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Conserved domains on  [gi|358439544|ref|NP_001240617|]
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MICOS complex subunit Mic60 isoform 5 [Mus musculus]

Protein Classification

MICOS complex subunit MIC60( domain architecture ID 12101363)

MICOS complex subunit MIC60 is a component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-667 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


:

Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 572.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  123 LPVAQSQKTKGD-----------TPASA--------------------ALAKSLEDALNRTSSVTLQTITAQNAAVQAVK 171
Cdd:pfam09731  81 EPKEEKKQVKIPrqsgvssevaeEEKEAtkdaaeakaqlpkseqekekALEEVLKEAISKAESATAVAKEAKDDAIQAVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  172 AHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadallkakeeleKMKTIIEDAKKREIAGATPHITAAEGR 251
Cdd:pfam09731 161 AHTDSLKEASDTAEISREKATDSALQKAEALAE--------------------KLKEVINLAKQSEEEAAPPLLDAAPET 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  252 LHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMSisdlagKLSTDDLNSLIAHAHR 331
Cdd:pfam09731 221 PPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKEDN------LLSNDDLNSLIAHAHR 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  332 RIDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQ 407
Cdd:pfam09731 295 EIDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTELERQ 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  408 AAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKA 487
Cdd:pfam09731 374 AEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKGLEKATSSHSEVEDENRKA 442

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  488 HQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 567
Cdd:pfam09731 443 QQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVS 522

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  568 MIDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLK 647
Cdd:pfam09731 523 LIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLK 598

                         650       660
                  ....*....|....*....|
gi 358439544  648 EARMTLETKQIVEILTAYAS 667
Cdd:pfam09731 599 EARRRLEVQQALELLQAEAA 618
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-667 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 572.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  123 LPVAQSQKTKGD-----------TPASA--------------------ALAKSLEDALNRTSSVTLQTITAQNAAVQAVK 171
Cdd:pfam09731  81 EPKEEKKQVKIPrqsgvssevaeEEKEAtkdaaeakaqlpkseqekekALEEVLKEAISKAESATAVAKEAKDDAIQAVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  172 AHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadallkakeeleKMKTIIEDAKKREIAGATPHITAAEGR 251
Cdd:pfam09731 161 AHTDSLKEASDTAEISREKATDSALQKAEALAE--------------------KLKEVINLAKQSEEEAAPPLLDAAPET 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  252 LHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMSisdlagKLSTDDLNSLIAHAHR 331
Cdd:pfam09731 221 PPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKEDN------LLSNDDLNSLIAHAHR 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  332 RIDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQ 407
Cdd:pfam09731 295 EIDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTELERQ 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  408 AAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKA 487
Cdd:pfam09731 374 AEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKGLEKATSSHSEVEDENRKA 442

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  488 HQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 567
Cdd:pfam09731 443 QQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVS 522

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  568 MIDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLK 647
Cdd:pfam09731 523 LIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLK 598

                         650       660
                  ....*....|....*....|
gi 358439544  648 EARMTLETKQIVEILTAYAS 667
Cdd:pfam09731 599 EARRRLEVQQALELLQAEAA 618
PTZ00121 PTZ00121
MAEBL; Provisional
 162-498 2.54e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.46  E-value: 2.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  162 AQNAAVQAVKAHSniLKTAMDNSEIAGEKKSAQWRTVEGALK--ERRKAVDEAADALLKAKEELEKMKTIIEDAK----- 234
Cdd:PTZ00121 1270 AAIKAEEARKADE--LKKAEEKKKADEAKKAEEKKKADEAKKkaEEAKKADEAKKKAEEAKKKADAAKKKAEEAKkaaea 1347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  235 -KREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDfRKELDSITPDITPGWKGMSISDL 313
Cdd:PTZ00121 1348 aKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEED-KKKADELKKAAAAKKKADEAKKK 1426

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  314 AGKLSTDDLNSLIAHAHRRIDQLNR--------ELAQQKATEKQHIELAleKHKLEEKRTFDSAVAKALEHHR----SEI 381
Cdd:PTZ00121 1427 AEEKKKADEAKKKAEEAKKADEAKKkaeeakkaEEAKKKAEEAKKADEA--KKKAEEAKKADEAKKKAEEAKKkadeAKK 1504

