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Conserved domains on  [gi|315434214|ref|NP_001186779|]
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small ribosomal subunit protein mS29 isoform 2 [Homo sapiens]

Protein Classification

mS29 family ribosomal protein( domain architecture ID 10562981)

mS29 family ribosomal protein is a component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DAP3 pfam10236
Mitochondrial ribosomal death-associated protein 3; This is a family of conserved proteins ...
65-359 8.23e-125

Mitochondrial ribosomal death-associated protein 3; This is a family of conserved proteins which were originally described as death-associated-protein-3 (DAP-3). The proteins carry a P-loop DNA-binding motif, and induce apoptosis. DAP3 has been shown to be a pro-apoptotic factor in the mitochondrial matrix and to be crucial for mitochondrial biogenesis and so has also been designated as MRP-S29 (mitochondrial ribosomal protein subunit 29).


:

Pssm-ID: 431160  Cd Length: 310  Bit Score: 361.23  E-value: 8.23e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434214   65 LMVRKPALELLHYLKNTSFAYPAIRYLLYGEKGTGKTLSLCHVIHFCAKQDWLILHIPDAHLWVKNCRDLLQSSYNKQRF 144
Cdd:pfam10236   1 LLVREETLELIKKLKAADKSKKVVRFVLTGEPGSGKSVLLLQAMAYALEKGWVVLHVPEAELWVNGTTDYAPDESNPKLY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434214  145 DQPLEASTWLKNFKTTNERFLNQIKVQEKYVWNKRESTEKGSPLGEVVEQGITRVRNATDAVGIVLKELKRQSSlgMFHL 224
Cdd:pfam10236  81 DQPMYTAALLRRIKKANEPVLSKIKLSQDYEWLKRESTPAGSTLLELLSLGINRANSAWDVFQALWKELTAQSK--RPPV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434214  225 LVAVDGINALWGRTTLKREDKSPIAPEELALVHNLRKM--MKNDWHGGAIVSALSQTGSLFKPRKAYLPQELLGKEGFDA 302
Cdd:pfam10236 159 LVAVDGFNALMGNTAYKDADFKPIHPHDLTLVRHFLDLlsGKSDFPNGGVVTVLAATSSSNTPRSPTLPIALLQEEARPQ 238
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 315434214  303 LDPFI---------------PILVSNYNPKEFESCIQYYLENNWLQHeKAPTEEGKKELLFLSNANPSLLER 359
Cdd:pfam10236 239 LDPYVkrydyvleakkgsvePFRVPGLTKEEARGLMEYYADSGWLQE-KVNEELVDEKLFLSGNGNPRELEK 309
 
Name Accession Description Interval E-value
DAP3 pfam10236
Mitochondrial ribosomal death-associated protein 3; This is a family of conserved proteins ...
65-359 8.23e-125

Mitochondrial ribosomal death-associated protein 3; This is a family of conserved proteins which were originally described as death-associated-protein-3 (DAP-3). The proteins carry a P-loop DNA-binding motif, and induce apoptosis. DAP3 has been shown to be a pro-apoptotic factor in the mitochondrial matrix and to be crucial for mitochondrial biogenesis and so has also been designated as MRP-S29 (mitochondrial ribosomal protein subunit 29).


Pssm-ID: 431160  Cd Length: 310  Bit Score: 361.23  E-value: 8.23e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434214   65 LMVRKPALELLHYLKNTSFAYPAIRYLLYGEKGTGKTLSLCHVIHFCAKQDWLILHIPDAHLWVKNCRDLLQSSYNKQRF 144
Cdd:pfam10236   1 LLVREETLELIKKLKAADKSKKVVRFVLTGEPGSGKSVLLLQAMAYALEKGWVVLHVPEAELWVNGTTDYAPDESNPKLY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434214  145 DQPLEASTWLKNFKTTNERFLNQIKVQEKYVWNKRESTEKGSPLGEVVEQGITRVRNATDAVGIVLKELKRQSSlgMFHL 224
Cdd:pfam10236  81 DQPMYTAALLRRIKKANEPVLSKIKLSQDYEWLKRESTPAGSTLLELLSLGINRANSAWDVFQALWKELTAQSK--RPPV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434214  225 LVAVDGINALWGRTTLKREDKSPIAPEELALVHNLRKM--MKNDWHGGAIVSALSQTGSLFKPRKAYLPQELLGKEGFDA 302
Cdd:pfam10236 159 LVAVDGFNALMGNTAYKDADFKPIHPHDLTLVRHFLDLlsGKSDFPNGGVVTVLAATSSSNTPRSPTLPIALLQEEARPQ 238
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 315434214  303 LDPFI---------------PILVSNYNPKEFESCIQYYLENNWLQHeKAPTEEGKKELLFLSNANPSLLER 359
Cdd:pfam10236 239 LDPYVkrydyvleakkgsvePFRVPGLTKEEARGLMEYYADSGWLQE-KVNEELVDEKLFLSGNGNPRELEK 309
 
Name Accession Description Interval E-value
DAP3 pfam10236
Mitochondrial ribosomal death-associated protein 3; This is a family of conserved proteins ...
65-359 8.23e-125

Mitochondrial ribosomal death-associated protein 3; This is a family of conserved proteins which were originally described as death-associated-protein-3 (DAP-3). The proteins carry a P-loop DNA-binding motif, and induce apoptosis. DAP3 has been shown to be a pro-apoptotic factor in the mitochondrial matrix and to be crucial for mitochondrial biogenesis and so has also been designated as MRP-S29 (mitochondrial ribosomal protein subunit 29).


Pssm-ID: 431160  Cd Length: 310  Bit Score: 361.23  E-value: 8.23e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434214   65 LMVRKPALELLHYLKNTSFAYPAIRYLLYGEKGTGKTLSLCHVIHFCAKQDWLILHIPDAHLWVKNCRDLLQSSYNKQRF 144
Cdd:pfam10236   1 LLVREETLELIKKLKAADKSKKVVRFVLTGEPGSGKSVLLLQAMAYALEKGWVVLHVPEAELWVNGTTDYAPDESNPKLY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434214  145 DQPLEASTWLKNFKTTNERFLNQIKVQEKYVWNKRESTEKGSPLGEVVEQGITRVRNATDAVGIVLKELKRQSSlgMFHL 224
Cdd:pfam10236  81 DQPMYTAALLRRIKKANEPVLSKIKLSQDYEWLKRESTPAGSTLLELLSLGINRANSAWDVFQALWKELTAQSK--RPPV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434214  225 LVAVDGINALWGRTTLKREDKSPIAPEELALVHNLRKM--MKNDWHGGAIVSALSQTGSLFKPRKAYLPQELLGKEGFDA 302
Cdd:pfam10236 159 LVAVDGFNALMGNTAYKDADFKPIHPHDLTLVRHFLDLlsGKSDFPNGGVVTVLAATSSSNTPRSPTLPIALLQEEARPQ 238
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 315434214  303 LDPFI---------------PILVSNYNPKEFESCIQYYLENNWLQHeKAPTEEGKKELLFLSNANPSLLER 359
Cdd:pfam10236 239 LDPYVkrydyvleakkgsvePFRVPGLTKEEARGLMEYYADSGWLQE-KVNEELVDEKLFLSGNGNPRELEK 309
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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