NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|332205957|ref|NP_001193771|]
View 

germ cell-specific gene 1 protein isoform 5 [Homo sapiens]

Protein Classification

GSG-1 domain-containing protein( domain architecture ID 10544657)

GSG-1 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GSG-1 pfam07803
GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a ...
 24-137 4.60e-67

GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumourigenesis of human testicular germ cell tumours. The region in question has four highly-conserved cysteine residues.


:

Pssm-ID: 462270  Cd Length: 109  Bit Score: 205.95  E-value: 4.60e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332205957   24 SGQRTLLSAILSMLSLSFSTTSLLSNYWFVGTQKVPKPLCEKGLAAKCFDMpvsldGDTNTSTQEVVQYNWETGDDRFSF 103
Cdd:pfam07803   1 RRRRALLSLILNLLALALSTTALLSSYWCEGTQKVPKPLCGKGKQTNCIDF-----GSSNTSDSEVVQYIWETGDDRFSF 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 332205957  104 RSFRSGMWLSCEETVEEPGERCRSFIELTPPAKR 137
Cdd:pfam07803  76 RYFHTGIWLSCEENIEGPGEKCRSFIELTPASER 109
 
Name Accession Description Interval E-value
GSG-1 pfam07803
GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a ...
 24-137 4.60e-67

GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumourigenesis of human testicular germ cell tumours. The region in question has four highly-conserved cysteine residues.


Pssm-ID: 462270  Cd Length: 109  Bit Score: 205.95  E-value: 4.60e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332205957   24 SGQRTLLSAILSMLSLSFSTTSLLSNYWFVGTQKVPKPLCEKGLAAKCFDMpvsldGDTNTSTQEVVQYNWETGDDRFSF 103
Cdd:pfam07803   1 RRRRALLSLILNLLALALSTTALLSSYWCEGTQKVPKPLCGKGKQTNCIDF-----GSSNTSDSEVVQYIWETGDDRFSF 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 332205957  104 RSFRSGMWLSCEETVEEPGERCRSFIELTPPAKR 137
Cdd:pfam07803  76 RYFHTGIWLSCEENIEGPGEKCRSFIELTPASER 109
 
Name Accession Description Interval E-value
GSG-1 pfam07803
GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a ...
 24-137 4.60e-67

GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumourigenesis of human testicular germ cell tumours. The region in question has four highly-conserved cysteine residues.


Pssm-ID: 462270  Cd Length: 109  Bit Score: 205.95  E-value: 4.60e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332205957   24 SGQRTLLSAILSMLSLSFSTTSLLSNYWFVGTQKVPKPLCEKGLAAKCFDMpvsldGDTNTSTQEVVQYNWETGDDRFSF 103
Cdd:pfam07803   1 RRRRALLSLILNLLALALSTTALLSSYWCEGTQKVPKPLCGKGKQTNCIDF-----GSSNTSDSEVVQYIWETGDDRFSF 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 332205957  104 RSFRSGMWLSCEETVEEPGERCRSFIELTPPAKR 137
Cdd:pfam07803  76 RYFHTGIWLSCEENIEGPGEKCRSFIELTPASER 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH