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Conserved domains on  [gi|357588419|ref|NP_001239495|]
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seizure 6-like protein 2 isoform 2 precursor [Mus musculus]

Protein Classification

CUB domain-containing protein; beta-2-glycoprotein 1( domain architecture ID 12869279)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein| beta-2-glycoprotein 1 is a heavily glycosylated plasma membrane-adhesion protein, which plays a role in blood coagulation and removal of apoptotic bodies

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 527-617 1.42e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 84.77  E-value: 1.42e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 527 CGGELSEPA-GVVLSPDWPQSYSPGQDCVWGLHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ 600
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                         90
                 ....*....|....*..
gi 357588419 601 PRRRLLSSGPDLTLQFQ 617
Cdd:cd00041   81 LPPPIISSGNSLTVRFR 97
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 665-828 5.76e-17

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 82.01  E-value: 5.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 665 GTVLTYQCEPGYELLGSDILTCQW----DLSWSAAPPACQKImTCADPGEITNGHRTASDAGFPVGSHVQYRCLPGYSLE 740
Cdd:PHA02927 105 GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLI 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 741 GAAVLTCYSRDtgtpkWSDRvPKCALKyePCLNPGVpENGY-QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpS 819
Cdd:PHA02927 184 GNSGVLCSGGE-----WSDP-PTCQIV--KCPHPTI-SNGYlSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPG--N 252


                 ....*....
gi 357588419 820 QWTSQPPLC 828
Cdd:PHA02927 253 TWQPELPKC 261
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 349-417 3.97e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.06  E-value: 3.97e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588419 349 CGGTIHNATLGRIVSPEPGGAAGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 417
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsYDYLEIYDGPSTSSPLL 73
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 173-285 8.06e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.82  E-value: 8.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 173 CNNNIS-EGEGFVESPDLGSTASRSvelLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGSpglaprlla 246
Cdd:cd00041    1 CGGTLTaSTSGTISSPNYPNNYPNN---LNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPST--------- 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 357588419 247 NSSMLGE------GQVLRSPTNRLLLHFQSPRVPRGNGFRIHYQA 285
Cdd:cd00041   69 SSPLLGRfcgstlPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 290-345 9.39e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.86  E-value: 9.39e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 357588419 290 CGFPPRPAHGDV--SVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTrpaWTGEPPSC 345
Cdd:cd00033    1 CPPPPVPENGTVtgSKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGG---WSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
466-523 4.70e-06

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 44.80  E-value: 4.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 357588419  466 PPFLAHGNVTTTDPEFHPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 523
Cdd:pfam00084   4 PPDIPNGKVSATKNEYNYGASVSYECDPGYRLV---GSPTITCQE--DGTWSPPFPEC 56
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 527-617 1.42e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 84.77  E-value: 1.42e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 527 CGGELSEPA-GVVLSPDWPQSYSPGQDCVWGLHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ 600
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                         90
                 ....*....|....*..
gi 357588419 601 PRRRLLSSGPDLTLQFQ 617
Cdd:cd00041   81 LPPPIISSGNSLTVRFR 97
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 665-828 5.76e-17

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 82.01  E-value: 5.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 665 GTVLTYQCEPGYELLGSDILTCQW----DLSWSAAPPACQKImTCADPGEITNGHRTASDAGFPVGSHVQYRCLPGYSLE 740
Cdd:PHA02927 105 GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLI 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 741 GAAVLTCYSRDtgtpkWSDRvPKCALKyePCLNPGVpENGY-QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpS 819
Cdd:PHA02927 184 GNSGVLCSGGE-----WSDP-PTCQIV--KCPHPTI-SNGYlSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPG--N 252


