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Conserved domains on  [gi|338968885|ref|NP_001229804|]
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elongator complex protein 2 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-481 1.51e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 119.36  E-value: 1.51e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885  54 LNGHTARVNCIQWickqdgSPSTE-LVSGGSDNQVIHWEIEDNQLLKAvhLQGHEGPVYAVHAVYQRrtsdpalcTLIVS 132
Cdd:cd00200    5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLRT--LKGHTGPVRDVAASADG--------TYLAS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 133 AAADSAVRLWSKKGPEvmCLQTLnfgNGFalalclsflpntdvtwktgqvergrawkppaslalcsrscDSMVSCyasil 212
Cdd:cd00200   69 GSSDKTIRLWDLETGE--CVRTL---TGH----------------------------------------TSYVSS----- 98

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 213 ckalwkeklhtfwhhnrISFLPSafrpIPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASC 292
Cdd:cd00200   99 -----------------VAFSPD----GRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGT--FVASS 153

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 293 SQDCLIRIWklyikstsletqDDDNIRLKentftienesvkiafavtleTVLAGHENWVNAVHWQPvfykDGvlqqpVRL 372
Cdd:cd00200  154 SQDGTIKLW------------DLRTGKCV--------------------ATLTGHTGEVNSVAFSP----DG-----EKL 192

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 373 LSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFNEDGSMIIAHAFHGALHLWkqntvNPREWTPEIVISGH 452
Cdd:cd00200  193 LSSSSDGTIKLW--DLSTGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVW-----DLRTGECVQTLSGH 260

                        410       420
                 ....*....|....*....|....*....
gi 338968885 453 FDGVQDLVWDPEGEFIITVGTDQTTRLFA 481
Cdd:cd00200  261 TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
339-761 1.48e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 1.48e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 339 TLETVLAGHENWVNAVHWQPVfykdgvlqqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFNEDG 418
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRSVAFSPDG 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 419 SMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIAR 498
Cdd:COG2319  133 KTLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLA-----TGKLLRT 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 499 PQIHGYDLKCLAminrF-----QFVSGADEKVLRVFsaprnfvenfcaitgqslnhvlcnqdsDLPEGATVPALGLSNKA 573
Cdd:COG2319  200 LTGHTGAVRSVA----FspdgkLLASGSADGTVRLW---------------------------DLATGKLLRTLTGHSGS 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 574 VFqgDIASQPSDEeeLLTSTGfeyqqvafqpsiltepptEDHLLQntLW-----PEVQKLYGHGYEIFCVTCNSSKTLLA 648
Cdd:COG2319  249 VR--SVAFSPDGR--LLASGS------------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDGKLLA 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 649 SACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTispefEPVFSLFAftnk 728
Cdd:COG2319  305 SGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-----ELLRTLTG---- 370

                        410       420       430
                 ....*....|....*....|....*....|...
gi 338968885 729 itsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 761
Cdd:COG2319  371 ----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
660-887 7.18e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 7.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 660 AIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWS 739
Cdd:COG2319   59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG----------HTGAVRS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 740 CDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehniGPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYT 818
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLW---DLAT-------GKLLRTLTGhSGAVTSVAF----SPDGKLLASGSDD-GTVRLWD 190

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 338968885 819 WKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkncS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 887
Cdd:COG2319  191 LATGKLLRTLTG------------HTGAVRSVAF---SpdGKL------------LASGSADGTVRLWDLA 234
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-481 1.51e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.36  E-value: 1.51e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885  54 LNGHTARVNCIQWickqdgSPSTE-LVSGGSDNQVIHWEIEDNQLLKAvhLQGHEGPVYAVHAVYQRrtsdpalcTLIVS 132
Cdd:cd00200    5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLRT--LKGHTGPVRDVAASADG--------TYLAS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 133 AAADSAVRLWSKKGPEvmCLQTLnfgNGFalalclsflpntdvtwktgqvergrawkppaslalcsrscDSMVSCyasil 212
Cdd:cd00200   69 GSSDKTIRLWDLETGE--CVRTL---TGH----------------------------------------TSYVSS----- 98

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 213 ckalwkeklhtfwhhnrISFLPSafrpIPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASC 292
Cdd:cd00200   99 -----------------VAFSPD----GRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGT--FVASS 153

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 293 SQDCLIRIWklyikstsletqDDDNIRLKentftienesvkiafavtleTVLAGHENWVNAVHWQPvfykDGvlqqpVRL 372
Cdd:cd00200  154 SQDGTIKLW------------DLRTGKCV--------------------ATLTGHTGEVNSVAFSP----DG-----EKL 192

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 373 LSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFNEDGSMIIAHAFHGALHLWkqntvNPREWTPEIVISGH 452
Cdd:cd00200  193 LSSSSDGTIKLW--DLSTGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVW-----DLRTGECVQTLSGH 260

                        410       420
                 ....*....|....*....|....*....
gi 338968885 453 FDGVQDLVWDPEGEFIITVGTDQTTRLFA 481
Cdd:cd00200  261 TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
21-479 1.26e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 1.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885  21 VLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWEIEDNQLLK 99
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF------SPdGKTLASGSADGTVRLWDLATGKLLR 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 100 AvhLQGHEGPVYAVhAVyqrrTSDPalcTLIVSAAADSAVRLWSKKGPEvmCLQTLNFGNGFALALCLSflPNtdvtwkt 179
Cdd:COG2319  157 T--LTGHSGAVTSV-AF----SPDG---KLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFS--PD------- 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 180 gqverGRawkppaslalcsrscdsmvscyasilckalwkeklhtfwhhnrisflpsafrpipILACGNDDCRIHIFAQQN 259
Cdd:COG2319  216 -----GK-------------------------------------------------------LLASGSADGTVRLWDLAT 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 260 DQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQDddnirlkentftienesvkiafavt 339
Cdd:COG2319  236 GKLLRTLT--GHSGSVRSVAFSPDGR--LLASGSADGTVRLW-------DLATGE------------------------- 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 340 LETVLAGHENWVNAVHWQPvfykDGVlqqpvRLLSASMDKTMILWAPDEESgvwleqvRVGEVGGNTLGFYDCQFNEDGS 419
Cdd:COG2319  280 LLRTLTGHSGGVNSVAFSP----DGK-----LLASGSDDGTVRLWDLATGK-------LLRTLTGHTGAVRSVAFSPDGK 343

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 420 MIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRL 479
Cdd:COG2319  344 TLASGSDDGTVRLW-----DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
339-761 1.48e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 1.48e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 339 TLETVLAGHENWVNAVHWQPVfykdgvlqqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFNEDG 418
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRSVAFSPDG 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 419 SMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIAR 498
Cdd:COG2319  133 KTLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLA-----TGKLLRT 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 499 PQIHGYDLKCLAminrF-----QFVSGADEKVLRVFsaprnfvenfcaitgqslnhvlcnqdsDLPEGATVPALGLSNKA 573
Cdd:COG2319  200 LTGHTGAVRSVA----FspdgkLLASGSADGTVRLW---------------------------DLATGKLLRTLTGHSGS 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 574 VFqgDIASQPSDEeeLLTSTGfeyqqvafqpsiltepptEDHLLQntLW-----PEVQKLYGHGYEIFCVTCNSSKTLLA 648
Cdd:COG2319  249 VR--SVAFSPDGR--LLASGS------------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDGKLLA 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 649 SACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTispefEPVFSLFAftnk 728
Cdd:COG2319  305 SGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-----ELLRTLTG---- 370

                        410       420       430
                 ....*....|....*....|....*....|...
gi 338968885 729 itsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 761
Cdd:COG2319  371 ----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 624-883 3.59e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.07  E-value: 3.59e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 624 EVQKLYGHGYEIFCVTCNSSKTLLASAckaakKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTW 703
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 704 SLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecdstddciEHNIGPCSSVLD 783
Cdd:cd00200  160 KLW---DLRTGKCVATLTG----------HTGEVNSVAFSPDGEKLLSSSSDGTIKLW----------DLSTGKCLGTLR 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 784 V-GGAVTAVSVCPvlhpsQRYVVAVGLECGKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqk 862
Cdd:cd00200  217 GhENGVNSVAFSP-----DGYLLASGSEDGTIRVWDLRTGECVQTL------------SGHTNSVTSLAWSP-DGKR--- 275

                        250       260
                 ....*....|....*....|.
gi 338968885 863 eaegaewlhFASCGEDHTVKI 883
Cdd:cd00200  276 ---------LASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
660-887 7.18e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 7.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 660 AIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWS 739
Cdd:COG2319   59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG----------HTGAVRS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 740 CDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehniGPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYT 818
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLW---DLAT-------GKLLRTLTGhSGAVTSVAF----SPDGKLLASGSDD-GTVRLWD 190

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 338968885 819 WKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkncS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 887
Cdd:COG2319  191 LATGKLLRTLTG------------HTGAVRSVAF---SpdGKL------------LASGSADGTVRLWDLA 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 733-761 1.51e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.51e-05
                           10        20
                   ....*....|....*....|....*....
gi 338968885   733 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 761
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
733-761 2.10e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 2.10e-05
                          10        20
                  ....*....|....*....|....*....
gi 338968885  733 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 761
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 261-302 4.80e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 4.80e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 338968885   261 QFQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWK 302
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
262-301 5.70e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 5.70e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 338968885  262 FQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIW 301
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 733-888 8.14e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 8.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 733 HSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecD-STDDCIEHNIGPCSSVLDVggavtavsvcpVLHPSQRYVVAVGLEc 811
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW---DlETGELLRTLKGHTGPVRDV-----------AASADGTYLASGSSD- 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 338968885 812 GKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqkeaegaewlhFASCGEDHTVKIHRVNK 888
Cdd:cd00200   73 KTIRLWDLETGECVRTL------------TGHTSYVSSVAFSP-DGRI------------LSSSSRDKTIKVWDVET 124
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-481 1.51e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.36  E-value: 1.51e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885  54 LNGHTARVNCIQWickqdgSPSTE-LVSGGSDNQVIHWEIEDNQLLKAvhLQGHEGPVYAVHAVYQRrtsdpalcTLIVS 132
Cdd:cd00200    5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLRT--LKGHTGPVRDVAASADG--------TYLAS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 133 AAADSAVRLWSKKGPEvmCLQTLnfgNGFalalclsflpntdvtwktgqvergrawkppaslalcsrscDSMVSCyasil 212
Cdd:cd00200   69 GSSDKTIRLWDLETGE--CVRTL---TGH----------------------------------------TSYVSS----- 98

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 213 ckalwkeklhtfwhhnrISFLPSafrpIPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASC 292
Cdd:cd00200   99 -----------------VAFSPD----GRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGT--FVASS 153

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 293 SQDCLIRIWklyikstsletqDDDNIRLKentftienesvkiafavtleTVLAGHENWVNAVHWQPvfykDGvlqqpVRL 372
Cdd:cd00200  154 SQDGTIKLW------------DLRTGKCV--------------------ATLTGHTGEVNSVAFSP----DG-----EKL 192

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 373 LSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFNEDGSMIIAHAFHGALHLWkqntvNPREWTPEIVISGH 452
Cdd:cd00200  193 LSSSSDGTIKLW--DLSTGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVW-----DLRTGECVQTLSGH 260

                        410       420
                 ....*....|....*....|....*....
gi 338968885 453 FDGVQDLVWDPEGEFIITVGTDQTTRLFA 481
Cdd:cd00200  261 TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
21-479 1.26e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 1.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885  21 VLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWEIEDNQLLK 99
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF------SPdGKTLASGSADGTVRLWDLATGKLLR 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 100 AvhLQGHEGPVYAVhAVyqrrTSDPalcTLIVSAAADSAVRLWSKKGPEvmCLQTLNFGNGFALALCLSflPNtdvtwkt 179
Cdd:COG2319  157 T--LTGHSGAVTSV-AF----SPDG---KLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFS--PD------- 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 180 gqverGRawkppaslalcsrscdsmvscyasilckalwkeklhtfwhhnrisflpsafrpipILACGNDDCRIHIFAQQN 259
Cdd:COG2319  216 -----GK-------------------------------------------------------LLASGSADGTVRLWDLAT 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 260 DQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQDddnirlkentftienesvkiafavt 339
Cdd:COG2319  236 GKLLRTLT--GHSGSVRSVAFSPDGR--LLASGSADGTVRLW-------DLATGE------------------------- 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 340 LETVLAGHENWVNAVHWQPvfykDGVlqqpvRLLSASMDKTMILWAPDEESgvwleqvRVGEVGGNTLGFYDCQFNEDGS 419
Cdd:COG2319  280 LLRTLTGHSGGVNSVAFSP----DGK-----LLASGSDDGTVRLWDLATGK-------LLRTLTGHTGAVRSVAFSPDGK 343

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 420 MIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRL 479
Cdd:COG2319  344 TLASGSDDGTVRLW-----DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
15-384 9.18e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.69  E-value: 9.18e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885  15 PNRVRGVlNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWEIE 93
Cdd:COG2319  120 TGAVRSV-AFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF------SPdGKLLASGSDDGTVRLWDLA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885  94 DNQLLKAvhLQGHEGPVYAVhAVyqrrTSDPalcTLIVSAAADSAVRLWSKKGPEvmCLQTLNFGNGFALAlcLSFLPNt 173
Cdd:COG2319  193 TGKLLRT--LTGHTGAVRSV-AF----SPDG---KLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRS--VAFSPD- 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 174 dvtwktGQVergrawkppasLALCSRscDSMVScyasilckaLW----KEKLHTF-WHHNRISFLpsAFRPI-PILACGN 247
Cdd:COG2319  258 ------GRL-----------LASGSA--DGTVR---------LWdlatGELLRTLtGHSGGVNSV--AFSPDgKLLASGS 307

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 248 DDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQdddnirlkentfti 327
Cdd:COG2319  308 DDGTVRLWDLATGKLLRTLT--GHTGAVRSVAFSPDGK--TLASGSDDGTVRLW-------DLATG-------------- 362

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 338968885 328 enesvkiafavTLETVLAGHENWVNAVHWQPvfykDGvlqqpVRLLSASMDKTMILW 384
Cdd:COG2319  363 -----------ELLRTLTGHTGAVTSVAFSP----DG-----RTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
339-761 1.48e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 1.48e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 339 TLETVLAGHENWVNAVHWQPVfykdgvlqqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFNEDG 418
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRSVAFSPDG 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 419 SMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIAR 498
Cdd:COG2319  133 KTLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLA-----TGKLLRT 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 499 PQIHGYDLKCLAminrF-----QFVSGADEKVLRVFsaprnfvenfcaitgqslnhvlcnqdsDLPEGATVPALGLSNKA 573
Cdd:COG2319  200 LTGHTGAVRSVA----FspdgkLLASGSADGTVRLW---------------------------DLATGKLLRTLTGHSGS 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 574 VFqgDIASQPSDEeeLLTSTGfeyqqvafqpsiltepptEDHLLQntLW-----PEVQKLYGHGYEIFCVTCNSSKTLLA 648
Cdd:COG2319  249 VR--SVAFSPDGR--LLASGS------------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDGKLLA 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 649 SACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTispefEPVFSLFAftnk 728
Cdd:COG2319  305 SGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-----ELLRTLTG---- 370