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  382 QAEQDRKVEEVRDAMENEMRTQLRR-QAAAHTDHLR--------DVLKVQEQELKYEFEQGLSEKLSEQE---LEFRR-- 447
Cdd:PTZ00121 1505 AAEAKKKADEAKKAEEAKKADEAKKaEEAKKADEAKkaeekkkaDELKKAEELKKAEEKKKAEEAKKAEEdknMALRKae 1584

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 358439544  448 --------RSQEQMDSFTLDINTAYARLRGIEQAvqshAVAEEEARKAHQLWLSVEALK 498
Cdd:PTZ00121 1585 eakkaeeaRIEEVMKLYEEEKKMKAEEAKKAEEA----KIKAEELKKAEEEKKKVEQLK 1639
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 193-490 4.72e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.40  E-value: 4.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 193 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKReiagatphITAAEGRLHNMIVDLDNVVKKVQAAQSE 272
Cdd:COG1196  232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE--------LEELELELEEAQAEEYELLAELARLEQD 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 273 AKVVSQYHELVVQARDDFRKELDSITpditpgwkgMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIE 352
Cdd:COG1196  304 IARLEERRRELEERLEELEEELAELE---------EELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 353 LALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQ 432
Cdd:COG1196  375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL 454

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 358439544 433 GLSEKLSEQELEFRRRS----QEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 490
Cdd:COG1196  455 EEEEEALLELLAELLEEaallEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLL 516
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 140-476 1.07e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.90  E-value: 1.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   140 ALAKSLEDALN-------RTSSVTLQ--TITAQNAAVQA-VKAHSNILKTamdNSEIagEKKSAQWRTVEGALKERRKAV 209
Cdd:TIGR02168  626 LVVDDLDNALElakklrpGYRIVTLDgdLVRPGGVITGGsAKTNSSILER---RREI--EELEEKIEELEEKIAELEKAL 700

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   210 DEAADALLKAKEELEKMKTIIEDaKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDD 289
Cdd:TIGR02168  701 AELRKELEELEEELEQLRKELEE-LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAE 779

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   290 FRKELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK-----------H 358
Cdd:TIGR02168  780 AEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIeelsedieslaA 859

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   359 KLEEKRTFDSAVAKALEHHrSEIQAEQDRKVEEVRDAMENEM---------RTQLRRQAAAHTDHLRDvLKVQEQELKYE 429
Cdd:TIGR02168  860 EIEELEELIEELESELEAL-LNERASLEEALALLRSELEELSeelreleskRSELRRELEELREKLAQ-LELRLEGLEVR 937

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 358439544   430 FEQgLSEKLSEQ---ELEFrrrSQEQMDSFTLDINTAYARLRGIEQAVQS 476
Cdd:TIGR02168  938 IDN-LQERLSEEyslTLEE---AEALENKIEDDEEEARRRLKRLENKIKE 983
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-667 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 572.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  123 LPVAQSQKTKGD-----------TPASA--------------------ALAKSLEDALNRTSSVTLQTITAQNAAVQAVK 171
Cdd:pfam09731  81 EPKEEKKQVKIPrqsgvssevaeEEKEAtkdaaeakaqlpkseqekekALEEVLKEAISKAESATAVAKEAKDDAIQAVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  172 AHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadallkakeeleKMKTIIEDAKKREIAGATPHITAAEGR 251
Cdd:pfam09731 161 AHTDSLKEASDTAEISREKATDSALQKAEALAE--------------------KLKEVINLAKQSEEEAAPPLLDAAPET 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  252 LHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMSisdlagKLSTDDLNSLIAHAHR 331
Cdd:pfam09731 221 PPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKEDN------LLSNDDLNSLIAHAHR 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  332 RIDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQ 407
Cdd:pfam09731 295 EIDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTELERQ 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  408 AAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKA 487
Cdd:pfam09731 374 AEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKGLEKATSSHSEVEDENRKA 442

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  488 HQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVA 567
Cdd:pfam09731 443 QQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVS 522

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  568 MIDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLK 647
Cdd:pfam09731 523 LIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLK 598

                         650       660
                  ....*....|....*....|
gi 358439544  648 EARMTLETKQIVEILTAYAS 667
Cdd:pfam09731 599 EARRRLEVQQALELLQAEAA 618
PTZ00121 PTZ00121
MAEBL; Provisional
 162-498 2.54e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.46  E-value: 2.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  162 AQNAAVQAVKAHSniLKTAMDNSEIAGEKKSAQWRTVEGALK--ERRKAVDEAADALLKAKEELEKMKTIIEDAK----- 234
Cdd:PTZ00121 1270 AAIKAEEARKADE--LKKAEEKKKADEAKKAEEKKKADEAKKkaEEAKKADEAKKKAEEAKKKADAAKKKAEEAKkaaea 1347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  235 -KREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDfRKELDSITPDITPGWKGMSISDL 313
Cdd:PTZ00121 1348 aKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEED-KKKADELKKAAAAKKKADEAKKK 1426

