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Conserved domains on  [gi|299758476|ref|NP_001177666|]
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nuclear factor 1 B-type isoform 1 [Homo sapiens]

Protein Classification

nuclear factor I( domain architecture ID 12106891)

nuclear factor I (NFI) is a CCAAT-box-binding protein active in transcription and DNA replication

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CTF_NFI pfam00859
CTF/NF-I family transcription modulation region;
209-489 2.76e-118

CTF/NF-I family transcription modulation region;


:

Pssm-ID: 459967 [Multi-domain]  Cd Length: 288  Bit Score: 348.83  E-value: 2.76e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476  209 EDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSqPYYHDMNSGVNLQRSLSSPPS--SKRPKTISIDENMEPSPT 286
Cdd:pfam00859   1 QDSFVTSGVFSVTELVRVSRTPVATGTGPNFSLGELQG-PLYYDLNPGVGLRRSLPSTSSsgSKRHKSGSMEDDVDTSPG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476  287 GDFYPSPSSPAAGSRTW-HERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIpgVAHSVIStRTPPPPSP 365
Cdd:pfam00859  80 GDYYRSPSSPASSSRNWpHDVEGGMSSPVKKKKPDKSDFSSPSPQDSSPRLMAFTQHHRPVI--AVHSGIS-RSPHPSSA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476  366 LPFPTQAILpPAPSSYFSHPTIRYPPHLnPQDTLKNYVP--SYDPSSPQTSQPNGSGQvvGKVPGHF--TPVLAPSPHPS 441
Cdd:pfam00859 157 LHFPSSSIL-QQPSSYFPHPAIRYPPHL-PQDPLKDLVSlaCYDPSSQQPSQPNGSGQ--GKVPGHFisTQMLAPPPHPP 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 299758476  442 AVRPVTLSMtDTKPITTSTEA---------YTASGTSQANRYVGLSPRDPSFLHQQQ 489
Cdd:pfam00859 233 VARPVPLPM-DTKPITTSTEGgassptsptYSAPGTPPANRFVGLGPRDPGFLYQAQ 288
NfI_DNAbd_pre-N pfam10524
Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific ...
10-47 8.30e-19

Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific DNA-binding proteins (also known as CTF or CAAT box transcription factor) functions both in viral DNA replication and in the regulation of gene expression in higher organizms. The N-terminal 200 residues contains the DNA-binding and dimerization domain, but also has an 8-47 residue highly conserved region 5' of this, whose function is not known. Deletion of the N-terminal 200 amino acids removes the DNA-binding activity, dimerization-ability and the stimulation of adenovirus DNA replication.


:

Pssm-ID: 463134  Cd Length: 41  Bit Score: 79.57  E-value: 8.30e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 299758476   10 QDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEK 47
Cdd:pfam10524   4 QEDFHPFIEALLPYVKAFAYTWFNLQAAKRRHYKKHDK 41
MH1 super family cl45991
MH1 domain; The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related ...
69-173 1.83e-17

MH1 domain; The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however. Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localization signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx.


The actual alignment was detected with superfamily member pfam03165:

Pssm-ID: 460833  Cd Length: 103  Bit Score: 77.80  E-value: 1.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476   69 KQKWASRLLAKLRKDIrqEYREDFVLTVTGK---KHPCCVLSN--------PDQKGKIRRIDClrqadKVWRL-DLVMVI 136
Cdd:pfam03165   1 LKKAVESLLKKLKKKI--QQLEELELAVESRgdpPTGCVTIPRsldgrlqvAGRKGLPHVIYC-----RLWRWpDLQSQH 73
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 299758476  137 LFKGIPLESTDGErlMKSPHCtnpalCVQPHHITVSV 173
Cdd:pfam03165  74 ELKAIPTCETAFE--SKKDEV-----CINPYHYSRVE 103
 
Name Accession Description Interval E-value
CTF_NFI pfam00859
CTF/NF-I family transcription modulation region;
209-489 2.76e-118

CTF/NF-I family transcription modulation region;


