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Conserved domains on  [gi|333805605|ref|NP_001201838|]
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zinc finger protein 48 isoform 1 [Homo sapiens]

Protein Classification

zf-H2C2_2 and COG5048 domain-containing protein( domain architecture ID 11779706)

protein containing domains SFP1, zf-H2C2_2, and COG5048

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-599 1.75e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 190 RPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCG--ICGKGFGDSSARIKHQRTHrGEQPPRPVVPRRQPSRAATAATQG 267
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTH-HNNPSDLNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 268 PKAQDKPYICTDCgkrfvlSCSLLSHQRSHlgpkPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLC-------PECGKGF 340
Cdd:COG5048  111 SSSSSNSNDNNLL------SSHSLPPSSRD----PQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpaNSLSKDP 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 341 ADSSARVKHLRTHSGERPHACPecdrTFSLSSTLLRHRLTHMEPQDFSFPGYPLPALIPSPPPPPLGTSPPLTPRSPSHS 420
Cdd:COG5048  181 SSNLSLLISSNVSTSIPSSSEN----SPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 421 GEPFGLPGLePEPGGPQAG----EPPPPLAGDKPHKCPECGKGFRRSSDLVKH--HRVHTGE--KPYLCPE--CGKGFAD 490
Cdd:COG5048  257 ASESPRSSL-PTASSQSSSpnesDSSSEKGFSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSR 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 491 SSARVKHLRTHRGERARPPPPSTLLRPHNPPGPvpmaPRPRVRAQPSG---PSQPHVC--GFCGKEFPRSSDLVKHRRTH 565
Cdd:COG5048  336 NDALKRHILLHTSISPAKEKLLNSSSKFSPLLN----NEPPQSLQQYKdlkNDKKSETlsNSCIRNFKRDSNLSLHIITH 411

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 333805605 566 TGEKP--YKCAECGKGFGDSSARIKHQRGHLVLTPF 599
Cdd:COG5048  412 LSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
zf-H2C2_2 pfam13465
Zinc-finger double domain;
126-149 1.23e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.23e-04
                          10        20
                  ....*....|....*....|....
gi 333805605  126 DLVKHQRTHTGEKPYKCGVCGKGF 149
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 51-215 1.41e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605  51 FKEEDLAPDHEVgnaSLKPEGIQNWDDlwvqreglgkPQPRDRGPRLLGEPRWGQASSDRAAVCGEcgksfRQMSDLVKH 130
Cdd:COG5189  280 FEESSLGFDYEF---IHKSVGNKEIRG----------GISTGEMIDVRKLPCTNSSSNGKLAHGGE-----RNIDTPSRM 341

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 131 QRThTGEKPYKCGV--CGKGFGDSSArIKHQRTHSGEKPYRARPPAQgppkIPRSRIPAGERPTICGECGKSFRQSSDLv 208
Cdd:COG5189  342 LKV-KDGKPYKCPVegCNKKYKNQNG-LKYHMLHGHQNQKLHENPSP----EKMNIFSAKDKPYRCEVCDKRYKNLNGL- 414


                 ....*..
gi 333805605 209 KHQRTHT 215
Cdd:COG5189  415 KYHRKHS 421
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-599 1.75e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 190 RPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCG--ICGKGFGDSSARIKHQRTHrGEQPPRPVVPRRQPSRAATAATQG 267
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTH-HNNPSDLNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 268 PKAQDKPYICTDCgkrfvlSCSLLSHQRSHlgpkPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLC-------PECGKGF 340
Cdd:COG5048  111 SSSSSNSNDNNLL------SSHSLPPSSRD----PQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpaNSLSKDP 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 341 ADSSARVKHLRTHSGERPHACPecdrTFSLSSTLLRHRLTHMEPQDFSFPGYPLPALIPSPPPPPLGTSPPLTPRSPSHS 420
Cdd:COG5048  181 SSNLSLLISSNVSTSIPSSSEN----SPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 421 GEPFGLPGLePEPGGPQAG----EPPPPLAGDKPHKCPECGKGFRRSSDLVKH--HRVHTGE--KPYLCPE--CGKGFAD 490
Cdd:COG5048  257 ASESPRSSL-PTASSQSSSpnesDSSSEKGFSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSR 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 491 SSARVKHLRTHRGERARPPPPSTLLRPHNPPGPvpmaPRPRVRAQPSG---PSQPHVC--GFCGKEFPRSSDLVKHRRTH 565
Cdd:COG5048  336 NDALKRHILLHTSISPAKEKLLNSSSKFSPLLN----NEPPQSLQQYKdlkNDKKSETlsNSCIRNFKRDSNLSLHIITH 411

