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Conserved domains on  [gi|305410791|ref|NP_001182032|]
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glutathione reductase, mitochondrial isoform 3 [Homo sapiens]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 1562436)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyr_redox_2 super family cl39093
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 63-469 0e+00

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


The actual alignment was detected with superfamily member TIGR01421:

Pssm-ID: 476868 [Multi-domain]  Cd Length: 450  Bit Score: 739.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791   63 ASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSC-EGKFNWR 141
Cdd:TIGR01421   1 KHYDYLVIGGGSGGIASARRAAEHGAKALLVEAKKLGGTCVNVGCVPKKVMWYASDLAERMHDAADYGFYQNdENTFNWP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  142 VIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDpkPTIEVSGKKYTAPHILIATGGMPSTPheSQIPGASLGITS 221
Cdd:TIGR01421  81 ELKEKRDAYVDRLNGIYQKNLEKNKVDVIFGHARFTKD--GTVEVNGRDYTAPHILIATGGKPSFP--ENIPGAELGTDS 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  222 DGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQ------- 294
Cdd:TIGR01421 157 DGFFALEELPKRVVIVGAGYIAVELAGVLHGLGSETHLVIRHERVLRSFDSMISETITEEYEKEGINVHKLSKpvkvekt 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  295 ---------------------------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIA 335
Cdd:TIGR01421 237 vegklvihfedgksiddvdeliwaigrkpntkglglenvGIKLNEKGQIIVDEYQNTNVPGIYALGDVVGKVELTPVAIA 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  336 AGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCA 415
Cdd:TIGR01421 317 AGRKLSERLFNGKTDDKLDYNNVPTVVFSHPPIGTIGLTEKEAIEKYGKENIKVYNSSFTPMYYAMTSEKQKCRMKLVCA 396

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 305410791  416 NKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 469
Cdd:TIGR01421 397 GKEEKVVGLHGIGDGVDEMLQGFAVAIKMGATKADFDNTVAIHPTSSEELVTMR 450
 
Name Accession Description Interval E-value
gluta_reduc_1 TIGR01421
glutathione-disulfide reductase, animal/bacterial; The tripeptide glutathione is an important ...
 63-469 0e+00

glutathione-disulfide reductase, animal/bacterial; The tripeptide glutathione is an important reductant, e.g., for maintaining the cellular thiol/disulfide status and for protecting against reactive oxygen species such as hydrogen peroxide. Glutathione-disulfide reductase regenerates reduced glutathione from oxidized glutathione (glutathione disulfide) + NADPH. This model represents one of two closely related subfamilies of glutathione-disulfide reductase. Both are closely related to trypanothione reductase, and separate models are built so each of the three can describe proteins with conserved function. This model describes glutathione-disulfide reductases of animals, yeast, and a number of animal-resident bacteria. [Energy metabolism, Electron transport]


Pssm-ID: 273614 [Multi-domain]  Cd Length: 450  Bit Score: 739.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791   63 ASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSC-EGKFNWR 141
Cdd:TIGR01421   1 KHYDYLVIGGGSGGIASARRAAEHGAKALLVEAKKLGGTCVNVGCVPKKVMWYASDLAERMHDAADYGFYQNdENTFNWP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  142 VIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDpkPTIEVSGKKYTAPHILIATGGMPSTPheSQIPGASLGITS 221
Cdd:TIGR01421  81 ELKEKRDAYVDRLNGIYQKNLEKNKVDVIFGHARFTKD--GTVEVNGRDYTAPHILIATGGKPSFP--ENIPGAELGTDS 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  222 DGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQ------- 294
Cdd:TIGR01421 157 DGFFALEELPKRVVIVGAGYIAVELAGVLHGLGSETHLVIRHERVLRSFDSMISETITEEYEKEGINVHKLSKpvkvekt 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  295 ---------------------------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIA 335
Cdd:TIGR01421 237 vegklvihfedgksiddvdeliwaigrkpntkglglenvGIKLNEKGQIIVDEYQNTNVPGIYALGDVVGKVELTPVAIA 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  336 AGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCA 415
Cdd:TIGR01421 317 AGRKLSERLFNGKTDDKLDYNNVPTVVFSHPPIGTIGLTEKEAIEKYGKENIKVYNSSFTPMYYAMTSEKQKCRMKLVCA 396

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 305410791  416 NKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 469
Cdd:TIGR01421 397 GKEEKVVGLHGIGDGVDEMLQGFAVAIKMGATKADFDNTVAIHPTSSEELVTMR 450
PRK06116 PRK06116
glutathione reductase; Validated
 65-469 0e+00

glutathione reductase; Validated


Pssm-ID: 235701 [Multi-domain]  Cd Length: 450  Bit Score: 613.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHA-DYGFPSCEGKFNWRVI 143
Cdd:PRK06116   5 YDLIVIGGGSGGIASANRAAMYGAKVALIEAKRLGGTCVNVGCVPKKLMWYGAQIAEAFHDYApGYGFDVTENKFDWAKL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 144 KEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTsDPKpTIEVSGKKYTAPHILIATGGMPSTPhesQIPGASLGITSDG 223
Cdd:PRK06116  85 IANRDAYIDRLHGSYRNGLENNGVDLIEGFARFV-DAH-TVEVNGERYTADHILIATGGRPSIP---DIPGAEYGITSDG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 224 FFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQ--------- 294
Cdd:PRK06116 160 FFALEELPKRVAVVGAGYIAVEFAGVLNGLGSETHLFVRGDAPLRGFDPDIRETLVEEMEKKGIRLHTNAVpkaveknad 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 295 ------------------------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGR 338
Cdd:PRK06116 240 gsltltledgetltvdcliwaigrepntdglglenaGVKLNEKGYIIVDEYQNTNVPGIYAVGDVTGRVELTPVAIAAGR 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 339 KLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKE 418
Cdd:PRK06116 320 RLSERLFNNKPDEKLDYSNIPTVVFSHPPIGTVGLTEEEAREQYGEDNVKVYRSSFTPMYTALTGHRQPCLMKLVVVGKE 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 305410791 419 EKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 469
Cdd:PRK06116 400 EKVVGLHGIGFGADEMIQGFAVAIKMGATKADFDNTVAIHPTAAEEFVTMR 450
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 65-469 4.53e-140

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 409.86  E-value: 4.53e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIK 144
Cdd:COG1249    4 YDLVVIGAGPGGYVAAIRAAQLGLKVALVEKGRLGGTCLNVGCIPSKALLHAAEVAHEARHAAEFGISAGAPSVDWAALM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 145 EKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTsDPKpTIEVSGKK-YTAPHILIATGGMPSTPhesQIPGAS--LGITS 221
Cdd:COG1249   84 ARKDKVVDRLRGGVEELLKKNGVDVIRGRARFV-DPH-TVEVTGGEtLTADHIVIATGSRPRVP---PIPGLDevRVLTS 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 222 DGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVL---KFSQ---- 294
Cdd:COG1249  159 DEALELEELPKSLVVIGGGYIGLEFAQIFARLGSEVTLVERGDRLLPGEDPEISEALEKALEKEGIDILtgaKVTSvekt 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 295 ----------------------------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAI 334
Cdd:COG1249  239 gdgvtvtledgggeeaveadkvlvatgrrpntdglgleaaGVELDERGGIKVDEYLRTSVPGIYAIGDVTGGPQLAHVAS 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 335 AAGRKLAHRLFEyKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYgiENVKTYSTSFTPMYHAVTKRKTKCVMKMVC 414
Cdd:COG1249  319 AEGRVAAENILG-KKPRPVDYRAIPSVVFTDPEIASVGLTEEEAREAG--IDVKVGKFPFAANGRALALGETEGFVKLIA 395

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 305410791 415 ANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 469
Cdd:COG1249  396 DAETGRILGAHIVGPHAGELIHEAALAMEMGLTVEDLADTIHAHPTLSEALKEAA 450
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 65-337 1.26e-46

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 163.26  E-value: 1.26e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791   65 YDYLVIGGGSGGLASARRAAELGARAAVVEshkLGGTCVNVGCVPKKVMWNTAvhsefmHDHadygfpscEGKFNWRVIK 144
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIE---DEGTCPYGGCVLSKALLGAA------EAP--------EIASLWADLY 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  145 EKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSdpKPTIEVSGKKYTAPHILIATGGMPSTPHesqIPGASLG------ 218
Cdd:pfam07992  64 KRKEEVVKKLNNGIEVLLGTEVVSIDPGAKKVVL--EELVDGDGETITYDRLVIATGARPRLPP---IPGVELNvgflvr 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  219 -ITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEV-------- 289
Cdd:pfam07992 139 tLDSAEALRLKLLPKRVVVVGGGYIGVELAAALAKLGKEVTLIEALDRLLRAFDEEISAALEKALEKNGVEVrlgtsvke 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  290 ----------------------------------LKFSQGIQTDDKGHIIVDEFQNTNVKGIYAVGDV-CGKALLTPVAI 334
Cdd:pfam07992 219 iigdgdgvevilkdgteidadlvvvaigrrpnteLLEAAGLELDERGGIVVDEYLRTSVPGIYAAGDCrVGGPELAQNAV 298


