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Conserved domains on  [gi|320202962|ref|NP_001189332|]
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ankyrin repeat and SOCS box protein 6 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 341-384 4.67e-24

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239695  Cd Length: 44  Bit Score: 93.28  E-value: 4.67e-24
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 320202962 341 SYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEH 384
Cdd:cd03725    1 SYPPPLKHLCRVFIRLCLRPWPVDVKVKALPLPDRLKWYLLPEH 44
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
17-259 4.42e-22

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.02  E-value: 4.42e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  17 LVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLN 96
Cdd:COG0666   35 LLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  97 FEDPvTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHEsSPLDLASEEpERLPCLQRLLDLGADVNAADKHGadvka 176
Cdd:COG0666  115 ARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN-TPLHLAAAN-GNLEIVKLLLEAGADVNARDNDG----- 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 177 ttkdgdtvFTCIIFLlgeTVGGDKEeaqminrfcfqVTRLLLAHGADPSEcPAHESLTHICLKSFKLHFPLLRFLLESGA 256
Cdd:COG0666  187 --------ETPLHLA---AENGHLE-----------IVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEAGA 243


                 ...
gi 320202962 257 AYN 259
Cdd:COG0666  244 DLN 246
 
Name Accession Description Interval E-value
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 341-384 4.67e-24

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 93.28  E-value: 4.67e-24
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 320202962 341 SYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEH 384
Cdd:cd03725    1 SYPPPLKHLCRVFIRLCLRPWPVDVKVKALPLPDRLKWYLLPEH 44
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
17-259 4.42e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.02  E-value: 4.42e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  17 LVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLN 96
Cdd:COG0666   35 LLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  97 FEDPvTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHEsSPLDLASEEpERLPCLQRLLDLGADVNAADKHGadvka 176
Cdd:COG0666  115 ARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN-TPLHLAAAN-GNLEIVKLLLEAGADVNARDNDG----- 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 177 ttkdgdtvFTCIIFLlgeTVGGDKEeaqminrfcfqVTRLLLAHGADPSEcPAHESLTHICLKSFKLHFPLLRFLLESGA 256
Cdd:COG0666  187 --------ETPLHLA---AENGHLE-----------IVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEAGA 243


                 ...
gi 320202962 257 AYN 259
Cdd:COG0666  244 DLN 246
Ank_2 pfam12796
Ankyrin repeats (3 copies);
73-168 4.23e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.97  E-value: 4.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962   73 LLKMAELGLTRAADVLLRHGANLNFEDPvTYYTALHIAVLRNQPDMVELLVHHgADVNRRDriHESSPLDLASEEpERLP 152
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD--NGRTALHYAARS-GHLE 75

                          90
                  ....*....|....*.
gi 320202962  153 CLQRLLDLGADVNAAD 168
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 88-256 8.46e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.04  E-value: 8.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  88 LLRHGANLNFEDPVTYyTALHIAVLRNQP---DMVELLVHHGADVNRRDRiHESSPLDLASEEPERLPCLQRLLDLGADV 164
Cdd:PHA03095  33 LLAAGADVNFRGEYGK-TPLHLYLHYSSEkvkDIVRLLLEAGADVNAPER-CGFTPLHLYLYNATTLDVIKLLIKAGADV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 165 NAADKHGadvkattkdgdtvFTCI-IFLLGETVGgdkeeaqminrfcFQVTRLLLAHGADPSECPAHE-SLTHICLKSFK 242
Cdd:PHA03095 111 NAKDKVG-------------RTPLhVYLSGFNIN-------------PKVIRLLLRKGADVNALDLYGmTPLAVLLKSRN 164