                        410       420       430
                 ....*....|....*....|....*....|...
gi 338968885 729 itsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 761
Cdd:COG2319  371 ----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
21-532 1.06e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 1.06e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885  21 VLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWIckqdgSPSTELVSGGSDNQVIHWEIEDNQLLka 100
Cdd:COG2319   41 SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-----PDGRLLASASADGTVRLWDLATGLLL-- 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 101 VHLQGHEGPVYAVhAVyqrrTSDpalCTLIVSAAADSAVRLWSKKGPEvmCLQTLNFGNGFALALclSFLPNtdvtwktg 180
Cdd:COG2319  114 RTLTGHTGAVRSV-AF----SPD---GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSV--AFSPD-------- 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 181 qverGRawkppaslalcsrscdsmvscyasilckalwkeklhtfwhhnrisflpsafrpipILACGNDDCRIHIFAQQND 260
Cdd:COG2319  174 ----GK-------------------------------------------------------LLASGSDDGTVRLWDLATG 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 261 QFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQdddnirlkentftienesvkiafavTL 340
Cdd:COG2319  195 KLLRTLT--GHTGAVRSVAFSPDGK--LLASGSADGTVRLW-------DLATG-------------------------KL 238

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 341 ETVLAGHENWVNAVHWQPvfykDGvlqqpVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVggntlgfYDCQFNEDGSM 420
Cdd:COG2319  239 LRTLTGHSGSVRSVAFSP----DG-----RLLASGSADGTVRLWDLATGELLRTLTGHSGGV-------NSVAFSPDGKL 302

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 421 IIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIARPQ 500
Cdd:COG2319  303 LASGSDDGTVRLW-----DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL---WDLA-----TGELLRTLT 369

                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 338968885 501 IHGYDLKCLAminrF-----QFVSGADEKVLRVFSAP 532
Cdd:COG2319  370 GHTGAVTSVA----FspdgrTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
215-706 7.08e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 7.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 215 ALWKEKLHTFWHHNRISFLPSAFRPIPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQ 294
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT--GHTGAVRSVAFSPDGK--TLASGSA 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 295 DCLIRIWklyikstSLETQdddnirlkentftienesvkiafavTLETVLAGHENWVNAVHWQPvfykDGVlqqpvRLLS 374
Cdd:COG2319  141 DGTVRLW-------DLATG-------------------------KLLRTLTGHSGAVTSVAFSP----DGK-----LLAS 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 375 ASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFNEDGSMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFD 454
Cdd:COG2319  180 GSDDGTVRLW--DLATGKLLRTLT-----GHTGAVRSVAFSPDGKLLASGSADGTVRLW-----DLATGKLLRTLTGHSG 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 455 GVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIARPQIHGYDLKCLAminrF-----QFVSGADEKVLRVF 529
Cdd:COG2319  248 SVRSVAFSPDGRLLASGSADGTVRL---WDLA-----TGELLRTLTGHSGGVNSVA----FspdgkLLASGSDDGTVRLW 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 530 SAPrnfvenfcaiTGQslnhvlcnqdsdlpegatvpalglsnkavfqgdiasqpsdeeelltstgfeyqqvafqpsilte 609
Cdd:COG2319  316 DLA----------TGK---------------------------------------------------------------- 321

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 610 pptedhllqntlwpEVQKLYGHGYEIFCVTCNSSKTLLASACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSP 689
Cdd:COG2319  322 --------------LLRTLTGHTGAVRSVAFSPDGKTLASGS-----DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382

                        490
                 ....*....|....*..
gi 338968885 690 NEKFLLAVSRDRTWSLW 706
Cdd:COG2319  383 DGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 21-385 1.04e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 1.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885  21 VLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWICKqdgspSTELVSGGSDNQVIHWEIEDNQLLKA 100
Cdd:cd00200   14 CVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASAD-----GTYLASGSSDKTIRLWDLETGECVRT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 101 vhLQGHEGPVYAVHAVyqrrtsdpALCTLIVSAAADSAVRLWSkkGPEVMCLQTLNFGNGFalALCLSFLPNTDVtwktg 180
Cdd:cd00200   89 --LTGHTSYVSSVAFS--------PDGRILSSSSRDKTIKVWD--VETGKCLTTLRGHTDW--VNSVAFSPDGTF----- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 181 qvergrawkppaslaLCSRSCDSMVScyasilckaLW----KEKLHTFWHH----NRISFLPSAFRpipILACGNDDCrI 252
Cdd:cd00200  150 ---------------VASSSQDGTIK---------LWdlrtGKCVATLTGHtgevNSVAFSPDGEK---LLSSSSDGT-I 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 253 HIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWKLYIKSTSletqdddnirlkentftienesv 332
Cdd:cd00200  202 KLWDLSTGKCLGTLR--GHENGVNSVAFSPDGY--LLASGSEDGTIRVWDLRTGECV----------------------- 254