                  ...
gi 305410791  335 AAG 337
Cdd:pfam07992 299 AQG 301
 
Name Accession Description Interval E-value
gluta_reduc_1 TIGR01421
glutathione-disulfide reductase, animal/bacterial; The tripeptide glutathione is an important ...
 63-469 0e+00

glutathione-disulfide reductase, animal/bacterial; The tripeptide glutathione is an important reductant, e.g., for maintaining the cellular thiol/disulfide status and for protecting against reactive oxygen species such as hydrogen peroxide. Glutathione-disulfide reductase regenerates reduced glutathione from oxidized glutathione (glutathione disulfide) + NADPH. This model represents one of two closely related subfamilies of glutathione-disulfide reductase. Both are closely related to trypanothione reductase, and separate models are built so each of the three can describe proteins with conserved function. This model describes glutathione-disulfide reductases of animals, yeast, and a number of animal-resident bacteria. [Energy metabolism, Electron transport]


Pssm-ID: 273614 [Multi-domain]  Cd Length: 450  Bit Score: 739.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791   63 ASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSC-EGKFNWR 141
Cdd:TIGR01421   1 KHYDYLVIGGGSGGIASARRAAEHGAKALLVEAKKLGGTCVNVGCVPKKVMWYASDLAERMHDAADYGFYQNdENTFNWP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  142 VIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDpkPTIEVSGKKYTAPHILIATGGMPSTPheSQIPGASLGITS 221
Cdd:TIGR01421  81 ELKEKRDAYVDRLNGIYQKNLEKNKVDVIFGHARFTKD--GTVEVNGRDYTAPHILIATGGKPSFP--ENIPGAELGTDS 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  222 DGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQ------- 294
Cdd:TIGR01421 157 DGFFALEELPKRVVIVGAGYIAVELAGVLHGLGSETHLVIRHERVLRSFDSMISETITEEYEKEGINVHKLSKpvkvekt 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  295 ---------------------------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIA 335
Cdd:TIGR01421 237 vegklvihfedgksiddvdeliwaigrkpntkglglenvGIKLNEKGQIIVDEYQNTNVPGIYALGDVVGKVELTPVAIA 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  336 AGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCA 415
Cdd:TIGR01421 317 AGRKLSERLFNGKTDDKLDYNNVPTVVFSHPPIGTIGLTEKEAIEKYGKENIKVYNSSFTPMYYAMTSEKQKCRMKLVCA 396

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 305410791  416 NKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 469
Cdd:TIGR01421 397 GKEEKVVGLHGIGDGVDEMLQGFAVAIKMGATKADFDNTVAIHPTSSEELVTMR 450
PRK06116 PRK06116
glutathione reductase; Validated
 65-469 0e+00

glutathione reductase; Validated


Pssm-ID: 235701 [Multi-domain]  Cd Length: 450  Bit Score: 613.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHA-DYGFPSCEGKFNWRVI 143
Cdd:PRK06116   5 YDLIVIGGGSGGIASANRAAMYGAKVALIEAKRLGGTCVNVGCVPKKLMWYGAQIAEAFHDYApGYGFDVTENKFDWAKL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 144 KEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTsDPKpTIEVSGKKYTAPHILIATGGMPSTPhesQIPGASLGITSDG 223
Cdd:PRK06116  85 IANRDAYIDRLHGSYRNGLENNGVDLIEGFARFV-DAH-TVEVNGERYTADHILIATGGRPSIP---DIPGAEYGITSDG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 224 FFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQ--------- 294
Cdd:PRK06116 160 FFALEELPKRVAVVGAGYIAVEFAGVLNGLGSETHLFVRGDAPLRGFDPDIRETLVEEMEKKGIRLHTNAVpkaveknad 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 295 ------------------------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGR 338
Cdd:PRK06116 240 gsltltledgetltvdcliwaigrepntdglglenaGVKLNEKGYIIVDEYQNTNVPGIYAVGDVTGRVELTPVAIAAGR 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 339 KLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKE 418
Cdd:PRK06116 320 RLSERLFNNKPDEKLDYSNIPTVVFSHPPIGTVGLTEEEAREQYGEDNVKVYRSSFTPMYTALTGHRQPCLMKLVVVGKE 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 305410791 419 EKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 469
Cdd:PRK06116 400 EKVVGLHGIGFGADEMIQGFAVAIKMGATKADFDNTVAIHPTAAEEFVTMR 450
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 65-469 4.53e-140

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 409.86  E-value: 4.53e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIK 144
Cdd:COG1249    4 YDLVVIGAGPGGYVAAIRAAQLGLKVALVEKGRLGGTCLNVGCIPSKALLHAAEVAHEARHAAEFGISAGAPSVDWAALM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 145 EKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTsDPKpTIEVSGKK-YTAPHILIATGGMPSTPhesQIPGAS--LGITS 221
Cdd:COG1249   84 ARKDKVVDRLRGGVEELLKKNGVDVIRGRARFV-DPH-TVEVTGGEtLTADHIVIATGSRPRVP---PIPGLDevRVLTS 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 222 DGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVL---KFSQ---- 294
Cdd:COG1249  159 DEALELEELPKSLVVIGGGYIGLEFAQIFARLGSEVTLVERGDRLLPGEDPEISEALEKALEKEGIDILtgaKVTSvekt 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 295 ----------------------------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAI 334
Cdd:COG1249  239 gdgvtvtledgggeeaveadkvlvatgrrpntdglgleaaGVELDERGGIKVDEYLRTSVPGIYAIGDVTGGPQLAHVAS 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 335 AAGRKLAHRLFEyKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYgiENVKTYSTSFTPMYHAVTKRKTKCVMKMVC 414
Cdd:COG1249  319 AEGRVAAENILG-KKPRPVDYRAIPSVVFTDPEIASVGLTEEEAREAG--IDVKVGKFPFAANGRALALGETEGFVKLIA 395

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 305410791 415 ANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 469
Cdd:COG1249  396 DAETGRILGAHIVGPHAGELIHEAALAMEMGLTVEDLADTIHAHPTLSEALKEAA 450
PTZ00058 PTZ00058
glutathione reductase; Provisional
 65-468 1.88e-130

glutathione reductase; Provisional


Pssm-ID: 185420 [Multi-domain]  Cd Length: 561  Bit Score: 388.97  E-value: 1.88e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGkFNWRVIK 144
Cdd:PTZ00058  49 YDLIVIGGGSGGMAAARRAARNKAKVALVEKDYLGGTCVNVGCVPKKIMFNAASIHDILENSRHYGFDTQFS-FNLPLLV 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 145 EKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEV---------------------------SGKKYTAPHIL 197
Cdd:PTZ00058 128 ERRDKYIRRLNDIYRQNLKKDNVEYFEGKGSLLSENQVLIKKvsqvdgeadesdddevtivsagvsqldDGQVIEGKNIL 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 198 IATGGMPSTPhesQIPGASLGITSDGFFQLEElPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTN 277
Cdd:PTZ00058 208 IAVGNKPIFP---DVKGKEFTISSDDFFKIKE-AKRIGIAGSGYIAVELINVVNRLGAESYIFARGNRLLRKFDETIINE 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 278 CTEELENAGVEVLKF----------SQGIQT-----------------------------------DDKGHIIVDEFQNT 312
Cdd:PTZ00058 284 LENDMKKNNINIITHanveeiekvkEKNLTIylsdgrkyehfdyviycvgrspntedlnlkalnikTPKGYIKVDDNQRT 363

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 313 NVKGIYAVGDVCGKAL----------------------------------LTPVAIAAGRKLAHRLFEYKEDsKLDYNNI 358
Cdd:PTZ00058 364 SVKHIYAVGDCCMVKKnqeiedlnllklyneepylkkkentsgesyynvqLTPVAINAGRLLADRLFGPFSR-TTNYKLI 442

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 359 PTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTK----RKTKCVMKMVCANKEEKVVGIHMQGLGCDEM 434
Cdd:PTZ00058 443 PSVIFSHPPIGTIGLSEQEAIDIYGKENVKIYESRFTNLFFSVYDmdpaQKEKTYLKLVCVGKEELIKGLHIVGLNADEI 522