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 333805605 566 TGEKP--YKCAECGKGFGDSSARIKHQRGHLVLTPF 599
Cdd:COG5048  412 LSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
zf-H2C2_2 pfam13465
Zinc-finger double domain;
557-580 7.86e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.86e-05
                          10        20
                  ....*....|....*....|....
gi 333805605  557 DLVKHRRTHTGEKPYKCAECGKGF 580
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
126-149 1.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.23e-04
                          10        20
                  ....*....|....*....|....
gi 333805605  126 DLVKHQRTHTGEKPYKCGVCGKGF 149
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 51-215 1.41e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605  51 FKEEDLAPDHEVgnaSLKPEGIQNWDDlwvqreglgkPQPRDRGPRLLGEPRWGQASSDRAAVCGEcgksfRQMSDLVKH 130
Cdd:COG5189  280 FEESSLGFDYEF---IHKSVGNKEIRG----------GISTGEMIDVRKLPCTNSSSNGKLAHGGE-----RNIDTPSRM 341

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 131 QRThTGEKPYKCGV--CGKGFGDSSArIKHQRTHSGEKPYRARPPAQgppkIPRSRIPAGERPTICGECGKSFRQSSDLv 208
Cdd:COG5189  342 LKV-KDGKPYKCPVegCNKKYKNQNG-LKYHMLHGHQNQKLHENPSP----EKMNIFSAKDKPYRCEVCDKRYKNLNGL- 414


                 ....*..
gi 333805605 209 KHQRTHT 215
Cdd:COG5189  415 KYHRKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 113-134 1.55e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|..
gi 333805605  113 VCGECGKSFRQMSDLVKHQRTH 134
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 428-570 2.48e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605  428 GLEpEPGGPQAGEPPPPLAGDKPHKCPE----CGKGFRRSSDLVKHHRVHtgeKPYLCPEcgkgfadsSARVKHLRTHRG 503
Cdd:PHA03247 2539 GLE-ELASDDAGDPPPPLPPAAPPAAPDrsvpPPRPAPRPSEPAVTSRAR---RPDAPPQ--------SARPRAPVDDRG 2606

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 333805605  504 ERARPPPPSTLLRPHNPPGPVPMAPRPRVRAQPSGPSQPHVCGFCGKEFPRSSDLVKHRRTHTGEKP 570
Cdd:PHA03247 2607 DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA 2673
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-599 1.75e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 190 RPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCG--ICGKGFGDSSARIKHQRTHrGEQPPRPVVPRRQPSRAATAATQG 267
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTH-HNNPSDLNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 268 PKAQDKPYICTDCgkrfvlSCSLLSHQRSHlgpkPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLC-------PECGKGF 340
Cdd:COG5048  111 SSSSSNSNDNNLL------SSHSLPPSSRD----PQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpaNSLSKDP 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 341 ADSSARVKHLRTHSGERPHACPecdrTFSLSSTLLRHRLTHMEPQDFSFPGYPLPALIPSPPPPPLGTSPPLTPRSPSHS 420
Cdd:COG5048  181 SSNLSLLISSNVSTSIPSSSEN----SPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 421 GEPFGLPGLePEPGGPQAG----EPPPPLAGDKPHKCPECGKGFRRSSDLVKH--HRVHTGE--KPYLCPE--CGKGFAD 490
Cdd:COG5048  257 ASESPRSSL-PTASSQSSSpnesDSSSEKGFSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSR 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 491 SSARVKHLRTHRGERARPPPPSTLLRPHNPPGPvpmaPRPRVRAQPSG---PSQPHVC--GFCGKEFPRSSDLVKHRRTH 565
Cdd:COG5048  336 NDALKRHILLHTSISPAKEKLLNSSSKFSPLLN----NEPPQSLQQYKdlkNDKKSETlsNSCIRNFKRDSNLSLHIITH 411

