|
Name |
Accession |
Description |
Interval |
E-value |
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
115-644 |
0e+00 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 727.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 115 HAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLI 194
Cdd:TIGR00927 437 HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLI 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 195 GVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYF 274
Cdd:TIGR00927 517 GVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYA 596
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 275 CYVVFMKFNVQVEKWVKQMINRNKVVKVTAPE-------AQAKPSAARDKDE---PTLPAKPRLQRGGSSASL------- 337
Cdd:TIGR00927 597 LYVFTMKWNKQIELWVKEQLSRRPVAKVMALGdlskgdvAEAEHTGERTGEEgerPTEAEGENGEESGGEAEQegetetk 676
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 338 --------------------------HNSLMRNSIFQLMIHTLDPLAEGRFREKASILHKIAKKKCHVDENERQNGAANH 391
Cdd:TIGR00927 677 genesegeipaerkgeqegegeieakEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVE 756
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 392 VE----KIELPNSTST---------------DVEM----------------------------------------TPSSD 412
Cdd:TIGR00927 757 TEgdrkETEHEGETEAegkededegeiqageDGEMkgdegaegkvehegeteagekdehegqsetqaddtevkdeTGEQE 836
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 413 ASEPVQ----------------NGNLSHNIEGAEAQTADEEED------------QPLSLAWPSETRKQVTFLIVFPIVF 464
Cdd:TIGR00927 837 LNAENQgeakqdekgvdggggsDGGDSEEEEEEEEEEEEEEEEeeeeeeeeeeneEPLSLEWPETRQKQAIYLFLLPIVF 916
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 465 PLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG 544
Cdd:TIGR00927 917 PLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG 996
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 545 DMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYF 624
Cdd:TIGR00927 997 DMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYF 1076
|
650 660
....*....|....*....|
gi 300796347 625 VFLVVSVLLEDRILTCPVSI 644
Cdd:TIGR00927 1077 VFLIISVMLEDRIISCPVSV 1096
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
155-629 |
2.96e-42 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 154.52 E-value: 2.96e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 155 EFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLT 234
Cdd:COG0530 2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 235 WWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMkfnvqvekwvkqminrnkvvkvtapeaqakpsaa 314
Cdd:COG0530 80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 315 rdkdeptlpakprlqrggssaslhnslmrnsifqlmihtldplaegrfrekasilhkiakkkchvdenerqngaanhvek 394
Cdd:COG0530 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 395 ielpnststdvemtpssdasepvqngnlshnIEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVfpivfplwitlpdvr 474
Cdd:COG0530 126 -------------------------------IRRARKEPAWEEVEEELEEKPKMSLWKALLLLVL--------------- 159
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 475 kpssrkffpitffgSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGS 554
Cdd:COG0530 160 --------------GLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGS 225
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300796347 555 NIFDITVGLPLPWLlytvihrFQPVAVSSNGL-FCAIVLLFIMLLFVILSIAlcKWRMNKILGFIMFGLYFVFLVV 629
Cdd:COG0530 226 NIFNILLVLGIGAL-------ITPIPVDPAVLsFDLPVMLAATLLLLGLLRT--GGRIGRWEGLLLLALYLAYLAL 292
|
|
| Na_Ca_ex |
pfam01699 |
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ... |
138-282 |
3.35e-31 |
|
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.
Pssm-ID: 426387 [Multi-domain] Cd Length: 149 Bit Score: 118.86 E-value: 3.35e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 138 HVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 217
Cdd:pfam01699 1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300796347 218 FVIGMCALFSREILNLTW----WPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKF 282
Cdd:pfam01699 81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
512-629 |
1.15e-14 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 75.45 E-value: 1.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 512 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTviHRFQPVAVSSNglfcaiv 591
Cdd:PRK10734 205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALISP--GEINPLAFSRD------- 275
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 300796347 592 lLFIMLLFVILSIALC---KWRMNKILGFIMFGLYFVFLVV 629
Cdd:PRK10734 276 -YWVMLLVSVIFALLCwrrKRRIGRGAGALLLGGFIVWLAM 315
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
115-644 |
0e+00 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 727.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 115 HAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLI 194
Cdd:TIGR00927 437 HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLI 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 195 GVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYF 274
Cdd:TIGR00927 517 GVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYA 596
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 275 CYVVFMKFNVQVEKWVKQMINRNKVVKVTAPE-------AQAKPSAARDKDE---PTLPAKPRLQRGGSSASL------- 337
