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Conserved domains on  [gi|319803131|ref|NP_001188390|]
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protein tweety homolog 1 isoform 3 [Homo sapiens]

Protein Classification

tweety family protein( domain architecture ID 10522668)

tweety family protein may function as a large-conductance Ca(2+)-activated chloride channel that plays a role in Ca(2+) signal transduction

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Tweety pfam04906
Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is ...
9-439 0e+00

Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in.


:

Pssm-ID: 461475  Cd Length: 429  Bit Score: 536.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131    9 PSAWVHLLHQLPRADFQLRPVPSVFAPQEQEYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGskiPSPGGG 88
Cdd:pfam04906   1 PPWWVYLLHRLPHFNLQFRRVSSTFRPEDDVYQQSLLLLASIAAACLALSLLFLLVYLICLCCCRRKEDER---PPADCC 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131   89 CVTWSCIVALLAGCTGIGIGFYGNSETSDGVSQLSSALLHANHTLSTIDHLVLETVERLGEAVRTELTTLEEVLEPRTEL 168
Cdd:pfam04906  78 CVTWSVVIATLVCCAAIGVGFYGNSETNDGVYQLTYSLRHANHTVSGIDDLVSDTTESLNETLEQHLTRLEEIFAKRTDY 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131  169 VAAARGARRQAEAAAQQLQGLAFWQGVPLSPLQVAENVSFVEEYRWLAYVLLLLLELLVCLFTLLGLAKQSKWLVIVMTV 248
Cdd:pfam04906 158 LQAVRFLQRQLANLIQQLAGLPFWKGAELSLTALAEQVDFYEWYRWLGYLLLLLLDLVICLVTLLGLARQSKCLLIGMCV 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131  249 MSLLVLVLSWGSMGLEAATAVGLSDFCSNPDPYVLNLTQEEtgLSSDILSYYLLCNRAVSNPFQQRLTLSQRALANIHSQ 328
Cdd:pfam04906 238 CGLLALVISWASLGLELATAVGTSDFCVDPDDYVVNQTGEE--LSSDILQYYLNCSQSLTNPFQQRLTESQRALVEMQDQ 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131  329 LLGLEREAVPQFPSAQKPLLSLEETLNVTEGNFHQLVALLHCRSLHKDYGAALRGLCEDALEGLLFLLLFSLLSAGALAT 408
Cdd:pfam04906 316 VQGLLRFAVPLFPTAQKDLLGIQGLLNSTERNLHQLTALLDCRSLHKDYLQALRGLCYDGLEGLLYLLLFSLLTALAFSS 395
                         410       420       430
                  ....*....|....*....|....*....|..
gi 319803131  409 ALCSLPRAWALFPPSDDYDDTD-DDDPFNPQQ 439
Cdd:pfam04906 396 IVCSDPHAWIYFQKRDRDYDDIdEEDPFNPQE 427
 
Name Accession Description Interval E-value
Tweety pfam04906
Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is ...
9-439 0e+00

Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in.


Pssm-ID: 461475  Cd Length: 429  Bit Score: 536.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131    9 PSAWVHLLHQLPRADFQLRPVPSVFAPQEQEYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGskiPSPGGG 88
Cdd:pfam04906   1 PPWWVYLLHRLPHFNLQFRRVSSTFRPEDDVYQQSLLLLASIAAACLALSLLFLLVYLICLCCCRRKEDER---PPADCC 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131   89 CVTWSCIVALLAGCTGIGIGFYGNSETSDGVSQLSSALLHANHTLSTIDHLVLETVERLGEAVRTELTTLEEVLEPRTEL 168
Cdd:pfam04906  78 CVTWSVVIATLVCCAAIGVGFYGNSETNDGVYQLTYSLRHANHTVSGIDDLVSDTTESLNETLEQHLTRLEEIFAKRTDY 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131  169 VAAARGARRQAEAAAQQLQGLAFWQGVPLSPLQVAENVSFVEEYRWLAYVLLLLLELLVCLFTLLGLAKQSKWLVIVMTV 248
Cdd:pfam04906 158 LQAVRFLQRQLANLIQQLAGLPFWKGAELSLTALAEQVDFYEWYRWLGYLLLLLLDLVICLVTLLGLARQSKCLLIGMCV 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131  249 MSLLVLVLSWGSMGLEAATAVGLSDFCSNPDPYVLNLTQEEtgLSSDILSYYLLCNRAVSNPFQQRLTLSQRALANIHSQ 328
Cdd:pfam04906 238 CGLLALVISWASLGLELATAVGTSDFCVDPDDYVVNQTGEE--LSSDILQYYLNCSQSLTNPFQQRLTESQRALVEMQDQ 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131  329 LLGLEREAVPQFPSAQKPLLSLEETLNVTEGNFHQLVALLHCRSLHKDYGAALRGLCEDALEGLLFLLLFSLLSAGALAT 408
Cdd:pfam04906 316 VQGLLRFAVPLFPTAQKDLLGIQGLLNSTERNLHQLTALLDCRSLHKDYLQALRGLCYDGLEGLLYLLLFSLLTALAFSS 395
                         410       420       430
                  ....*....|....*....|....*....|..
gi 319803131  409 ALCSLPRAWALFPPSDDYDDTD-DDDPFNPQQ 439
Cdd:pfam04906 396 IVCSDPHAWIYFQKRDRDYDDIdEEDPFNPQE 427
Tweety_N cd07912
N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a ...
6-422 6.01e-163