Pssm-ID: 459967 [Multi-domain]  Cd Length: 288  Bit Score: 348.83  E-value: 2.76e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476  209 EDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSqPYYHDMNSGVNLQRSLSSPPS--SKRPKTISIDENMEPSPT 286
Cdd:pfam00859   1 QDSFVTSGVFSVTELVRVSRTPVATGTGPNFSLGELQG-PLYYDLNPGVGLRRSLPSTSSsgSKRHKSGSMEDDVDTSPG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476  287 GDFYPSPSSPAAGSRTW-HERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIpgVAHSVIStRTPPPPSP 365
Cdd:pfam00859  80 GDYYRSPSSPASSSRNWpHDVEGGMSSPVKKKKPDKSDFSSPSPQDSSPRLMAFTQHHRPVI--AVHSGIS-RSPHPSSA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476  366 LPFPTQAILpPAPSSYFSHPTIRYPPHLnPQDTLKNYVP--SYDPSSPQTSQPNGSGQvvGKVPGHF--TPVLAPSPHPS 441
Cdd:pfam00859 157 LHFPSSSIL-QQPSSYFPHPAIRYPPHL-PQDPLKDLVSlaCYDPSSQQPSQPNGSGQ--GKVPGHFisTQMLAPPPHPP 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 299758476  442 AVRPVTLSMtDTKPITTSTEA---------YTASGTSQANRYVGLSPRDPSFLHQQQ 489
Cdd:pfam00859 233 VARPVPLPM-DTKPITTSTEGgassptsptYSAPGTPPANRFVGLGPRDPGFLYQAQ 288
NfI_DNAbd_pre-N pfam10524
Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific ...
10-47 8.30e-19

Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific DNA-binding proteins (also known as CTF or CAAT box transcription factor) functions both in viral DNA replication and in the regulation of gene expression in higher organizms. The N-terminal 200 residues contains the DNA-binding and dimerization domain, but also has an 8-47 residue highly conserved region 5' of this, whose function is not known. Deletion of the N-terminal 200 amino acids removes the DNA-binding activity, dimerization-ability and the stimulation of adenovirus DNA replication.


Pssm-ID: 463134  Cd Length: 41  Bit Score: 79.57  E-value: 8.30e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 299758476   10 QDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEK 47
Cdd:pfam10524   4 QEDFHPFIEALLPYVKAFAYTWFNLQAAKRRHYKKHDK 41
MH1 pfam03165
MH1 domain; The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related ...
69-173 1.83e-17

MH1 domain; The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however. Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localization signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx.


Pssm-ID: 460833  Cd Length: 103  Bit Score: 77.80  E-value: 1.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476   69 KQKWASRLLAKLRKDIrqEYREDFVLTVTGK---KHPCCVLSN--------PDQKGKIRRIDClrqadKVWRL-DLVMVI 136
Cdd:pfam03165   1 LKKAVESLLKKLKKKI--QQLEELELAVESRgdpPTGCVTIPRsldgrlqvAGRKGLPHVIYC-----RLWRWpDLQSQH 73
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 299758476  137 LFKGIPLESTDGErlMKSPHCtnpalCVQPHHITVSV 173
Cdd:pfam03165  74 ELKAIPTCETAFE--SKKDEV-----CINPYHYSRVE 103
DWA smart00523
Domain A in dwarfin family proteins;
68-176 8.64e-17

Domain A in dwarfin family proteins;


Pssm-ID: 214708  Cd Length: 109  Bit Score: 75.88  E-value: 8.64e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476    68 IKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPC--CVLSNPDQKGKirridcLRQADKVWRLDLVMVILFKGIPLES 145
Cdd:smart00523   1 VEEKWAKKATESLLKKLKKKQLEELLQAVESKGGPPtrCVLIPRSLDGR------LQVAHRKGLPHVLYCRLFRWPDLQS 74
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 299758476   146 tdGERLMKSPHC------TNPALCVQPHHITVSVKEL 176
Cdd:smart00523  75 --PHELKALPTCehafesKSDEVCCNPYHYSRVERPE 109
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
265-438 1.03e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.98  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476 265 SPPSSKRPKTISIDEnmepSPTGDFYP-SPSSPAAGSR-TWHERDQDMSSPTTMKKPEKPlfssASPQDSSPRLSTFPQH 342
Cdd:PTZ00449 608 RPKSPKLPELLDIPK----SPKRPESPkSPKRPPPPQRpSSPERPEGPKIIKSPKPPKSP----KPPFDPKFKEKFYDDY 679
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476 343 hhpgIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPtiRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQV 422
Cdd:PTZ00449 680 ----LDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTP--RPLPPKLPRDEEFPFEPIGDPDAEQPDDIEFFTPP 753
                        170
                 ....*....|....*..
gi 299758476 423 VGK-VPGHFTPVLAPSP 438
Cdd:PTZ00449 754 EEErTFFHETPADTPLP 770
 