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 338968885 333 kiafavtleTVLAGHENWVNAVHWQPvfykDGvlqqpVRLLSASMDKTMILWA 385
Cdd:cd00200  255 ---------QTLSGHTNSVTSLAWSP----DG-----KRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 270-761 3.06e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 3.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 270 GHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQDddnirlkentftienesvkiafavtLETVLAGHEN 349
Cdd:cd00200    7 GHTGGVTCVAFSPDGK--LLATGSGDGTIKVW-------DLETGE-------------------------LLRTLKGHTG 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 350 WVNAVHWQPVFYKdgvlqqpvrLLSASMDKTMILWapDEESGVwleqvRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGA 429
Cdd:cd00200   53 PVRDVAASADGTY---------LASGSSDKTIRLW--DLETGE-----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 430 LHLWKQNTVnprewTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapwkrkdqsqvtwheiarpqihgYDLKCL 509
Cdd:cd00200  117 IKVWDVETG-----KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL------------------------WDLRTG 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 510 aminrfqfvsgadeKVLRVFSAPRNFVeNFCAITGQSLNHVLCNQDSDlpegatvpalglsnkavfqgdiasqpsdeeel 589
Cdd:cd00200  168 --------------KCVATLTGHTGEV-NSVAFSPDGEKLLSSSSDGT-------------------------------- 200

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 590 ltstgfeyqqvafqpsiltepptedhllqntlwpevqklyghgyeifcvtcnssktllasackaakkehaaIILWNTTSW 669
Cdd:cd00200  201 -----------------------------------------------------------------------IKLWDLSTG 209

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 670 KQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRT---WSLWKKqdtispefEPVFSLFAftnkitsvHSRIIWSCDWSPDS 746
Cdd:cd00200  210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTirvWDLRTG--------ECVQTLSG--------HTNSVTSLAWSPDG 273

                        490
                 ....*....|....*
gi 338968885 747 KYFFTGSRDKKVVVW 761
Cdd:cd00200  274 KRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
624-883 6.61e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 6.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 624 EVQKLYGHGYEIFCVTCNSSKTLLASACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTW 703
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGS-----ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 704 SLWKKQDTispefEPVFSLfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehniGPCSSVLD 783
Cdd:COG2319  187 RLWDLATG-----KLLRTL--------TGHTGAVRSVAFSPDGKLLASGSADGTVRLW---DLAT-------GKLLRTLT 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 784 V-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWkncS--GKTe 860
Cdd:COG2319  244 GhSGSVRSVAF----SPDGRLLASGSAD-GTVRLWDLATGELLRTL------------TGHSGGVNSVAF---SpdGKL- 302

                        250       260
                 ....*....|....*....|...
gi 338968885 861 qkeaegaewlhFASCGEDHTVKI 883
Cdd:COG2319  303 -----------LASGSDDGTVRL 314
WD40 COG2319
WD40 repeat [General function prediction only];
364-761 1.14e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 1.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 364 GVLQQPVRLLSASMDKTMILWAPDEESGVWLE--QVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTvnpr 441
Cdd:COG2319   34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAaaGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT---- 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 442 eWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIARPQIHGYDLKCLAminrF-----Q 516
Cdd:COG2319  110 -GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL---WDLA-----TGKLLRTLTGHSGAVTSVA----FspdgkL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 517 FVSGADEKVLRVFSAPrnfvenfcaiTGQslnhvlcnqdsdlpegatvpalglsnkavfqgdiasqpsdeeelltstgfe 596
Cdd:COG2319  177 LASGSDDGTVRLWDLA----------TGK--------------------------------------------------- 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 597 yqqvafqpsiltepptedhllqntlwpEVQKLYGHGYEIFCVTCNSSKTLLASACkaakkEHAAIILWNTTSWKQVQNLV 676
Cdd:COG2319  196 ---------------------------LLRTLTGHTGAVRSVAFSPDGKLLASGS-----ADGTVRLWDLATGKLLRTLT 243