                        170
                 ....*....|....
gi 320202962 243 LHFPLLRFLLESGA 256
Cdd:PHA03095 165 ANVELLRLLIDAGA 178
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 343-381 4.25e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 51.78  E-value: 4.25e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 320202962  343 PPPLKHLCRVAIRLYLQPWPVDvKVKALPLPDRLKWYLL 381
Cdd:pfam07525   2 PRSLQHLCRLAIRRALGKRRLG-AIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 344-383 3.43e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 43.17  E-value: 3.43e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 320202962   344 PPLKHLCRVAIRLYLQpwpvdvKVKALPLPDRLKWYLLSE 383
Cdd:smart00969   1 RSLQHLCRLAIRRSLG------GIDKLPLPPRLKDYLLYY 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 104-130 3.17e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.65  E-value: 3.17e-05
                           10        20
                   ....*....|....*....|....*..
gi 320202962   104 YTALHIAVLRNQPDMVELLVHHGADVN 130
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 102-132 1.78e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 43.64  E-value: 1.78e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 320202962 102 TYY---TALHIAVLRNQPDMVELLVHHGADVNRR 132
Cdd:cd22196   90 SYYkgqTALHIAIERRNMHLVELLVQNGADVHAR 123
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 14-175 1.83e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 40.45  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962   14 YQPLVDAILGSLGIQDPERQESLdrpsYVASEESRILVLTELLERKAHSPFyqegVSNALLKMAELGLTRAADVLLRH-- 91
Cdd:TIGR00870  34 YRDLEEPKKLNINCPDRLGRSAL----FVAAIENENLELTELLLNLSCRGA----VGDTLLHAISLEYVDAVEAILLHll 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962   92 -----GANLNF---EDPVTYY---TALHIAVLRNQPDMVELLVHHGADVNRR---DRIHESSPLDLASEEPERL------ 151
Cdd:TIGR00870 106 aafrkSGPLELandQYTSEFTpgiTALHLAAHRQNYEIVKLLLERGASVPARacgDFFVKSQGVDSFYHGESPLnaaacl 185

                         170       180
                  ....*....|....*....|....*..
gi 320202962  152 --PCLQRLL-DLGADVNAADKHGADVK 175
Cdd:TIGR00870 186 gsPSIVALLsEDPADILTADSLGNTLL 212
 
Name Accession Description Interval E-value
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 341-384 4.67e-24

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 93.28  E-value: 4.67e-24
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 320202962 341 SYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEH 384
Cdd:cd03725    1 SYPPPLKHLCRVFIRLCLRPWPVDVKVKALPLPDRLKWYLLPEH 44
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
17-259 4.42e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.02  E-value: 4.42e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  17 LVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLN 96
Cdd:COG0666   35 LLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  97 FEDPvTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHEsSPLDLASEEpERLPCLQRLLDLGADVNAADKHGadvka 176
Cdd:COG0666  115 ARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN-TPLHLAAAN-GNLEIVKLLLEAGADVNARDNDG----- 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 177 ttkdgdtvFTCIIFLlgeTVGGDKEeaqminrfcfqVTRLLLAHGADPSEcPAHESLTHICLKSFKLHFPLLRFLLESGA 256
Cdd:COG0666  187 --------ETPLHLA---AENGHLE-----------IVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEAGA 243


                 ...
gi 320202962 257 AYN 259
Cdd:COG0666  244 DLN 246
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-173 3.77e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.07  E-value: 3.77e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  29 DPERQESLDR-PSYVASEESRILVLTELLERKAhSPFYQEGVSN-ALLKMAELGLTRAADVLLRHGANLNFEDPvTYYTA 106
Cdd:COG0666  112 DVNARDKDGEtPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNtPLHLAAANGNLEIVKLLLEAGADVNARDN-DGETP 189

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320202962 107 LHIAVLRNQPDMVELLVHHGADVNRRDRIHEsSPLDLASEEpERLPCLQRLLDLGADVNAADKHGAD 173
Cdd:COG0666  190 LHLAAENGHLEIVKLLLEAGADVNAKDNDGK-TALDLAAEN-GNLEIVKLLLEAGADLNAKDKDGLT 254
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 341-383 3.84e-13