Name Accession Description Interval E-value
CTF_NFI pfam00859
CTF/NF-I family transcription modulation region;
209-489 2.76e-118

CTF/NF-I family transcription modulation region;


Pssm-ID: 459967 [Multi-domain]  Cd Length: 288  Bit Score: 348.83  E-value: 2.76e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476  209 EDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSqPYYHDMNSGVNLQRSLSSPPS--SKRPKTISIDENMEPSPT 286
Cdd:pfam00859   1 QDSFVTSGVFSVTELVRVSRTPVATGTGPNFSLGELQG-PLYYDLNPGVGLRRSLPSTSSsgSKRHKSGSMEDDVDTSPG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476  287 GDFYPSPSSPAAGSRTW-HERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIpgVAHSVIStRTPPPPSP 365
Cdd:pfam00859  80 GDYYRSPSSPASSSRNWpHDVEGGMSSPVKKKKPDKSDFSSPSPQDSSPRLMAFTQHHRPVI--AVHSGIS-RSPHPSSA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476  366 LPFPTQAILpPAPSSYFSHPTIRYPPHLnPQDTLKNYVP--SYDPSSPQTSQPNGSGQvvGKVPGHF--TPVLAPSPHPS 441
Cdd:pfam00859 157 LHFPSSSIL-QQPSSYFPHPAIRYPPHL-PQDPLKDLVSlaCYDPSSQQPSQPNGSGQ--GKVPGHFisTQMLAPPPHPP 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 299758476  442 AVRPVTLSMtDTKPITTSTEA---------YTASGTSQANRYVGLSPRDPSFLHQQQ 489
Cdd:pfam00859 233 VARPVPLPM-DTKPITTSTEGgassptsptYSAPGTPPANRFVGLGPRDPGFLYQAQ 288
NfI_DNAbd_pre-N pfam10524
Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific ...
10-47 8.30e-19

Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific DNA-binding proteins (also known as CTF or CAAT box transcription factor) functions both in viral DNA replication and in the regulation of gene expression in higher organizms. The N-terminal 200 residues contains the DNA-binding and dimerization domain, but also has an 8-47 residue highly conserved region 5' of this, whose function is not known. Deletion of the N-terminal 200 amino acids removes the DNA-binding activity, dimerization-ability and the stimulation of adenovirus DNA replication.


Pssm-ID: 463134  Cd Length: 41  Bit Score: 79.57  E-value: 8.30e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 299758476   10 QDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEK 47
Cdd:pfam10524   4 QEDFHPFIEALLPYVKAFAYTWFNLQAAKRRHYKKHDK 41
MH1 pfam03165
MH1 domain; The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related ...
69-173 1.83e-17

MH1 domain; The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however. Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localization signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx.


Pssm-ID: 460833  Cd Length: 103  Bit Score: 77.80  E-value: 1.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476   69 KQKWASRLLAKLRKDIrqEYREDFVLTVTGK---KHPCCVLSN--------PDQKGKIRRIDClrqadKVWRL-DLVMVI 136
Cdd:pfam03165   1 LKKAVESLLKKLKKKI--QQLEELELAVESRgdpPTGCVTIPRsldgrlqvAGRKGLPHVIYC-----RLWRWpDLQSQH 73
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 299758476  137 LFKGIPLESTDGErlMKSPHCtnpalCVQPHHITVSV 173
Cdd:pfam03165  74 ELKAIPTCETAFE--SKKDEV-----CINPYHYSRVE 103
DWA smart00523
Domain A in dwarfin family proteins;
68-176 8.64e-17

Domain A in dwarfin family proteins;