                 ....*....
gi 357588419 820 QWTSQPPLC 828
Cdd:PHA02927 253 TWQPELPKC 261
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 349-417 3.97e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.06  E-value: 3.97e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588419 349 CGGTIHNATLGRIVSPEPGGAAGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 417
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsYDYLEIYDGPSTSSPLL 73
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 644-700 5.25e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 61.32  E-value: 5.25e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 357588419 644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 700
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 173-285 8.06e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.82  E-value: 8.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 173 CNNNIS-EGEGFVESPDLGSTASRSvelLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGSpglaprlla 246
Cdd:cd00041    1 CGGTLTaSTSGTISSPNYPNNYPNN---LNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPST--------- 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 357588419 247 NSSMLGE------GQVLRSPTNRLLLHFQSPRVPRGNGFRIHYQA 285
Cdd:cd00041   69 SSPLLGRfcgstlPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
527-617 1.68e-11

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 61.93  E-value: 1.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419  527 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGLHVQEEKRILLQVEILNVRE-----GDMLTLFDGDGPSARVLAQLRGPQP 601
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDhdecgYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90
                  ....*....|....*.
gi 357588419  602 RRRLLSSGPDLTLQFQ 617
Cdd:pfam00431  81 PEDIVSSSNQMTIKFV 96
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 644-699 1.85e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 59.85  E-value: 1.85e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 357588419   644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 699
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 536-617 2.23e-11

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 61.25  E-value: 2.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419   536 GVVLSPDWPQSYSPGQDCVWGLHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ-PRRRLLSSG 609
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPSASSPLLGRFCGSEaPPPVISSSS 80


                   ....*...
gi 357588419   610 PDLTLQFQ 617
Cdd:smart00042  81 NSLTLTFV 88
Sushi pfam00084
Sushi repeat (SCR repeat);
644-699 8.09e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 8.09e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 357588419  644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 699
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 290-345 9.39e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.86  E-value: 9.39e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 357588419 290 CGFPPRPAHGDV--SVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTrpaWTGEPPSC 345
Cdd:cd00033    1 CPPPPVPENGTVtgSKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGG---WSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 290-345 1.61e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.15  E-value: 1.61e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 357588419   290 CGFPPRPAHGDVSV--TDLHPGGTATFHCDSGYQLQGEETLICLNGTRpaWTGEPPSC 345
Cdd:smart00032   1 CPPPPDIENGTVTSssGTYSYGDTVTYSCDPGYTLIGSSTITCLENGT--WSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
290-345 9.78e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 52.12  E-value: 9.78e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 357588419  290 CGFPPRPAHGDVSVTD--LHPGGTATFHCDSGYQLQGEETLICL-NGTrpaWTGEPPSC 345
Cdd:pfam00084   1 CPPPPDIPNGKVSATKneYNYGASVSYECDPGYRLVGSPTITCQeDGT---WSPPFPEC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 359-417 1.53e-07

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 50.08  E-value: 1.53e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588419   359 GRIVSPEPGGAAGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN----DRLMVRSGGSPLSPVI 417
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSASSPLL 63
Sushi pfam00084
Sushi repeat (SCR repeat);
466-523 4.70e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 44.80  E-value: 4.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 357588419  466 PPFLAHGNVTTTDPEFHPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 523
Cdd:pfam00084   4 PPDIPNGKVSATKNEYNYGASVSYECDPGYRLV---GSPTITCQE--DGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 465-524 2.58e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.45  E-value: 2.58e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 465 FPPFLAHGNVTTTDPEFHPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPACK 524
Cdd:cd00033    3 PPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLV---GSSTITCTE--NGGWSPPPPTCE 57
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 182-283 3.67e-05

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 43.53  E-value: 3.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419   182 GFVESPDLGSTASRSvelLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGggsPGLAPRLLAN--SSMLGEg 254
Cdd:smart00042   1 GTITSPNYPQSYPNN---LDCVWTIRAPPGYRIELQFTDFDLESSDNceydyVEIYDG---PSASSPLLGRfcGSEAPP- 73

                           90       100
                   ....*....|....*....|....*....
gi 357588419   255 QVLRSPTNRLLLHFQSPRVPRGNGFRIHY 283
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
349-417 5.82e-05

