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Conserved domains on  [gi|333033811|ref|NP_001193933|]
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UDP-glucuronosyltransferase 2B28 isoform 2 precursor [Homo sapiens]

Protein Classification

UDP-glycosyltransferase family protein( domain architecture ID 11989770)

UDP-glycosyltransferase family protein similar to UDP-glucuronosyltransferase (UDPGT), which is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

EC:  2.4.-.-
Gene Ontology:  GO:0008194|GO:0006486
SCOP:  3001586

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
UDPGT pfam00201
UDP-glucoronosyl and UDP-glucosyl transferase;
24-335 4.36e-174

UDP-glucoronosyl and UDP-glucosyl transferase;


:

Pssm-ID: 278624 [Multi-domain]  Cd Length: 499  Bit Score: 492.31  E-value: 4.36e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811   24 GKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRW-SDIQK 102
Cdd:pfam00201   1 GKVLVWPMDGSHWMNMKGILEELVQRGHEVTVLRPSASISIGPGKPSNLKFETYPTSATKEELENPFPKRQMQWfEEASF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811  103 DSFWLYFSQEQEilweFHDIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTIER 182
Cdd:pfam00201  81 GTVWSYFSALQE----YSDGYRVTCKELVGNKKLMTKLQESSFDVVLADPVWPCGELLAELLHIPTVYSLRFVPGYAAEK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811  183 HSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDmKKWDQFYSEVLGRPTTLFETMGKADIWLMRNSW 262
Cdd:pfam00201 157 VSGGLPSPPSYVPVILSDLSDHMTFMERVKNMLIMLYFDFWFQCFP-RKWDQFASEVLGRPVTLPELMSKASVWLIRSYW 235
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 333033811  263 SFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTAERANVIATALAKIPQKI 335
Cdd:pfam00201 236 DLEFPRPLLPNMDFIGGLHCKPAKPLPQEMEAFVQSSGEHGVVVFSLGSMVSNIPEEKANAIASALAQIPQKV 308
 
Name Accession Description Interval E-value
UDPGT pfam00201
UDP-glucoronosyl and UDP-glucosyl transferase;
24-335 4.36e-174

UDP-glucoronosyl and UDP-glucosyl transferase;


Pssm-ID: 278624 [Multi-domain]  Cd Length: 499  Bit Score: 492.31  E-value: 4.36e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811   24 GKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRW-SDIQK 102
Cdd:pfam00201   1 GKVLVWPMDGSHWMNMKGILEELVQRGHEVTVLRPSASISIGPGKPSNLKFETYPTSATKEELENPFPKRQMQWfEEASF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811  103 DSFWLYFSQEQEilweFHDIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTIER 182
Cdd:pfam00201  81 GTVWSYFSALQE----YSDGYRVTCKELVGNKKLMTKLQESSFDVVLADPVWPCGELLAELLHIPTVYSLRFVPGYAAEK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811  183 HSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDmKKWDQFYSEVLGRPTTLFETMGKADIWLMRNSW 262
Cdd:pfam00201 157 VSGGLPSPPSYVPVILSDLSDHMTFMERVKNMLIMLYFDFWFQCFP-RKWDQFASEVLGRPVTLPELMSKASVWLIRSYW 235
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 333033811  263 SFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTAERANVIATALAKIPQKI 335
Cdd:pfam00201 236 DLEFPRPLLPNMDFIGGLHCKPAKPLPQEMEAFVQSSGEHGVVVFSLGSMVSNIPEEKANAIASALAQIPQKV 308
GT1_Gtf-like cd03784
UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of ...
25-335 1.10e-25

UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.


Pssm-ID: 340817 [Multi-domain]  Cd Length: 404  Bit Score: 106.10  E-value: 1.10e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811  25 KVLVWT-GEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAftlKLEVYPTSLTKTEFENiimqqvKRWSDIQKD 103
Cdd:cd03784    2 RILFVPfPGQGHVNPMLPLAKALAARGHEVTVATPPFNFADLVEAA---GLTFVPVGDDPDELEL------DSETNLGPD 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811 104 SFWLYFSQEQEILWEFHDIFRNFCKDvvsnkkvmkklqESRFDIIFADAFFPCGELLAALLNIPFVySLCFTPgytierh 183
Cdd:cd03784   73 SLLELLRRLLKAADELLDDLLAALRS------------SWKPDLVIADPFAYAGPLVAEELGIPSV-RLFTGP------- 132
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811 184 SGGLIFPPSYIPVVMSKLSDQMTFMERVKNMiyvlyfdfwfqmcdmKKWDQFYSEVLGRPTTLFETMGKADIW--LMRNS 261
Cdd:cd03784  133 ATLLSAYLHPFGVLNLLLSSLLEPELFLDPL---------------LEVLDRLRERLGLPPFSLVLLLLRLVPplYVIGP 197
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 333033811 262 WSFQFPHPFLPNIDFVGGL-HCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTAERANVIATALAKIPQKI 335
Cdd:cd03784  198 TFPSLPPDRPRLPSVLGGLrIVPKNGPLPDELWEWLDKQPPRSVVYVSFGSMVRDLPEELLELIAEALASLGQRF 272
YjiC COG1819
UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];
25-58 2.83e-03

UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];


Pssm-ID: 441424 [Multi-domain]  Cd Length: 268  Bit Score: 38.68  E-value: 2.83e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 333033811  25 KVLVWT-GEYSHWMNMKTILKELVQRGHEVTVLAS 58
Cdd:COG1819    1 RILFVTlGGRGHVNPLLALARALRARGHEVTFATG 35
 
Name Accession Description Interval E-value
UDPGT pfam00201
UDP-glucoronosyl and UDP-glucosyl transferase;
24-335 4.36e-174

UDP-glucoronosyl and UDP-glucosyl transferase;


Pssm-ID: 278624 [Multi-domain]  Cd Length: 499  Bit Score: 492.31  E-value: 4.36e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811   24 GKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRW-SDIQK 102
Cdd:pfam00201   1 GKVLVWPMDGSHWMNMKGILEELVQRGHEVTVLRPSASISIGPGKPSNLKFETYPTSATKEELENPFPKRQMQWfEEASF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811  103 DSFWLYFSQEQEilweFHDIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTIER 182
Cdd:pfam00201  81 GTVWSYFSALQE----YSDGYRVTCKELVGNKKLMTKLQESSFDVVLADPVWPCGELLAELLHIPTVYSLRFVPGYAAEK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811  183 HSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDmKKWDQFYSEVLGRPTTLFETMGKADIWLMRNSW 262
Cdd:pfam00201 157 VSGGLPSPPSYVPVILSDLSDHMTFMERVKNMLIMLYFDFWFQCFP-RKWDQFASEVLGRPVTLPELMSKASVWLIRSYW 235
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 333033811  263 SFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTAERANVIATALAKIPQKI 335
Cdd:pfam00201 236 DLEFPRPLLPNMDFIGGLHCKPAKPLPQEMEAFVQSSGEHGVVVFSLGSMVSNIPEEKANAIASALAQIPQKV 308
GT1_Gtf-like cd03784
UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of ...
25-335 1.10e-25

UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.


Pssm-ID: 340817 [Multi-domain]  Cd Length: 404  Bit Score: 106.10  E-value: 1.10e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811  25 KVLVWT-GEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAftlKLEVYPTSLTKTEFENiimqqvKRWSDIQKD 103
Cdd:cd03784    2 RILFVPfPGQGHVNPMLPLAKALAARGHEVTVATPPFNFADLVEAA---GLTFVPVGDDPDELEL------DSETNLGPD 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811 104 SFWLYFSQEQEILWEFHDIFRNFCKDvvsnkkvmkklqESRFDIIFADAFFPCGELLAALLNIPFVySLCFTPgytierh 183
Cdd:cd03784   73 SLLELLRRLLKAADELLDDLLAALRS------------SWKPDLVIADPFAYAGPLVAEELGIPSV-RLFTGP------- 132
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811 184 SGGLIFPPSYIPVVMSKLSDQMTFMERVKNMiyvlyfdfwfqmcdmKKWDQFYSEVLGRPTTLFETMGKADIW--LMRNS 261
Cdd:cd03784  133 ATLLSAYLHPFGVLNLLLSSLLEPELFLDPL---------------LEVLDRLRERLGLPPFSLVLLLLRLVPplYVIGP 197
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 333033811 262 WSFQFPHPFLPNIDFVGGL-HCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTAERANVIATALAKIPQKI 335
Cdd:cd03784  198 TFPSLPPDRPRLPSVLGGLrIVPKNGPLPDELWEWLDKQPPRSVVYVSFGSMVRDLPEELLELIAEALASLGQRF 272
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
25-170 9.99e-05

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 43.87  E-value: 9.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811  25 KVLVWTGEY------SHWMNMKtILKELVQRGHEVTVLASSASILFDPNDAftlklevyptsLTKTEFENIIMQQVKRWS 98
Cdd:cd03794    1 KILLISQYYpppkgaAAARVYE-LAKELVRRGHEVTVLTPSPNYPLGRIFA-----------GATETKDGIRVIRVKLGP 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333033811  99 dIQKDSF----WLYFSQEQEILWEFhdifrnfckdvvsnkkvmkKLQESRFDIIFA---DAFF-PCGELLAALLNIPFVY 170
Cdd:cd03794   69 -IKKNGLirrlLNYLSFALAALLKL-------------------LVREERPDVIIAyspPITLgLAALLLKKLRGAPFIL 128
YjiC COG1819
UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];
25-58 2.83e-03

UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];


Pssm-ID: 441424 [Multi-domain]  Cd Length: 268  Bit Score: 38.68  E-value: 2.83e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 333033811  25 KVLVWT-GEYSHWMNMKTILKELVQRGHEVTVLAS 58
Cdd:COG1819    1 RILFVTlGGRGHVNPLLALARALRARGHEVTFATG 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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