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Conserved domains on  [gi|328887949|ref|NP_001192244|]
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metalloreductase STEAP4 isoform 1 [Homo sapiens]

Protein Classification

COG2085 and Ferric_reduct domain-containing protein( domain architecture ID 11946522)

COG2085 and Ferric_reduct domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
24-190 6.43e-46

Predicted dinucleotide-binding enzyme [General function prediction only];


:

Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 158.02  E-value: 6.43e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949  24 IFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLP----SGAEVLSYSEAAKKSGIIIIAIHREHY-DFLTELTEVLNG 98
Cdd:COG2085    3 IIGTGNIGSALARRLAAAGHEVVIGSRDPEKAAALAaelgPGARAGTNAEAAAAADVVVLAVPYEAVpDVLESLGDALAG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949  99 KILVDISNNLKINQYP-------ESNAEYLAHLVPGAHVVKAFNTISAWALQSGALDAS--RQVFVCGNDSKAKQRVMDI 169
Cdd:COG2085   83 KIVIDATNPLPERDGFildppggGSAAELVAALLPGARVVKAFNTIGAAVLADPARPAGgrRDVFVAGDDAEAKAVVAAL 162

                        170       180
                 ....*....|....*....|.
gi 328887949 170 VRNLGLTPMDQGSLMAAKEIE 190
Cdd:COG2085  163 IEDLGFDPVDAGPLANARRLE 183
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 249-394 4.30e-10

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


:

Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 57.28  E-value: 4.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949  249 ITALTLLALVYLPGVIAAILQLYRGTKYrrfpdwlDHWMLCRKQLGLVALGFAFLHVLYTLVIPIRYYVRwrlgnltvtq 328
Cdd:pfam01794   3 ILALALLPLLLLLALRNNPLEWLTGLSY-------DRLLLFHRWLGRLAFLLALLHVILYLIYWLRFSLE---------- 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 328887949  329 ailkkenpfSTSSAWLSDSYVALGILGFFLFVLLGITSLPSVSNAvNWREFRFVQSKLGYLTLILC 394
Cdd:pfam01794  66 ---------GILDLLLKRPYNILGIIALVLLVLLAITSLPPFRRL-SYELFLYLHILLAVAFLLLV 121
 
Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
24-190 6.43e-46

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 158.02  E-value: 6.43e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949  24 IFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLP----SGAEVLSYSEAAKKSGIIIIAIHREHY-DFLTELTEVLNG 98
Cdd:COG2085    3 IIGTGNIGSALARRLAAAGHEVVIGSRDPEKAAALAaelgPGARAGTNAEAAAAADVVVLAVPYEAVpDVLESLGDALAG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949  99 KILVDISNNLKINQYP-------ESNAEYLAHLVPGAHVVKAFNTISAWALQSGALDAS--RQVFVCGNDSKAKQRVMDI 169
Cdd:COG2085   83 KIVIDATNPLPERDGFildppggGSAAELVAALLPGARVVKAFNTIGAAVLADPARPAGgrRDVFVAGDDAEAKAVVAAL 162

                        170       180
                 ....*....|....*....|.
gi 328887949 170 VRNLGLTPMDQGSLMAAKEIE 190
Cdd:COG2085  163 IEDLGFDPVDAGPLANARRLE 183
npdG TIGR01915
NADPH-dependent F420 reductase; This model represents a subset of a parent family described by ...
 26-191 5.76e-19

NADPH-dependent F420 reductase; This model represents a subset of a parent family described by pfam03807. Unlike the parent family, members of this family are found only in species with evidence of coenzyme F420. All members of this family are believed to act as NADPH-dependent F420 reductase. [Energy metabolism, Electron transport]