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 677 FHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTISPEFEPVFslfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDK 756
Cdd:COG2319  244 GHSGSVRSVAFSPDGRLLASGSADGTVRLW---DLATGELLRTL----------TGHSGGVNSVAFSPDGKLLASGSDDG 310


                 ....*
gi 338968885 757 KVVVW 761
Cdd:COG2319  311 TVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
621-883 1.29e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 1.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 621 LW-----PEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLL 695
Cdd:COG2319  146 LWdlatgKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 696 AVSRDRTWSLWkkqDTISPEfePVFSLfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehni 775
Cdd:COG2319  221 SGSADGTVRLW---DLATGK--LLRTL--------TGHSGSVRSVAFSPDGRLLASGSADGTVRLW---DLAT------- 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 776 GPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYTWKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWKN 854
Cdd:COG2319  278 GELLRTLTGhSGGVNSVAF----SPDGKLLASGSDD-GTVRLWDLATGKLLRTLTG------------HTGAVRSVAFSP 340

                        250       260
                 ....*....|....*....|....*....
gi 338968885 855 cSGKTeqkeaegaewlhFASCGEDHTVKI 883
Cdd:COG2319  341 -DGKT------------LASGSDDGTVRL 356
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 624-883 3.59e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.07  E-value: 3.59e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 624 EVQKLYGHGYEIFCVTCNSSKTLLASAckaakKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTW 703
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 704 SLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecdstddciEHNIGPCSSVLD 783
Cdd:cd00200  160 KLW---DLRTGKCVATLTG----------HTGEVNSVAFSPDGEKLLSSSSDGTIKLW----------DLSTGKCLGTLR 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 784 V-GGAVTAVSVCPvlhpsQRYVVAVGLECGKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqk 862
Cdd:cd00200  217 GhENGVNSVAFSP-----DGYLLASGSEDGTIRVWDLRTGECVQTL------------SGHTNSVTSLAWSP-DGKR--- 275

                        250       260
                 ....*....|....*....|.
gi 338968885 863 eaegaewlhFASCGEDHTVKI 883
Cdd:cd00200  276 ---------LASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 624-883 6.43e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 6.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 624 EVQKLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTW 703
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGT-----IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 704 SLWKKQDTispefEPVFSLFAFTNKitsvhsriIWSCDWSPDSKYFFTGSRDKKVVVWgecdstddciEHNIGPCSSVL- 782
Cdd:cd00200   76 RLWDLETG-----ECVRTLTGHTSY--------VSSVAFSPDGRILSSSSRDKTIKVW----------DVETGKCLTTLr 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 783 DVGGAVTAVSVcpvlHPSQRYVVAVGLECgkiCLYTWkktdqvpEINDWtHCVETsqSQSHTLAIRKLCWkncSGKTEqk 862
Cdd:cd00200  133 GHTDWVNSVAF----SPDGTFVASSSQDG---TIKLW-------DLRTG-KCVAT--LTGHTGEVNSVAF---SPDGE-- 190

                        250       260
                 ....*....|....*....|.
gi 338968885 863 eaegaewlHFASCGEDHTVKI 883
Cdd:cd00200  191 --------KLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
616-887 3.10e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.72  E-value: 3.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 616 LLQNTLWPEVQKLYGHGYEIFCVTCNSSKTLLASACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLL 695
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS-----ADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 696 AVSRDRTWSLWkkqDTISPEFEPVFslfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehni 775
Cdd:COG2319  137 SGSADGTVRLW---DLATGKLLRTL----------TGHSGAVTSVAFSPDGKLLASGSDDGTVRLW---DLAT------- 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 776 GPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYTWKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkn 854
Cdd:COG2319  194 GKLLRTLTGhTGAVRSVAF----SPDGKLLASGSAD-GTVRLWDLATGKLLRTLTG------------HSGSVRSVAF-- 254

