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Conserved domains on  [gi|343183403|ref|NP_001230261|]
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seizure 6-like protein 2 isoform 5 precursor [Homo sapiens]

Protein Classification

CUB and CCP domain-containing protein( domain architecture ID 12870549)

CUB and CCP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 527-617 1.71e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 84.77  E-value: 1.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 527 CGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ 600
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                         90
                 ....*....|....*..
gi 343183403 601 PRRRLLSSGPDLTLQFQ 617
Cdd:cd00041   81 LPPPIISSGNSLTVRFR 97
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 665-828 6.32e-17

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 81.62  E-value: 6.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 665 GTVLTYQCEPGYELLGSDILTCQW----DLSWSAAPPACQKImTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLE 740
Cdd:PHA02927 105 GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLI 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 741 GAAMLTCYSRDtgtpkWSDRvPKCALKyePCLNPGVpENGY-QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpS 819
Cdd:PHA02927 184 GNSGVLCSGGE-----WSDP-PTCQIV--KCPHPTI-SNGYlSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPG--N 252


                 ....*....
gi 343183403 820 QWTSQPPLC 828
Cdd:PHA02927 253 TWQPELPKC 261
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 349-417 2.63e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.83  E-value: 2.63e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 343183403 349 CGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 417
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsYDYLEIYDGPSTSSPLL 73
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 173-285 5.88e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 63.20  E-value: 5.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 173 CNNNIS-EGEGYVESPDLGSPVSRtlgLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGSpglaprlla 246
Cdd:cd00041    1 CGGTLTaSTSGTISSPNYPNNYPN---NLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPST--------- 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 343183403 247 NSSMLGE------GQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQA 285
Cdd:cd00041   69 SSPLLGRfcgstlPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 290-345 2.82e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


:

Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.77  E-value: 2.82e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 343183403   290 CGFPPRPAHGDVSV--TDLHPGGTATFHCDSGYQLQGEETLICLNGTrpSWNGETPSC 345
Cdd:smart00032   1 CPPPPDIENGTVTSssGTYSYGDTVTYSCDPGYTLIGSSTITCLENG--TWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
464-523 2.24e-06

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.57  E-value: 2.24e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 343183403  464 CFAPF-LAHGNVTTTDPEYRPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 523
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRLV---GSPTITCQE--DGTWSPPFPEC 56
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 527-617 1.71e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 84.77  E-value: 1.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 527 CGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ 600
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                         90
                 ....*....|....*..
gi 343183403 601 PRRRLLSSGPDLTLQFQ 617
Cdd:cd00041   81 LPPPIISSGNSLTVRFR 97
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 665-828 6.32e-17

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 81.62  E-value: 6.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 665 GTVLTYQCEPGYELLGSDILTCQW----DLSWSAAPPACQKImTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLE 740
Cdd:PHA02927 105 GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLI 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 741 GAAMLTCYSRDtgtpkWSDRvPKCALKyePCLNPGVpENGY-QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpS 819
Cdd:PHA02927 184 GNSGVLCSGGE-----WSDP-PTCQIV--KCPHPTI-SNGYlSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPG--N 252


                 ....*....
gi 343183403 820 QWTSQPPLC 828
Cdd:PHA02927 253 TWQPELPKC 261
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 349-417 2.63e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.83  E-value: 2.63e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 343183403 349 CGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 417
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsYDYLEIYDGPSTSSPLL 73
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 644-700 4.88e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 61.71  E-value: 4.88e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 343183403 644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 700
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 173-285 5.88e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 63.20  E-value: 5.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 173 CNNNIS-EGEGYVESPDLGSPVSRtlgLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGSpglaprlla 246
Cdd:cd00041    1 CGGTLTaSTSGTISSPNYPNNYPN---NLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPST--------- 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 343183403 247 NSSMLGE------GQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQA 285
Cdd:cd00041   69 SSPLLGRfcgstlPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
527-617 1.18e-11

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 62.31  E-value: 1.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403  527 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-----GDMLTLFDGDGPSARVLAQLRGPQP 601
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDhdecgYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90
                  ....*....|....*.
gi 343183403  602 RRRLLSSGPDLTLQFQ 617
Cdd:pfam00431  81 PEDIVSSSNQMTIKFV 96
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 644-699 1.47e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 60.23  E-value: 1.47e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 343183403   644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 699
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 536-617 2.55e-11

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 60.87  E-value: 2.55e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403   536 GVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ-PRRRLLSSG 609
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPSASSPLLGRFCGSEaPPPVISSSS 80