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 63.28  E-value: 3.84e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 320202962 341 SYPPPLKHLCRVAIRLYLQPWPvDVKVKALPLPDRLKWYLLSE 383
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRR-LELIKKLPLPPRLKDYLLYE 42
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 343-383 8.69e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 59.41  E-value: 8.69e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 320202962 343 PPPLKHLCRVAIRLYLQPWPVDvKVKALPLPDRLKWYLLSE 383
Cdd:cd03587    2 PRSLQHLCRLAIRRCLGKRRLD-LIDKLPLPPRLKDYLLYK 41
Ank_2 pfam12796
Ankyrin repeats (3 copies);
73-168 4.23e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.97  E-value: 4.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962   73 LLKMAELGLTRAADVLLRHGANLNFEDPvTYYTALHIAVLRNQPDMVELLVHHgADVNRRDriHESSPLDLASEEpERLP 152
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD--NGRTALHYAARS-GHLE 75

                          90
                  ....*....|....*.
gi 320202962  153 CLQRLLDLGADVNAAD 168
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-259 7.91e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.28  E-value: 7.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  50 LVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADV 129
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 130 NRRDRiHESSPLDLASEEpERLPCLQRLLDLGADVNAAD-----------------------KHGADVKATTKDGDTVFT 186
Cdd:COG0666   81 NAKDD-GGNTLLHAAARN-GDLEIVKLLLEAGADVNARDkdgetplhlaayngnleivklllEAGADVNAQDNDGNTPLH 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320202962 187 CIIFllgetvGGDKEeaqminrfcfqVTRLLLAHGADPsECPAHESLTHICLKSFKLHFPLLRFLLESGAAYN 259
Cdd:COG0666  159 LAAA------NGNLE-----------IVKLLLEAGADV-NARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213
PHA03095 PHA03095
ankyrin-like protein; Provisional
 88-256 8.46e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.04  E-value: 8.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  88 LLRHGANLNFEDPVTYyTALHIAVLRNQP---DMVELLVHHGADVNRRDRiHESSPLDLASEEPERLPCLQRLLDLGADV 164
Cdd:PHA03095  33 LLAAGADVNFRGEYGK-TPLHLYLHYSSEkvkDIVRLLLEAGADVNAPER-CGFTPLHLYLYNATTLDVIKLLIKAGADV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 165 NAADKHGadvkattkdgdtvFTCI-IFLLGETVGgdkeeaqminrfcFQVTRLLLAHGADPSECPAHE-SLTHICLKSFK 242
Cdd:PHA03095 111 NAKDKVG-------------RTPLhVYLSGFNIN-------------PKVIRLLLRKGADVNALDLYGmTPLAVLLKSRN 164

                        170
                 ....*....|....
gi 320202962 243 LHFPLLRFLLESGA 256
Cdd:PHA03095 165 ANVELLRLLIDAGA 178
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 343-381 4.25e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 51.78  E-value: 4.25e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 320202962  343 PPPLKHLCRVAIRLYLQPWPVDvKVKALPLPDRLKWYLL 381
Cdd:pfam07525   2 PRSLQHLCRLAIRRALGKRRLG-AIDKLPLPPLLKDYLL 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
42-133 6.18e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.81  E-value: 6.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962   42 VASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGanlNFEDPVTYYTALHIAVLRNQPDMVEL 121
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA---DVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 320202962  122 LVHHGADVNRRD 133
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 117-256 2.73e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.33  E-value: 2.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 117 DMVELLVHHGADVNRRDrIHESSPLD--LASEEPERLPCLQRLLDLGADVNAADKHGadvkattkdgDTVFTCIIFLlge 194
Cdd:PHA03095  28 EEVRRLLAAGADVNFRG-EYGKTPLHlyLHYSSEKVKDIVRLLLEAGADVNAPERCG----------FTPLHLYLYN--- 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320202962 195 tvggdKEEAQMInrfcfqvtRLLLAHGAD-PSECPAHESLTHICLKSFKLHFPLLRFLLESGA 256
Cdd:PHA03095  94 -----ATTLDVI--------KLLIKAGADvNAKDKVGRTPLHVYLSGFNINPKVIRLLLRKGA 143
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 88-190 3.89e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.59  E-value: 3.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  88 LLRHGANLNfedPVTYY--TALHIAVLRNQPD--MVELLVHHGADVNRRDRI---------------HESSPLDLASEEP 148
Cdd:PHA03100 127 LLDNGANVN---IKNSDgeNLLHLYLESNKIDlkILKLLIDKGVDINAKNRVnyllsygvpinikdvYGFTPLHYAVYNN 203