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 333805605 566 TGEKP--YKCAECGKGFGDSSARIKHQRGHLVLTPF 599
Cdd:COG5048  412 LSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
114-499 3.60e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 3.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 114 CGECGKSFRQMSDLVKHQRTHTGEKPYKCGV--CGKGFGDSSARIKHQRTH----------------------------- 162
Cdd:COG5048   36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHhnnpsdlnskslplsnskasssslsssss 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 163 -------------SGEKPYRARPPAQGPPKIPRSRIPAGERPTICGE--------------CGKSFRQSSDLVKHQRTHT 215
Cdd:COG5048  116 nsndnnllsshslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslSKDPSSNLSLLISSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 216 GEKPYKCGicgkgFGDSSARIKHQRTHRGEQPPRPVVPRRQPS--RAATAATQGPKAQDKPYICTDCGKRFVLS-----C 288
Cdd:COG5048  196 IPSSSENS-----PLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlSPKSLLSQSPSSLSSSDSSSSASESPRSSlptasS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 289 SLLSHQRSHLGP-----KPFGCDVCGKEFARGSDLVKHLR--VHTGE--KPYLCPE--CGKGFADSSARVKHLRTHSGER 357
Cdd:COG5048  271 QSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 358 PHACPECDRTFSLSStllrhrLTHMEPQDFSFPGYPLpalipsppppplgtsppltprSPSHSGEPFGLPGLEPEPGGPQ 437
Cdd:COG5048  351 PAKEKLLNSSSKFSP------LLNNEPPQSLQQYKDL---------------------KNDKKSETLSNSCIRNFKRDSN 403

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 333805605 438 AGEPPPPLAGDKPH--KCPECGKGFRRSSDLVKHHRVHTgEKPYLCPECGKGFADSSARVKHLR 499
Cdd:COG5048  404 LSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-599 6.12e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 6.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 300 PKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLC--PECGKGFADSSARVKHLRTHSGERPHAC--PECDRTFSLSSTLL 375
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 376 RH------RLTHMEPQDFSFPGYPL-----------PALIPSPPPPPLGTSPPLTPRSPSHSGEPFGLPGLEPEPGGPQA 438
Cdd:COG5048  111 SSsssnsnDNNLLSSHSLPPSSRDPqlpdllsisnlRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 439 GEPPPPlagdKPHKCPECGKGFRRSSDLVKHHRVHTGEKPYLCPECGKGFADSSarVKHLRTHRGERARPPPPSTLLRPH 518
Cdd:COG5048  191 NVSTSI----PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 519 NPPGPVPMA-PRPRVRAQPSGPSQPHVCGFCGKEFPRSSDLVKHRRT--HTGE--KPYKCAE--CGKGFGDSSARIKHQR 591
Cdd:COG5048  265 LPTASSQSSsPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344