Pssm-ID: 273873  Cd Length: 219  Bit Score: 85.23  E-value: 5.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949   26 GTGDFGRSLGLKMLQCGYSVVFGSRNPQKT---------TLLPSGAEV----LSYSEAAKKSGIIIIAIHREHY-DFLTE 91
Cdd:TIGR01915   8 GTGDQGKGLALRLAKAGNKIIIGSRDLEKAeeaaakaleELGHGGSDIkvtgADNAEAAKRADVVILAVPWDHVlKTLES 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949   92 LTEVLNGKILVDISNNL--------KINQYPE-SNAEYLAHLVP-GAHVVKAFNTISAWALQSGALDASRQVFVCGNDSK 161
Cdd:TIGR01915  88 LRDELSGKLVISPVVPLasdggkgaRYLPPEEgSAAEQAAALLPeTSRVVAAFHNLSAVLLQDVDDEVDCDVLVCGDDEE 167

                         170       180       190
                  ....*....|....*....|....*....|.
gi 328887949  162 AKQRVMDIVRNL-GLTPMDQGSLMAAKEIEK 191
Cdd:TIGR01915 168 AKEVVAELAGRIdGLRALDAGPLENAAIVES 198
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
23-107 1.19e-16

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 74.96  E-value: 1.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949   23 CIFGTGDFGRSLGLKMLQCG-YSVVFG-SRNPQKTTLL----PSGAEVLSYSEAAKKSGIIIIAIHREHY-DFLTELTEV 95
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAGpHEVVVAnSRNPEKAEELaeeyGVGATAVDNEEAAEEADVVFLAVKPEDApDVLSELSDL 80

                          90
                  ....*....|..
gi 328887949   96 LNGKILVDISNN 107
Cdd:pfam03807  81 LKGKIVISIAAG 92
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 249-394 4.30e-10

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 57.28  E-value: 4.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949  249 ITALTLLALVYLPGVIAAILQLYRGTKYrrfpdwlDHWMLCRKQLGLVALGFAFLHVLYTLVIPIRYYVRwrlgnltvtq 328
Cdd:pfam01794   3 ILALALLPLLLLLALRNNPLEWLTGLSY-------DRLLLFHRWLGRLAFLLALLHVILYLIYWLRFSLE---------- 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 328887949  329 ailkkenpfSTSSAWLSDSYVALGILGFFLFVLLGITSLPSVSNAvNWREFRFVQSKLGYLTLILC 394
Cdd:pfam01794  66 ---------GILDLLLKRPYNILGIIALVLLVLLAITSLPPFRRL-SYELFLYLHILLAVAFLLLV 121
MsrQ COG2717
Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide ...
 277-397 8.15e-03

Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases [Energy production and conversion];


Pssm-ID: 442030  Cd Length: 200  Bit Score: 37.47  E-value: 8.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949 277 RRFPDWLDhWMLCRKQLGLVALGFAFLHVLYTLVIpiryYVRWRLGNLtvTQAILKKenpfstssawlsdSYVALGILGF 356
Cdd:COG2717   62 RRLTGWPW-LLRLRRMLGLWAFFYALLHLLAYLWL----DLGFDLALI--WADIVKR-------------PYITVGFAAF 121

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 328887949 357 FLFVLLGITSlpsvsnavnwreFRFVQSKLG----------YLTLILCTAH 397
Cdd:COG2717  122 LLLLPLALTS------------TNAAIRRLGrrwkrlhrlvYLAAVLAVLH 160
 
Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
24-190 6.43e-46

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 158.02  E-value: 6.43e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949  24 IFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLP----SGAEVLSYSEAAKKSGIIIIAIHREHY-DFLTELTEVLNG 98
Cdd:COG2085    3 IIGTGNIGSALARRLAAAGHEVVIGSRDPEKAAALAaelgPGARAGTNAEAAAAADVVVLAVPYEAVpDVLESLGDALAG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949  99 KILVDISNNLKINQYP-------ESNAEYLAHLVPGAHVVKAFNTISAWALQSGALDAS--RQVFVCGNDSKAKQRVMDI 169
Cdd:COG2085   83 KIVIDATNPLPERDGFildppggGSAAELVAALLPGARVVKAFNTIGAAVLADPARPAGgrRDVFVAGDDAEAKAVVAAL 162