Cdd:TIGR00927 597 LYVFTMKWNKQIELWVKEQLSRRPVAKVMALGdlskgdvAEAEHTGERTGEEgerPTEAEGENGEESGGEAEQegetetk 676
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 338 --------------------------HNSLMRNSIFQLMIHTLDPLAEGRFREKASILHKIAKKKCHVDENERQNGAANH 391
Cdd:TIGR00927 677 genesegeipaerkgeqegegeieakEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVE 756
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 392 VE----KIELPNSTST---------------DVEM----------------------------------------TPSSD 412
Cdd:TIGR00927 757 TEgdrkETEHEGETEAegkededegeiqageDGEMkgdegaegkvehegeteagekdehegqsetqaddtevkdeTGEQE 836
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 413 ASEPVQ----------------NGNLSHNIEGAEAQTADEEED------------QPLSLAWPSETRKQVTFLIVFPIVF 464
Cdd:TIGR00927 837 LNAENQgeakqdekgvdggggsDGGDSEEEEEEEEEEEEEEEEeeeeeeeeeeneEPLSLEWPETRQKQAIYLFLLPIVF 916
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 465 PLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG 544
Cdd:TIGR00927 917 PLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG 996
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 545 DMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYF 624
Cdd:TIGR00927 997 DMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYF 1076
|
650 660
....*....|....*....|
gi 300796347 625 VFLVVSVLLEDRILTCPVSI 644
Cdd:TIGR00927 1077 VFLIISVMLEDRIISCPVSV 1096
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
137-626 |
2.12e-92 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 288.07 E-value: 2.12e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 137 LHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNI 216
Cdd:TIGR00367 1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 217 LFVIGMCALFSrEILNLTWWpLFRDVSFYIVDLIMLIIFFLDNVimwWESLLLLTAYFCYVVFMKFNVQVEKWVKQminr 296
Cdd:TIGR00367 81 LLILGLSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQ---ISRIDGVVLLILYIVYLLFLVKNERWVKY---- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 297 nkvvkvtapeaqakpsaardkdeptlpakprlqrggssaslhnslmrnsifqlmihtldplaEGRFREkasilhkiakkk 376
Cdd:TIGR00367 152 --------------------------------------------------------------DTYTEE------------ 157
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 377 cHVDENERqngaanhvekielpnststdvemtpssdasepvqngnlshniegaeaqtadeeedqplslawpsetRKQVTF 456
Cdd:TIGR00367 158 -NLDENNR------------------------------------------------------------------RPQIFF 170
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 457 LIVFPIVFplwitlpdvrkpssrkffpitffgsITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSV 536
Cdd:TIGR00367 171 SLVLLIIG-------------------------LIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSL 225
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 537 IVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTviHRFQPVAVSSNGLFCAIVLLFIMLLFVIlSIALCKWrmnkiLG 616
Cdd:TIGR00367 226 AAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMP--IPVEPLAYNLDAPVMVIVTLLLMLFFKT-SMKLGRW-----EG 297
|
490
....*....|
gi 300796347 617 FIMFGLYFVF 626
Cdd:TIGR00367 298 ILLLALYIAY 307
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
155-629 |
2.96e-42 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 154.52 E-value: 2.96e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 155 EFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLT 234
Cdd:COG0530 2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 235 WWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMkfnvqvekwvkqminrnkvvkvtapeaqakpsaa 314
Cdd:COG0530 80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 315 rdkdeptlpakprlqrggssaslhnslmrnsifqlmihtldplaegrfrekasilhkiakkkchvdenerqngaanhvek 394
Cdd:COG0530 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 395 ielpnststdvemtpssdasepvqngnlshnIEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVfpivfplwitlpdvr 474
Cdd:COG0530 126 -------------------------------IRRARKEPAWEEVEEELEEKPKMSLWKALLLLVL--------------- 159
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 475 kpssrkffpitffgSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGS 554
Cdd:COG0530 160 --------------GLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGS 225
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300796347 555 NIFDITVGLPLPWLlytvihrFQPVAVSSNGL-FCAIVLLFIMLLFVILSIAlcKWRMNKILGFIMFGLYFVFLVV 629
Cdd:COG0530 226 NIFNILLVLGIGAL-------ITPIPVDPAVLsFDLPVMLAATLLLLGLLRT--GGRIGRWEGLLLLALYLAYLAL 292
|
|
| Na_Ca_ex |
pfam01699 |
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ... |
138-282 |
3.35e-31 |
|
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.
Pssm-ID: 426387 [Multi-domain] Cd Length: 149 Bit Score: 118.86 E-value: 3.35e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 138 HVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 217
Cdd:pfam01699 1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300796347 218 FVIGMCALFSREILNLTW----WPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKF 282
Cdd:pfam01699 81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
|
|
| Na_Ca_ex |
pfam01699 |
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ... |
481-632 |
3.19e-29 |
|
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.
