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Conserved domains on  [gi|300934782|ref|NP_001177957|]
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transportin-3 isoform 2 [Homo sapiens]

Protein Classification

exportin/importin beta family protein( domain architecture ID 10658450)

exportin/importin beta family protein such as human exportin-T, which mediates the nuclear export of aminoacylated tRNAs or transportin-3 (importin), which transports target proteins into the nucleus

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 121-249 1.49e-20

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


:

Pssm-ID: 462459  Cd Length: 147  Bit Score: 88.82  E-value: 1.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300934782  121 SWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHS-RSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAG-TDEKML 198
Cdd:pfam08389  23 NWPTFFPDLISLLSSNPTGCELFLRILKVLPEEIFDfSRTSLTQDRNNRLKDLLRSNMEQILELLLQILEASQnANSELV 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 300934782  199 MKVFRCLGSWFNlgVLDSNFMANNKLLALLFEVLQQDKtssnLHEAASDCV 249
Cdd:pfam08389 103 EAVLKCLGSWLS--WIPIGLIVNNPLLNLLFSLLNDPD----LREAAVECL 147
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 33-96 3.54e-08

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


:

Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 50.70  E-value: 3.54e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 300934782    33 WLGELQRSVHAWEISDQLLQIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQN 96
Cdd:smart00913   4 QLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
 
Name Accession Description Interval E-value
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 121-249 1.49e-20

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


Pssm-ID: 462459  Cd Length: 147  Bit Score: 88.82  E-value: 1.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300934782  121 SWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHS-RSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAG-TDEKML 198
Cdd:pfam08389  23 NWPTFFPDLISLLSSNPTGCELFLRILKVLPEEIFDfSRTSLTQDRNNRLKDLLRSNMEQILELLLQILEASQnANSELV 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 300934782  199 MKVFRCLGSWFNlgVLDSNFMANNKLLALLFEVLQQDKtssnLHEAASDCV 249
Cdd:pfam08389 103 EAVLKCLGSWLS--WIPIGLIVNNPLLNLLFSLLNDPD----LREAAVECL 147
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 33-96 3.54e-08

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 50.70  E-value: 3.54e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 300934782    33 WLGELQRSVHAWEISDQLLQIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQN 96
Cdd:smart00913   4 QLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
 
Name Accession Description Interval E-value
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 121-249 1.49e-20

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


Pssm-ID: 462459  Cd Length: 147  Bit Score: 88.82  E-value: 1.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300934782  121 SWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHS-RSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAG-TDEKML 198
Cdd:pfam08389  23 NWPTFFPDLISLLSSNPTGCELFLRILKVLPEEIFDfSRTSLTQDRNNRLKDLLRSNMEQILELLLQILEASQnANSELV 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 300934782  199 MKVFRCLGSWFNlgVLDSNFMANNKLLALLFEVLQQDKtssnLHEAASDCV 249
Cdd:pfam08389 103 EAVLKCLGSWLS--WIPIGLIVNNPLLNLLFSLLNDPD----LREAAVECL 147
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 33-96 3.54e-08

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 50.70  E-value: 3.54e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 300934782    33 WLGELQRSVHAWEISDQLLQIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQN 96
Cdd:smart00913   4 QLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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