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Conserved domains on  [gi|324073496|ref|NP_001191261|]
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guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2b [Danio rerio]

Protein Classification

guanine nucleotide-binding protein subunit gamma( domain architecture ID 11260168)

guanine nucleotide-binding protein (G protein) subunit gamma is part of heterotrimeric G protein and is required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GGL smart00224
G protein gamma subunit-like motifs;
8-69 6.25e-16

G protein gamma subunit-like motifs;


:

Pssm-ID: 128520  Cd Length: 63  Bit Score: 64.61  E-value: 6.25e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 324073496    8 KEILKMELDQLKVEVNTARTAVSATAPEIIAFVEGLSAEDPLVKGVPEDKNPFKE-KGGCIIT 69
Cdd:smart00224  1 KDQLRKEVEQLRKELSRERIKVSKAAEELLAYCEQHAEEDPLLTGPPPSKNPFIEdKTSCWIL 63
 
Name Accession Description Interval E-value
GGL smart00224
G protein gamma subunit-like motifs;
8-69 6.25e-16

G protein gamma subunit-like motifs;


Pssm-ID: 128520  Cd Length: 63  Bit Score: 64.61  E-value: 6.25e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 324073496    8 KEILKMELDQLKVEVNTARTAVSATAPEIIAFVEGLSAEDPLVKGVPEDKNPFKE-KGGCIIT 69
Cdd:smart00224  1 KDQLRKEVEQLRKELSRERIKVSKAAEELLAYCEQHAEEDPLLTGPPPSKNPFIEdKTSCWIL 63
G-gamma pfam00631
GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the ...
 5-66 5.89e-14

GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta. All organizms that posses a G-beta possess a G-gamma.


Pssm-ID: 459879 [Multi-domain]  Cd Length: 69  Bit Score: 59.67  E-value: 5.89e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 324073496   5 MSDKEILKMELDQLKVEVNTARTAVSATAPEIIAFVEGLSAEDPLVKGV---PEDKNPFKEKGGC 66
Cdd:pfam00631  1 KQLKLKLKREIEQLREELKRERIKVSKACEELIDYCEQRSTKDPLLPGVwgpPAGENPWREDDGC 65
GGL cd00068
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta ...
 11-64 2.30e-13

G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors


Pssm-ID: 238024  Cd Length: 57  Bit Score: 57.68  E-value: 2.30e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 324073496 11 LKMELDQLKVEVNTARTAVSATAPEIIAFVEGLSAEDPLVKGVPEDKNPFKEKG 64
Cdd:cd00068   4 LKKEVEQLRKELSRERLKVSKAAAELLKYCEQNAENDPLLTGPPSPSNPWIEKK 57
 
Name Accession Description Interval E-value
GGL smart00224
G protein gamma subunit-like motifs;
8-69 6.25e-16

G protein gamma subunit-like motifs;


Pssm-ID: 128520  Cd Length: 63  Bit Score: 64.61  E-value: 6.25e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 324073496    8 KEILKMELDQLKVEVNTARTAVSATAPEIIAFVEGLSAEDPLVKGVPEDKNPFKE-KGGCIIT 69
Cdd:smart00224  1 KDQLRKEVEQLRKELSRERIKVSKAAEELLAYCEQHAEEDPLLTGPPPSKNPFIEdKTSCWIL 63
G-gamma pfam00631
GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the ...
 5-66 5.89e-14

GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta. All organizms that posses a G-beta possess a G-gamma.


Pssm-ID: 459879 [Multi-domain]  Cd Length: 69  Bit Score: 59.67  E-value: 5.89e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 324073496   5 MSDKEILKMELDQLKVEVNTARTAVSATAPEIIAFVEGLSAEDPLVKGV---PEDKNPFKEKGGC 66
Cdd:pfam00631  1 KQLKLKLKREIEQLREELKRERIKVSKACEELIDYCEQRSTKDPLLPGVwgpPAGENPWREDDGC 65
GGL cd00068
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta ...
 11-64 2.30e-13

G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors


Pssm-ID: 238024  Cd Length: 57  Bit Score: 57.68  E-value: 2.30e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 324073496 11 LKMELDQLKVEVNTARTAVSATAPEIIAFVEGLSAEDPLVKGVPEDKNPFKEKG 64
Cdd:cd00068   4 LKKEVEQLRKELSRERLKVSKAAAELLKYCEQNAENDPLLTGPPSPSNPWIEKK 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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