                        490       500       510
                 ....*....|....*....|....*....|....
gi 305410791 435 LQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 468
Cdd:PTZ00058 523 LQGFAVALKMNATKADFDETIPIHPTAAEEFVTM 556
gluta_reduc_2 TIGR01424
glutathione-disulfide reductase, plant; The tripeptide glutathione is an important reductant, ...
 65-469 9.24e-122

glutathione-disulfide reductase, plant; The tripeptide glutathione is an important reductant, e.g., for maintaining the cellular thiol/disulfide status and for protecting against reactive oxygen species such as hydrogen peroxide. Glutathione-disulfide reductase regenerates reduced glutathione from oxidized glutathione (glutathione disulfide) + NADPH. This model represents one of two closely related subfamilies of glutathione-disulfide reductase. Both are closely related to trypanothione reductase, and separate models are built so each of the three can describe proteins with conserved function. This model describes glutathione-disulfide reductases of plants and some bacteria, including cyanobacteria. [Energy metabolism, Electron transport]


Pssm-ID: 213618 [Multi-domain]  Cd Length: 446  Bit Score: 362.59  E-value: 9.24e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791   65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIK 144
Cdd:TIGR01424   3 YDLFVIGAGSGGVRAARLAAALGAKVAIAEEFRVGGTCVIRGCVPKKLMVYASQFAEHFEDAAGYGWTVGKARFDWKKLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  145 EKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTsDPKpTIEV--SGKKYTAPHILIATGGMPSTPhesQIPGASLGITSD 222
Cdd:TIGR01424  83 AAKDQEIARLSGLYRKGLANAGAELLDGRAELV-GPN-TVEVlaSGKTYTAEKILIAVGGRPPKP---ALPGHELGITSN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  223 GFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVL---------KFS 293
Cdd:TIGR01424 158 EAFHLPTLPKSILIAGGGYIAVEFAGIFRGLGVQTTLIYRGKEILRGFDDDMRRGLAAALEERGIRILpedsitsisKDD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  294 Q------------------------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAG 337
Cdd:TIGR01424 238 DgrlkatlskheeivadvvlfatgrspntnglgleaaGVRLNDLGAIAVDEYSRTSTPSIYAVGDVTDRINLTPVAIHEA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  338 RKLAHRLFeYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGieNVKTYSTSFTPMYHAVTKRKTKCVMKMVCANK 417
Cdd:TIGR01424 318 TCFAETEF-GNNPTSFDHDLIATAVFSQPPIGTVGLTEEEARRKFG--DIEVYRAEFRPMKATFSGRQEKTLMKLVVDAK 394

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 305410791  418 EEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 469
Cdd:TIGR01424 395 DDKVLGAHMVGPDAAEIIQGLAIALKMGATKDDFDSTVAVHPTSAEELVTMR 446
TGR TIGR01438
thioredoxin and glutathione reductase selenoprotein; This homodimeric, FAD-containing member ...
 65-468 8.83e-103

thioredoxin and glutathione reductase selenoprotein; This homodimeric, FAD-containing member of the pyridine nucleotide disulfide oxidoreductase family contains a C-terminal motif Cys-SeCys-Gly, where SeCys is selenocysteine encoded by TGA (in some sequence reports interpreted as a stop codon). In some members of this subfamily, Cys-SeCys-Gly is replaced by Cys-Cys-Gly. The reach of the selenium atom at the C-term arm of the protein is proposed to allow broad substrate specificity.


Pssm-ID: 273624 [Multi-domain]  Cd Length: 484  Bit Score: 315.25  E-value: 8.83e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791   65 YDYLVIGGGSGGLASARRAAELGARAAVVESHK---------LGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCE 135
Cdd:TIGR01438   3 YDLIVIGGGSGGLAAAKEAAAYGAKVMLLDFVTptplgtrwgIGGTCVNVGCIPKKLMHQAALLGQALKDSRNYGWKVEE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  136 G-KFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSdpKPTIEVSGKK-----YTAPHILIATGGMPSTPhe 209
Cdd:TIGR01438  83 TvKHDWKRLVEAVQNHIGSLNWGYRVALREKKVKYENAYAEFVD--KHRIKATNKKgkekiYSAERFLIATGERPRYP-- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  210 sQIPGAS-LGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRhDKVLRSFDSMISTNCTEELENAGV- 287
Cdd:TIGR01438 159 -GIPGAKeLCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVR-SILLRGFDQDCANKVGEHMEEHGVk 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  288 -----EVLKFSQ-----------------------------------------GIQTDDK-GHIIVDEFQNTNVKGIYAV 320
Cdd:TIGR01438 237 fkrqfVPIKVEQieakvlveftdstngieeeydtvllaigrdactrklnlenvGVKINKKtGKIPADEEEQTNVPYIYAV 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  321 GDVC-GKALLTPVAIAAGRKLAHRLFEyKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYH 399
Cdd:TIGR01438 317 GDILeDKPELTPVAIQAGRLLAQRLFK-GSTVICDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENVEVFHSYFWPLEW 395

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 305410791  400 AVTKRK--TKCVMKMVCANKE-EKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 468
Cdd:TIGR01438 396 TIPSRDnhNKCYAKLVCNKKEnERVVGFHVVGPNAGEVTQGFAAALRCGLTKKDLDNTIGIHPVCAEVFTTL 467
PLN02546 PLN02546
glutathione reductase
 65-469 1.40e-102

glutathione reductase


Pssm-ID: 215301 [Multi-domain]  Cd Length: 558  Bit Score: 317.20  E-value: 1.40e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  65 YDYLVIGGGSGGLASARRAAELGARAAVVE----------SHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFP-S 133
Cdd:PLN02546  80 FDLFTIGAGSGGVRASRFASNFGASAAVCElpfatissdtLGGVGGTCVLRGCVPKKLLVYASKYSHEFEESRGFGWKyE 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 134 CEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTsDPKpTIEVSGKKYTAPHILIATGGMPSTPhesQIP 213
Cdd:PLN02546 160 TEPKHDWNTLIANKNAELQRLTGIYKNILKNAGVTLIEGRGKIV-DPH-TVDVDGKLYTARNILIAVGGRPFIP---DIP 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 214 GASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVE----- 288
Cdd:PLN02546 235 GIEHAIDSDAALDLPSKPEKIAIVGGGYIALEFAGIFNGLKSDVHVFIRQKKVLRGFDEEVRDFVAEQMSLRGIEfhtee 314

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 289 ----VLK-----------------FSQ-------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKAL 328
Cdd:PLN02546 315 spqaIIKsadgslslktnkgtvegFSHvmfatgrkpntknlgleevGVKMDKNGAIEVDEYSRTSVPSIWAVGDVTDRIN 394

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 329 LTPVAIAAGRKLAHRLFEyKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGieNVKTYSTSFTPMYHAVTKRKTKC 408
Cdd:PLN02546 395 LTPVALMEGGALAKTLFG-NEPTKPDYRAVPSAVFSQPPIGQVGLTEEQAIEEYG--DVDVFTANFRPLKATLSGLPDRV 471

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 305410791 409 VMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 469
Cdd:PLN02546 472 FMKLIVCAKTNKVLGVHMCGEDAPEIIQGFAVAVKAGLTKADFDATVGIHPTAAEEFVTMR 532
PLN02507 PLN02507
glutathione reductase
 65-469 2.56e-99

glutathione reductase


Pssm-ID: 215281 [Multi-domain]  Cd Length: 499  Bit Score: 306.74  E-value: 2.56e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  65 YDYLVIGGGSGGLASARRAAELGARAAVVE----------SHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSC 134
Cdd:PLN02507  26 FDLFVIGAGSGGVRAARFSANFGAKVGICElpfhpissesIGGVGGTCVIRGCVPKKILVYGATFGGEFEDAKNYGWEIN 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 135 EG-KFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTsDPKpTIEV-----SGKKYTAPHILIATGGMPSTPH 208
Cdd:PLN02507 106 EKvDFNWKKLLQKKTDEILRLNGIYKRLLANAGVKLYEGEGKIV-GPN-EVEVtqldgTKLRYTAKHILIATGSRAQRPN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 209 esqIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGV- 287
Cdd:PLN02507 184 ---IPGKELAITSDEALSLEELPKRAVVLGGGYIAVEFASIWRGMGATVDLFFRKELPLRGFDDEMRAVVARNLEGRGIn 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 288 --------EVLKFSQGIQT-----------------------------------DDKGHIIVDEFQNTNVKGIYAVGDVC 324
Cdd:PLN02507 261 lhprtnltQLTKTEGGIKVitdhgeefvadvvlfatgrapntkrlnleavgvelDKAGAVKVDEYSRTNIPSIWAIGDVT 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 325 GKALLTPVAIAAGRKLAHRLFEyKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIhKYGIENVKTYSTSFTPMYHAVTKR 404
Cdd:PLN02507 341 NRINLTPVALMEGTCFAKTVFG-GQPTKPDYENVACAVFCIPPLSVVGLSEEEAV-EQAKGDILVFTSSFNPMKNTISGR 418

