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Conserved domains on  [gi|303521460|ref|NP_001181921|]
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7SK snRNA methylphosphate capping enzyme isoform B [Homo sapiens]

Protein Classification

Bin3 domain-containing protein( domain architecture ID 10536334)

Bin3 domain-containing protein is a class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Danio rerio pre-miRNA 5'-monophosphate methyltransferase\tthat specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His))

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 106-214 1.89e-69

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


:

Pssm-ID: 462022  Cd Length: 109  Bit Score: 207.78  E-value: 1.89e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303521460  106 YDVVLCLSLTKWVHLNWGDEGLKRMFRRIYRHLRPGGILVLEPQPWSSYGKRKTLTETIYKNYYRIQLKPEQFSSYLTSp 185
Cdd:pfam06859   1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRPGGVLILEPQPWKSYKKAKRLSETIKANYKTIQLRPEDFEEYLLS- 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 303521460  186 DVGFSSYELVA-TPHNTSKGFQRPVYLFHK 214
Cdd:pfam06859  80 EVGFESVEELGsTPEGKSKGFDRPIYLFRK 109
 
Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 106-214 1.89e-69

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


Pssm-ID: 462022  Cd Length: 109  Bit Score: 207.78  E-value: 1.89e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303521460  106 YDVVLCLSLTKWVHLNWGDEGLKRMFRRIYRHLRPGGILVLEPQPWSSYGKRKTLTETIYKNYYRIQLKPEQFSSYLTSp 185
Cdd:pfam06859   1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRPGGVLILEPQPWKSYKKAKRLSETIKANYKTIQLRPEDFEEYLLS- 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 303521460  186 DVGFSSYELVA-TPHNTSKGFQRPVYLFHK 214
Cdd:pfam06859  80 EVGFESVEELGsTPEGKSKGFDRPIYLFRK 109
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 80-147 1.95e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 42.42  E-value: 1.95e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 303521460  80 FPNNVVFVTGNYvldrDDLVEAQTPEYDVVLCLSLTKWVHLNWgdeglKRMFRRIYRHLRPGGILVLE 147
Cdd:cd02440   45 LADNVEVLKGDA----EELPPEADESFDVIISDPPLHHLVEDL-----ARFLEEARRLLKPGGVLVLT 103
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 82-146 1.51e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 40.68  E-value: 1.51e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 303521460  82 NNVVFVTGNYvldRDDLVEAQtpeYDVVLCLSLTKWVhlnwGDEGLKRMFRRIYRHLRPGGILVL 146
Cdd:COG2230  101 DRVEVRLADY---RDLPADGQ---FDAIVSIGMFEHV----GPENYPAYFAKVARLLKPGGRLLL 155
 
Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 106-214 1.89e-69

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


Pssm-ID: 462022  Cd Length: 109  Bit Score: 207.78  E-value: 1.89e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303521460  106 YDVVLCLSLTKWVHLNWGDEGLKRMFRRIYRHLRPGGILVLEPQPWSSYGKRKTLTETIYKNYYRIQLKPEQFSSYLTSp 185
Cdd:pfam06859   1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRPGGVLILEPQPWKSYKKAKRLSETIKANYKTIQLRPEDFEEYLLS- 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 303521460  186 DVGFSSYELVA-TPHNTSKGFQRPVYLFHK 214
Cdd:pfam06859  80 EVGFESVEELGsTPEGKSKGFDRPIYLFRK 109
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 80-147 1.95e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 42.42  E-value: 1.95e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 303521460  80 FPNNVVFVTGNYvldrDDLVEAQTPEYDVVLCLSLTKWVHLNWgdeglKRMFRRIYRHLRPGGILVLE 147
Cdd:cd02440   45 LADNVEVLKGDA----EELPPEADESFDVIISDPPLHHLVEDL-----ARFLEEARRLLKPGGVLVLT 103
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 106-142 1.32e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 39.85  E-value: 1.32e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 303521460  106 YDVVLCLSLtkWVHLNWGDegLKRMFRRIYRHLRPGG 142
Cdd:pfam13649  64 FDLVVSSGV--LHHLPDPD--LEAALREIARVLKPGG 96
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 82-146 1.51e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 40.68  E-value: 1.51e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 303521460  82 NNVVFVTGNYvldRDDLVEAQtpeYDVVLCLSLTKWVhlnwGDEGLKRMFRRIYRHLRPGGILVL 146
Cdd:COG2230  101 DRVEVRLADY---RDLPADGQ---FDAIVSIGMFEHV----GPENYPAYFAKVARLLKPGGRLLL 155
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
83-147 2.13e-04