                 ....*...
gi 333805605 592 GHLVLTPF 599
Cdd:COG5048  345 LHTSISPA 352
zf-H2C2_2 pfam13465
Zinc-finger double domain;
557-580 7.86e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.86e-05
                          10        20
                  ....*....|....*....|....
gi 333805605  557 DLVKHRRTHTGEKPYKCAECGKGF 580
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
317-341 8.18e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 8.18e-05
                          10        20
                  ....*....|....*....|....*
gi 333805605  317 DLVKHLRVHTGEKPYLCPECGKGFA 341
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 451-473 1.17e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 1.17e-04
                          10        20
                  ....*....|....*....|...
gi 333805605  451 HKCPECGKGFRRSSDLVKHHRVH 473
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
126-149 1.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.23e-04
                          10        20
                  ....*....|....*....|....
gi 333805605  126 DLVKHQRTHTGEKPYKCGVCGKGF 149
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
206-229 1.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.85e-04
                          10        20
                  ....*....|....*....|....
gi 333805605  206 DLVKHQRTHTGEKPYKCGICGKGF 229
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
465-489 2.68e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.68e-04
                          10        20
                  ....*....|....*....|....*
gi 333805605  465 DLVKHHRVHTGEKPYLCPECGKGFA 489
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 194-214 4.32e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 4.32e-04
                          10        20
                  ....*....|....*....|.
gi 333805605  194 CGECGKSFRQSSDLVKHQRTH 214
Cdd:pfam00096   3 CPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 216-284 5.17e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 5.17e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 333805605 216 GEKPYKCGI--CGKGFGDSSArIKHQRTHRGEQPPRPVVPRRQPsraataaTQGPKAQDKPYICTDCGKRF 284
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNG-LKYHMLHGHQNQKLHENPSPEK-------MNIFSAKDKPYRCEVCDKRY 408
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
524-591 6.20e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 6.20e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 524 VPMAPRPRVRAQPSGPSQPHVCGFCGKEFPRSSDLVKHRRTHTGEKPYKCA--ECGKGFGDSSARIKHQR 591
Cdd:COG5048   15 VLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLR 84
zf-H2C2_2 pfam13465
Zinc-finger double domain;
348-369 7.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.51e-04
                          10        20
                  ....*....|....*....|..
gi 333805605  348 KHLRTHSGERPHACPECDRTFS 369
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
271-573 8.91e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 8.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 271 QDKPYICTDCGKRFVLSCSLLSHQRSHLGPKPFGCDVCGKEFARG--SDLVKHLRVHTGEKP------------------ 330
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSdlnskslplsnskassss 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 331 ---------YLCPECGKGFADSSARVKH--LRTHSGERPHACPEC--DRTFSLSSTLLRHRLTHMepqdfSFPGYPLPAL 397
Cdd:COG5048  110 lsssssnsnDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPGNnsSSVNTPQSNSLHPPLPAN-----SLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 398 IPSPPPPPLGTSPPLTPRSPSHS--GEPFGLPGLEPEpggpqagEPPPPLAGDKPHKCPECGKGFRRSSDLVKHHRVHTG 475
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSsySIPSSSSDQNLE-------NSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 476 EKPYLCPECGKGFADSSARVKHLRTHRGERARPPPPSTLLRPHNPPGPVPMaprPRVRAQPSGPSQPHVCGF--CGKEFP 553
Cdd:COG5048  258 SESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRH---LRSVNHSGESLKPFSCPYslCGKLFS 334

                        330       340
                 ....*....|....*....|
gi 333805605 554 RSSDLVKHRRTHTGEKPYKC 573
Cdd:COG5048  335 RNDALKRHILLHTSISPAKE 354
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 51-215 1.41e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605  51 FKEEDLAPDHEVgnaSLKPEGIQNWDDlwvqreglgkPQPRDRGPRLLGEPRWGQASSDRAAVCGEcgksfRQMSDLVKH 130
Cdd:COG5189  280 FEESSLGFDYEF---IHKSVGNKEIRG----------GISTGEMIDVRKLPCTNSSSNGKLAHGGE-----RNIDTPSRM 341

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605 131 QRThTGEKPYKCGV--CGKGFGDSSArIKHQRTHSGEKPYRARPPAQgppkIPRSRIPAGERPTICGECGKSFRQSSDLv 208
Cdd:COG5189  342 LKV-KDGKPYKCPVegCNKKYKNQNG-LKYHMLHGHQNQKLHENPSP----EKMNIFSAKDKPYRCEVCDKRYKNLNGL- 414


                 ....*..
gi 333805605 209 KHQRTHT 215
Cdd:COG5189  415 KYHRKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 113-134 1.55e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|..
gi 333805605  113 VCGECGKSFRQMSDLVKHQRTH 134
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 543-565 1.83e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.83e-03
                          10        20
                  ....*....|....*....|...
gi 333805605  543 HVCGFCGKEFPRSSDLVKHRRTH 565
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 428-570 2.48e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333805605  428 GLEpEPGGPQAGEPPPPLAGDKPHKCPE----CGKGFRRSSDLVKHHRVHtgeKPYLCPEcgkgfadsSARVKHLRTHRG 503
Cdd:PHA03247 2539 GLE-ELASDDAGDPPPPLPPAAPPAAPDrsvpPPRPAPRPSEPAVTSRAR---RPDAPPQ--------SARPRAPVDDRG 2606

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 333805605  504 ERARPPPPSTLLRPHNPPGPVPMAPRPRVRAQPSGPSQPHVCGFCGKEFPRSSDLVKHRRTHTGEKP 570
Cdd:PHA03247 2607 DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA 2673
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 220-242 7.08e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.08e-03
                          10        20
                  ....*....|....*....|...
gi 333805605  220 YKCGICGKGFGDSSARIKHQRTH 242
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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