proteins which appears to have a highly ...
 13-130 1.07e-49

Zinc finger-containing protein; This is a family of proteins which appears to have a highly conserved zinc finger domain at the C terminal end, described as -C-X2-CH-X3-H-X5-C-X2-C-. The structure is predicted to contain a coiled coil. Members are annotated as being tumour-associated antigen HCA127 in humans but this could not confirmed.


The actual alignment was detected with superfamily member pfam10146:

Pssm-ID: 462963 [Multi-domain]  Cd Length: 213  Bit Score: 159.47  E-value: 1.07e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842342   13 SIKEIRNKTLQMEKIKARLKAEFEALESEERHLKEYKQEMDLLLQEKMAHVEELRLIHADINVMENTIKQSENDLNKLLE 92
Cdd:pfam10146   1 ALKDIRHKTAQLEKLKERLLKELEAHENEEKCLKEYKKEMELLLQEKMAHVEELRLIHADINKMEKVIKEAEEERNRVLE 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 295842342   93 STRRLHDEYKPLKEHVDALRMT-LGLQRLPDLCEEEEKL 130
Cdd:pfam10146  81 GAVRLHEEYIPLKLEIDRMRRElLGLEELPLLHEEEEDL 119
 
Name Accession Description Interval E-value
zf-C4H2 pfam10146
Zinc finger-containing protein; This is a family of proteins which appears to have a highly ...
 13-130 1.07e-49

Zinc finger-containing protein; This is a family of proteins which appears to have a highly conserved zinc finger domain at the C terminal end, described as -C-X2-CH-X3-H-X5-C-X2-C-. The structure is predicted to contain a coiled coil. Members are annotated as being tumour-associated antigen HCA127 in humans but this could not confirmed.


Pssm-ID: 462963 [Multi-domain]  Cd Length: 213  Bit Score: 159.47  E-value: 1.07e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842342   13 SIKEIRNKTLQMEKIKARLKAEFEALESEERHLKEYKQEMDLLLQEKMAHVEELRLIHADINVMENTIKQSENDLNKLLE 92
Cdd:pfam10146   1 ALKDIRHKTAQLEKLKERLLKELEAHENEEKCLKEYKKEMELLLQEKMAHVEELRLIHADINKMEKVIKEAEEERNRVLE 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 295842342   93 STRRLHDEYKPLKEHVDALRMT-LGLQRLPDLCEEEEKL 130
Cdd:pfam10146  81 GAVRLHEEYIPLKLEIDRMRRElLGLEELPLLHEEEEDL 119
 
Name Accession Description Interval E-value
zf-C4H2 pfam10146
Zinc finger-containing protein; This is a family of proteins which appears to have a highly ...
 13-130 1.07e-49

Zinc finger-containing protein; This is a family of proteins which appears to have a highly conserved zinc finger domain at the C terminal end, described as -C-X2-CH-X3-H-X5-C-X2-C-. The structure is predicted to contain a coiled coil. Members are annotated as being tumour-associated antigen HCA127 in humans but this could not confirmed.


Pssm-ID: 462963 [Multi-domain]  Cd Length: 213  Bit Score: 159.47  E-value: 1.07e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842342   13 SIKEIRNKTLQMEKIKARLKAEFEALESEERHLKEYKQEMDLLLQEKMAHVEELRLIHADINVMENTIKQSENDLNKLLE 92
Cdd:pfam10146   1 ALKDIRHKTAQLEKLKERLLKELEAHENEEKCLKEYKKEMELLLQEKMAHVEELRLIHADINKMEKVIKEAEEERNRVLE 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 295842342   93 STRRLHDEYKPLKEHVDALRMT-LGLQRLPDLCEEEEKL 130
Cdd:pfam10146  81 GAVRLHEEYIPLKLEIDRMRRElLGLEELPLLHEEEEDL 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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