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 320202962 149 eRLPCLQRLLDLGADVNaadkhgadvkATTKDGDtvfTCIIF 190
Cdd:PHA03100 204 -NPEFVKYLLDLGANPN----------LVNKYGD---TPLHI 231
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 88-171 1.11e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.43  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  88 LLRHGANLNFEDpVTYYTALHI-----AVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGA 162
Cdd:PHA03100  54 LLDNGADINSST-KNNSTPLHYlsnikYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVEYLLDNGA 132


                 ....*....
gi 320202962 163 DVNAADKHG 171
Cdd:PHA03100 133 NVNIKNSDG 141
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
41-170 1.43e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.57  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  41 YVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPvTYYTALHIAVLRNQPDMVE 120
Cdd:COG0666  158 HLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN-DGKTALDLAAENGNLEIVK 236

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 320202962 121 LLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKH 170
Cdd:COG0666  237 LLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLL 286
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 87-168 2.97e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.11  E-value: 2.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  87 VLLRHGANLNFEDPVTYyTALHIAVLR-NQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERlpcLQRLLDLGADVN 165
Cdd:PHA02878 219 ILLENGASTDARDKCGN-TPLHISVGYcKDYDILKLLLEHGVDVNAKSYILGLTALHSSIKSERK---LKLLLEYGADIN 294


                 ...
gi 320202962 166 AAD 168
Cdd:PHA02878 295 SLN 297
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 344-383 3.43e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 43.17  E-value: 3.43e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 320202962   344 PPLKHLCRVAIRLYLQpwpvdvKVKALPLPDRLKWYLLSE 383
Cdd:smart00969   1 RSLQHLCRLAIRRSLG------GIDKLPLPPRLKDYLLYY 34
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 87-259 4.78e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 48.34  E-value: 4.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  87 VLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIhESSPLDLASEEpERLPCLQRLLDLGADVNA 166
Cdd:PHA02878 152 LLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKT-NNSPLHHAVKH-YNKPIVHILLENGASTDA 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 167 ADKHGadvkaTTKDGDTVFTCIifllgetvggdkeeaqminrfCFQVTRLLLAHGADPSECPAHESLT--HICLKSFKlh 244
Cdd:PHA02878 230 RDKCG-----NTPLHISVGYCK---------------------DYDILKLLLEHGVDVNAKSYILGLTalHSSIKSER-- 281

                        170
                 ....*....|....*
gi 320202962 245 fpLLRFLLESGAAYN 259
Cdd:PHA02878 282 --KLKLLLEYGADIN 294
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 104-134 4.94e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 43.05  E-value: 4.94e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 320202962  104 YTALHIAVLR-NQPDMVELLVHHGADVNRRDR 134
Cdd:pfam00023   3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank_5 pfam13857
Ankyrin repeats (many copies);
88-144 6.66e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 6.66e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 320202962   88 LLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRiHESSPLDLA 144
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDE-EGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 82-255 8.11e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 47.71  E-value: 8.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  82 TRAADVLLRHGANLNfeDPVTY-YTALHIAVL-RNQPDMVELLVHHGADVNRRDRIHEsSPLDLASEEPERLPCLQR-LL 158
Cdd:PHA03095  63 KDIVRLLLEAGADVN--APERCgFTPLHLYLYnATTLDVIKLLIKAGADVNAKDKVGR-TPLHVYLSGFNINPKVIRlLL 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 159 DLGADVNAADKHGAdvkattkdgdtvfTCIIFLLGETvggdkeeaqminRFCFQVTRLLLAHGADPSECPA-HESLTHIC 237
Cdd:PHA03095 140 RKGADVNALDLYGM-------------TPLAVLLKSR------------NANVELLRLLIDAGADVYAVDDrFRSLLHHH 194