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  314 AGKLSTDDLNSLIAHAHRRIDQLNR--------ELAQQKATEKQHIELAleKHKLEEKRTFDSAVAKALEHHR----SEI 381
Cdd:PTZ00121 1427 AEEKKKADEAKKKAEEAKKADEAKKkaeeakkaEEAKKKAEEAKKADEA--KKKAEEAKKADEAKKKAEEAKKkadeAKK 1504

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  382 QAEQDRKVEEVRDAMENEMRTQLRR-QAAAHTDHLR--------DVLKVQEQELKYEFEQGLSEKLSEQE---LEFRR-- 447
Cdd:PTZ00121 1505 AAEAKKKADEAKKAEEAKKADEAKKaEEAKKADEAKkaeekkkaDELKKAEELKKAEEKKKAEEAKKAEEdknMALRKae 1584

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 358439544  448 --------RSQEQMDSFTLDINTAYARLRGIEQAvqshAVAEEEARKAHQLWLSVEALK 498
Cdd:PTZ00121 1585 eakkaeeaRIEEVMKLYEEEKKMKAEEAKKAEEA----KIKAEELKKAEEEKKKVEQLK 1639
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 193-490 4.72e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.40  E-value: 4.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 193 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKReiagatphITAAEGRLHNMIVDLDNVVKKVQAAQSE 272
Cdd:COG1196  232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE--------LEELELELEEAQAEEYELLAELARLEQD 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 273 AKVVSQYHELVVQARDDFRKELDSITpditpgwkgMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIE 352
Cdd:COG1196  304 IARLEERRRELEERLEELEEELAELE---------EELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 353 LALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQ 432
Cdd:COG1196  375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL 454

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 358439544 433 GLSEKLSEQELEFRRRS----QEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 490
Cdd:COG1196  455 EEEEEALLELLAELLEEaallEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLL 516
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
193-421 2.95e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.68  E-value: 2.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  193 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKR----EIAGATPHITAAEGRLHNmiVDLDNVVKKVQA 268
Cdd:COG4913   692 EQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRleaaEDLARLELRALLEERFAA--ALGDAVERELRE 769

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  269 ------AQSEAKVVSQYHELV--------------------VQARDDFRKELDSITPDITPG-----------WKGMSIS 311
Cdd:COG4913   770 nleeriDALRARLNRAEEELEramrafnrewpaetadldadLESLPEYLALLDRLEEDGLPEyeerfkellneNSIEFVA 849

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  312 DLAGKLSTDdlnslIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEE 391
Cdd:COG4913   850 DLLSKLRRA-----IREIKERIDPLNDSLKRIPFGPGRYLRLEARPRPDPEVREFRQELRAVTSGASLFDEELSEARFAA 924

                         250       260       270
                  ....*....|....*....|....*....|.
gi 358439544  392 VRDAMEnemrtQLRRQAAAHTDH-LRDVLKV 421
Cdd:COG4913   925 LKRLIE-----RLRSEEEESDRRwRARVLDV 950
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 140-476 1.07e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.90  E-value: 1.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   140 ALAKSLEDALN-------RTSSVTLQ--TITAQNAAVQA-VKAHSNILKTamdNSEIagEKKSAQWRTVEGALKERRKAV 209
Cdd:TIGR02168  626 LVVDDLDNALElakklrpGYRIVTLDgdLVRPGGVITGGsAKTNSSILER---RREI--EELEEKIEELEEKIAELEKAL 700

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   210 DEAADALLKAKEELEKMKTIIEDaKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDD 289
Cdd:TIGR02168  701 AELRKELEELEEELEQLRKELEE-LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAE 779

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   290 FRKELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK-----------H 358
Cdd:TIGR02168  780 AEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIeelsedieslaA 859