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 305410791 405 KTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 469
Cdd:PLN02507 419 QEKTVMKLIVDAETDKVLGASMCGPDAPEIMQGIAVALKCGATKAQFDSTVGIHPSAAEEFVTMR 483
PTZ00052 PTZ00052
thioredoxin reductase; Provisional
 65-468 1.26e-86

thioredoxin reductase; Provisional


Pssm-ID: 185416 [Multi-domain]  Cd Length: 499  Bit Score: 274.01  E-value: 1.26e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  65 YDYLVIGGGSGGLASARRAAELGARAAVVESHK---------LGGTCVNVGCVPKKVMWNTA-VHSEFMHDHADYGFpSC 134
Cdd:PTZ00052   6 YDLVVIGGGSGGMAAAKEAAAHGKKVALFDYVKpstqgtkwgLGGTCVNVGCVPKKLMHYAAnIGSIFHHDSQMYGW-KT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 135 EGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKK--YTAPHILIATGGMPSTPHEsqI 212
Cdd:PTZ00052  85 SSSFNWGKLVTTVQNHIRSLNFSYRTGLRSSKVEYINGLAKLKDEHTVSYGDNSQEetITAKYILIATGGRPSIPED--V 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 213 PGA-SLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRhDKVLRSFDSMISTNCTEELENAGVEVLK 291
Cdd:PTZ00052 163 PGAkEYSITSDDIFSLSKDPGKTLIVGASYIGLETAGFLNELGFDVTVAVR-SIPLRGFDRQCSEKVVEYMKEQGTLFLE 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 292 -----------------FSQG---------------------------IQTDDKGHIIVDEfQNTNVKGIYAVGDVC-GK 326
Cdd:PTZ00052 242 gvvpiniekmddkikvlFSDGttelfdtvlyatgrkpdikglnlnaigVHVNKSNKIIAPN-DCTNIPNIFAVGDVVeGR 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 327 ALLTPVAIAAGRKLAHRLFEyKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRK- 405
Cdd:PTZ00052 321 PELTPVAIKAGILLARRLFK-QSNEFIDYTFIPTTIFTPIEYGACGYSSEAAIAKYGEDDIEEYLQEFNTLEIAAVHREk 399

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 305410791 406 --------------TKCVMKMVC-ANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 468
Cdd:PTZ00052 400 herarkdeydfdvsSNCLAKLVCvKSEDNKVVGFHFVGPNAGEITQGFSLALKLGAKKSDFDSMIGIHPTDAEVFMNL 477
trypano_reduc TIGR01423
trypanothione-disulfide reductase; Trypanothione, a glutathione-modified derivative of ...
 64-469 2.17e-86

trypanothione-disulfide reductase; Trypanothione, a glutathione-modified derivative of spermidine, is (in its reduced form) an important antioxidant found in trypanosomatids (Crithidia, Leishmania, Trypanosoma). This model describes trypanothione reductase, a possible antitrypanosomal drug target closely related to some forms of glutathione reductase.


Pssm-ID: 200098 [Multi-domain]  Cd Length: 486  Bit Score: 273.00  E-value: 2.17e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791   64 SYDYLVIGGGSGGLASARRAAEL-GARAAVVESHK---------LGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYG--F 131
Cdd:TIGR01423   3 AFDLVVIGAGSGGLEAGWNAATLyKKRVAVVDVQThhgppfyaaLGGTCVNVGCVPKKLMVTGAQYMDTLRESAGFGweF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  132 PSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSH-IEIIRGHAAF----------TSDPKPTIEvsgKKYTAPHILIAT 200
Cdd:TIGR01423  83 DRSSVKANWKALIAAKNKAVLDINKSYEGMFADTEgLTFFLGWGALedknvvlvreSADPKSAVK---ERLQAEHILLAT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  201 GGMPSTPhesQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSA---LGSKTSLMIRHDKVLRSFDSMISTN 277
Cdd:TIGR01423 160 GSWPQML---GIPGIEHCISSNEAFYLDEPPRRVLTVGGGFISVEFAGIFNAykpRGGKVTLCYRNNMILRGFDSTLRKE 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  278 CTEELENAGVEVLK------------------FSQGIQTD---------------------------DKGHIIVDEFQNT 312
Cdd:TIGR01423 237 LTKQLRANGINIMTnenpakvtlnadgskhvtFESGKTLDvdvvmmaigrvprtqtlqldkvgveltKKGAIQVDEFSRT 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  313 NVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEdSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYgiENVKTYST 392
Cdd:TIGR01423 317 NVPNIYAIGDVTDRVMLTPVAINEGAAFVDTVFGNKP-RKTDHTRVASAVFSIPPIGTCGLVEEDAAKKF--EKVAVYES 393

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 305410791  393 SFTPMYHAVTKRK-TKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 469
Cdd:TIGR01423 394 SFTPLMHNISGSKyKKFVAKIVTNHADGTVLGVHLLGDSSPEIIQAVGICLKLNAKISDFYNTIGVHPTSAEELCSMR 471
PRK06370 PRK06370
FAD-containing oxidoreductase;
64-468 2.63e-78

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 251.28  E-value: 2.63e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEG-KFNWRV 142
Cdd:PRK06370   5 RYDAIVIGAGQAGPPLAARAAGLGMKVALIERGLLGGTCVNTGCVPTKTLIASARAAHLARRAAEYGVSVGGPvSVDFKA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 143 IKEKRDAYVSRLNAIYQNNLTK-SHIEIIRGHAAFTSdpKPTIEVSGKKYTAPHILIATGGMPSTPHesqIPG-ASLG-I 219
Cdd:PRK06370  85 VMARKRRIRARSRHGSEQWLRGlEGVDVFRGHARFES--PNTVRVGGETLRAKRIFINTGARAAIPP---IPGlDEVGyL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 220 TSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEV------LKFS 293
Cdd:PRK06370 160 TNETIFSLDELPEHLVIIGGGYIGLEFAQMFRRFGSEVTVIERGPRLLPREDEDVAAAVREILEREGIDVrlnaecIRVE 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 294 Q-----------------------------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPV 332
Cdd:PRK06370 240 RdgdgiavgldcnggapeitgshilvavgrvpntddlgleaaGVETDARGYIKVDDQLRTTNPGIYAAGDCNGRGAFTHT 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 333 AIAAGRKLAHRLFEyKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAiHKYGIeNVKTYSTSFTPMYHAVTKRKTKCVMKM 412
Cdd:PRK06370 320 AYNDARIVAANLLD-GGRRKVSDRIVPYATYTDPPLARVGMTEAEA-RKSGR-RVLVGTRPMTRVGRAVEKGETQGFMKV 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 305410791 413 VCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 468
Cdd:PRK06370 397 VVDADTDRILGATILGVHGDEMIHEILDAMYAGAPYTTLSRAIHIHPTVSELIPTL 452
PRK06416 PRK06416
dihydrolipoamide dehydrogenase; Reviewed
 64-465 1.16e-72

dihydrolipoamide dehydrogenase; Reviewed


Pssm-ID: 235798 [Multi-domain]  Cd Length: 462  Bit Score: 236.58  E-value: 1.16e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVI 143
Cdd:PRK06416   4 EYDVIVIGAGPGGYVAAIRAAQLGLKVAIVEKEKLGGTCLNRGCIPSKALLHAAERADEARHSEDFGIKAENVGIDFKKV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 144 KEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSdpKPTIEV----SGKKYTAPHILIATGgmpSTPHEsqIPGASLG- 218
Cdd:PRK06416  84 QEWKNGVVNRLTGGVEGLLKKNKVDIIRGEAKLVD--PNTVRVmtedGEQTYTAKNIILATG---SRPRE--LPGIEIDg 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 219 ---ITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVL---KF 292
Cdd:PRK06416 157 rviWTSDEALNLDEVPKSLVVIGGGYIGVEFASAYASLGAEVTIVEALPRILPGEDKEISKLAERALKKRGIKIKtgaKA 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 293 SQGIQTD-------------------------------------------DKGHIIVDEFQNTNVKGIYAVGDvcgkall 329
Cdd:PRK06416 237 KKVEQTDdgvtvtledggkeetleadyvlvavgrrpntenlgleelgvktDRGFIEVDEQLRTNVPNIYAIGD------- 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 330 tpvaIAAGRKLAHRLF-EYK--------EDSKLDYNNIPTVVFSHPPIGTVGLTEDEAihKYGIENVKTYSTSFTPMYHA 400
Cdd:PRK06416 310 ----IVGGPMLAHKASaEGIiaaeaiagNPHPIDYRGIPAVTYTHPEVASVGLTEAKA--KEEGFDVKVVKFPFAGNGKA 383

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 305410791 401 VTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 465
Cdd:PRK06416 384 LALGETDGFVKLIFDKKDGEVLGAHMVGARASELIQEAQLAINWEATPEDLALTIHPHPTLSEAL 448
lipoamide_DH TIGR01350
dihydrolipoamide dehydrogenase; This model describes dihydrolipoamide dehydrogenase, a ...
 64-463 5.16e-72

dihydrolipoamide dehydrogenase; This model describes dihydrolipoamide dehydrogenase, a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system. This family includes a few members known to have distinct functions (ferric leghemoglobin reductase and NADH:ferredoxin oxidoreductase) but that may be predicted by homology to act as dihydrolipoamide dehydrogenase as well. The motif GGXCXXXGCXP near the N-terminus contains a redox-active disulfide.