                        170
                 ....*....|....*...
gi 320202962 238 LKSFKLHFPLLRFLLESG 255
Cdd:PHA03095 195 LQSFKPRARIVRELIRAG 212
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 74-170 1.14e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.97  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  74 LKMAELGLTRAADV--------LLRHGANLNFEDpVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIhESSPLDLAS 145
Cdd:PHA03100 156 LKILKLLIDKGVDInaknrvnyLLSYGVPINIKD-VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKY-GDTPLHIAI 233

                         90       100
                 ....*....|....*....|....*
gi 320202962 146 eEPERLPCLQRLLDLGADVNAADKH 170
Cdd:PHA03100 234 -LNNNKEIFKLLLNNGPSIKTIIET 257
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 103-259 1.93e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.58  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 103 YYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHeSSPLDLASEEPERLPCLQRLLDL----GADVNAADKHGAdvkatt 178
Cdd:PHA03100  35 PVLPLYLAKEARNIDVVKILLDNGADINSSTKNN-STPLHYLSNIKYNLTDVKEIVKLlleyGANVNAPDNNGI------ 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 179 kdgdtvfTCIIFLLGETVGgdkeEAQMINrfcfqvtrLLLAHGADPSEC-PAHESLTHICLKSFKLHFPLLRFLLESGAA 257
Cdd:PHA03100 108 -------TPLLYAISKKSN----SYSIVE--------YLLDNGANVNIKnSDGENLLHLYLESNKIDLKILKLLIDKGVD 168


                 ..
gi 320202962 258 YN 259
Cdd:PHA03100 169 IN 170
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 104-130 3.17e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.65  E-value: 3.17e-05
                           10        20
                   ....*....|....*....|....*..
gi 320202962   104 YTALHIAVLRNQPDMVELLVHHGADVN 130
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 26-242 7.53e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.49  E-value: 7.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  26 GIQDPERQEsLDRPSYVASEESRILVLteLLERKAHSPFYQEGVSN-ALLKMAELGLTRAADVLLRHGANLNFEDpVTYY 104
Cdd:PHA02878 127 NIQTIDLVY-IDKKSKDDIIEAEITKL--LLSYGADINMKDRHKGNtALHYATENKDQRLTELLLSYGANVNIPD-KTNN 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 105 TALHIAVLRNQPDMVELLVHHGADVNRRDRiHESSPLDLASEEPERLPCLQRLLDLGADVNAAD---------------- 168
Cdd:PHA02878 203 SPLHHAVKHYNKPIVHILLENGASTDARDK-CGNTPLHISVGYCKDYDILKLLLEHGVDVNAKSyilgltalhssikser 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 169 ------KHGADVKATTKDGDTVFTCIIfllgetvggdkeeaqmINRFCFQVTRLLlahgadpsecpahesLTHICLKSFK 242
Cdd:PHA02878 282 klklllEYGADINSLNSYKLTPLSSAV----------------KQYLCINIGRIL---------------ISNICLLKRI 330
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 105-168 1.23e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 44.28  E-value: 1.23e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320202962 105 TALHIAVLRNQPDM-VELLVHHGADVNRRDRiHESSPLDLASEEPERLPCLQRLLDLGADVNAAD 168
Cdd:PHA02876 410 TALHFALCGTNPYMsVKTLIDRGANVNSKNK-DLSTPLHYACKKNCKLDVIEMLLDNGADVNAIN 473
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 103-130 1.28e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.78  E-value: 1.28e-04
                          10        20
                  ....*....|....*....|....*...
gi 320202962  103 YYTALHIAVLRNQPDMVELLVHHGADVN 130
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 343-382 1.48e-04