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 43.05  E-value: 5.82e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588419  349 CGGTIHNATlGRIVSPEPGGAAGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 417
Cdd:pfam00431   1 CGGVLTDSS-GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHdecgYDYVEIRDGPSASSPLL 72
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 465-523 9.06e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.97  E-value: 9.06e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 357588419   465 FPPFLAHGNVTTTDPEFHPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 523
Cdd:smart00032   3 PPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLI---GSSTITCLE--NGTWSPPPPTC 56
CUB pfam00431
CUB domain;
201-283 3.29e-03

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 38.04  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419  201 DCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGspglaprllANSSMLGE------GQVLRSPTNRLLLHFQ 269
Cdd:pfam00431  26 DCVWLIRAPPGFRVKLTFQDFELEDHDEcgydyVEIRDGPS---------ASSPLLGRfcgsgiPEDIVSSSNQMTIKFV 96

                          90
                  ....*....|....
gi 357588419  270 SPRVPRGNGFRIHY 283
Cdd:pfam00431  97 SDASVQKRGFKATY 110
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 527-617 1.42e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 84.77  E-value: 1.42e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 527 CGGELSEPA-GVVLSPDWPQSYSPGQDCVWGLHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ 600
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                         90
                 ....*....|....*..
gi 357588419 601 PRRRLLSSGPDLTLQFQ 617
Cdd:cd00041   81 LPPPIISSGNSLTVRFR 97
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 665-828 5.76e-17

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 82.01  E-value: 5.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 665 GTVLTYQCEPGYELLGSDILTCQW----DLSWSAAPPACQKImTCADPGEITNGHRTASDAGFPVGSHVQYRCLPGYSLE 740
Cdd:PHA02927 105 GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLI 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 741 GAAVLTCYSRDtgtpkWSDRvPKCALKyePCLNPGVpENGY-QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpS 819
Cdd:PHA02927 184 GNSGVLCSGGE-----WSDP-PTCQIV--KCPHPTI-SNGYlSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPG--N 252


                 ....*....
gi 357588419 820 QWTSQPPLC 828
Cdd:PHA02927 253 TWQPELPKC 261
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 349-417 3.97e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.06  E-value: 3.97e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588419 349 CGGTIHNATLGRIVSPEPGGAAGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 417
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsYDYLEIYDGPSTSSPLL 73
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 665-837 1.21e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 71.99  E-value: 1.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 665 GTVLTYQCEPGY--ELLGSDILTCQWDlSWSAAPPACQKimTCADPGEITNGHRTASDAGFpvGSHVQYRCLPGYSLEGA 742
Cdd:PHA02927  47 GDTIEYLCLPGYrkQKMGPIYAKCTGT-GWTLFNQCIKR--RCPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGE 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 743 AVLTCYSRDTGTPKWSDRVPKCalKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpsQWt 822
Cdd:PHA02927 122 SKSYCELGSTGSMVWNPEAPIC--ESVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGG---EW- 195

                        170
                 ....*....|....*
gi 357588419 823 SQPPLCKVTQTTDPS 837
Cdd:PHA02927 196 SDPPTCQIVKCPHPT 210
PHA02639 PHA02639
EEV host range protein; Provisional
 701-839 3.87e-13

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 71.23  E-value: 3.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 701 KIMTCADPGEITNGHRTASDAGFPVGSHVQYRCLPGYSLEGAAVLTCYsRDTGTPKWSDRVPKCALKyePCLNPGVPENG 780
Cdd:PHA02639  18 KSIYCDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCI-KDKNNAIWSNKAPFCMLK--ECNDPPSIING 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588419 781 YQTLYKHHYQAGESLRFFCYE----GFELIGEVTITCVpgHPSQWTSQPPLCKVTQTTDPSRQ 839
Cdd:PHA02639  95 KIYNKREMYKVGDEIYYVCNEhkgvQYSLVGNEKITCI--QDKSWKPDPPICKMINCRFPALQ 155
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 644-700 5.25e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 61.32  E-value: 5.25e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 357588419 644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 700
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 771-829 7.99e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 60.94  E-value: 7.99e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 357588419 771 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpSQWTSQPPLCK 829
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN--GGWSPPPPTCE 57
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 173-285 8.06e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.82  E-value: 8.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 173 CNNNIS-EGEGFVESPDLGSTASRSvelLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGSpglaprlla 246
Cdd:cd00041    1 CGGTLTaSTSGTISSPNYPNNYPNN---LNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPST--------- 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 357588419 247 NSSMLGE------GQVLRSPTNRLLLHFQSPRVPRGNGFRIHYQA 285
Cdd:cd00041   69 SSPLLGRfcgstlPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
527-617 1.68e-11