Pssm-ID: 426387 [Multi-domain] Cd Length: 149 Bit Score: 113.08 E-value: 3.19e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 481 FFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDIT 560
Cdd:pfam01699 1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300796347 561 VGLPLPWLLYTVIHRFQPVAVSSnGLFCAIVLLFIMLLFVILSIALckWRMNKILGFIMFGLYFVFLVVSVL 632
Cdd:pfam01699 81 LVLGLSALIGPVKVDSLLLKLDL-GVLLLVALLLLLLLLLLLLPLF--GRLSRFEGLVLLLLYIVYLVFQIV 149
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
114-280 |
1.80e-21 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 95.20 E-value: 1.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 114 DHAQGDYPKDIFSLEERRKGAIILHVIGMIymfiALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSL 193
Cdd:COG0530 132 EPAWEEVEEELEEKPKMSLWKALLLLVLGL----ALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSI 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 194 IGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLTWWPLFRDVSFYIVDLIMLIIFFL-DNVIMWWESLLLLTA 272
Cdd:COG0530 208 VAARKGEDDLAVGNIIGSNIFNILLVLGIGALITP--IPVDPAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLAL 285
|
....*...
gi 300796347 273 YFCYVVFM 280
Cdd:COG0530 286 YLAYLALL 293
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
504-636 |
1.74e-17 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 83.26 E-value: 1.74e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 504 AHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYtvihrfqPVAVSS 583
Cdd:COG0530 8 ADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIR-------PLAVDR 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 300796347 584 NGLFCAI-VLLFIMLLFVILSIALckwRMNKILGFIMFGLYFVFLVVSVLLEDR 636
Cdd:COG0530 81 RVLRRDLpFLLLASLLLLALLLDG---TLSRIDGVILLLLYVLYLYYLIRRARK 131
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
103-276 |
4.17e-15 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 76.59 E-value: 4.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 103 LSKEGESENSTDHAQGDYPKDIFSLEerrkgAIILHVIGMIYMFIALAIvcdefFVPSLTVITEKLGISDDVAGATFMAA 182
Cdd:TIGR00367 145 NERWVKYDTYTEENLDENNRRPQIFF-----SLVLLIIGLIGLVVGSRL-----LVDGAVKIAEILGISEKIIGLTLLAI 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 183 GGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSR-EILNLTwwpLFRDVSF-YIVDLIMLIIFFLDNV 260
Cdd:TIGR00367 215 GTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMPiPVEPLA---YNLDAPVmVIVTLLLMLFFKTSMK 291
|
170
....*....|....*.
gi 300796347 261 IMWWESLLLLTAYFCY 276
Cdd:TIGR00367 292 LGRWEGILLLALYIAY 307
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
76-380 |
4.32e-15 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 79.07 E-value: 4.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 76 PRVAQGYHQRTLLDLNDKILDYTPQPPLSKEGESENSTDHAQGD----------YPKDIfSLEERRKGAIILHVIgMIYM 145
Cdd:TIGR00845 8 PLFSVGFHLLTAVSLLFLHVDHARALTEASSSGSNTGECTGSYYckegvilpiwEPQNP-SVGDKIARATVYFVA-MVYM 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 146 FIALAIVCDEFfVPSLTVITEK-----------------LGI-SDDVAGATFMAAGGSAPELFTSLIGV----FIAhSNV 203
Cdd:TIGR00845 86 FLGVSIIADRF-MASIEVITSQekeitikkpngettvttVRIwNETVSNLTLMALGSSAPEILLSVIEVcghnFEA-GDL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 204 GIGTIVGSAVFNILFVIGMCALF-----SREILNL------TWWPLFRDVSFYIVdlimlIIFFLDNVIMWWESLLLLTA 272
Cdd:TIGR00845 164 GPSTIVGSAAFNMFIIIAICVYVipdgeTRKIKHLrvffvtAAWSVFAYVWLYLI-----LAVFSPGVVEVWEGLLTFFF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 273 YFCYVVFmkfnvqveKWV--KQMINRNKVVKVTAPEAQAKPSAARDKDEPTLPAKPRLQRGgssasLHNSLMRNSIFQLM 350
Cdd:TIGR00845 239 FPLCVVF--------AWVadRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSKTEIEMDGK-----MVNSHVDNFLDGAL 305
|
330 340 350
....*....|....*....|....*....|
gi 300796347 351 IHTLDPLAEGRfREKASILHKIAKKKCHVD 380
Cdd:TIGR00845 306 VLEVKEFDEAR-REMIRILKELKQKHPDKD 334
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
512-629 |
1.15e-14 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 75.45 E-value: 1.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 512 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTviHRFQPVAVSSNglfcaiv 591
Cdd:PRK10734 205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALISP--GEINPLAFSRD------- 275
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 300796347 592 lLFIMLLFVILSIALC---KWRMNKILGFIMFGLYFVFLVV 629
Cdd:PRK10734 276 -YWVMLLVSVIFALLCwrrKRRIGRGAGALLLGGFIVWLAM 315
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
507-634 |
7.87e-13 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 69.66 E-value: 7.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 507 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytvihrFQPVAVSSNGL 586