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 38.73  E-value: 1.48e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 320202962 343 PPPLKHLCRVAIRLYLqpwPVDvKVKALPLPDRLKWYLLS 382
Cdd:cd03717    3 VRSLQHLCRFVIRQCT---RRD-LIDQLPLPRRLKDYLKE 38
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 102-132 1.78e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 43.64  E-value: 1.78e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 320202962 102 TYY---TALHIAVLRNQPDMVELLVHHGADVNRR 132
Cdd:cd22196   90 SYYkgqTALHIAIERRNMHLVELLVQNGADVHAR 123
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 83-240 4.16e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.26  E-value: 4.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  83 RAADVLLRHGANLNFEDpVTYYTALHIAVlrNQP---DMVELLVHHGADVNRRDRIHEsSPLDLASEEPERLPCLQRLLD 159
Cdd:PHA02874 235 RSAIELLINNASINDQD-IDGSTPLHHAI--NPPcdiDIIDILLYHKADISIKDNKGE-NPIDTAFKYINKDPVIKDIIA 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 160 LGADVNAADK-HGADV--KATTKDgDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLThi 236
Cdd:PHA02874 311 NAVLIKEADKlKDSDFleHIEIKD-NKEFSDFIKECNEEIEDMKKTKCGCDKNIFDLCLIRIKHKFDGNEDSIKDYLN-- 387


                 ....
gi 320202962 237 CLKS 240
Cdd:PHA02874 388 CLDD 391
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 32-162 6.60e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 6.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  32 RQESLDRPSYVASEESRI---LVLTELLERKAHSPFY----QEGVSNALLKM--------AELGLTRAADVLLRHGANLN 96
Cdd:PTZ00322  30 KPISFERMAAIQEEIARIdthLEALEATENKDATPDHnlttEEVIDPVVAHMltvelcqlAASGDAVGARILLTGGADPN 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320202962  97 FEDpvtYY--TALHIAVLRNQPDMVELLVHHGADVNRRDRiHESSPLDLASEEPER------LPCLQRLLDLGA 162
Cdd:PTZ00322 110 CRD---YDgrTPLHIACANGHVQVVRVLLEFGADPTLLDK-DGKTPLELAEENGFRevvqllSRHSQCHFELGA 179
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 105-253 7.07e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 41.79  E-value: 7.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 105 TALHIAVLRNQPDMVELLVHHGADVNRRD-----RIHESS-------PLDLA----SEEPERLpclqrLLDLGADVnaad 168
Cdd:cd21882   75 TALHIAIENRNLNLVRLLVENGADVSARAtgrffRKSPGNlfyfgelPLSLAactnQEEIVRL-----LLENGAQP---- 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 169 khgADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINrfcfqvtrLLLAHGA--DPS----ECPAHESLTHICLKSFK 242
Cdd:cd21882  146 ---AALEAQDSLGNTVLHALVLQADNTPENSAFVCQMYN--------LLLSYGAhlDPTqqleEIPNHQGLTPLKLAAVE 214

                        170
                 ....*....|.
gi 320202962 243 LHFPLLRFLLE 253
Cdd:cd21882  215 GKIVMFQHILQ 225
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 344-380 7.60e-04

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 37.02  E-value: 7.60e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 320202962 344 PPLKHLCRVAIRLYLQPWpvdvKVKALPLPDRLKWYL 380
Cdd:cd03733    4 SSLQHLCRMALRRVMTTQ----QVLALPIPKKMKEFL 36
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 341-382 8.62e-04

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 36.89  E-value: 8.62e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 320202962   341 SYPPPLKHLCRVAIRLYLQPWpvdvKVKALPLPDRLKWYLLS 382
Cdd:smart00253   5 SNVPSLQHLCRFTIRRCTRTD----QIKTLPLPPKLKDYLSY 42
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 7-130 9.00e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 40.74  E-value: 9.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962   7 FRRIIFEYQPLVDAILgSLGIqDPERQESLDRPSYVaseesrilvltellerkahspfyqegvsNALLKMAELGLTRAAD 86
Cdd:PHA02884  38 YSSIKFHYTDIIDAIL-KLGA-DPEAPFPLSENSKT----------------------------NPLIYAIDCDNDDAAK 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 320202962  87 VLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVN 130
Cdd:PHA02884  88 LLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILLSYGADIN 131
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 69-165 9.24e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 40.74  E-value: 9.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  69 VSNALLKMAELGLTRAADVLLRHGANLNFEDP---VTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLaS 145
Cdd:PHA02884  33 IANILYSSIKFHYTDIIDAILKLGADPEAPFPlseNSKTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYI-S 111