Pssm-ID: 273568 [Multi-domain]  Cd Length: 460  Bit Score: 234.84  E-value: 5.16e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791   64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAvhsEFMHD--HA-DYGFPSCEGKFNW 140
Cdd:TIGR01350   1 AYDVIVIGGGPGGYVAAIRAAQLGLKVALVEKEYLGGTCLNVGCIPTKALLHSA---EVYDEikHAkDLGIEVENVSVDW 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  141 RVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSdpKPTIEVSGKKY----TAPHILIATGGMPSTPHESQIPGAS 216
Cdd:TIGR01350  78 EKMQKRKNKVVKKLVGGVSGLLKKNKVTVIKGEAKFLD--PGTVSVTGENGeetlEAKNIIIATGSRPRSLPGPFDFDGK 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  217 LGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVL------ 290
Cdd:TIGR01350 156 VVITSTGALNLEEVPESLVIIGGGVIGIEFASIFASLGSKVTVIEMLDRILPGEDAEVSKVLQKALKKKGVKILtntkvt 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  291 ---------KFSQ-------------------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLT 330
Cdd:TIGR01350 236 aveknddqvTYENkggetetltgekvlvavgrkpnteglgleklGVELDERGRIVVDEYMRTNVPGIYAIGDVIGGPMLA 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  331 PVAIAAGRKLAHRLFEyKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGieNVKTYSTSFTPMYHAVTKRKTKCVM 410
Cdd:TIGR01350 316 HVASHEGIVAAENIAG-KEPAHIDYDAVPSVIYTDPEVASVGLTEEQAKEAGY--DVKIGKFPFAANGKALALGETDGFV 392

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 305410791  411 KMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSE 463
Cdd:TIGR01350 393 KIIADKKTGEILGAHIIGPHATELISEAALAMELEGTVEELARTIHPHPTLSE 445
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 64-463 8.52e-72

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 234.30  E-value: 8.52e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVI 143
Cdd:PRK06292   3 KYDVIVIGAGPAGYVAARRAAKLGKKVALIEKGPLGGTCLNVGCIPSKALIAAAEAFHEAKHAEEFGIHADGPKIDFKKV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 144 KEKRDAYVSRL-NAIYQNNLTKSHIEIIRGHAAFTsDPKpTIEVSGKKYTAPHILIATGGmpSTPhesQIPGASLG---- 218
Cdd:PRK06292  83 MARVRRERDRFvGGVVEGLEKKPKIDKIKGTARFV-DPN-TVEVNGERIEAKNIVIATGS--RVP---PIPGVWLIlgdr 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 219 -ITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELE-------NAGVEVL 290
Cdd:PRK06292 156 lLTSDDAFELDKLPKSLAVIGGGVIGLELGQALSRLGVKVTVFERGDRILPLEDPEVSKQAQKILSkefkiklGAKVTSV 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 291 KFSQ---------------------------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTP 331
Cdd:PRK06292 236 EKSGdekveelekggktetieadyvlvatgrrpntdglglentGIELDERGRPVVDEHTQTSVPGIYAAGDVNGKPPLLH 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 332 VAIAAGRKLAHRLFEYKEDsKLDYNNIPTVVFSHPPIGTVGLTEDEAIhKYGIE-NVKTYSTSFTPMYHAvtKRKTKCVM 410
Cdd:PRK06292 316 EAADEGRIAAENAAGDVAG-GVRYHPIPSVVFTDPQIASVGLTEEELK-AAGIDyVVGEVPFEAQGRARV--MGKNDGFV 391

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 305410791 411 KMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSE 463
Cdd:PRK06292 392 KVYADKKTGRLLGAHIIGPDAEHLIHLLAWAMQQGLTVEDLLRMPFYHPTLSE 444
MerA TIGR02053
mercury(II) reductase; This model represents the mercuric reductase found in the mer operon ...
 65-465 2.09e-69

mercury(II) reductase; This model represents the mercuric reductase found in the mer operon for the detoxification of mercury compounds. MerA is a FAD-containing flavoprotein which reduces Hg(II) to Hg(0) utilizing NADPH. [Cellular processes, Detoxification]


Pssm-ID: 273944 [Multi-domain]  Cd Length: 463  Bit Score: 228.08  E-value: 2.09e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791   65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWnTAVHSEFMHDHADYGFPSCEGKFNW-RVI 143
Cdd:TIGR02053   1 YDLVIIGSGAAAFAAAIKAAELGASVAMVERGPLGGTCVNVGCVPSKMLL-RAAEVAHYARKPPFGGLAATVAVDFgELL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  144 KEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDpkPTIEVSGKKYT--APHILIATGGMPSTPHesqIPG-ASLG-I 219
Cdd:TIGR02053  80 EGKREVVEELRHEKYEDVLSSYGVDYLRGRARFKDP--KTVKVDLGREVrgAKRFLIATGARPAIPP---IPGlKEAGyL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  220 TSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQ----- 294
Cdd:TIGR02053 155 TSEEALALDRIPESLAVIGGGAIGVELAQAFARLGSEVTILQRSDRLLPREEPEISAAVEEALAEEGIEVVTSAQvkavs 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  295 ------------------------------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPV 332
Cdd:TIGR02053 235 vrgggkiitvekpggqgeveadellvatgrrpntdglglekaGVKLDERGGILVDETLRTSNPGIYAAGDVTGGLQLEYV 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  333 AIAAGRKLAHRLFEYKEdSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKyGIEnVKTYSTSFTPMYHAVTKRKTKCVMKM 412
Cdd:TIGR02053 315 AAKEGVVAAENALGGAN-AKLDLLVIPRVVFTDPAVASVGLTEAEAQKA-GIE-CDCRTLPLTNVPRARINRDTRGFIKL 391

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 305410791  413 VCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 465
Cdd:TIGR02053 392 VAEPGTGKVLGVQVVAPEAAEVINEAALAIRAGMTVDDLIDTLHPFPTMAEGL 444
PRK07846 PRK07846
mycothione reductase; Reviewed
 89-379 2.18e-52

mycothione reductase; Reviewed


Pssm-ID: 181142 [Multi-domain]  Cd Length: 451  Bit Score: 182.85  E-value: 2.18e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  89 RAAVVESHKLGGTCVNVGCVPKKVMWNTA-VHSEFMHDhADYGFPSCEGKFNWRVIkekRDAYVSRLNAI------YQNN 161
Cdd:PRK07846  24 RIAIVEKGTFGGTCLNVGCIPTKMFVYAAdVARTIREA-ARLGVDAELDGVRWPDI---VSRVFGRIDPIaaggeeYRGR 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 162 LTkSHIEIIRGHAAFTsDPKpTIEV-SGKKYTAPHILIATGGMPSTPhesQIPGASlGI---TSDGFFQLEELPGRSVIV 237
Cdd:PRK07846 100 DT-PNIDVYRGHARFI-GPK-TLRTgDGEEITADQVVIAAGSRPVIP---PVIADS-GVryhTSDTIMRLPELPESLVIV 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 238 GAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTE---------------ELENAG--------------VE 288
Cdd:PRK07846 173 GGGFIAAEFAHVFSALGVRVTVVNRSGRLLRHLDDDISERFTElaskrwdvrlgrnvvGVSQDGsgvtlrlddgstveAD 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 289 VLKFSQG--------------IQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLD 354
Cdd:PRK07846 253 VLLVATGrvpngdlldaaaagVDVDEDGRVVVDEYQRTSAEGVFALGDVSSPYQLKHVANHEARVVQHNLLHPDDLIASD 332

