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Conserved domains on  [gi|296010880|ref|NP_001171556|]
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zinc finger X-chromosomal protein isoform 1 [Homo sapiens]

Protein Classification

Zfx_Zfy_act and COG5048 domain-containing protein( domain architecture ID 12057220)

protein containing domains Zfx_Zfy_act, ROS_MUCR, and COG5048

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 70-410 0e+00

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


:

Pssm-ID: 461400  Cd Length: 328  Bit Score: 547.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880   70 DVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSMPEHVLTGDSIHVSDVGHVGH 149
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVSEGVIIPEQVLDSEVAIEVSLDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEVGHLEH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880  150 VGHvehvvhdsVVEAEIVTDPLTTDVVSEEVLVADCASEAVIDANGIPVDQQDDDKGNCEDYLMISLDDAGKIEHDGSSG 229
Cdd:pfam04704  81 VIH--------DSEREIVTDALTADMVSEEVLVADCASEAVIDASGVPLETQDDDKSNCEDYLMISLDDGEKLDHIGSTP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880  230 MTMDTESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVNDSQPE 309
Cdd:pfam04704 153 LTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQE 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880  310 DEDLNVAEIADEVYMEVIVGEEDaaaaaaAAAVHEQQMDDNEI-KTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESA 388
Cdd:pfam04704 233 DEDLNVAEIADEVYMEVIVGEED------AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKNGTASALLHIDESA 306

                         330       340
                  ....*....|....*....|..
gi 296010880  389 GLGRLAKQKPKKRRRPDSRQYQ 410
Cdd:pfam04704 307 SLDRLLKQKPKKKRRGESRQYQ 328
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
543-805 1.52e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880 543 SKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSA--DSSNLKTHVkTKHSKEMPFKCDICLLTFSDTKEV 620
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHL-RTHHNNPSDLNSKSLPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880 621 QQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMC-DKGFHRPSELKKHVAA---------------- 683
Cdd:COG5048  108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLpanslskdpssnlsll 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880 684 ------HKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCK--RCRKGFRQQSELKKHMKTHSGR--KVYQCEYCE 753
Cdd:COG5048  188 issnvsTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNsqLSPKSLLSQSPSSLSSSDSSSSasESPRSSLPT 267

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 296010880 754 YSTTDASGFKRHVISIHTKDYPHRCEYCKKGF------RRPSEKNQHIMRHHKEVGLP 805
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGFSLPIKSKQCNISFsrssplTRHLRSVNHSGESLKPFSCP 325
ROS_MUCR super family cl19880
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 377-457 4.90e-04

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


The actual alignment was detected with superfamily member pfam05443:

Pssm-ID: 473244  Cd Length: 122  Bit Score: 40.52  E-value: 4.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880  377 TASALLHIDESAGLGRLAKQKP----KKRRRPDSrqyqtaiIIgpdghpltvypCMICGKKFKSrgfLKRHMKNHpeHLA 452
Cdd:pfam05443  31 VHAALAGLGEGAAPPAEEEPVPavpiKKSITPDY-------II-----------CLEDGKPFKT---LKRHLTAH--GLT 87


                  ....*
gi 296010880  453 KKKYR 457
Cdd:pfam05443  88 PEEYR 92
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 70-410 0e+00

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 547.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880   70 DVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSMPEHVLTGDSIHVSDVGHVGH 149
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVSEGVIIPEQVLDSEVAIEVSLDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEVGHLEH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880  150 VGHvehvvhdsVVEAEIVTDPLTTDVVSEEVLVADCASEAVIDANGIPVDQQDDDKGNCEDYLMISLDDAGKIEHDGSSG 229
Cdd:pfam04704  81 VIH--------DSEREIVTDALTADMVSEEVLVADCASEAVIDASGVPLETQDDDKSNCEDYLMISLDDGEKLDHIGSTP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880  230 MTMDTESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVNDSQPE 309
Cdd:pfam04704 153 LTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQE 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880  310 DEDLNVAEIADEVYMEVIVGEEDaaaaaaAAAVHEQQMDDNEI-KTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESA 388
Cdd:pfam04704 233 DEDLNVAEIADEVYMEVIVGEED------AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKNGTASALLHIDESA 306

                         330       340
                  ....*....|....*....|..
gi 296010880  389 GLGRLAKQKPKKRRRPDSRQYQ 410
Cdd:pfam04704 307 SLDRLLKQKPKKKRRGESRQYQ 328
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
543-805 1.52e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880 543 SKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSA--DSSNLKTHVkTKHSKEMPFKCDICLLTFSDTKEV 620
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHL-RTHHNNPSDLNSKSLPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880 621 QQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMC-DKGFHRPSELKKHVAA---------------- 683
Cdd:COG5048  108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLpanslskdpssnlsll 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880 684 ------HKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCK--RCRKGFRQQSELKKHMKTHSGR--KVYQCEYCE 753
Cdd:COG5048  188 issnvsTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNsqLSPKSLLSQSPSSLSSSDSSSSasESPRSSLPT 267

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 296010880 754 YSTTDASGFKRHVISIHTKDYPHRCEYCKKGF------RRPSEKNQHIMRHHKEVGLP 805
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGFSLPIKSKQCNISFsrssplTRHLRSVNHSGESLKPFSCP 325
zf-H2C2_2 pfam13465
Zinc-finger double domain;
562-586 3.37e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.37e-05
                          10        20
                  ....*....|....*....|....*
gi 296010880  562 ELKKHMRIHTGEKPYQCQYCEYRSA 586
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
ROS_MUCR pfam05443
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 377-457 4.90e-04

