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Conserved domains on  [gi|325651970|ref|NP_001188388|]
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zinc finger protein 513 isoform 2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12142358)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-363 1.84e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 1.84e-05
                          10        20
                  ....*....|....*....|....
gi 325651970  340 NLKRHQRVHTGEKPYKCPLCPYAC 363
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
352-425 3.54e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 3.54e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 325651970 352 KPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQS--MNLKRHMLRHTGEKPFRCATCAYTTGHWDNY 425
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
130-155 4.52e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.52e-05
                          10        20
                  ....*....|....*....|....*.
gi 325651970  130 NLTRHTRTHTGEKPYRCPHCPFACSS 155
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
312-337 2.97e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.97e-04
                          10        20
                  ....*....|....*....|....*.
gi 325651970  312 HLARHMKTHSGEKPFRCARCPYASAH 337
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
102-127 4.49e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.49e-04
                          10        20
                  ....*....|....*....|....*.
gi 325651970  102 HLKRHMQTHSGEKPFRCGRCPYASAQ 127
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-363 1.84e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 1.84e-05
                          10        20
                  ....*....|....*....|....
gi 325651970  340 NLKRHQRVHTGEKPYKCPLCPYAC 363
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
352-425 3.54e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 3.54e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 325651970 352 KPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQS--MNLKRHMLRHTGEKPFRCATCAYTTGHWDNY 425
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
130-155 4.52e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.52e-05
                          10        20
                  ....*....|....*....|....*.
gi 325651970  130 NLTRHTRTHTGEKPYRCPHCPFACSS 155
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
310-388 1.60e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651970 310 PNHLARHMKTHSG-EKPFRCARCPYASAHLDNLKRHQR--VHTGE--KPYKCP--LCPYACGNLANLKRHGRIHSGDKPF 382
Cdd:COG5048  273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352


                 ....*.
gi 325651970 383 RCSLCN 388
Cdd:COG5048  353 KEKLLN 358
zf-H2C2_2 pfam13465
Zinc-finger double domain;
396-419 2.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.26e-04
                          10        20
                  ....*....|....*....|....
gi 325651970  396 NLKRHMLRHTGEKPFRCATCAYTT 419
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
312-337 2.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.97e-04
                          10        20
                  ....*....|....*....|....*.
gi 325651970  312 HLARHMKTHSGEKPFRCARCPYASAH 337
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
102-127 4.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.49e-04
                          10        20
                  ....*....|....*....|....*.
gi 325651970  102 HLKRHMQTHSGEKPFRCGRCPYASAQ 127
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-363 1.84e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 1.84e-05
                          10        20
                  ....*....|....*....|....
gi 325651970  340 NLKRHQRVHTGEKPYKCPLCPYAC 363
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
352-425 3.54e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 3.54e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 325651970 352 KPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQS--MNLKRHMLRHTGEKPFRCATCAYTTGHWDNY 425
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
130-155 4.52e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.52e-05
                          10        20
                  ....*....|....*....|....*.
gi 325651970  130 NLTRHTRTHTGEKPYRCPHCPFACSS 155
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
310-388 1.60e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651970 310 PNHLARHMKTHSG-EKPFRCARCPYASAHLDNLKRHQR--VHTGE--KPYKCP--LCPYACGNLANLKRHGRIHSGDKPF 382
Cdd:COG5048  273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352


                 ....*.
gi 325651970 383 RCSLCN 388
Cdd:COG5048  353 KEKLLN 358
zf-H2C2_2 pfam13465
Zinc-finger double domain;
396-419 2.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.26e-04
                          10        20
                  ....*....|....*....|....
gi 325651970  396 NLKRHMLRHTGEKPFRCATCAYTT 419
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
312-337 2.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.97e-04
                          10        20
                  ....*....|....*....|....*.
gi 325651970  312 HLARHMKTHSGEKPFRCARCPYASAH 337
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
102-127 4.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.49e-04
                          10        20
                  ....*....|....*....|....*.
gi 325651970  102 HLKRHMQTHSGEKPFRCGRCPYASAQ 127
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
114-166 5.13e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 5.13e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 325651970 114 KPFRCGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFAC--SSLGNLRRHQRTH 166
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKsfSRPLELSRHLRTH 86
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
294-415 1.07e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651970 294 SDKGFAC--SLCPFATHYPNHLARHMKTHSGEKPFRC--ARCPYASAHLDNLKRHQRV--HTGEKPYKCPLCPYACGNLA 367
Cdd:COG5048  318 SLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRN 397

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 325651970 368 NLKRHGRI-----HSGDKP--FRCSLCNYSCNQSMNLKRHMLRHTGEKPFRCATC 415
Cdd:COG5048  398 FKRDSNLSlhiitHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL 452
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
294-396 1.21e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651970 294 SDKGFACSLCPFATHYPNHLARHMKTHSGEKPFRCARCPYASAH--LDNLKRHQRVHTGEKPYKCPlcpyACGNLANLKr 371
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNS----KSLPLSNSK- 104

                         90       100
                 ....*....|....*....|....*
gi 325651970 372 hgriHSGDKPFRCSLCNYSCNQSMN 396
Cdd:COG5048  105 ----ASSSSLSSSSSNSNDNNLLSS 125
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
382-406 2.23e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 35.60  E-value: 2.23e-03
                          10        20
                  ....*....|....*....|....*
gi 325651970  382 FRCSLCNYSCNQSMNLKRHMLRHTG 406
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-393 3.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 325651970  368 NLKRHGRIHSGDKPFRCSLCNYSCNQ 393
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 144-166 4.91e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.91e-03
                          10        20
                  ....*....|....*....|...
gi 325651970  144 YRCPHCPFACSSLGNLRRHQRTH 166
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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