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Conserved domains on  [gi|298160998|ref|NP_001177171|]
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intraflagellar transport protein 80 homolog isoform b [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-156 1.29e-18

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 1.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998   2 LRSTLAQQGTPVYSVAWGPDSeKVLYTAG--KQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 79
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDG-KLLASGSadGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998  80 -SYGRPLYNSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCD-KTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 156
Cdd:COG2319  275 lATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDdGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-395 5.61e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 5.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998  46 QWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRPLYNSQPHEHPITSVAWAPDGELFAVGSF-HTLRLcdktgW 123
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDlETGELLRTLKGHTGPVRDVAASADGTYLASGSSdKTIRL-----W 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998 124 SYALEKPN------TGSIFNIAWSIDGTQIAGACGNGHVVFahvveqhWEWKNFQVTLTkrramqvrnvlndavdLLEFR 197
Cdd:cd00200   79 DLETGECVrtltghTSYVSSVAFSPDGRILSSSSRDKTIKV-------WDVETGKCLTT----------------LRGHT 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998 198 DRVikaslnyAHLVVSTSLQcYVFSTKNWNTPIIFDLKEGTVSLILQAERHFLlvdgSSIYLYSYEGRFISSpkfpgmrt 277
Cdd:cd00200  136 DWV-------NSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATLTGHTGEV----NSVAFSPDGEKLLSS-------- 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998 278 dilnaqtvslSNDtiairdkadeKIIFLFEASTGKPLGDgkFLSHKNEILEIALDQKGL-----TNDRKIAFIDKNRDLC 352
Cdd:cd00200  196 ----------SSD----------GTIKLWDLSTGKCLGT--LRGHENGVNSVAFSPDGYllasgSEDGTIRVWDLRTGEC 253

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 298160998 353 ITSVKrfGKEEQiiklgtmVHTLAWNDTCNILC-GLQDTRFIVW 395
Cdd:cd00200  254 VQTLS--GHTNS-------VTSLAWSPDGKRLAsGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-156 1.29e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 1.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998   2 LRSTLAQQGTPVYSVAWGPDSeKVLYTAG--KQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 79
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDG-KLLASGSadGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998  80 -SYGRPLYNSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCD-KTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 156
Cdd:COG2319  275 lATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDdGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-176 2.15e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 2.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998  12 PVYSVAWGPDSeKVLYTAG--KQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRPLYNS 88
Cdd:cd00200   95 YVSSVAFSPDG-RILSSSSrdKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDlRTGKCVATL 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998  89 QPHEHPITSVAWAPDGELFAVGSF-HTLRLCD-KTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHVVFahvveqhW 166
Cdd:cd00200  174 TGHTGEVNSVAFSPDGEKLLSSSSdGTIKLWDlSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV-------W 246

                        170
                 ....*....|
gi 298160998 167 EWKNFQVTLT 176
Cdd:cd00200  247 DLRTGECVQT 256
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-395 5.61e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 5.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998  46 QWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRPLYNSQPHEHPITSVAWAPDGELFAVGSF-HTLRLcdktgW 123
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDlETGELLRTLKGHTGPVRDVAASADGTYLASGSSdKTIRL-----W 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998 124 SYALEKPN------TGSIFNIAWSIDGTQIAGACGNGHVVFahvveqhWEWKNFQVTLTkrramqvrnvlndavdLLEFR 197
Cdd:cd00200   79 DLETGECVrtltghTSYVSSVAFSPDGRILSSSSRDKTIKV-------WDVETGKCLTT----------------LRGHT 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998 198 DRVikaslnyAHLVVSTSLQcYVFSTKNWNTPIIFDLKEGTVSLILQAERHFLlvdgSSIYLYSYEGRFISSpkfpgmrt 277
Cdd:cd00200  136 DWV-------NSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATLTGHTGEV----NSVAFSPDGEKLLSS-------- 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998 278 dilnaqtvslSNDtiairdkadeKIIFLFEASTGKPLGDgkFLSHKNEILEIALDQKGL-----TNDRKIAFIDKNRDLC 352
Cdd:cd00200  196 ----------SSD----------GTIKLWDLSTGKCLGT--LRGHENGVNSVAFSPDGYllasgSEDGTIRVWDLRTGEC 253

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 298160998 353 ITSVKrfGKEEQiiklgtmVHTLAWNDTCNILC-GLQDTRFIVW 395
Cdd:cd00200  254 VQTLS--GHTNS-------VTSLAWSPDGKRLAsGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 82-119 3.59e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.59e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 298160998    82 GRPLYNSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCD 119
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDdGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
82-119 1.56e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.56e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 298160998   82 GRPLYNSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCD 119
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDdGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-156 1.29e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 1.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998   2 LRSTLAQQGTPVYSVAWGPDSeKVLYTAG--KQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 79
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDG-KLLASGSadGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998  80 -SYGRPLYNSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCD-KTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 156
Cdd:COG2319  275 lATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDdGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354
WD40 COG2319
WD40 repeat [General function prediction only];
2-156 2.84e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.27  E-value: 2.84e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998   2 LRSTLAQQGTPVYSVAWGPDSEKVLyTAG--KQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 79
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLA-SGSadGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998  80 SY-GRPLYNSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCD-KTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 156
Cdd:COG2319  191 LAtGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAdGTVRLWDlATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270
WD40 COG2319
WD40 repeat [General function prediction only];
2-156 4.80e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.89  E-value: 4.80e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998   2 LRSTLAQQGTPVYSVAWGPDSeKVLYTAG--KQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 79
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDG-RLLASGSadGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998  80 -SYGRPLYNSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCD-KTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 156
Cdd:COG2319  317 lATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDdGTVRLWDlATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
2-119 2.40e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 2.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998   2 LRSTLAQQGTPVYSVAWGPDSeKVLYTAGKQLIIK--PLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 79
Cdd:COG2319  280 LLRTLTGHSGGVNSVAFSPDG-KLLASGSDDGTVRlwDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 298160998  80 -SYGRPLYNSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCD 119
Cdd:COG2319  359 lATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAdGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
2-156 4.38e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 4.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998   2 LRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIK-PLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD- 79
Cdd:COG2319   28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLlDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDl 107