                        330       340
                 ....*....|....*....|....*
gi 305410791 355 YNNIPTVVFSHPPIGTVGLTEDEAI 379
Cdd:PRK07846 333 HRFVPAAVFTHPQIASVGLTENEAR 357
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 65-337 1.26e-46

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 163.26  E-value: 1.26e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791   65 YDYLVIGGGSGGLASARRAAELGARAAVVEshkLGGTCVNVGCVPKKVMWNTAvhsefmHDHadygfpscEGKFNWRVIK 144
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIE---DEGTCPYGGCVLSKALLGAA------EAP--------EIASLWADLY 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  145 EKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSdpKPTIEVSGKKYTAPHILIATGGMPSTPHesqIPGASLG------ 218
Cdd:pfam07992  64 KRKEEVVKKLNNGIEVLLGTEVVSIDPGAKKVVL--EELVDGDGETITYDRLVIATGARPRLPP---IPGVELNvgflvr 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  219 -ITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEV-------- 289
Cdd:pfam07992 139 tLDSAEALRLKLLPKRVVVVGGGYIGVELAAALAKLGKEVTLIEALDRLLRAFDEEISAALEKALEKNGVEVrlgtsvke 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  290 ----------------------------------LKFSQGIQTDDKGHIIVDEFQNTNVKGIYAVGDV-CGKALLTPVAI 334
Cdd:pfam07992 219 iigdgdgvevilkdgteidadlvvvaigrrpnteLLEAAGLELDERGGIVVDEYLRTSVPGIYAAGDCrVGGPELAQNAV 298


                  ...
gi 305410791  335 AAG 337
Cdd:pfam07992 299 AQG 301
Pyr_redox_dim pfam02852
Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; This family includes both ...
 358-468 2.26e-44

Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.


Pssm-ID: 427019 [Multi-domain]  Cd Length: 109  Bit Score: 151.17  E-value: 2.26e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  358 IPTVVFSHPPIGTVGLTEDEAIHKYGieNVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQG 437
Cdd:pfam02852   1 IPSVVFTDPEIASVGLTEEEAKEKGG--EVKVGKFPFAANGRALAYGDTDGFVKLVADRETGKILGAHIVGPNAGELIQE 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 305410791  438 FAVAVKMGATKADFDNTVAIHPTSSEELVTL 468
Cdd:pfam02852  79 AALAIKMGATVEDLANTIHIHPTLSEALVEA 109
PRK13748 PRK13748
putative mercuric reductase; Provisional
 69-443 1.11e-40

putative mercuric reductase; Provisional


Pssm-ID: 184298 [Multi-domain]  Cd Length: 561  Bit Score: 153.38  E-value: 1.11e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  69 VIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHA-DYGFPSCEGKFNWRVIKEKR 147
Cdd:PRK13748 103 VIGSGGAAMAAALKAVEQGARVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRESPfDGGIAATVPTIDRSRLLAQQ 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 148 DAYVSRL-NAIYQNNL-TKSHIEIIRGHAAFTSDPKPTIEV---SGKKYTAPHILIATGGMPSTPhesQIPG--ASLGIT 220
Cdd:PRK13748 183 QARVDELrHAKYEGILdGNPAITVLHGEARFKDDQTLIVRLndgGERVVAFDRCLIATGASPAVP---PIPGlkETPYWT 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 221 SDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSfDSMISTNCTEELENAGVEVLKFSQ------ 294
Cdd:PRK13748 260 STEALVSDTIPERLAVIGSSVVALELAQAFARLGSKVTILARSTLFFRE-DPAIGEAVTAAFRAEGIEVLEHTQasqvah 338

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 295 -------------------------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAG 337
Cdd:PRK13748 339 vdgefvlttghgelradkllvatgrapntrslaldaaGVTVNAQGAIVIDQGMRTSVPHIYAAGDCTDQPQFVYVAAAAG 418

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 338 RKLAHRLfeYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAiHKYGIENV-KTYSTSFTPmyHAVTKRKTKCVMKMVCAN 416
Cdd:PRK13748 419 TRAAINM--TGGDAALDLTAMPAVVFTDPQVATVGYSEAEA-HHDGIETDsRTLTLDNVP--RALANFDTRGFIKLVIEE 493

                        410       420
                 ....*....|....*....|....*..
gi 305410791 417 KEEKVVGIHMQGLGCDEMLQGFAVAVK 443
Cdd:PRK13748 494 GSGRLIGVQAVAPEAGELIQTAALAIR 520
PRK06327 PRK06327
dihydrolipoamide dehydrogenase; Validated
 65-463 3.47e-40

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235779 [Multi-domain]  Cd Length: 475  Bit Score: 150.46  E-value: 3.47e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  65 YDYLVIGGGSGGLASARRAAELGARAAVVESHK-------LGGTCVNVGCVPKKVMWNTAVHSEFM-HDHADYGFPSCEG 136
Cdd:PRK06327   5 FDVVVIGAGPGGYVAAIRAAQLGLKVACIEAWKnpkgkpaLGGTCLNVGCIPSKALLASSEEFENAgHHFADHGIHVDGV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 137 KFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTS--DPKPTIEVSGKKY---TAPHILIATGgmpSTPHEsq 211
Cdd:PRK06327  85 KIDVAKMIARKDKVVKKMTGGIEGLFKKNKITVLKGRGSFVGktDAGYEIKVTGEDEtviTAKHVIIATG---SEPRH-- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 212 IPGASLG----ITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELE---- 283
Cdd:PRK06327 160 LPGVPFDnkiiLDNTGALNFTEVPKKLAVIGAGVIGLELGSVWRRLGAEVTILEALPAFLAAADEQVAKEAAKAFTkqgl 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 284 --NAGVEVLKFSQ------------------------------------------GIQTDDKGHIIVDEFQNTNVKGIYA 319
Cdd:PRK06327 240 diHLGVKIGEIKTggkgvsvaytdadgeaqtlevdklivsigrvpntdglgleavGLKLDERGFIPVDDHCRTNVPNVYA 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 320 VGDVCGKALLTPVAIAAGRKLAHRLFEYKEdsKLDYNNIPTVVFSHPPIGTVGLTEDEAIhKYGIEnVKTYSTSFTPMYH 399
Cdd:PRK06327 320 IGDVVRGPMLAHKAEEEGVAVAERIAGQKG--HIDYNTIPWVIYTSPEIAWVGKTEQQLK-AEGVE-YKAGKFPFMANGR 395

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 305410791 400 AVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSE 463
Cdd:PRK06327 396 ALAMGEPDGFVKIIADAKTDEILGVHVIGPNASELIAEAVVAMEFKASSEDIARICHAHPTLSE 459
PRK07251 PRK07251
FAD-containing oxidoreductase;
65-465 5.31e-40

FAD-containing oxidoreductase;


Pssm-ID: 180907 [Multi-domain]  Cd Length: 438  Bit Score: 149.13  E-value: 5.31e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKL--GGTCVNVGCVPKKVMWNTAVHsefmhdHADYGfpscegkfnwRV 142
Cdd:PRK07251   4 YDLIVIGFGKAGKTLAAKLASAGKKVALVEESKAmyGGTCINIGCIPTKTLLVAAEK------NLSFE----------QV 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 143 IKEKrDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPkpTIEVSG----KKYTAPHILIATGGMPSTPhesQIPG--AS 216
Cdd:PRK07251  68 MATK-NTVTSRLRGKNYAMLAGSGVDLYDAEAHFVSNK--VIEVQAgdekIELTAETIVINTGAVSNVL---PIPGlaDS 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 217 LGI-TSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMIS----------------TNCT 279
Cdd:PRK07251 142 KHVyDSTGIQSLETLPERLGIIGGGNIGLEFAGLYNKLGSKVTVLDAASTILPREEPSVAalakqymeedgitfllNAHT 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 280 EELENAGVEVLKFSQG---------------------------IQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPV 332
Cdd:PRK07251 222 TEVKNDGDQVLVVTEDetyrfdallyatgrkpnteplglentdIELTERGAIKVDDYCQTSVPGVFAVGDVNGGPQFTYI 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 333 AIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHavTKRKTKCVMKM 412
Cdd:PRK07251 302 SLDDFRIVFGYLTGDGSYTLEDRGNVPTTMFITPPLSQVGLTEKEAKEAGLPYAVKELLVAAMPRAH--VNNDLRGAFKV 379