N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; The protein product of the Drosophila tweety (tty) gene is thought to form a trans-membrane protein with five membrane-spanning regions and a cytoplasmic C-terminus. This N-terminal domain contains the putative transmembrane spanning regions. Tweety has been suggested as a candidate for a large conductance chloride channel, both in vertebrate and insect cells. Three human homologs have been identified and designated TTYH1-3. TTYH2 has been associated with the progression of cancer, and Drosophila melanogaster tweety has been assumed to play a role in development. TTYH2, and TTYH3 bind to and are ubiquinated by Nedd4-2, a HECT type E3 ubiquitin ligase, which most likely plays a role in controlling the cellular levels of tweety family proteins.


Pssm-ID: 143653  Cd Length: 418  Bit Score: 466.03  E-value: 6.01e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131   6 GYRPSAWVHLLHQLPRADFQLRPVPSVFAPQEQEYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPpgsKIPSP 85
Cdd:cd07912    1 MYKAPWLVKLLHSLPHLNFTFHRVNSTFNPEDEIYQQSLLILASIPAACLILSLLFLLVYLITRCCDRKPTE---ERPRH 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131  86 GGGCVTWSCIVALLAGCTGIGIGFYGNSETSDGVSQLSSALLHANHTLSTIDHLVLETVERLGEAVRTELTTLEEVLEPR 165
Cdd:cd07912   78 SICCLKWSLVIATLLCCAAIGVGLYGNDETHDGVVQLTYSLRNANHTVAGIDNQTSDTEASLNVTVEPQLTNLEDIFDAR 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131 166 ---TELVAAARGARRQAEAAAQQLQGLAFWQGVPLSPLQVAENVSFVEEYRWLAYVLLLLLELLVCLFTLLGLAKQSKWL 242
Cdd:cd07912  158 vnkTDYLQIVQGLQQMATNAAQQLTGIPFWSLVGVSLTKLADQVSLYESYRWLAYLGLLSLLLVICLVLLVGLARHSRCL 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131 243 VIVMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSNPDPYVLNLTQeeTGLSSDILSYYLLCNRAVSNPFQQRLTLSQRAL 322
Cdd:cd07912  238 LIVFSVCGLFALIISWLSLGLYLASAVALSDFCVDPDDYVRNQTP--SGLSSDILQYYLTCEPSTTNPFQQRLTESQRAL 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131 323 ANIHSQLLGLEREAVPQFPSAQKPLLSLEETLNVTEGNFHQLVALLHCRSLHKDYGAALRGLCEDALEGLLFLLLFSLLS 402
Cdd:cd07912  316 TNMQSQVQGLLREAVFEFPTAEDNLLSLQGDLNSTEINLHQLTALLDCRGLHKDYVEALRGLCYDGLEGLLYLLLFSLLA 395
                        410       420
                 ....*....|....*....|
gi 319803131 403 AGALATALCSLPRAWALFPP 422
Cdd:cd07912  396 ALLFTILVCVDSHTWIYIRK 415
 
Name Accession Description Interval E-value
Tweety pfam04906
Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is ...
9-439 0e+00

Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in.