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 338968885 855 cS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 887
Cdd:COG2319  255 -SpdGRL------------LASGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 448-781 3.14e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 3.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 448 VISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKDQSQVTwheiaRPQIH-GYDLKCLAMINRFQFVSGADEKVL 526
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKV---WDLETGELLR-----TLKGHtGPVRDVAASADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 527 RVFsaprnfvenfcaitgqslnhvlcnqdsDLPEGATVPALGLSNKAVFQGDIasqpSDEEELLTSTGFeyqqvafqpsi 606
Cdd:cd00200   76 RLW---------------------------DLETGECVRTLTGHTSYVSSVAF----SPDGRILSSSSR----------- 113

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 607 ltepptedhllQNTLW-------PEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTSWKQVQNLVFHS 679
Cdd:cd00200  114 -----------DKTIKvwdvetgKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT-----IKLWDLRTGKCVATLTGHT 177

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 680 LTVTQMAFSPNEKFLLAVSRDRTWSLWKKQdtispEFEPVFSLFAftnkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVV 759
Cdd:cd00200  178 GEVNSVAFSPDGEKLLSSSSDGTIKLWDLS-----TGKCLGTLRG--------HENGVNSVAFSPDGYLLASGSEDGTIR 244

                        330       340
                 ....*....|....*....|....*.
gi 338968885 760 VW----GECDSTddCIEHNiGPCSSV 781
Cdd:cd00200  245 VWdlrtGECVQT--LSGHT-NSVTSL 267
WD40 COG2319
WD40 repeat [General function prediction only];
15-143 5.87e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 5.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885  15 PNRVRGVlNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWEIE 93
Cdd:COG2319  288 SGGVNSV-AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF------SPdGKTLASGSDDGTVRLWDLA 360

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 338968885  94 DNQLLKAvhLQGHEGPVYAVHAVYQRRTsdpalctlIVSAAADSAVRLWS 143
Cdd:COG2319  361 TGELLRT--LTGHTGAVTSVAFSPDGRT--------LASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
660-887 7.18e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 7.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 660 AIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWS 739
Cdd:COG2319   59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG----------HTGAVRS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 740 CDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehniGPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYT 818
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLW---DLAT-------GKLLRTLTGhSGAVTSVAF----SPDGKLLASGSDD-GTVRLWD 190

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 338968885 819 WKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkncS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 887
Cdd:COG2319  191 LATGKLLRTLTG------------HTGAVRSVAF---SpdGKL------------LASGSADGTVRLWDLA 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 733-761 1.51e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.51e-05
                           10        20
                   ....*....|....*....|....*....
gi 338968885   733 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 761
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
733-761 2.10e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 2.10e-05
                          10        20
                  ....*....|....*....|....*....
gi 338968885  733 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 761
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 668-707 1.89e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.89e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 338968885   668 SWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWK 707
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 261-302 4.80e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 4.80e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 338968885   261 QFQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWK 302
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
262-301 5.70e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 5.70e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 338968885  262 FQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIW 301
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 733-888 8.14e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 8.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968885 733 HSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecD-STDDCIEHNIGPCSSVLDVggavtavsvcpVLHPSQRYVVAVGLEc 811
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW---DlETGELLRTLKGHTGPVRDV-----------AASADGTYLASGSSD- 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 338968885 812 GKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqkeaegaewlhFASCGEDHTVKIHRVNK 888
Cdd:cd00200   73 KTIRLWDLETGECVRTL------------TGHTSYVSSVAFSP-DGRI------------LSSSSRDKTIKVWDVET 124
WD40 pfam00400
WD domain, G-beta repeat;
669-706 1.10e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 338968885  669 WKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLW 706
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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