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 61.93  E-value: 1.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419  527 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGLHVQEEKRILLQVEILNVRE-----GDMLTLFDGDGPSARVLAQLRGPQP 601
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDhdecgYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90
                  ....*....|....*.
gi 357588419  602 RRRLLSSGPDLTLQFQ 617
Cdd:pfam00431  81 PEDIVSSSNQMTIKFV 96
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 644-699 1.85e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 59.85  E-value: 1.85e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 357588419   644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 699
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 536-617 2.23e-11

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 61.25  E-value: 2.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419   536 GVVLSPDWPQSYSPGQDCVWGLHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ-PRRRLLSSG 609
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPSASSPLLGRFCGSEaPPPVISSSS 80


                   ....*...
gi 357588419   610 PDLTLQFQ 617
Cdd:smart00042  81 NSLTLTFV 88
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 705-764 5.86e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 58.31  E-value: 5.86e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419   705 CADPGEITNGHRTASDAGFPVGSHVQYRCLPGYSLEGAAVLTCysrdTGTPKWSDRVPKC 764
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITC----LENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
644-699 8.09e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 8.09e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 357588419  644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 699
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 705-764 8.27e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 58.24  E-value: 8.27e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 705 CADPGEITNGHRTASDAGFPVGSHVQYRCLPGYSLEGAAVLTCysrdTGTPKWSDRVPKC 764
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITC----TENGGWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 290-345 9.39e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.86  E-value: 9.39e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 357588419 290 CGFPPRPAHGDV--SVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTrpaWTGEPPSC 345
Cdd:cd00033    1 CPPPPVPENGTVtgSKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGG---WSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 771-828 1.11e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.54  E-value: 1.11e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 357588419   771 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpSQWTSQPPLC 828
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLEN--GTWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 290-345 1.61e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.15  E-value: 1.61e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 357588419   290 CGFPPRPAHGDVSV--TDLHPGGTATFHCDSGYQLQGEETLICLNGTRpaWTGEPPSC 345
Cdd:smart00032   1 CPPPPDIENGTVTSssGTYSYGDTVTYSCDPGYTLIGSSTITCLENGT--WSPPPPTC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 668-828 8.13e-10

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 60.78  E-value: 8.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 668 LTYQCEPGYEllgSDILTCQwDLSWSAAPpACQKIMTCADPGEITNGHRTASDAGFPVGSHVQYRC----LPGYSLEGAA 743
Cdd:PHA02831  46 LEYKCNNNFD---KVFVTCN-NGSWSTKN-MCIGKRNCKDPVTILNGYIKNKKDQYSFGDSVTYACkvnkLEKYSIVGNE 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 744 VLTCYSRdtgtpKWSDRVPKCAL---KYePCLnpgvpENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCvpGHPSQ 820
Cdd:PHA02831 121 TVKCINK-----QWVPKYPVCKLircKY-PAL-----QNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTC--DINSI 187


                 ....*...
gi 357588419 821 WTSQPPLC 828
Cdd:PHA02831 188 WYPGIPKC 195
PHA02639 PHA02639
EEV host range protein; Provisional
 665-835 8.77e-10