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 39.04  E-value: 2.13e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 303521460  83 NVVFVTGnyvldrdDLVEAQTPE-YDVVLCLSLTKWVhlnwgdEGLKRMFRRIYRHLRPGGILVLE 147
Cdd:COG4106   47 NVRFVVA-------DLRDLDPPEpFDLVVSNAALHWL------PDHAALLARLAAALAPGGVLAVQ 99
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
93-146 1.12e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 38.44  E-value: 1.12e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 303521460  93 LDRDDLVEAQTPE--YDVVLCL-SLTkwvhlNWGDegLKRMFRRIYRHLRPGGILVL 146
Cdd:COG4976   93 LLVADLADLAEPDgrFDLIVAAdVLT-----YLGD--LAAVFAGVARALKPGGLFIF 142
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 82-148 1.22e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 38.74  E-value: 1.22e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 303521460  82 NNVVFVTGNYvldrDDLVEAQTPEYDVVLCLSLtkWVHLNwgDEGLKRMFRRIYRHLRPGGILVLEP 148
Cdd:COG0500   75 GNVEFLVADL----AELDPLPAESFDLVVAFGV--LHHLP--PEEREALLRELARALKPGGVLLLSA 133
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 81-144 3.11e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 35.81  E-value: 3.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 303521460   81 PNNVVFVTgnyvLDRDDLVEAQTPEYDVVLCLSltkwVHLNWGDegLKRMFRRIYRHLRPGGIL 144
Cdd:pfam08242  45 LLNAVRVE----LFQLDLGELDPGSFDVVVASN----VLHHLAD--PRAVLRNIRRLLKPGGVL 98
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 97-147 3.62e-03

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 36.15  E-value: 3.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 303521460  97 DLVEAQTPE--YDVVLCLSltkwV--HLnwgdEGLKRMFRRIYRHLRPGGILVLE 147
Cdd:COG2227   77 DLEDLPLEDgsFDLVICSE----VleHL----PDPAALLRELARLLKPGGLLLLS 123
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 106-146 6.98e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 35.74  E-value: 6.98e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 303521460 106 YDVVLCLsltkWVHLNWGDegLKRMFRRIYRHLRPGGILVL 146
Cdd:COG2226   88 FDLVISS----FVLHHLPD--PERALAEIARVLKPGGRLVV 122
Methyltransf_2 pfam00891
O-methyltransferase domain; This family includes a range of O-methyltransferases. These ...
 66-147 7.50e-03

O-methyltransferase domain; This family includes a range of O-methyltransferases. These enzymes utilize S-adenosyl methionine.


Pssm-ID: 395719 [Multi-domain]  Cd Length: 208  Bit Score: 36.23  E-value: 7.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303521460   66 AAPQVPLDGADTSVfpnnvVFVTGNYVLDRddlveaqTPEYDVVLclslTKWVHLNWGDEGLKRMFRRIYRHLRPGG-IL 144
Cdd:pfam00891  98 AAPTHFSAGEEPRV-----TFHGGDFFKDS-------LPEADAYI----LKRVLHDWSDEKCVKLLKRCYKACPAGGkVI 161


                  ...
gi 303521460  145 VLE 147
Cdd:pfam00891 162 LVE 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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