Pssm-ID: 461475  Cd Length: 429  Bit Score: 536.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131    9 PSAWVHLLHQLPRADFQLRPVPSVFAPQEQEYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGskiPSPGGG 88
Cdd:pfam04906   1 PPWWVYLLHRLPHFNLQFRRVSSTFRPEDDVYQQSLLLLASIAAACLALSLLFLLVYLICLCCCRRKEDER---PPADCC 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131   89 CVTWSCIVALLAGCTGIGIGFYGNSETSDGVSQLSSALLHANHTLSTIDHLVLETVERLGEAVRTELTTLEEVLEPRTEL 168
Cdd:pfam04906  78 CVTWSVVIATLVCCAAIGVGFYGNSETNDGVYQLTYSLRHANHTVSGIDDLVSDTTESLNETLEQHLTRLEEIFAKRTDY 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131  169 VAAARGARRQAEAAAQQLQGLAFWQGVPLSPLQVAENVSFVEEYRWLAYVLLLLLELLVCLFTLLGLAKQSKWLVIVMTV 248
Cdd:pfam04906 158 LQAVRFLQRQLANLIQQLAGLPFWKGAELSLTALAEQVDFYEWYRWLGYLLLLLLDLVICLVTLLGLARQSKCLLIGMCV 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131  249 MSLLVLVLSWGSMGLEAATAVGLSDFCSNPDPYVLNLTQEEtgLSSDILSYYLLCNRAVSNPFQQRLTLSQRALANIHSQ 328
Cdd:pfam04906 238 CGLLALVISWASLGLELATAVGTSDFCVDPDDYVVNQTGEE--LSSDILQYYLNCSQSLTNPFQQRLTESQRALVEMQDQ 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131  329 LLGLEREAVPQFPSAQKPLLSLEETLNVTEGNFHQLVALLHCRSLHKDYGAALRGLCEDALEGLLFLLLFSLLSAGALAT 408
Cdd:pfam04906 316 VQGLLRFAVPLFPTAQKDLLGIQGLLNSTERNLHQLTALLDCRSLHKDYLQALRGLCYDGLEGLLYLLLFSLLTALAFSS 395
                         410       420       430
                  ....*....|....*....|....*....|..
gi 319803131  409 ALCSLPRAWALFPPSDDYDDTD-DDDPFNPQQ 439
Cdd:pfam04906 396 IVCSDPHAWIYFQKRDRDYDDIdEEDPFNPQE 427
Tweety_N cd07912
N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a ...
6-422 6.01e-163

N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; The protein product of the Drosophila tweety (tty) gene is thought to form a trans-membrane protein with five membrane-spanning regions and a cytoplasmic C-terminus. This N-terminal domain contains the putative transmembrane spanning regions. Tweety has been suggested as a candidate for a large conductance chloride channel, both in vertebrate and insect cells. Three human homologs have been identified and designated TTYH1-3. TTYH2 has been associated with the progression of cancer, and Drosophila melanogaster tweety has been assumed to play a role in development. TTYH2, and TTYH3 bind to and are ubiquinated by Nedd4-2, a HECT type E3 ubiquitin ligase, which most likely plays a role in controlling the cellular levels of tweety family proteins.


Pssm-ID: 143653  Cd Length: 418  Bit Score: 466.03  E-value: 6.01e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131   6 GYRPSAWVHLLHQLPRADFQLRPVPSVFAPQEQEYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPpgsKIPSP 85
Cdd:cd07912    1 MYKAPWLVKLLHSLPHLNFTFHRVNSTFNPEDEIYQQSLLILASIPAACLILSLLFLLVYLITRCCDRKPTE---ERPRH 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131  86 GGGCVTWSCIVALLAGCTGIGIGFYGNSETSDGVSQLSSALLHANHTLSTIDHLVLETVERLGEAVRTELTTLEEVLEPR 165
Cdd:cd07912   78 SICCLKWSLVIATLLCCAAIGVGLYGNDETHDGVVQLTYSLRNANHTVAGIDNQTSDTEASLNVTVEPQLTNLEDIFDAR 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131 166 ---TELVAAARGARRQAEAAAQQLQGLAFWQGVPLSPLQVAENVSFVEEYRWLAYVLLLLLELLVCLFTLLGLAKQSKWL 242
Cdd:cd07912  158 vnkTDYLQIVQGLQQMATNAAQQLTGIPFWSLVGVSLTKLADQVSLYESYRWLAYLGLLSLLLVICLVLLVGLARHSRCL 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131 243 VIVMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSNPDPYVLNLTQeeTGLSSDILSYYLLCNRAVSNPFQQRLTLSQRAL 322
Cdd:cd07912  238 LIVFSVCGLFALIISWLSLGLYLASAVALSDFCVDPDDYVRNQTP--SGLSSDILQYYLTCEPSTTNPFQQRLTESQRAL 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319803131 323 ANIHSQLLGLEREAVPQFPSAQKPLLSLEETLNVTEGNFHQLVALLHCRSLHKDYGAALRGLCEDALEGLLFLLLFSLLS 402
Cdd:cd07912  316 TNMQSQVQGLLREAVFEFPTAEDNLLSLQGDLNSTEINLHQLTALLDCRGLHKDYVEALRGLCYDGLEGLLYLLLFSLLA 395
                        410       420
                 ....*....|....*....|
gi 319803131 403 AGALATALCSLPRAWALFPP 422
Cdd:cd07912  396 ALLFTILVCVDSHTWIYIRK 415
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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