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Conserved domains on  [gi|315467854|ref|NP_001186809|]
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early growth response protein 3 isoform 2 [Homo sapiens]

Protein Classification

DUF3446 and COG5048 domain-containing protein( domain architecture ID 12112506)

DUF3446 and COG5048 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 49-135 4.86e-10

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


:

Pssm-ID: 463400  Cd Length: 104  Bit Score: 56.00  E-value: 4.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315467854   49 GKFAFDSP----SNWCQDNIISLMSaGILGV-PPASGALSTQTSTAS-----------MVQPPQGDVEAMYPALPPY--S 110
Cdd:pfam11928   1 GKFSIDPQypggGSLWPEGLISLVS-GLVGMaNPPSSSSSSSPSSSSspnssgplctmSCSVQSSEMEHIYSAPPPYpsS 79

                          90       100
                  ....*....|....*....|....*
gi 315467854  111 NCGDLYSEPVSFHDPQGNPGLAYSP 135
Cdd:pfam11928  80 GCGDLYQDPSAFLSTPSGPPLAYPP 104
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-338 1.63e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 1.63e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 315467854 265 KPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSD--ERKRHAKIHLKQKEKKAEKGGAPSASSAPP 338
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
231-295 5.95e-04

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 5.95e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 315467854 231 PLHERPHACPaeGCDRRFSRSDELTRHLRIHTGHKPFQCRICMR--SFSRSDHLTTHIRTHTGEKPF 295
Cdd:COG5048   28 SNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSD 92
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 49-135 4.86e-10

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 56.00  E-value: 4.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315467854   49 GKFAFDSP----SNWCQDNIISLMSaGILGV-PPASGALSTQTSTAS-----------MVQPPQGDVEAMYPALPPY--S 110
Cdd:pfam11928   1 GKFSIDPQypggGSLWPEGLISLVS-GLVGMaNPPSSSSSSSPSSSSspnssgplctmSCSVQSSEMEHIYSAPPPYpsS 79

                          90       100
                  ....*....|....*....|....*
gi 315467854  111 NCGDLYSEPVSFHDPQGNPGLAYSP 135
Cdd:pfam11928  80 GCGDLYQDPSAFLSTPSGPPLAYPP 104
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-338 1.63e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 1.63e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 315467854 265 KPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSD--ERKRHAKIHLKQKEKKAEKGGAPSASSAPP 338
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-306 2.23e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 2.23e-06
                          10        20
                  ....*....|....*....|....*.
gi 315467854  281 HLTTHIRTHTGEKPFACEFCGRKFAR 306
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-295 5.95e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 5.95e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 315467854 231 PLHERPHACPaeGCDRRFSRSDELTRHLRIHTGHKPFQCRICMR--SFSRSDHLTTHIRTHTGEKPF 295
Cdd:COG5048   28 SNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSD 92
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 237-261 2.05e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.05e-03
                          10        20
                  ....*....|....*....|....*
gi 315467854  237 HACPaeGCDRRFSRSDELTRHLRIH 261
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 266-313 7.20e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.39  E-value: 7.20e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 315467854 266 PFQCRICMRSFSRSDHLTTHIRTHTGEKpfACEFCGRKFARSDERKRH 313
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
ZnF_C2H2 smart00355
zinc finger;
267-289 9.12e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 33.21  E-value: 9.12e-03
                           10        20
                   ....*....|....*....|...
gi 315467854   267 FQCRICMRSFSRSDHLTTHIRTH 289
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 49-135 4.86e-10

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 56.00  E-value: 4.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315467854   49 GKFAFDSP----SNWCQDNIISLMSaGILGV-PPASGALSTQTSTAS-----------MVQPPQGDVEAMYPALPPY--S 110
Cdd:pfam11928   1 GKFSIDPQypggGSLWPEGLISLVS-GLVGMaNPPSSSSSSSPSSSSspnssgplctmSCSVQSSEMEHIYSAPPPYpsS 79