Pssm-ID: 214708  Cd Length: 109  Bit Score: 75.88  E-value: 8.64e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476    68 IKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPC--CVLSNPDQKGKirridcLRQADKVWRLDLVMVILFKGIPLES 145
Cdd:smart00523   1 VEEKWAKKATESLLKKLKKKQLEELLQAVESKGGPPtrCVLIPRSLDGR------LQVAHRKGLPHVLYCRLFRWPDLQS 74
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 299758476   146 tdGERLMKSPHC------TNPALCVQPHHITVSVKEL 176
Cdd:smart00523  75 --PHELKALPTCehafesKSDEVCCNPYHYSRVERPE 109
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
265-438 1.03e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.98  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476 265 SPPSSKRPKTISIDEnmepSPTGDFYP-SPSSPAAGSR-TWHERDQDMSSPTTMKKPEKPlfssASPQDSSPRLSTFPQH 342
Cdd:PTZ00449 608 RPKSPKLPELLDIPK----SPKRPESPkSPKRPPPPQRpSSPERPEGPKIIKSPKPPKSP----KPPFDPKFKEKFYDDY 679
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476 343 hhpgIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPtiRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQV 422
Cdd:PTZ00449 680 ----LDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTP--RPLPPKLPRDEEFPFEPIGDPDAEQPDDIEFFTPP 753
                        170
                 ....*....|....*..
gi 299758476 423 VGK-VPGHFTPVLAPSP 438
Cdd:PTZ00449 754 EEErTFFHETPADTPLP 770
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
255-472 1.04e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.83  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476  255 SGVNLQRSLSSPPSSKrpKTISIDENMEPSPTGD------FYPSPSSPAAGSRTwheRDQDMSSPTTMKKPEKPLFSSAS 328
Cdd:pfam05109 450 SSTHVPTNLTAPASTG--PTVSTADVTSPTPAGTtsgaspVTPSPSPRDNGTES---KAPDMTSPTSAVTTPTPNATSPT 524
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476  329 PQDSSPRlstfPQHHHPGIPGVAhsvistrtppppsplpfPTQAILPPAPSSYFSHPTIRYPphlNPQDTLKNYVPSYDP 408
Cdd:pfam05109 525 PAVTTPT----PNATSPTLGKTS-----------------PTSAVTTPTPNATSPTPAVTTP---TPNATIPTLGKTSPT 580
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 299758476  409 SSPQTSQPNGSGQVVGKVpghfTPVLAPSPHpsavrpvTLSMTDTKPITTS--TEAYTASGTSQAN 472
Cdd:pfam05109 581 SAVTTPTPNATSPTVGET----SPQANTTNH-------TLGGTSSTPVVTSppKNATSAVTTGQHN 635
Enamelin pfam15362
Enamelin; ENAMELIN is involved in the mineralization and structural organization of enamel. It ...
289-329 1.08e-03

Enamelin; ENAMELIN is involved in the mineralization and structural organization of enamel. It is necessary for the extension of enamel during the secretory stage of dental enamel formation. The proteins are expressed in teeth, particularly in odontoblasts, ameloblasts and cementoblasts.


Pssm-ID: 464672 [Multi-domain]  Cd Length: 907  Bit Score: 41.74  E-value: 1.08e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 299758476  289 FYPSPSSPAAGSRTWHERDQdmsSPTTMKKPEKPLFSSASP 329
Cdd:pfam15362 393 YDPRENSPYLRSNTWDERDD---SPNTMGQPENPLYPMNTP 430
PHA03247 PHA03247
large tegument protein UL36; Provisional
264-482 1.27e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476  264 SSPPSSKRPKTISIDENmepSPTGDFYPSPSSPA-------AGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRL 336
Cdd:PHA03247 2590 DAPPQSARPRAPVDDRG---DPRGPAPPSPLPPDthapdppPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR 2666
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299758476  337 STFPqhhhpgipgvahsvisTRTPPPPSPLPFPTQAILPP--APSSYFSHPTiryPPHLNPQdtlknyvPSYDPSSPQTS 414
Cdd:PHA03247 2667 ARRL----------------GRAAQASSPPQRPRRRAARPtvGSLTSLADPP---PPPPTPE-------PAPHALVSATP 2720
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 299758476  415 QPNGSGQVVGKVPghfTPVLAPSPHPSAVRPVTlSMTDTKPITTSTEAYTASGTSQANRYVGLSPRDP 482
Cdd:PHA03247 2721 LPPGPAAARQASP---ALPAAPAPPAVPAGPAT-PGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT 2784
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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