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 60.83  E-value: 8.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 665 GTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPACQkIMTCADPGEITNGHRTASDAGFPVGSHVQYRCLP----GY 737
Cdd:PHA02639  43 GKLIEYTCNTDYALIGDRFRTCIKDKNnaiWSNKAPFCM-LKECNDPPSIINGKIYNKREMYKVGDEIYYVCNEhkgvQY 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 738 SLEGAAVLTCysrdTGTPKWSDRVPKCalKYEPCLNPGVPE---NGYQTLYKHHYQAgeSLRFFCYEGFELIGEVTITCv 814
Cdd:PHA02639 122 SLVGNEKITC----IQDKSWKPDPPIC--KMINCRFPALQNgyiNGIPSNKKFYYKT--RVGFSCKSGFDLVGEKYSTC- 192

                        170       180
                 ....*....|....*....|.
gi 357588419 815 pGHPSQWTSQPPLCKVTQTTD 835
Cdd:PHA02639 193 -NINATWFPSIPTCVRNKPID 212
Sushi pfam00084
Sushi repeat (SCR repeat);
705-764 2.77e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 53.66  E-value: 2.77e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419  705 CADPGEITNGHRTASDAGFPVGSHVQYRCLPGYSLEGAAVLTCysrdTGTPKWSDRVPKC 764
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITC----QEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
290-345 9.78e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 52.12  E-value: 9.78e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 357588419  290 CGFPPRPAHGDVSVTD--LHPGGTATFHCDSGYQLQGEETLICL-NGTrpaWTGEPPSC 345
Cdd:pfam00084   1 CPPPPDIPNGKVSATKneYNYGASVSYECDPGYRLVGSPTITCQeDGT---WSPPFPEC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 359-417 1.53e-07

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 50.08  E-value: 1.53e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588419   359 GRIVSPEPGGAAGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN----DRLMVRSGGSPLSPVI 417
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSASSPLL 63
Sushi pfam00084
Sushi repeat (SCR repeat);
771-828 4.69e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.49  E-value: 4.69e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 357588419  771 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpSQWTSQPPLC 828
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQED--GTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
466-523 4.70e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 44.80  E-value: 4.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 357588419  466 PPFLAHGNVTTTDPEFHPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 523
Cdd:pfam00084   4 PPDIPNGKVSATKNEYNYGASVSYECDPGYRLV---GSPTITCQE--DGTWSPPFPEC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 664-773 1.05e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 47.63  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 664 RGTVLTYQCEPG-----YELLGSDILTCQWDLSWSAAPPACqKIMTCADPGeITNGHRTA--SDAGFPVGSHVQYRCLPG 736
Cdd:PHA02817  44 IGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVC-KIIRCRFPA-LQNGFVNGipDSKKFYYESEVSFSCKPG 121

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 357588419 737 YSLEGAAVLTCYSRDTgtpkWSDRVPKCaLKYEPCLN 773
Cdd:PHA02817 122 FVLIGTKYSVCGINSS----WIPKVPIC-SRDNITYN 153
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 713-836 2.40e-05

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 46.95  E-value: 2.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 713 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAVLtcYSRDTGTpKWSdRVPKCALKYepCLNPGVPENGYQTLYKHHYqaG 792
Cdd:PHA02927  34 NSVETDANANYNIGDTIEYLCLPGYRKQKMGPI--YAKCTGT-GWT-LFNQCIKRR--CPSPRDIDNGQLDIGGVDF--G 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 357588419 793 ESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPPLCKVTQTTDP 836
Cdd:PHA02927 106 SSITYSCNSGYQLIGESKSYCELGSTGSmvWNPEAPICESVKCQSP 151
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 465-524 2.58e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.45  E-value: 2.58e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 465 FPPFLAHGNVTTTDPEFHPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPACK 524
Cdd:cd00033    3 PPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLV---GSSTITCTE--NGGWSPPPPTCE 57
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 182-283 3.67e-05

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 43.53  E-value: 3.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419   182 GFVESPDLGSTASRSvelLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGggsPGLAPRLLAN--SSMLGEg 254
Cdd:smart00042   1 GTITSPNYPQSYPNN---LDCVWTIRAPPGYRIELQFTDFDLESSDNceydyVEIYDG---PSASSPLLGRfcGSEAPP- 73