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 298160998  80 SYGRPLYNSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCD-KTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 156
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAdGTVRLWDlATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-176 2.15e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 2.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998  12 PVYSVAWGPDSeKVLYTAG--KQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRPLYNS 88
Cdd:cd00200   95 YVSSVAFSPDG-RILSSSSrdKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDlRTGKCVATL 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998  89 QPHEHPITSVAWAPDGELFAVGSF-HTLRLCD-KTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHVVFahvveqhW 166
Cdd:cd00200  174 TGHTGEVNSVAFSPDGEKLLSSSSdGTIKLWDlSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV-------W 246

                        170
                 ....*....|
gi 298160998 167 EWKNFQVTLT 176
Cdd:cd00200  247 DLRTGECVQT 256
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-156 2.34e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 2.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998  12 PVYSVAWGPDSEKvLYTAG--KQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRPLYNS 88
Cdd:cd00200   53 PVRDVAASADGTY-LASGSsdKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDvETGKCLTTL 131

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998  89 QPHEHPITSVAWAPDGELFAVGSF-HTLRLCD-KTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 156
Cdd:cd00200  132 RGHTDWVNSVAFSPDGTFVASSSQdGTIKLWDlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTI 201
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-156 2.81e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 2.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998   2 LRSTLAQQGTPVYSVAWGPDSeKVLYTAG--KQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 79
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDG-KLLATGSgdGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998  80 -SYGRPLYNSQPHEHPITSVAWAPDGELFAVGSFhtlrlcDKTGWSYALEKPN--------TGSIFNIAWSIDGTQIAGA 150
Cdd:cd00200   80 lETGECVRTLTGHTSYVSSVAFSPDGRILSSSSR------DKTIKVWDVETGKclttlrghTDWVNSVAFSPDGTFVASS 153


                 ....*.
gi 298160998 151 CGNGHV 156
Cdd:cd00200  154 SQDGTI 159
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-117 6.24e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 6.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998  12 PVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQW-KAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSY-GRPLYNSQ 89
Cdd:cd00200  179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTlRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRtGECVQTLS 258

                         90       100
                 ....*....|....*....|....*....
gi 298160998  90 PHEHPITSVAWAPDGELFAVGSF-HTLRL 117
Cdd:cd00200  259 GHTNSVTSLAWSPDGKRLASGSAdGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-395 5.61e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 5.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998  46 QWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRPLYNSQPHEHPITSVAWAPDGELFAVGSF-HTLRLcdktgW 123
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDlETGELLRTLKGHTGPVRDVAASADGTYLASGSSdKTIRL-----W 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998 124 SYALEKPN------TGSIFNIAWSIDGTQIAGACGNGHVVFahvveqhWEWKNFQVTLTkrramqvrnvlndavdLLEFR 197
Cdd:cd00200   79 DLETGECVrtltghTSYVSSVAFSPDGRILSSSSRDKTIKV-------WDVETGKCLTT----------------LRGHT 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998 198 DRVikaslnyAHLVVSTSLQcYVFSTKNWNTPIIFDLKEGTVSLILQAERHFLlvdgSSIYLYSYEGRFISSpkfpgmrt 277
Cdd:cd00200  136 DWV-------NSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATLTGHTGEV----NSVAFSPDGEKLLSS-------- 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998 278 dilnaqtvslSNDtiairdkadeKIIFLFEASTGKPLGDgkFLSHKNEILEIALDQKGL-----TNDRKIAFIDKNRDLC 352
Cdd:cd00200  196 ----------SSD----------GTIKLWDLSTGKCLGT--LRGHENGVNSVAFSPDGYllasgSEDGTIRVWDLRTGEC 253

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 298160998 353 ITSVKrfGKEEQiiklgtmVHTLAWNDTCNILC-GLQDTRFIVW 395
Cdd:cd00200  254 VQTLS--GHTNS-------VTSLAWSPDGKRLAsGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-150 2.23e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 2.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298160998   2 LRSTLAQQGTPVYSVAWGPDSeKVLYTAGKQLIIKPLQPNAKVLQW--KAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 79
Cdd:cd00200  127 CLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGKCVAtlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 298160998  80 -SYGRPLYNSQPHEHPITSVAWAPDGELFAVGSF-HTLRLcdktgWSYALEKPN------TGSIFNIAWSIDGTQIAGA 150
Cdd:cd00200  206 lSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEdGTIRV-----WDLRTGECVqtlsghTNSVTSLAWSPDGKRLASG 279
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 82-119 3.59e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.59e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 298160998    82 GRPLYNSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCD 119
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDdGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 44-79 7.51e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 7.51e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 298160998    44 VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 79
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
82-119 1.56e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.56e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 298160998   82 GRPLYNSQPHEHPITSVAWAPDGELFAVGSF-HTLRLCD 119
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDdGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
44-79 3.50e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.50e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 298160998   44 VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 79
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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