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Conserved domains on  [gi|325910845|ref|NP_001191799|]
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CCN family member 4 isoform 4 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 35-117 1.00e-03

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member pfam00007:

Pssm-ID: 473907  Cd Length: 105  Bit Score: 35.84  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325910845   35 EASMNFTLAGCISTRSYQPKYC-GVCM--------------DNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNL 99
Cdd:pfam00007   8 NYTISVEKEGCTSCKTINTTICaGYCYtrdpvykdgrravsQRVCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCHCGN 87

                          90
                  ....*....|....*...
gi 325910845  100 sCRNPNDIFADLESYPDF 117
Cdd:pfam00007  88 -CPTDNSDCTRLSLQPDS 104
 
Name Accession Description Interval E-value
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 35-117 1.00e-03

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 35.84  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325910845   35 EASMNFTLAGCISTRSYQPKYC-GVCM--------------DNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNL 99
Cdd:pfam00007   8 NYTISVEKEGCTSCKTINTTICaGYCYtrdpvykdgrravsQRVCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCHCGN 87

                          90
                  ....*....|....*...
gi 325910845  100 sCRNPNDIFADLESYPDF 117
Cdd:pfam00007  88 -CPTDNSDCTRLSLQPDS 104
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 37-101 5.54e-03

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 33.53  E-value: 5.54e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 325910845    37 SMNFTLAGCiSTRSYQPKYC-GVCMD------------NRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSC 101
Cdd:smart00041   5 RQTITYNGC-TSVTVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPNC 81
 
Name Accession Description Interval E-value
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 35-117 1.00e-03

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 35.84  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325910845   35 EASMNFTLAGCISTRSYQPKYC-GVCM--------------DNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNL 99
Cdd:pfam00007   8 NYTISVEKEGCTSCKTINTTICaGYCYtrdpvykdgrravsQRVCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCHCGN 87

                          90
                  ....*....|....*...
gi 325910845  100 sCRNPNDIFADLESYPDF 117
Cdd:pfam00007  88 -CPTDNSDCTRLSLQPDS 104
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 37-101 5.54e-03

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 33.53  E-value: 5.54e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 325910845    37 SMNFTLAGCiSTRSYQPKYC-GVCMD------------NRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSC 101
Cdd:smart00041   5 RQTITYNGC-TSVTVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPNC 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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