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 305410791 413 VCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 465
Cdd:PRK07251 380 VVNTETKEILGATLFGEGSQEIINLITMAMDNKIPYTYFKKQIFTHPTMAENL 432
PRK05249 PRK05249
Si-specific NAD(P)(+) transhydrogenase;
65-378 9.01e-35

Si-specific NAD(P)(+) transhydrogenase;


Pssm-ID: 235373 [Multi-domain]  Cd Length: 461  Bit Score: 134.90  E-value: 9.01e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  65 YDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYgfpscegkfnwRVI 143
Cdd:PRK05249   6 YDLVVIGSGPAGEGAAMQAAKLGKRVAVIERYRnVGGGCTHTGTIPSKALREAVLRLIGFNQNPLY-----------SSY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 144 KEKRDAYVSRLNA-----------IYQNNLTKSHIEIIRGHAAFTsDPKpTIEVSG-----KKYTAPHILIATGGMPSTP 207
Cdd:PRK05249  75 RVKLRITFADLLAradhvinkqveVRRGQYERNRVDLIQGRARFV-DPH-TVEVECpdgevETLTADKIVIATGSRPYRP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 208 HESQIPGASLgITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLrSF-DSMISTNCTEELENAG 286
Cdd:PRK05249 153 PDVDFDHPRI-YDSDSILSLDHLPRSLIIYGAGVIGCEYASIFAALGVKVTLINTRDRLL-SFlDDEISDALSYHLRDSG 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 287 VeVLKFSQ---------------------------------------------GIQTDDKGHIIVDE-FQnTNVKGIYAV 320
Cdd:PRK05249 231 V-TIRHNEevekveggddgvivhlksgkkikadcllyangrtgntdglnlenaGLEADSRGQLKVNEnYQ-TAVPHIYAV 308

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 305410791 321 GDVCGKALLTPVAIAAGRKLAHRLFEykEDSKLDYNNIPTVVFSHPPIGTVGLTEDEA 378
Cdd:PRK05249 309 GDVIGFPSLASASMDQGRIAAQHAVG--EATAHLIEDIPTGIYTIPEISSVGKTEQEL 364
PRK08010 PRK08010
pyridine nucleotide-disulfide oxidoreductase; Provisional
 65-465 9.36e-35

pyridine nucleotide-disulfide oxidoreductase; Provisional


Pssm-ID: 181196 [Multi-domain]  Cd Length: 441  Bit Score: 134.76  E-value: 9.36e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  65 YDYLVIGGGSGGLASARRAAELGARAAVVESHK--LGGTCVNVGCVPKKVMwntavhsefMHDHADYGfpscegkfNWRV 142
Cdd:PRK08010   4 YQAVIIGFGKAGKTLAVTLAKAGWRVALIEQSNamYGGTCINIGCIPTKTL---------VHDAQQHT--------DFVR 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 143 IKEKRDAYVSRL-NAIYQNNLTKSHIEIIRGHAAFTSD-------PKPTIEVSGKKytaphILIATGG---MPSTPHESQ 211
Cdd:PRK08010  67 AIQRKNEVVNFLrNKNFHNLADMPNIDVIDGQAEFINNhslrvhrPEGNLEIHGEK-----IFINTGAqtvVPPIPGITT 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 212 IPGAslgITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLK 291
Cdd:PRK08010 142 TPGV---YDSTGLLNLKELPGHLGILGGGYIGVEFASMFANFGSKVTILEAASLFLPREDRDIADNIATILRDQGVDIIL 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 292 FSQ-------------------------------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKAL 328
Cdd:PRK08010 219 NAHverishhenqvqvhsehaqlavdalliasgrqpataslhpenaGIAVNERGAIVVDKYLHTTADNIWAMGDVTGGLQ 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 329 LTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPmyHAVTKRKTKC 408
Cdd:PRK08010 299 FTYISLDDYRIVRDELLGEGKRSTDDRKNVPYSVFMTPPLSRVGMTEEQARESGADIQVVTLPVAAIP--RARVMNDTRG 376

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 305410791 409 VMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 465
Cdd:PRK08010 377 VLKAIVDNKTQRILGASLLCVDSHEMINIVKMVMDAGLPYSILRDQIFTHPSMSESL 433
PTZ00153 PTZ00153
lipoamide dehydrogenase; Provisional
 65-465 2.39e-25

lipoamide dehydrogenase; Provisional


Pssm-ID: 173442 [Multi-domain]  Cd Length: 659  Bit Score: 109.23  E-value: 2.39e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  65 YDYLVIGGGSGGLASARRAAELGARAAVVESHK--LGGTCVNVGCVPKK-VMWNTAVHSEFMHDHADYGF---------- 131
Cdd:PTZ00153 117 YDVGIIGCGVGGHAAAINAMERGLKVIIFTGDDdsIGGTCVNVGCIPSKaLLYATGKYRELKNLAKLYTYgiytnafkng 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 132 ------------------PSCEGKFNWRVIKEKRDAYVSRLnAIYQNNLTKSHIEII--RGHAAFtsdpKPTI--EVSGK 189
Cdd:PTZ00153 197 kndpvernqlvadtvqidITKLKEYTQSVIDKLRGGIENGL-KSKKFCKNSEHVQVIyeRGHIVD----KNTIksEKSGK 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 190 KYTAPHILIATGGMPSTPHESQIPGASLgITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGS-------------- 255
Cdd:PTZ00153 272 EFKVKNIIIATGSTPNIPDNIEVDQKSV-FTSDTAVKLEGLQNYMGIVGMGIIGLEFMDIYTALGSevvsfeyspqllpl 350

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 256 --------------KTSLMIRHDKVLRSF-------------------------------------DS-MISTNCTEELE 283
Cdd:PTZ00153 351 ldadvakyfervflKSKPVRVHLNTLIEYvragkgnqpviighserqtgesdgpkknmndiketyvDScLVATGRKPNTN 430

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 284 NAGVEVLKfsqgIQTdDKGHIIVDEF------QNTNVKGIYAVGDVCGKALLTPVA----------IAAGRKLAHRLFEY 347
Cdd:PTZ00153 431 NLGLDKLK----IQM-KRGFVSVDEHlrvlreDQEVYDNIFCIGDANGKQMLAHTAshqalkvvdwIEGKGKENVNINVE 505

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 348 KEDSK-LDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTySTSFtpmYHAVTK----------------------- 403
Cdd:PTZ00153 506 NWASKpIIYKNIPSVCYTTPELAFIGLTEKEAKELYPPDNVGV-EISF---YKANSKvlcennisfpnnsknnsynkgky 581

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 305410791 404 ---RKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 465
Cdd:PTZ00153 582 ntvDNTEGMVKIVYLKDTKEILGMFIVGSYASILIHEGVLAINLKLSVKDLAHMVHSHPTISEVL 646
PRK07845 PRK07845
flavoprotein disulfide reductase; Reviewed
 83-377 1.68e-22

flavoprotein disulfide reductase; Reviewed


Pssm-ID: 236112 [Multi-domain]  Cd Length: 466  Bit Score: 99.93  E-value: 1.68e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  83 AAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKfNWRVIKEKRDAYVSRLnAIYQ--- 159
Cdd:PRK07845  20 AAQLGADVTVIERDGLGGAAVLTDCVPSKTLIATAEVRTELRRAAELGIRFIDDG-EARVDLPAVNARVKAL-AAAQsad 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 160 --NNLTKSHIEIIRGHAAFTS--DPKPTIEVS---GKKYT--APHILIATGgmpSTPHEsqIPGASlgitSDG------- 223
Cdd:PRK07845  98 irARLEREGVRVIAGRGRLIDpgLGPHRVKVTtadGGEETldADVVLIATG---ASPRI--LPTAE----PDGeriltwr 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 224 -FFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSmistNCTEELENA----GVEVLKFSQ---- 294
Cdd:PRK07845 169 qLYDLDELPEHLIVVGSGVTGAEFASAYTELGVKVTLVSSRDRVLPGEDA----DAAEVLEEVfarrGMTVLKRSRaesv 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 295 ----------------------------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAI 334
Cdd:PRK07845 245 ertgdgvvvtltdgrtvegshalmavgsvpntaglgleeaGVELTPSGHITVDRVSRTSVPGIYAAGDCTGVLPLASVAA 324

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 305410791 335 AAGR-KLAHRLFEykEDSKLDYNNIPTVVFSHPPIGTVGLTEDE 377
Cdd:PRK07845 325 MQGRiAMYHALGE--AVSPLRLKTVASNVFTRPEIATVGVSQAA 366
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 162-344 2.17e-20