                         90       100
                 ....*....|....*....|
gi 320202962 146 EEPERLPCLQRLLDLGADVN 165
Cdd:PHA02884 112 VLHGCLKCLEILLSYGADIN 131
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 344-380 1.13e-03

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 36.41  E-value: 1.13e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 320202962 344 PPLKHLCRVAIRLYLQPWpvdvKVKALPLPDRLKWYL 380
Cdd:cd03745    4 PSLRHLCRKALRHFLTTY----QVLALPIPKKMKEFL 36
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 343-381 1.47e-03

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 36.13  E-value: 1.47e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 320202962 343 PPPLKHLCRVAIRLYLQPWPVDvKVKALPLPDRLKWYLL 381
Cdd:cd03718    3 PLPLMDLCRRRVRVALGRDRLE-EIEQLPLPPSLKNYLL 40
Ank_4 pfam13637
Ankyrin repeats (many copies);
103-158 1.49e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 1.49e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 320202962  103 YYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHEsSPLDLASEEpERLPCLQRLL 158
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGE-TALHFAASN-GNVEVLKLLL 54
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 14-175 1.83e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 40.45  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962   14 YQPLVDAILGSLGIQDPERQESLdrpsYVASEESRILVLTELLERKAHSPFyqegVSNALLKMAELGLTRAADVLLRH-- 91
Cdd:TIGR00870  34 YRDLEEPKKLNINCPDRLGRSAL----FVAAIENENLELTELLLNLSCRGA----VGDTLLHAISLEYVDAVEAILLHll 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962   92 -----GANLNF---EDPVTYY---TALHIAVLRNQPDMVELLVHHGADVNRR---DRIHESSPLDLASEEPERL------ 151
Cdd:TIGR00870 106 aafrkSGPLELandQYTSEFTpgiTALHLAAHRQNYEIVKLLLERGASVPARacgDFFVKSQGVDSFYHGESPLnaaacl 185

                         170       180
                  ....*....|....*....|....*..
gi 320202962  152 --PCLQRLL-DLGADVNAADKHGADVK 175
Cdd:TIGR00870 186 gsPSIVALLsEDPADILTADSLGNTLL 212
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 343-381 2.11e-03

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 35.96  E-value: 2.11e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 320202962 343 PPPLKHLCRVAIRLYLQPWPVD--VKVKALPLPDRLKWYLL 381
Cdd:cd03731    3 PRPLKHLCRLKIRKLMGLQKLQqpSSMKKLPLPPALKRYIL 43
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 75-181 2.33e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 40.24  E-value: 2.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  75 KMAELGLTRAadvLLRHGANLNFEDPvTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERlpcl 154
Cdd:PLN03192 631 KRNDLTAMKE---LLKQGLNVDSEDH-QGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDDFSPTELRELLQKR---- 702

                         90       100
                 ....*....|....*....|....*..
gi 320202962 155 qrllDLGADVNAADKHGADVKATTKDG 181
Cdd:PLN03192 703 ----ELGHSITIVDSVPADEPDLGRDG 725
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 39-171 2.45e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.59  E-value: 2.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  39 PSYVASEESRILVLTELLE--RKAHSPFYQEGVSNALL--KMAELGLTRaadVLLRHGANLNFEDpVTYYTALHIAVLRN 114
Cdd:PHA02875  71 ELHDAVEEGDVKAVEELLDlgKFADDVFYKDGMTPLHLatILKKLDIMK---LLIARGADPDIPN-TDKFSPLHLAVMMG 146