                   ....*...
gi 343183403   610 PDLTLQFQ 617
Cdd:smart00042  81 NSLTLTFV 88
Sushi pfam00084
Sushi repeat (SCR repeat);
644-699 7.23e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 7.23e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 343183403  644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 699
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 290-345 2.82e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.77  E-value: 2.82e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 343183403   290 CGFPPRPAHGDVSV--TDLHPGGTATFHCDSGYQLQGEETLICLNGTrpSWNGETPSC 345
Cdd:smart00032   1 CPPPPDIENGTVTSssGTYSYGDTVTYSCDPGYTLIGSSTITCLENG--TWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 290-345 5.07e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.93  E-value: 5.07e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 343183403 290 CGFPPRPAHGDV--SVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTrpsWNGETPSC 345
Cdd:cd00033    1 CPPPPVPENGTVtgSKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGG---WSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
290-345 1.72e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 51.35  E-value: 1.72e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 343183403  290 CGFPPRPAHGDVSVTD--LHPGGTATFHCDSGYQLQGEETLICLNGtrPSWNGETPSC 345
Cdd:pfam00084   1 CPPPPDIPNGKVSATKneYNYGASVSYECDPGYRLVGSPTITCQED--GTWSPPFPEC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 359-417 5.01e-08

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 51.62  E-value: 5.01e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 343183403   359 GRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN----DRLMVRSGGSPLSPVI 417
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSASSPLL 63
Sushi pfam00084
Sushi repeat (SCR repeat);
464-523 2.24e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.57  E-value: 2.24e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 343183403  464 CFAPF-LAHGNVTTTDPEYRPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 523
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRLV---GSPTITCQE--DGTWSPPFPEC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 182-283 9.90e-06

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 45.07  E-value: 9.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403   182 GYVESPDLGSPVSRtlgLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGggsPGLAPRLLAN--SSMLGEg 254
Cdd:smart00042   1 GTITSPNYPQSYPN---NLDCVWTIRAPPGYRIELQFTDFDLESSDNceydyVEIYDG---PSASSPLLGRfcGSEAPP- 73

                           90       100
                   ....*....|....*....|....*....
gi 343183403   255 QVLRSPTNRLLLHFQSPRVPRGGGFRIHY 283
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
349-417 5.11e-05

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 43.44  E-value: 5.11e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 343183403  349 CGGTIHNATlGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 417
Cdd:pfam00431   1 CGGVLTDSS-GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHdecgYDYVEIRDGPSASSPLL 72
CUB pfam00431
CUB domain;
173-283 1.22e-04

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 42.28  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403  173 CNNNISEGEGYVESPDLGSPVSRtlgLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGspglaprllAN 247
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPP---NKDCVWLIRAPPGFRVKLTFQDFELEDHDEcgydyVEIRDGPS---------AS 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 343183403  248 SSMLGE------GQVLRSPTNRLLLHFQSPRVPRGGGFRIHY 283
Cdd:pfam00431  69 SPLLGRfcgsgiPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 467-524 1.53e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 40.52  E-value: 1.53e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 343183403 467 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPACK 524
Cdd:cd00033    5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTLV---GSSTITCTE--NGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 467-523 5.73e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.66  E-value: 5.73e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 343183403   467 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 523
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTLI---GSSTITCLE--NGTWSPPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 276-345 2.03e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 41.18  E-value: 2.03e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 343183403 276 GGGFRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPS--WNGETPSC 345
Cdd:PHA02927  72 GTGWTLFNQCIKRRCPSPRDIDNGQLDIGGVDFGSSITYSCNSGYQLIGESKSYCELGSTGSmvWNPEAPIC 143
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 527-617 1.71e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 84.77  E-value: 1.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 527 CGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ 600
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                         90
                 ....*....|....*..
gi 343183403 601 PRRRLLSSGPDLTLQFQ 617
Cdd:cd00041   81 LPPPIISSGNSLTVRFR 97
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 665-828 6.32e-17

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 81.62  E-value: 6.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 665 GTVLTYQCEPGYELLGSDILTCQW----DLSWSAAPPACQKImTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLE 740
Cdd:PHA02927 105 GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLI 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 741 GAAMLTCYSRDtgtpkWSDRvPKCALKyePCLNPGVpENGY-QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpS 819
Cdd:PHA02927 184 GNSGVLCSGGE-----WSDP-PTCQIV--KCPHPTI-SNGYlSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPG--N 252


                 ....*....
gi 343183403 820 QWTSQPPLC 828
Cdd:PHA02927 253 TWQPELPKC 261
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 349-417 2.63e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.83  E-value: 2.63e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 343183403 349 CGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 417
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsYDYLEIYDGPSTSSPLL 73
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 665-830 8.46e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 69.68  E-value: 8.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 665 GTVLTYQCEPGY--ELLGSDILTCQWDlSWSAAPPACQKimTCADPGEIANGHRTASDAGFpvGSHVQYRCLPGYSLEGA 742
Cdd:PHA02927  47 GDTIEYLCLPGYrkQKMGPIYAKCTGT-GWTLFNQCIKR--RCPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGE 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 743 AMLTCYSRDTGTPKWSDRVPKCalKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpsQWt 822
Cdd:PHA02927 122 SKSYCELGSTGSMVWNPEAPIC--ESVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGG---EW- 195


                 ....*...
gi 343183403 823 SQPPLCKV 830
Cdd:PHA02927 196 SDPPTCQI 203
PHA02639 PHA02639
EEV host range protein; Provisional
 701-830 1.83e-12

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 68.92  E-value: 1.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 701 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYsRDTGTPKWSDRVPKCALKyePCLNPGVPENG 780
Cdd:PHA02639  18 KSIYCDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCI-KDKNNAIWSNKAPFCMLK--ECNDPPSIING 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 343183403 781 YQTLYKHHYQAGESLRFFCYE----GFELIGEVTITCVpgHPSQWTSQPPLCKV 830
Cdd:PHA02639  95 KIYNKREMYKVGDEIYYVCNEhkgvQYSLVGNEKITCI--QDKSWKPDPPICKM 146
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 644-700 4.88e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 61.71  E-value: 4.88e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 343183403 644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 700
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 173-285 5.88e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 63.20  E-value: 5.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 173 CNNNIS-EGEGYVESPDLGSPVSRtlgLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGSpglaprlla 246
Cdd:cd00041    1 CGGTLTaSTSGTISSPNYPNNYPN---NLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPST--------- 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 343183403 247 NSSMLGE------GQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQA 285
Cdd:cd00041   69 SSPLLGRfcgstlPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 771-829 6.80e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 61.32  E-value: 6.80e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 343183403 771 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpSQWTSQPPLCK 829
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN--GGWSPPPPTCE 57
CUB pfam00431
CUB domain;
527-617 1.18e-11

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 62.31  E-value: 1.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403  527 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-----GDMLTLFDGDGPSARVLAQLRGPQP 601
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDhdecgYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90
                  ....*....|....*.
gi 343183403  602 RRRLLSSGPDLTLQFQ 617
Cdd:pfam00431  81 PEDIVSSSNQMTIKFV 96
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 644-699 1.47e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 60.23  E-value: 1.47e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 343183403   644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 699
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 536-617 2.55e-11

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 60.87  E-value: 2.55e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403   536 GVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ-PRRRLLSSG 609
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPSASSPLLGRFCGSEaPPPVISSSS 80


                   ....*...
gi 343183403   610 PDLTLQFQ 617
Cdd:smart00042  81 NSLTLTFV 88
Sushi pfam00084
Sushi repeat (SCR repeat);
644-699 7.23e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 7.23e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 343183403  644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 699
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 705-764 8.29e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.92  E-value: 8.29e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403   705 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCysrdTGTPKWSDRVPKC 764
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITC----LENGTWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 771-828 8.88e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.92  E-value: 8.88e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 343183403   771 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpSQWTSQPPLC 828
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLEN--GTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 705-764 1.04e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.86  E-value: 1.04e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 705 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCysrdTGTPKWSDRVPKC 764
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITC----TENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 290-345 2.82e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.77  E-value: 2.82e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 343183403   290 CGFPPRPAHGDVSV--TDLHPGGTATFHCDSGYQLQGEETLICLNGTrpSWNGETPSC 345
Cdd:smart00032   1 CPPPPDIENGTVTSssGTYSYGDTVTYSCDPGYTLIGSSTITCLENG--TWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 290-345 5.07e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.93  E-value: 5.07e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 343183403 290 CGFPPRPAHGDV--SVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTrpsWNGETPSC 345
Cdd:cd00033    1 CPPPPVPENGTVtgSKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGG---WSPPPPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 665-828 9.34e-10

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 60.83  E-value: 9.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 665 GTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPACQkIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLP----GY 737
Cdd:PHA02639  43 GKLIEYTCNTDYALIGDRFRTCIKDKNnaiWSNKAPFCM-LKECNDPPSIINGKIYNKREMYKVGDEIYYVCNEhkgvQY 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 738 SLEGAAMLTCysrdTGTPKWSDRVPKCalKYEPCLNPGVPE---NGYQTLYKHHYQAgeSLRFFCYEGFELIGEVTITCv 814
Cdd:PHA02639 122 SLVGNEKITC----IQDKSWKPDPPIC--KMINCRFPALQNgyiNGIPSNKKFYYKT--RVGFSCKSGFDLVGEKYSTC- 192

                        170
                 ....*....|....
gi 343183403 815 pGHPSQWTSQPPLC 828
Cdd:PHA02639 193 -NINATWFPSIPTC 205
PHA02831 PHA02831
EEV host range protein; Provisional
 668-828 1.09e-09

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 60.39  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 668 LTYQCEPGYEllgSDILTCQwDLSWSAAPpACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRC----LPGYSLEGAA 743
Cdd:PHA02831  46 LEYKCNNNFD---KVFVTCN-NGSWSTKN-MCIGKRNCKDPVTILNGYIKNKKDQYSFGDSVTYACkvnkLEKYSIVGNE 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 744 MLTCYSRdtgtpKWSDRVPKCAL---KYePCLnpgvpENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCvpGHPSQ 820
Cdd:PHA02831 121 TVKCINK-----QWVPKYPVCKLircKY-PAL-----QNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTC--DINSI 187


                 ....*...
gi 343183403 821 WTSQPPLC 828
Cdd:PHA02831 188 WYPGIPKC 195
Sushi pfam00084
Sushi repeat (SCR repeat);
290-345 1.72e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 51.35  E-value: 1.72e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 343183403  290 CGFPPRPAHGDVSVTD--LHPGGTATFHCDSGYQLQGEETLICLNGtrPSWNGETPSC 345
Cdd:pfam00084   1 CPPPPDIPNGKVSATKneYNYGASVSYECDPGYRLVGSPTITCQED--GTWSPPFPEC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 359-417 5.01e-08

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 51.62  E-value: 5.01e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 343183403   359 GRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN----DRLMVRSGGSPLSPVI 417
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSASSPLL 63
Sushi pfam00084
Sushi repeat (SCR repeat);
705-764 6.90e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 49.81  E-value: 6.90e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403  705 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCysrdTGTPKWSDRVPKC 764
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITC----QEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
771-828 4.36e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.49  E-value: 4.36e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 343183403  771 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpSQWTSQPPLC 828
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQED--GTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
464-523 2.24e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.57  E-value: 2.24e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 343183403  464 CFAPF-LAHGNVTTTDPEYRPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 523
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRLV---GSPTITCQE--DGTWSPPFPEC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 182-283 9.90e-06

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 45.07  E-value: 9.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403   182 GYVESPDLGSPVSRtlgLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGggsPGLAPRLLAN--SSMLGEg 254
Cdd:smart00042   1 GTITSPNYPQSYPN---NLDCVWTIRAPPGYRIELQFTDFDLESSDNceydyVEIYDG---PSASSPLLGRfcGSEAPP- 73

                           90       100
                   ....*....|....*....|....*....
gi 343183403   255 QVLRSPTNRLLLHFQSPRVPRGGGFRIHY 283
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKRGFSARY 102
PHA02817 PHA02817
EEV Host range protein; Provisional
 664-773 1.04e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 47.63  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 664 RGTVLTYQCEPG-----YELLGSDILTCQWDLSWSAAPPACqKIMTCADPGeIANGHRTA--SDAGFPVGSHVQYRCLPG 736
Cdd:PHA02817  44 IGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVC-KIIRCRFPA-LQNGFVNGipDSKKFYYESEVSFSCKPG 121

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 343183403 737 YSLEGAAMLTCYSRDTgtpkWSDRVPKCaLKYEPCLN 773
Cdd:PHA02817 122 FVLIGTKYSVCGINSS----WIPKVPIC-SRDNITYN 153
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 713-829 2.34e-05

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 46.95  E-value: 2.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 713 NGHRTASDAGFPVGSHVQYRCLPGYSLEgaAMLTCYSRDTGTpKWSdRVPKCALKYepCLNPGVPENGYQTLYKHHYqaG 792
Cdd:PHA02927  34 NSVETDANANYNIGDTIEYLCLPGYRKQ--KMGPIYAKCTGT-GWT-LFNQCIKRR--CPSPRDIDNGQLDIGGVDF--G 105