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 91.80  E-value: 2.17e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 162 LTKSHIEIIRGHAAFTSDP-KPTIEV-SGKKYTAPHILIATGGMPSTPhesQIPGASL-GITSDGFFQ--------LEEL 230
Cdd:COG0446   46 FERKGIDVRTGTEVTAIDPeAKTVTLrDGETLSYDKLVLATGARPRPP---PIPGLDLpGVFTLRTLDdadalreaLKEF 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 231 PGRS-VIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQ--------------- 294
Cdd:COG0446  123 KGKRaVVIGGGPIGLELAEALRKRGLKVTLVERAPRLLGVLDPEMAALLEEELREHGVELRLGETvvaidgddkvavtlt 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 295 --------------------------GIQTDDKGHIIVDEFQNTNVKGIYAVGDVC-------GKALLTPVAIAA---GR 338
Cdd:COG0446  203 dgeeipadlvvvapgvrpntelakdaGLALGERGWIKVDETLQTSDPDVYAAGDCAevphpvtGKTVYIPLASAAnkqGR 282


                 ....*.
gi 305410791 339 KLAHRL 344
Cdd:COG0446  283 VAAENI 288
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
83-337 8.87e-18

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 83.63  E-value: 8.87e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791  83 AAELGARAAVVESHKLGGTCVNVGCVpkkvmwntavhsefmhdhADY-GFP-SCEGKfnwrvikekrdAYVSRLnaiyQN 160
Cdd:COG0492   19 AARAGLKTLVIEGGEPGGQLATTKEI------------------ENYpGFPeGISGP-----------ELAERL----RE 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 161 NLTKSHIEIIRGHA---AFTSDPKpTIEV-SGKKYTAPHILIATGGMPSTPhesQIPGA--------SLGITSDGFFqle 228
Cdd:COG0492   66 QAERFGAEILLEEVtsvDKDDGPF-RVTTdDGTEYEAKAVIIATGAGPRKL---GLPGEeefegrgvSYCATCDGFF--- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 229 eLPGRSV-IVGAGYIAVEMAGILSALGSKTSLMIRHDKvLRSFDSMI--------------------------------- 274
Cdd:COG0492  139 -FRGKDVvVVGGGDSALEEALYLTKFASKVTLIHRRDE-LRASKILVerlranpkievlwntevteiegdgrvegvtlkn 216

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 305410791 275 -STNCTEELENAGV----------EVLKfSQGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTpVAIAAG 337
Cdd:COG0492  217 vKTGEEKELEVDGVfvaiglkpntELLK-GLGLELDEDGYIVVDEDMETSVPGVFAAGDVRDYKYRQ-AATAAG 288
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 233-302 1.63e-17

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 76.86  E-value: 1.63e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 305410791  233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQ--GIQTDDKG 302
Cdd:pfam00070   1 RVVVVGGGYIGLELAGALARLGSKVTVVERRDRLLPGFDPEIAKILQEKLEKNGIEFLLNTTveAIEGNGDG 72
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
166-344 4.79e-11

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 64.39  E-value: 4.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 166 HIEIIRGHAAFTSDPKP-TIEV-SGKKYTAPHILIATGGMPSTPhesQIPGASLgitsDGFFQL----------EELPG- 232
Cdd:COG1251   70 GIDLRLGTRVTAIDRAArTVTLaDGETLPYDKLVLATGSRPRVP---PIPGADL----PGVFTLrtlddadalrAALAPg 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 233 -RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVL-RSFDSMISTNCTEELENAGVEV-----------------LKFS 293
Cdd:COG1251  143 kRVVVIGGGLIGLEAAAALRKRGLEVTVVERAPRLLpRQLDEEAGALLQRLLEALGVEVrlgtgvteiegddrvtgVRLA 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 294 QG--IQTD----------------------DKGhIIVDEFQNTNVKGIYAVGDVC-------GKAL--LTPVAIAAGRKL 340
Cdd:COG1251  223 DGeeLPADlvvvaigvrpntelaraaglavDRG-IVVDDYLRTSDPDIYAAGDCAehpgpvyGRRVleLVAPAYEQARVA 301


                 ....
gi 305410791 341 AHRL 344
Cdd:COG1251  302 AANL 305
PRK09564 PRK09564
coenzyme A disulfide reductase; Reviewed
 196-389 1.20e-09

coenzyme A disulfide reductase; Reviewed


Pssm-ID: 181958 [Multi-domain]  Cd Length: 444  Bit Score: 60.05  E-value: 1.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 196 ILIATGGMPSTPhesQIPGASLGITS------DG-----FFQLEELPgRSVIVGAGYIAVEMAGILSALGSKTSLMIRHD 264
Cdd:PRK09564 107 LMIATGARPIIP---PIKNINLENVYtlksmeDGlalkeLLKDEEIK-NIVIIGAGFIGLEAVEAAKHLGKNVRIIQLED 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 265 KVL-RSFDSMISTNCTEELENAGV------------------------------------------EVLKfSQGIQTDDK 301
Cdd:PRK09564 183 RILpDSFDKEITDVMEEELRENGVelhlnefvksligedkvegvvtdkgeyeadvvivatgvkpntEFLE-DTGLKTLKN 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 302 GHIIVDEFQNTNVKGIYAVGD-------VCGKALLTPVAIAA---GRKLAHRLFEYKEDSKLDYNNIPTVVFSHpPIGTV 371
Cdd:PRK09564 262 GAIIVDEYGETSIENIYAAGDcatiyniVSNKNVYVPLATTAnklGRMVGENLAGRHVSFKGTLGSACIKVLDL-EAART 340

                        250
                 ....*....|....*...
gi 305410791 372 GLTEDEAiHKYGIeNVKT 389
Cdd:PRK09564 341 GLTEEEA-KKLGI-DYKT 356
PRK13512 PRK13512
coenzyme A disulfide reductase; Provisional
 213-343 1.74e-08

coenzyme A disulfide reductase; Provisional


Pssm-ID: 184103 [Multi-domain]  Cd Length: 438  Bit Score: 56.33  E-value: 1.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 213 PGAS---LGITSDGFFQLEELPG--------------RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMIS 275
Cdd:PRK13512 113 PGASansLGFESDITFTLRNLEDtdaidqfikanqvdKALVVGAGYISLEVLENLYERGLHPTLIHRSDKINKLMDADMN 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 276 TNCTEELENAGV------EVL------------------------------KF--SQGIQTDDKGHIIVDEFQNTNVKGI 317
Cdd:PRK13512 193 QPILDELDKREIpyrlneEIDaingnevtfksgkvehydmiiegvgthpnsKFieSSNIKLDDKGFIPVNDKFETNVPNI 272

                        170       180       190
                 ....*....|....*....|....*....|.
gi 305410791 318 YAVGDVCGKA-----LLTPVAIAAGrklAHR 343
Cdd:PRK13512 273 YAIGDIITSHyrhvdLPASVPLAWG---AHR 300
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
195-362 6.28e-08

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 54.37  E-value: 6.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 195 HILIATGgmpSTPHESQIPGA---SLGI-TSDGFFQL-EEL-----------PGRSVIVGAGYIAVEMAGILSAL----- 253
Cdd:COG1252  100 YLVIATG---SVTNFFGIPGLaehALPLkTLEDALALrERLlaaferaerrrLLTIVVVGGGPTGVELAGELAELlrkll 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 254 ------GSKTSLMI--RHDKVLRSFDSMISTNCTEELENAGVEVLKFSQ------------------------------- 294
Cdd:COG1252  177 rypgidPDKVRITLveAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRvtevdadgvtledgeeipadtviwaagvkap 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410791 295 ------GIQTDDKGHIIVDEF-QNTNVKGIYAVGDVC-----GKALLTPVAIAA---GRKLAH---RLFEYKEDSKLDYN 356
Cdd:COG1252  257 plladlGLPTDRRGRVLVDPTlQVPGHPNVFAIGDCAavpdpDGKPVPKTAQAAvqqAKVLAKniaALLRGKPLKPFRYR 336


                 ....*.
gi 305410791 357 NIPTVV 362
Cdd:COG1252  337 DKGCLA 342
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 295-342 9.12e-05

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 44.74  E-value: 9.12e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 305410791 295 GIQTDDKGHIIVDEF-QNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAH 342
Cdd:COG0493  381 GLELDKRGTIVVDEEtYQTSLPGVFAGGDAVRGPSLVVWAIAEGRKAAR 429
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 293-347 1.05e-03

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 41.32  E-value: 1.05e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 305410791 293 SQGIQTDDKGHIIVDEFQ-NTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEY 347
Cdd:PRK11749 395 TPGLELNRWGTIIADDETgRTSLPGVFAGGDIVTGAATVVWAVGDGKDAAEAIHEY 450
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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