                        170       180
                 ....*....|....*....|.
gi 328887949 170 VRNLGLTPMDQGSLMAAKEIE 190
Cdd:COG2085  163 IEDLGFDPVDAGPLANARRLE 183
npdG TIGR01915
NADPH-dependent F420 reductase; This model represents a subset of a parent family described by ...
 26-191 5.76e-19

NADPH-dependent F420 reductase; This model represents a subset of a parent family described by pfam03807. Unlike the parent family, members of this family are found only in species with evidence of coenzyme F420. All members of this family are believed to act as NADPH-dependent F420 reductase. [Energy metabolism, Electron transport]


Pssm-ID: 273873  Cd Length: 219  Bit Score: 85.23  E-value: 5.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949   26 GTGDFGRSLGLKMLQCGYSVVFGSRNPQKT---------TLLPSGAEV----LSYSEAAKKSGIIIIAIHREHY-DFLTE 91
Cdd:TIGR01915   8 GTGDQGKGLALRLAKAGNKIIIGSRDLEKAeeaaakaleELGHGGSDIkvtgADNAEAAKRADVVILAVPWDHVlKTLES 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949   92 LTEVLNGKILVDISNNL--------KINQYPE-SNAEYLAHLVP-GAHVVKAFNTISAWALQSGALDASRQVFVCGNDSK 161
Cdd:TIGR01915  88 LRDELSGKLVISPVVPLasdggkgaRYLPPEEgSAAEQAAALLPeTSRVVAAFHNLSAVLLQDVDDEVDCDVLVCGDDEE 167

                         170       180       190
                  ....*....|....*....|....*....|.
gi 328887949  162 AKQRVMDIVRNL-GLTPMDQGSLMAAKEIEK 191
Cdd:TIGR01915 168 AKEVVAELAGRIdGLRALDAGPLENAAIVES 198
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
23-107 1.19e-16

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 74.96  E-value: 1.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949   23 CIFGTGDFGRSLGLKMLQCG-YSVVFG-SRNPQKTTLL----PSGAEVLSYSEAAKKSGIIIIAIHREHY-DFLTELTEV 95
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAGpHEVVVAnSRNPEKAEELaeeyGVGATAVDNEEAAEEADVVFLAVKPEDApDVLSELSDL 80

                          90
                  ....*....|..
gi 328887949   96 LNGKILVDISNN 107
Cdd:pfam03807  81 LKGKIVISIAAG 92
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 249-394 4.30e-10

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 57.28  E-value: 4.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949  249 ITALTLLALVYLPGVIAAILQLYRGTKYrrfpdwlDHWMLCRKQLGLVALGFAFLHVLYTLVIPIRYYVRwrlgnltvtq 328
Cdd:pfam01794   3 ILALALLPLLLLLALRNNPLEWLTGLSY-------DRLLLFHRWLGRLAFLLALLHVILYLIYWLRFSLE---------- 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 328887949  329 ailkkenpfSTSSAWLSDSYVALGILGFFLFVLLGITSLPSVSNAvNWREFRFVQSKLGYLTLILC 394
Cdd:pfam01794  66 ---------GILDLLLKRPYNILGIIALVLLVLLAITSLPPFRRL-SYELFLYLHILLAVAFLLLV 121
MsrQ COG2717
Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide ...
 277-397 8.15e-03

Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases [Energy production and conversion];


Pssm-ID: 442030  Cd Length: 200  Bit Score: 37.47  E-value: 8.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328887949 277 RRFPDWLDhWMLCRKQLGLVALGFAFLHVLYTLVIpiryYVRWRLGNLtvTQAILKKenpfstssawlsdSYVALGILGF 356
Cdd:COG2717   62 RRLTGWPW-LLRLRRMLGLWAFFYALLHLLAYLWL----DLGFDLALI--WADIVKR-------------PYITVGFAAF 121

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 328887949 357 FLFVLLGITSlpsvsnavnwreFRFVQSKLG----------YLTLILCTAH 397
Cdd:COG2717  122 LLLLPLALTS------------TNAAIRRLGrrwkrlhrlvYLAAVLAVLH 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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