                          90       100
                  ....*....|....*....|....*
gi 315467854  111 NCGDLYSEPVSFHDPQGNPGLAYSP 135
Cdd:pfam11928  80 GCGDLYQDPSAFLSTPSGPPLAYPP 104
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-338 1.63e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 1.63e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 315467854 265 KPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSD--ERKRHAKIHLKQKEKKAEKGGAPSASSAPP 338
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-306 2.23e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 2.23e-06
                          10        20
                  ....*....|....*....|....*.
gi 315467854  281 HLTTHIRTHTGEKPFACEFCGRKFAR 306
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 222-315 1.00e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315467854 222 KYPNRPSKTpLHERPHACPAEGCDRRFSRSDELTRHlRIHtGHK-----PFQCRICMRSFSRSDhltthirthtgeKPFA 296
Cdd:COG5189  336 DTPSRMLKV-KDGKPYKCPVEGCNKKYKNQNGLKYH-MLH-GHQnqklhENPSPEKMNIFSAKD------------KPYR 400

                         90
                 ....*....|....*....
gi 315467854 297 CEFCGRKFARSDERKRHAK 315
Cdd:COG5189  401 CEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
253-278 1.10e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.10e-05
                          10        20
                  ....*....|....*....|....*.
gi 315467854  253 ELTRHLRIHTGHKPFQCRICMRSFSR 278
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 267-289 3.17e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 3.17e-04
                          10        20
                  ....*....|....*....|...
gi 315467854  267 FQCRICMRSFSRSDHLTTHIRTH 289
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-295 5.95e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 5.95e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 315467854 231 PLHERPHACPaeGCDRRFSRSDELTRHLRIHTGHKPFQCRICMR--SFSRSDHLTTHIRTHTGEKPF 295
Cdd:COG5048   28 SNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSD 92
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-340 8.02e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 8.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315467854 244 CDRRFSRSDELTRHLR--IHTG--HKPFQCRI--CMRSFSRSDHLTTHIRTHTGEKPFAC--EFCGRKFARSDERKRHAK 315
Cdd:COG5048  295 CNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQS 374

                         90       100
                 ....*....|....*....|....*.
gi 315467854 316 IHLKQKEKK-AEKGGAPSASSAPPVS 340
Cdd:COG5048  375 LQQYKDLKNdKKSETLSNSCIRNFKR 400
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 267-289 2.02e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 35.31  E-value: 2.02e-03
                          10        20
                  ....*....|....*....|...
gi 315467854  267 FQCRICMRSFSRSDHLTTHIRTH 289
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 237-261 2.05e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.05e-03
                          10        20
                  ....*....|....*....|....*
gi 315467854  237 HACPaeGCDRRFSRSDELTRHLRIH 261
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
239-318 2.06e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 40.00  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315467854 239 CPAEGCDRRFSRSDELTRHLRIHtgHKPFQCRICMR---------SFSRSDHLTTHIRTHTGEKPFA----CEFCGRKFA 305
Cdd:COG5236  154 CPKSKCHRRCGSLKELKKHYKAQ--HGFVLCSECIGnkkdfwneiRLFRSSTLRDHKNGGLEEEGFKghplCIFCKIYFY 231

                         90
                 ....*....|....*...
gi 315467854 306 RSDE-----RKRHAKIHL 318
Cdd:COG5236  232 DDDElrrhcRLRHEACHI 249
PHA00733 PHA00733
hypothetical protein
 266-313 7.20e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.39  E-value: 7.20e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 315467854 266 PFQCRICMRSFSRSDHLTTHIRTHTGEKpfACEFCGRKFARSDERKRH 313
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
ZnF_C2H2 smart00355
zinc finger;
267-289 9.12e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 33.21  E-value: 9.12e-03
                           10        20
                   ....*....|....*....|...
gi 315467854   267 FQCRICMRSFSRSDHLTTHIRTH 289
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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