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   359 KLEEKRTFDSAVAKALEHHrSEIQAEQDRKVEEVRDAMENEM---------RTQLRRQAAAHTDHLRDvLKVQEQELKYE 429
Cdd:TIGR02168  860 EIEELEELIEELESELEAL-LNERASLEEALALLRSELEELSeelreleskRSELRRELEELREKLAQ-LELRLEGLEVR 937

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 358439544   430 FEQgLSEKLSEQ---ELEFrrrSQEQMDSFTLDINTAYARLRGIEQAVQS 476
Cdd:TIGR02168  938 IDN-LQERLSEEyslTLEE---AEALENKIEDDEEEARRRLKRLENKIKE 983
PTZ00121 PTZ00121
MAEBL; Provisional
 119-490 1.43e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.60  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  119 KDSKLPVAQSQKTKGDTPASAALAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHsNILKTAMDNSEIAGEKKSAQWRTV 198
Cdd:PTZ00121 1406 KADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAE-EAKKKAEEAKKADEAKKKAEEAKK 1484

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  199 EGALKERRKAVDEAADALLKAKEELEK---MKTIIEDAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSE-AK 274
Cdd:PTZ00121 1485 ADEAKKKAEEAKKKADEAKKAAEAKKKadeAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEeKK 1564

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  275 VVSQYHELVVQARDDFRKELDSITPDITPGWKGMSISDLAGKLSTDDLNSLiAHAHRRIDQLNRELAQQKATEKQHIELA 354
Cdd:PTZ00121 1565 KAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA-EEAKIKAEELKKAEEEKKKVEQLKKKEA 1643

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  355 LEKHKLEE--KRTFDSAVAKALEHHRSEiqaEQDRKVEEVRDAMENEMrtqlrrqaaahtdhlrdvlKVQEQELKYEFEQ 432
Cdd:PTZ00121 1644 EEKKKAEElkKAEEENKIKAAEEAKKAE---EDKKKAEEAKKAEEDEK-------------------KAAEALKKEAEEA 1701

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 358439544  433 GLSEKLSEQELEFRRRSQEQMDSftldintAYARLRGIEQAVQShavAEEEARKAHQL 490
Cdd:PTZ00121 1702 KKAEELKKKEAEEKKKAEELKKA-------EEENKIKAEEAKKE---AEEDKKKAEEA 1749
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 370-489 4.50e-05

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 43.89  E-value: 4.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  370 VAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAhtdhlrdvlKVQEQELKYEFEQGLSEKLSEQELEFRRRS 449
Cdd:pfam15346  24 VEEELEKRKDEIEAEVERRVEEARKIMEKQVLEELEREREA---------ELEEERRKEEEERKKREELERILEENNRKI 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 358439544  450 QEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQ 489
Cdd:pfam15346  95 EEAQRKEAEERLAMLEEQRRMKEERQRREKEEEEREKREQ 134
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 320-488 2.92e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 44.29  E-value: 2.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   320 DDLNSLIAHAHRRIDQLNREL--AQQKATEKQ-HIELALEKH-----KLEEKRTFDSAVAKALEHHRSEIQ------AEQ 385
Cdd:TIGR02169  691 SSLQSELRRIENRLDELSQELsdASRKIGEIEkEIEQLEQEEeklkeRLEELEEDLSSLEQEIENVKSELKeleariEEL 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   386 DRKVEEVRDAMEN-----------EMRTQLRRQAAAHTDhLRDVLKVQEQEL-KYEFEQGLSEKLSEQELEFRRRSQEQM 453
Cdd:TIGR02169  771 EEDLHKLEEALNDlearlshsripEIQAELSKLEEEVSR-IEARLREIEQKLnRLTLEKEYLEKEIQELQEQRIDLKEQI 849

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 358439544   454 DSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 488
Cdd:TIGR02169  850 KSIEKEIENLNGKKEELEEELEELEAALRDLESRL 884
PTZ00121 PTZ00121
MAEBL; Provisional
 331-507 5.91e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 5.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  331 RRIDQLNR-ELAQQKATEKQHIElalEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQaa 409
Cdd:PTZ00121 1224 KKAEAVKKaEEAKKDAEEAKKAE---EERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKA-- 1298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  410 ahtdhlRDVLKVQEQELKYEfEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARlRGIEQAVQSHAVAEEEARKAHQ 489
Cdd:PTZ00121 1299 ------EEKKKADEAKKKAE-EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA-KAEAEAAADEAEAAEEKAEAAE 1370