Cdd:TIGR00367 28 IARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAI-------FSPIIVDKDWL 100
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 300796347 587 FCAIvlLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSVLLE 634
Cdd:TIGR00367 101 RRDI--LFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLLFLVKNE 146
|
|
| PLN03151 |
PLN03151 |
cation/calcium exchanger; Provisional |
140-631 |
2.43e-11 |
|
cation/calcium exchanger; Provisional
Pssm-ID: 215604 [Multi-domain] Cd Length: 650 Bit Score: 66.71 E-value: 2.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 140 IGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSlIGVFIAHS--NVGIGTIVGSAVFNIL 217
Cdd:PLN03151 145 VWLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKDagEVGLNSVLGGAVFVTC 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 218 FVIGMCAL-FSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMinR 296
Cdd:PLN03151 224 VVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEILRKHARRL--K 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 297 NKVVKVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGSSASLHNSL---MRNSifQLMIHTLDPLAEGRFREKASILHKIa 373
Cdd:PLN03151 302 LDVVTPLLPVQGSIFSPSVEEDESMYSPLLESDTESDVPRLQTSLpqwMWAS--NVAIYSNHFAKGSVHDEERPPWGWT- 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 374 kkkchvDENERQNGAANHVEK----IELPnststdveMTPSSDASEP-VQNGNLSHNIEGAEAQTAdeeedqPLSLA--W 446
Cdd:PLN03151 379 ------DEGAEVESSLFSCSKlfslLEMP--------LTIPRRLTIPiVEEDRWSKTYAVASASLA------PVLLAflW 438
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 447 -----PSETRKQVTFLIVFPIVFPLWI-----TLPDvrKPSSRKFFPIT---FFGSITWIAVFSYLMVWWAHQVGETIGI 513
Cdd:PLN03151 439 ssqddVSLQARIAAYFIGVAIGSTLGFlaykyTEPD--RPPRRFLIPWVlggFIMSIVWFYMIANELVALLVAFGVIFGI 516
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 514 SEEIMGLTILAAGTSIPDLITSVIVARKGlGD---MAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAV-SSNGLFCA 589
Cdd:PLN03151 517 NPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAGPMFNTLVGLGMSMLLGAWSKSPESYMLpEDSSLFYT 595
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 300796347 590 IVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSV 631
Cdd:PLN03151 596 MGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRV 637
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
139-227 |
7.74e-10 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 60.82 E-value: 7.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 139 VIGMIYMFIALAIVCDeffvpSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILF 218
Cdd:PRK10734 180 GIALIIMPMATRMVID-----NATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVI 254
|
....*....
gi 300796347 219 VIGMCALFS 227
Cdd:PRK10734 255 VLGLPALIS 263
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
500-614 |
1.72e-07 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 53.50 E-value: 1.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 500 MVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLytvihrfQPV 579
Cdd:PRK10734 22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALI-------RPF 94
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 300796347 580 AVSSN------------GLFCAIVLLFIML-----LFVILSIALCKWRMNKI 614
Cdd:PRK10734 95 TVHSDvlrrelplmllvSVLAGSVLYDGQLsrsdgIFLLLLAVLWLLFIVKI 146
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
105-287 |
3.31e-06 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 50.38 E-value: 3.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 105 KEGESENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIY-MFIALAIV----CDEFFVPS-------------LTV--- 163
Cdd:TIGR00927 877 EEEEEEEEEEEEENEEPLSLEWPETRQKQAIYLFLLPIVFpLWLTVPDVrrqeARKFFVITflgsimwiamfsyLMVwwa 956
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 164 --ITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRD 241
Cdd:TIGR00927 957 hqVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSN 1036
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 300796347 242 VSFYIVDLIMLIIFFLDNVIM---W-WESLLLLTAYFCYVVFMKFNVQVE 287
Cdd:TIGR00927 1037 GLFCAIVLLFLMLLFVISSIAsckWrMNKILGFTMFLLYFVFLIISVMLE 1086
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
485-616 |
1.54e-05 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 48.25 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796347 485 TFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG-DMAVSSSVGSNIFDITVGL 563
Cdd:TIGR00845 758 CFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLGI 837
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 300796347 564 PLPWLLYTVIHRFQ--PVAVSSNGLFCAiVLLFIMLLFVILSIALCkwRMNKILG 616
Cdd:TIGR00845 838 GVAWSIAAIYHAANgtQFKVSPGTLAFS-VTLFTIFAFICIGVLLY--RRRPEIG 889
|
|
|