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 320202962 115 QPDMVELLVHHGADVNRRDrIHESSPLDLASEEPERLPClQRLLDLGADVNAADKHG 171
Cdd:PHA02875 147 DIKGIELLIDHKACLDIED-CCGCTPLIIAMAKGDIAIC-KMLLDSGANIDYFGKNG 201
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 68-130 3.00e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.59  E-value: 3.00e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320202962  68 GVSNALLKMAElGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVN 130
Cdd:PHA02875 168 GCTPLIIAMAK-GDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCN 229
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 343-381 3.17e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 35.59  E-value: 3.17e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 320202962 343 PPPLKHLCRVAI-----RLYLQpwpVDVKVKALPLPDRLKWYLL 381
Cdd:cd03730    3 PRSLKHLCRLKIracmgRLRLR---CPVFMSFLPLPNRLKAYIL 43
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 37-174 3.59e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.61  E-value: 3.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  37 DRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAEL-GLTRAADVLLRHGANLNFEdPVT--YY---TALHIA 110
Cdd:cd22192   18 ESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALyDNLEAAVVLMEAAPELVNE-PMTsdLYqgeTALHIA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962 111 VLRNQPDMVELLVHHGADVNR--------RDRIHE-----SSPLDLA----SEEPERLpclqrLLDLGADVNAADKHGAD 173
Cdd:cd22192   97 VVNQNLNLVRELIARGADVVSpratgtffRPGPKNliyygEHPLSFAacvgNEEIVRL-----LIEHGADIRAQDSLGNT 171


                 .
gi 320202962 174 V 174
Cdd:cd22192  172 V 172
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 41-166 4.37e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 39.28  E-value: 4.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  41 YVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGL-TRAADVLLRHGANLNFEDPVtYYTALHIA-VLRNQPDM 118
Cdd:PHA02876 279 HASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRL-YITPLHQAsTLDRNKDI 357

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 320202962 119 VELLVHHGADVNRRDrIHESSPLDLASEEpERLPCLQRLLDLGADVNA 166
Cdd:PHA02876 358 VITLLELGANVNARD-YCDKTPIHYAAVR-NNVVIINTLLDYGADIEA 403
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 81-168 4.56e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 39.28  E-value: 4.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202962  81 LTRAADVLLRHGANLNFEDpVTYYTALHIaVLRNQPDM--VELLVHHGADVNRRDRIHeSSPLDLASEEPERLPCLQRLL 158
Cdd:PHA02876 286 LSRLVPKLLERGADVNAKN-IKGETPLYL-MAKNGYDTenIRTLIMLGADVNAADRLY-ITPLHQASTLDRNKDIVITLL 362

                         90
                 ....*....|
gi 320202962 159 DLGADVNAAD 168
Cdd:PHA02876 363 ELGANVNARD 372
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 344-380 4.95e-03

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 34.44  E-value: 4.95e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 320202962 344 PPLKHLCRVAIRlylqpwPVDVKVKALPLPDRLKWYL 380
Cdd:cd03736    4 PSLQHLCRITIN------KCTRQIQELPLPTRLKDYL 34
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 89-134 5.56e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 39.01  E-value: 5.56e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 320202962  89 LRHGANLNFEDpvTYY---TALHIAVLRNQPDMVELLVHHGADVNRRDR 134
Cdd:cd22193   61 LKRFINAEYTD--EYYegqTALHIAIERRQGDIVALLVENGADVHAHAK 107
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 83-130 5.62e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.89  E-value: 5.62e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 320202962  83 RAADVLLRHGANLNFEDpVTYYTALHIAVLRNQPDMVELLVHHGADVN 130
Cdd:PHA02876 159 LIAEMLLEGGADVNAKD-IYCITPIHYAAERGNAKMVNLLLSYGADVN 205
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 341-381 5.63e-03

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 34.43  E-value: 5.63e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 320202962 341 SYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLL 381
Cdd:cd03727    1 SAPGTLKALARYAVRRSLGVQYLPEAVKQLPLPRSVKEYLL 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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