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Conserved domains on  [gi|296841087|ref|NP_001171897|]
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microphthalmia-associated transcription factor isoform 8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MITF_TFEB_C_3_N super family cl24504
MITF/TFEB/TFEC/TFE3 N-terminus; This domain is found at the N-terminus of several ...
 9-88 7.45e-19

MITF/TFEB/TFEC/TFE3 N-terminus; This domain is found at the N-terminus of several transcription factors including microphthalmia-associated transcription factor, transcription factor EB, transcription factor EC and transcription factor E3.


The actual alignment was detected with superfamily member pfam15951:

Pssm-ID: 464952  Cd Length: 151  Bit Score: 75.17  E-value: 7.45e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841087    9 HYQVQTHLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPP--------VPGSSAPNSPMAMLTL 80
Cdd:pfam15951  59 VLKVQTHLENPTKYHIQQAQRQQVKQYLSTTYGAKQALIPSASPPPPAQSPPPRTSplmrgnqlPPGNSAPNSPMAMLSI 138


                  ....*...
gi 296841087   81 NSNCEKEF 88
Cdd:pfam15951 139 GSSEEKEI 146
 
Name Accession Description Interval E-value
MITF_TFEB_C_3_N pfam15951
MITF/TFEB/TFEC/TFE3 N-terminus; This domain is found at the N-terminus of several ...
 9-88 7.45e-19

MITF/TFEB/TFEC/TFE3 N-terminus; This domain is found at the N-terminus of several transcription factors including microphthalmia-associated transcription factor, transcription factor EB, transcription factor EC and transcription factor E3.


Pssm-ID: 464952  Cd Length: 151  Bit Score: 75.17  E-value: 7.45e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841087    9 HYQVQTHLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPP--------VPGSSAPNSPMAMLTL 80
Cdd:pfam15951  59 VLKVQTHLENPTKYHIQQAQRQQVKQYLSTTYGAKQALIPSASPPPPAQSPPPRTSplmrgnqlPPGNSAPNSPMAMLSI 138


                  ....*...
gi 296841087   81 NSNCEKEF 88
Cdd:pfam15951 139 GSSEEKEI 146
 
Name Accession Description Interval E-value
MITF_TFEB_C_3_N pfam15951
MITF/TFEB/TFEC/TFE3 N-terminus; This domain is found at the N-terminus of several ...
 9-88 7.45e-19

MITF/TFEB/TFEC/TFE3 N-terminus; This domain is found at the N-terminus of several transcription factors including microphthalmia-associated transcription factor, transcription factor EB, transcription factor EC and transcription factor E3.


Pssm-ID: 464952  Cd Length: 151  Bit Score: 75.17  E-value: 7.45e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841087    9 HYQVQTHLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPP--------VPGSSAPNSPMAMLTL 80
Cdd:pfam15951  59 VLKVQTHLENPTKYHIQQAQRQQVKQYLSTTYGAKQALIPSASPPPPAQSPPPRTSplmrgnqlPPGNSAPNSPMAMLSI 138


                  ....*...
gi 296841087   81 NSNCEKEF 88
Cdd:pfam15951 139 GSSEEKEI 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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