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 343183403 793 ESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPPLCK 829
Cdd:PHA02927 106 SSITYSCNSGYQLIGESKSYCELGSTGSmvWNPEAPICE 144
CUB pfam00431
CUB domain;
349-417 5.11e-05

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 43.44  E-value: 5.11e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 343183403  349 CGGTIHNATlGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 417
Cdd:pfam00431   1 CGGVLTDSS-GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHdecgYDYVEIRDGPSASSPLL 72
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 665-764 6.70e-05

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 45.85  E-value: 6.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 665 GTVLTYQCEPGYELLGSDILTCQWDlSWSAAPPACQKimtCADPgEIANGhrTASDAGFPVGSHVQYRCLPGYSLEGAAM 744
Cdd:PHA02954 150 GEHITINCDVGYEVIGASYISCTAN-SWNVIPSCQQK---CDIP-SLSNG--LISGSTFSIGGVIHLSCKSGFTLTGSPS 222

                         90       100
                 ....*....|....*....|
gi 343183403 745 LTCYSrdtgtPKWSDRVPKC 764
Cdd:PHA02954 223 STCID-----GKWNPVLPIC 237
CUB pfam00431
CUB domain;
173-283 1.22e-04

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 42.28  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403  173 CNNNISEGEGYVESPDLGSPVSRtlgLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGspglaprllAN 247
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPP---NKDCVWLIRAPPGFRVKLTFQDFELEDHDEcgydyVEIRDGPS---------AS 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 343183403  248 SSMLGE------GQVLRSPTNRLLLHFQSPRVPRGGGFRIHY 283
Cdd:pfam00431  69 SPLLGRfcgsgiPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 467-524 1.53e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 40.52  E-value: 1.53e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 343183403 467 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPACK 524
Cdd:cd00033    5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTLV---GSSTITCTE--NGGWSPPPPTCE 57
PHA02817 PHA02817
EEV Host range protein; Provisional
 705-828 2.67e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 43.39  E-value: 2.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 705 CADPGEIANGHRTASDAGFPVGSHVQYRC------LPgYSLEGAAMLTCySRDTgtpKWSDRVPKCAL---KYePCLNPG 775
Cdd:PHA02817  24 CCYPPSIKNGYIYNKKTEYNIGSNVTFFCgnntrgVR-YTLVGEKNIIC-EKDG---KWNKEFPVCKIircRF-PALQNG 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 343183403 776 VPeNGYQTLYKHHYQagESLRFFCYEGFELIGEVTITCvpGHPSQWTSQPPLC 828
Cdd:PHA02817  98 FV-NGIPDSKKFYYE--SEVSFSCKPGFVLIGTKYSVC--GINSSWIPKVPIC 145
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 467-523 5.73e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.66  E-value: 5.73e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 343183403   467 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 523
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTLI---GSSTITCLE--NGTWSPPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 276-345 2.03e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 41.18  E-value: 2.03e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 343183403 276 GGGFRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPS--WNGETPSC 345
Cdd:PHA02927  72 GTGWTLFNQCIKRRCPSPRDIDNGQLDIGGVDFGSSITYSCNSGYQLIGESKSYCELGSTGSmvWNPEAPIC 143
PHA02817 PHA02817
EEV Host range protein; Provisional
 764-830 2.22e-03

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 40.69  E-value: 2.22e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 343183403 764 CALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEG-----FELIGEVTITCvpGHPSQWTSQPPLCKV 830
Cdd:PHA02817  17 SLCDLNKCCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIIC--EKDGKWNKEFPVCKI 86
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 723-835 8.17e-03

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 39.30  E-value: 8.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343183403 723 FPVGSHVQYRCLPGYSLEGAAMLTCYSRdtgtpKWsDRVPKCALKYE-PCLNPGVpengyqtLYKHHYQAGESLRFFCYE 801
Cdd:PHA02954 147 YSFGEHITINCDVGYEVIGASYISCTAN-----SW-NVIPSCQQKCDiPSLSNGL-------ISGSTFSIGGVIHLSCKS 213

                         90       100       110
                 ....*....|....*....|....*....|....
gi 343183403 802 GFELIGEVTITCVPGhpsQWTSQPPLCKVAYEEL 835
Cdd:PHA02954 214 GFTLTGSPSSTCIDG---KWNPVLPICVRSNEEF 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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