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


Pssm-ID: 428475  Cd Length: 122  Bit Score: 40.52  E-value: 4.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880  377 TASALLHIDESAGLGRLAKQKP----KKRRRPDSrqyqtaiIIgpdghpltvypCMICGKKFKSrgfLKRHMKNHpeHLA 452
Cdd:pfam05443  31 VHAALAGLGEGAAPPAEEEPVPavpiKKSITPDY-------II-----------CLEDGKPFKT---LKRHLTAH--GLT 87


                  ....*
gi 296010880  453 KKKYR 457
Cdd:pfam05443  88 PEEYR 92
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 70-410 0e+00

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 547.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880   70 DVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSMPEHVLTGDSIHVSDVGHVGH 149
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVSEGVIIPEQVLDSEVAIEVSLDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEVGHLEH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880  150 VGHvehvvhdsVVEAEIVTDPLTTDVVSEEVLVADCASEAVIDANGIPVDQQDDDKGNCEDYLMISLDDAGKIEHDGSSG 229
Cdd:pfam04704  81 VIH--------DSEREIVTDALTADMVSEEVLVADCASEAVIDASGVPLETQDDDKSNCEDYLMISLDDGEKLDHIGSTP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880  230 MTMDTESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVNDSQPE 309
Cdd:pfam04704 153 LTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQE 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880  310 DEDLNVAEIADEVYMEVIVGEEDaaaaaaAAAVHEQQMDDNEI-KTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESA 388
Cdd:pfam04704 233 DEDLNVAEIADEVYMEVIVGEED------AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKNGTASALLHIDESA 306

                         330       340
                  ....*....|....*....|..
gi 296010880  389 GLGRLAKQKPKKRRRPDSRQYQ 410
Cdd:pfam04704 307 SLDRLLKQKPKKKRRGESRQYQ 328
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
543-805 1.52e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880 543 SKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSA--DSSNLKTHVkTKHSKEMPFKCDICLLTFSDTKEV 620
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHL-RTHHNNPSDLNSKSLPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880 621 QQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMC-DKGFHRPSELKKHVAA---------------- 683
Cdd:COG5048  108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLpanslskdpssnlsll 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880 684 ------HKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCK--RCRKGFRQQSELKKHMKTHSGR--KVYQCEYCE 753
Cdd:COG5048  188 issnvsTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNsqLSPKSLLSQSPSSLSSSDSSSSasESPRSSLPT 267

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 296010880 754 YSTTDASGFKRHVISIHTKDYPHRCEYCKKGF------RRPSEKNQHIMRHHKEVGLP 805
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGFSLPIKSKQCNISFsrssplTRHLRSVNHSGESLKPFSCP 325
zf-H2C2_2 pfam13465
Zinc-finger double domain;
562-586 3.37e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.37e-05
                          10        20
                  ....*....|....*....|....*
gi 296010880  562 ELKKHMRIHTGEKPYQCQYCEYRSA 586
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
511-654 1.87e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880 511 KEKGANKMHKCKFCEYETAEQGLLNRHLLAVH---SKNFPHICVE--CGKGFRHPSELKKHMRIHTGEKPYQCQYC---- 581
Cdd:COG5048  282 SEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNhsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnsss 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880 582 ------------------------EYRSADSSNLKTHVKTKHSKEMP----------FKCDICLLTFSDTKEVQQHALIH 627
Cdd:COG5048  362 kfspllnneppqslqqykdlkndkKSETLSNSCIRNFKRDSNLSLHIithlsfrpynCKNPPCSKSFNRHYNLIPHKKIH 441

                        170       180
                 ....*....|....*....|....*..
gi 296010880 628 QESKTHQCLHCDhKSSNSSDLKRHIIS 654
Cdd:COG5048  442 TNHAPLLCSILK-SFRRDLDLSNHGKD 467
ROS_MUCR pfam05443
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 377-457 4.90e-04

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


Pssm-ID: 428475  Cd Length: 122  Bit Score: 40.52  E-value: 4.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010880  377 TASALLHIDESAGLGRLAKQKP----KKRRRPDSrqyqtaiIIgpdghpltvypCMICGKKFKSrgfLKRHMKNHpeHLA 452
Cdd:pfam05443  31 VHAALAGLGEGAAPPAEEEPVPavpiKKSITPDY-------II-----------CLEDGKPFKT---LKRHLTAH--GLT 87


                  ....*
gi 296010880  453 KKKYR 457
Cdd:pfam05443  88 PEEYR 92
zf-H2C2_2 pfam13465
Zinc-finger double domain;
733-757 6.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.02e-04
                          10        20
                  ....*....|....*....|....*
gi 296010880  733 ELKKHMKTHSGRKVYQCEYCEYSTT 757
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 548-570 1.04e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.04e-03
                          10        20
                  ....*....|....*....|...
gi 296010880  548 HICVECGKGFRHPSELKKHMRIH 570
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 719-741 1.05e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.05e-03
                          10        20
                  ....*....|....*....|...
gi 296010880  719 FRCKRCRKGFRQQSELKKHMKTH 741
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 425-447 5.73e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.73e-03
                          10        20
                  ....*....|....*....|...
gi 296010880  425 YPCMICGKKFKSRGFLKRHMKNH 447
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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