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Conserved domains on  [gi|319996652|ref|NP_001188406|]
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neuropilin and tolloid-like protein 2 isoform 2 precursor [Homo sapiens]

Protein Classification

CUB and LDLa domain-containing protein( domain architecture ID 10035862)

CUB and LDLa (low-density lipoprotein receptor class A) domain-containing protein similar to mammalian neuropilin and tolloid-like protein 2, an accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3, that increases kainate-receptor channel activity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 45-158 8.79e-38

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 134.46  E-value: 8.79e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319996652  45 CGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFdEHYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGV 124
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF-EDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 319996652 125 KSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSF 158
Cdd:cd00041   80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 198-284 4.99e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.82  E-value: 4.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319996652 198 VDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVMLKTG-IGVIRMWADEGSRLS 276
Cdd:cd00041   26 LNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIISSGnSLTVRFRSDSSVTGR 105


                 ....*...
gi 319996652 277 RFRMLFTS 284
Cdd:cd00041  106 GFKATYSA 113
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 290-324 1.45e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.45e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 319996652 290 CTSSTFFCHSNMCINNSLVCNGVQNCAYPWDENHC 324
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 45-158 8.79e-38

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 134.46  E-value: 8.79e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319996652  45 CGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFdEHYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGV 124
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF-EDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 319996652 125 KSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSF 158
Cdd:cd00041   80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
45-156 1.78e-35

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 128.18  E-value: 1.78e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319996652   45 CGIWVRTSNGgHFASPNYPDSYPPNKECIYILEAAPRQRIELTFdEHYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGV 124
Cdd:pfam00431   1 CGGVLTDSSG-SISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGS 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 319996652  125 KSPPLIRSTGRFMWIKFSSDEELEGLGFRAKY 156
Cdd:pfam00431  79 GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 55-156 1.74e-34

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 125.20  E-value: 1.74e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319996652    55 GHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDeHYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGVKSPP-LIRST 133
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFT-DFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPpVISSS 79

                           90       100
                   ....*....|....*....|...
gi 319996652   134 GRFMWIKFSSDEELEGLGFRAKY 156
Cdd:smart00042  80 SNSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 198-284 4.99e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.82  E-value: 4.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319996652 198 VDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVMLKTG-IGVIRMWADEGSRLS 276
Cdd:cd00041   26 LNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIISSGnSLTVRFRSDSSVTGR 105


                 ....*...
gi 319996652 277 RFRMLFTS 284
Cdd:cd00041  106 GFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 198-254 1.96e-09

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 55.09  E-value: 1.96e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 319996652   198 VDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVAN 254
Cdd:smart00042  16 LDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAP 72
CUB pfam00431
CUB domain;
198-249 1.07e-08

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 53.07  E-value: 1.07e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 319996652  198 VDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFC 249
Cdd:pfam00431  25 KDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFC 76
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 290-324 1.45e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.45e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 319996652 290 CTSSTFFCHSNMCINNSLVCNGVQNCAYPWDENHC 324
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 290-316 9.55e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 36.84  E-value: 9.55e-04
                           10        20
                   ....*....|....*....|....*..
gi 319996652   290 CTSSTFFCHSNMCINNSLVCNGVQNCA 316
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCG 28
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 45-158 8.79e-38

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 134.46  E-value: 8.79e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319996652  45 CGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFdEHYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGV 124
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF-EDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 319996652 125 KSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSF 158
Cdd:cd00041   80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
45-156 1.78e-35

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 128.18  E-value: 1.78e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319996652   45 CGIWVRTSNGgHFASPNYPDSYPPNKECIYILEAAPRQRIELTFdEHYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGV 124
Cdd:pfam00431   1 CGGVLTDSSG-SISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGS 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 319996652  125 KSPPLIRSTGRFMWIKFSSDEELEGLGFRAKY 156
Cdd:pfam00431  79 GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 55-156 1.74e-34

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 125.20  E-value: 1.74e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319996652    55 GHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDeHYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGVKSPP-LIRST 133
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFT-DFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPpVISSS 79

                           90       100
                   ....*....|....*....|...
gi 319996652   134 GRFMWIKFSSDEELEGLGFRAKY 156
Cdd:smart00042  80 SNSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 198-284 4.99e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.82  E-value: 4.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319996652 198 VDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVMLKTG-IGVIRMWADEGSRLS 276
Cdd:cd00041   26 LNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIISSGnSLTVRFRSDSSVTGR 105


                 ....*...
gi 319996652 277 RFRMLFTS 284
Cdd:cd00041  106 GFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 198-254 1.96e-09

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 55.09  E-value: 1.96e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 319996652   198 VDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVAN 254
Cdd:smart00042  16 LDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAP 72
CUB pfam00431
CUB domain;
198-249 1.07e-08

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 53.07  E-value: 1.07e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 319996652  198 VDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFC 249
Cdd:pfam00431  25 KDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFC 76
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 290-324 1.45e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.45e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 319996652 290 CTSSTFFCHSNMCINNSLVCNGVQNCAYPWDENHC 324
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 290-316 9.55e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 36.84  E-value: 9.55e-04
                           10        20
                   ....*....|....*....|....*..
gi 319996652   290 CTSSTFFCHSNMCINNSLVCNGVQNCA 316
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCG 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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