                         170
                  ....*....|....*...
gi 358439544  490 LWLSVEALKYSMKTSSAE 507
Cdd:PTZ00121 1371 KKKEEAKKKADAAKKKAE 1388
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 191-441 6.17e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 43.29  E-value: 6.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   191 KSAQWRTVEGALKERRKAVDEAADAL-LKAKEELEKMKTiiedAKKREIAGATPHitaaEGRLHNMIVDLDNVVKKV-QA 268
Cdd:pfam12128  716 KQAYWQVVEGALDAQLALLKAAIAARrSGAKAELKALET----WYKRDLASLGVD----PDVIAKLKREIRTLERKIeRI 787

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   269 AQSEAKVVSQ---YHELVVQARDDFRKELDSITpditpgwkgMSISDLagklsTDDLNSLIAHAHRRIDQLNRELaqqKA 345
Cdd:pfam12128  788 AVRRQEVLRYfdwYQETWLQRRPRLATQLSNIE---------RAISEL-----QQQLARLIADTKLRRAKLEMER---KA 850

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   346 TEKQHIELALEKHKLeekRTFDSAVAKALEHHRSE----IQAEQDRKVEEVRDAMENEMrtqlrRQAAAHTDHLRDVLKV 421
Cdd:pfam12128  851 SEKQQVRLSENLRGL---RCEMSKLATLKEDANSEqaqgSIGERLAQLEDLKLKRDYLS-----ESVKKYVEHFKNVIAD 922

                          250       260
                   ....*....|....*....|
gi 358439544   422 QEQELKYEFEQGLSEKLSEQ 441
Cdd:pfam12128  923 HSGSGLAETWESLREEDHYQ 942
COG4223 COG4223
Uncharacterized conserved protein [Function unknown];
434-668 1.03e-03

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443367 [Multi-domain]  Cd Length: 259  Bit Score: 41.57  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 434 LSEKLSEQELEFRRRSQEQMDsftLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSaemptiPL 513
Cdd:COG4223   39 LEARLAALRAALAAAREAVAA---AAAAALEARLAALEAKAAAPEAEAAAAARAAALALAAAALRAAVERGQ------PF 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 514 GSAVEAIRVNCSDNEFTQALTAAippesLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLlfppk 593
Cdd:COG4223  110 AAELAALEALAPDAPALAALAAF-----AATGVPTLAALRAEFPAAARAALAAARAPEADASWLDRLLAFARSLV----- 179

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 358439544 594 QLKPPAElyPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYASA 668
Cdd:COG4223  180 TVRRVGP--VEGDDPDAILARAEAALAAGDLAGALAELEALPEAAQAAAAPWIAKAEARLAADAALQALAAQALA 252
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 339-511 1.05e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  339 ELAQQKATEKQHIELALEKHKLEEKRtfdsavaKALEHHRSeiQAEQDRKVEEVRDAMENEMRTqlRRQAAAHTDHLRDV 418
Cdd:pfam17380 449 ERVRLEEQERQQQVERLRQQEEERKR-------KKLELEKE--KRDRKRAEEQRRKILEKELEE--RKQAMIEEERKRKL 517

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  419 LKVQEQELK---YEFEQ---GLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRgiEQAVQSHAVAEEEARKAHQLWL 492
Cdd:pfam17380 518 LEKEMEERQkaiYEEERrreAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMER--EREMMRQIVESEKARAEYEATT 595

                         170       180
                  ....*....|....*....|.
gi 358439544  493 SVEALK--YSMKTSSAEMPTI 511
Cdd:pfam17380 596 PITTIKpiYRPRISEYQPPDV 616
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
327-470 1.22e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  327 AHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEkrtfDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMR----- 401
Cdd:COG4913   647 REALQRLAEYSWDEIDVASAEREIAELEAELERLDA----SSDDLAALEEQLEELEAELEELEEELDELKGEIGRlekel 722

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  402 TQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSE-KLSEQELEFRRRSQEQMDSFTLDINTAYARLRGI 470
Cdd:COG4913   723 EQAEEELDELQDRLEAAEDLARLELRALLEERFAAaLGDAVERELRENLEERIDALRARLNRAEEELERA 792
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 338-487 2.82e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 2.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 338 RELaQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRdamenEMRTQLRRQAAAHTDHLRD 417
Cdd:COG1196  216 REL-KEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELE-----ELRLELEELELELEEAQAE 289