                           90       100
                   ....*....|....*....|....*....
gi 357588419   255 QVLRSPTNRLLLHFQSPRVPRGNGFRIHY 283
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
349-417 5.82e-05

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 43.05  E-value: 5.82e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588419  349 CGGTIHNATlGRIVSPEPGGAAGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 417
Cdd:pfam00431   1 CGGVLTDSS-GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHdecgYDYVEIRDGPSASSPLL 72
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 665-764 7.07e-05

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 45.85  E-value: 7.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 665 GTVLTYQCEPGYELLGSDILTCQWDlSWSAAPPACQKimtCADPgEITNGhrTASDAGFPVGSHVQYRCLPGYSLEGAAV 744
Cdd:PHA02954 150 GEHITINCDVGYEVIGASYISCTAN-SWNVIPSCQQK---CDIP-SLSNG--LISGSTFSIGGVIHLSCKSGFTLTGSPS 222

                         90       100
                 ....*....|....*....|
gi 357588419 745 LTCYSrdtgtPKWSDRVPKC 764
Cdd:PHA02954 223 STCID-----GKWNPVLPIC 237
PHA02817 PHA02817
EEV Host range protein; Provisional
 705-828 8.77e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 44.93  E-value: 8.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 705 CADPGEITNGHRTASDAGFPVGSHVQYRC------LPgYSLEGAAVLTCySRDTgtpKWSDRVPKCAL---KYePCLNPG 775
Cdd:PHA02817  24 CCYPPSIKNGYIYNKKTEYNIGSNVTFFCgnntrgVR-YTLVGEKNIIC-EKDG---KWNKEFPVCKIircRF-PALQNG 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 357588419 776 VPeNGYQTLYKHHYQagESLRFFCYEGFELIGEVTITCvpGHPSQWTSQPPLC 828
Cdd:PHA02817  98 FV-NGIPDSKKFYYE--SEVSFSCKPGFVLIGTKYSVC--GINSSWIPKVPIC 145
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 465-523 9.06e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.97  E-value: 9.06e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 357588419   465 FPPFLAHGNVTTTDPEFHPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 523
Cdd:smart00032   3 PPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLI---GSSTITCLE--NGTWSPPPPTC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 764-839 6.35e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 42.24  E-value: 6.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419 764 CALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEG-----FELIGEVTITCvpGHPSQWTSQPPLCKVTQTTDPSR 838
Cdd:PHA02817  17 SLCDLNKCCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIIC--EKDGKWNKEFPVCKIIRCRFPAL 94


                 .
gi 357588419 839 Q 839
Cdd:PHA02817  95 Q 95
PHA02831 PHA02831
EEV host range protein; Provisional
 771-839 2.24e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 40.75  E-value: 2.24e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588419 771 CLNPGVPENGYQTLYKHHYQAGESLRFFC----YEGFELIGEVTITCVPGhpsQWTSQPPLCKVTQTTDPSRQ 839
Cdd:PHA02831  78 CKDPVTILNGYIKNKKDQYSFGDSVTYACkvnkLEKYSIVGNETVKCINK---QWVPKYPVCKLIRCKYPALQ 147
CUB pfam00431
CUB domain;
201-283 3.29e-03

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 38.04  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588419  201 DCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGspglaprllANSSMLGE------GQVLRSPTNRLLLHFQ 269
Cdd:pfam00431  26 DCVWLIRAPPGFRVKLTFQDFELEDHDEcgydyVEIRDGPS---------ASSPLLGRfcgsgiPEDIVSSSNQMTIKFV 96

                          90
                  ....*....|....
gi 357588419  270 SPRVPRGNGFRIHY 283
Cdd:pfam00431  97 SDASVQKRGFKATY 110
PHA02639 PHA02639
EEV host range protein; Provisional
 771-842 4.61e-03

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 40.03  E-value: 4.61e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588419 771 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPG-HPSQWTSQPPLCKVTQTTDPSRQLEG 842
Cdd:PHA02639  22 CDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDkNNAIWSNKAPFCMLKECNDPPSIING 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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