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 418 VLKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKA 487
Cdd:COG1196  290 EYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAE 359
PTZ00121 PTZ00121
MAEBL; Provisional
 126-456 2.94e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  126 AQSQKTKGDTPASAALAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHSNilKTAMDNSEIAGEKKSA-QWRTVEGALK- 203
Cdd:PTZ00121 1459 AEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEA--KKKADEAKKAEEAKKAdEAKKAEEAKKa 1536

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  204 -ERRKAVDEAADALLKAKEELEKMKTI--IEDAKKREIAGATPHITA-----AEGRLHNMIVDLDNVVKKVQAAQSEAKV 275
Cdd:PTZ00121 1537 dEAKKAEEKKKADELKKAEELKKAEEKkkAEEAKKAEEDKNMALRKAeeakkAEEARIEEVMKLYEEEKKMKAEEAKKAE 1616

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  276 VSQYHELVVQARDDFRKELDSITPDITPGWKG---MSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIE 352
Cdd:PTZ00121 1617 EAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKaeeLKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKK 1696

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544  353 LALEKHKLEEKRTFDSAVAKALEHHRSEiQAEQDRKVEEVRDAMENEMRT--QLRRQAAAHTD--HLRDVLKVQEQELKY 428
Cdd:PTZ00121 1697 EAEEAKKAEELKKKEAEEKKKAEELKKA-EEENKIKAEEAKKEAEEDKKKaeEAKKDEEEKKKiaHLKKEEEKKAEEIRK 1775

                         330       340       350
                  ....*....|....*....|....*....|..
gi 358439544  429 E----FEQGLSEKLSEQELEFRRRSQEQMDSF 456
Cdd:PTZ00121 1776 EkeavIEEELDEEDEKRRMEVDKKIKDIFDNF 1807
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 334-452 3.27e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 40.72  E-value: 3.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544   334 DQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHtd 413
Cdd:TIGR00618  256 LKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAH-- 333

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 358439544   414 hlrdvlkvQEQELKYEFEQGLSEKLSEQELEFRRRSQEQ 452
Cdd:TIGR00618  334 --------VKQQSSIEEQRRLLQTLHSQEIHIRDAHEVA 364
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 212-449 4.27e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.13  E-value: 4.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 212 AADALLKAKEELEKMKTIIEdAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFR 291
Cdd:COG4942   18 QADAAAEAEAELEQLQQEIA-ELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 292 KELDSITPDITP----GWKGMSISDLAGKLSTDDLNSLIAHAhRRIDQLNRELAQQ-KATEKQHIELALEKHKLEEKRTF 366
Cdd:COG4942   97 AELEAQKEELAEllraLYRLGRQPPLALLLSPEDFLDAVRRL-QYLKYLAPARREQaEELRADLAELAALRAELEAERAE 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 367 DSAVAKALEHHRSEIQAEQDRKveevrdameNEMRTQLRRQAAAHTDHLRDvLKVQEQELkyefeQGLSEKLSEQELEFR 446
Cdd:COG4942  176 LEALLAELEEERAALEALKAER---------QKLLARLEKELAELAAELAE-LQQEAEEL-----EALIARLEAEAAAAA 240


                 ...
gi 358439544 447 RRS 449
Cdd:COG4942  241 ERT 243
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 137-444 8.13e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.53  E-value: 8.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 137 ASAALAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHsNILKTAMDNSEIAGE-----KKSAQWRTVEGAL-------KE 204
Cdd:COG1196  457 EEEALLELLAELLEEAALLEAALAELLEELAEAAARL-LLLLEAEADYEGFLEgvkaaLLLAGLRGLAGAVavligveAA 535

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 205 RRKAVDEAADALLKAK--EELEKMKTIIEDAKKREIAGAT--PHITAAEGRLHNMIVDLDNVVKKVQAAQSEAkvvsQYH 280
Cdd:COG1196  536 YEAALEAALAAALQNIvvEDDEVAAAAIEYLKAAKAGRATflPLDKIRARAALAAALARGAIGAAVDLVASDL----REA 611

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 281 ELVVQARDDFRKELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKL 360
Cdd:COG1196  612 DARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEE 691

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439544 361 EEKRTFDSAVAKALEHHRSEIQAEQDRKVEEvrdamENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSE 440
Cdd:COG1196  692 ELELEEALLAEEEEERELAEAEEERLEEELE-----EEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELE 766


                 ....
gi 358439544 441 QELE 444
Cdd:COG1196  767 RELE 770
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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