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Conserved domains on  [gi|371873395|ref|NP_001243097|]
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zinc finger protein 620 isoform b [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
108-252 7.52e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 7.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371873395 108 KSFECKECGKYFRYNSLLIRHQ--IIHTGK--KPFKCKE--CGKGLSSDTALIQHQRIHTGEKPYECK--ECGKAFSSSS 179
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371873395 180 VFLQHQRFH-----TGEKLYEC--NECWKTFSCSSSFTVHQRMHTGEKPYECK--ECGKRLSSNTALTQHQRIHTGEKPF 250
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                 ..
gi 371873395 251 EC 252
Cdd:COG5048  448 LC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
265-288 1.31e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|....
gi 371873395  265 LIQHQRVHTGEKPYECKVCGKTFS 288
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
108-252 7.52e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 7.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371873395 108 KSFECKECGKYFRYNSLLIRHQ--IIHTGK--KPFKCKE--CGKGLSSDTALIQHQRIHTGEKPYECK--ECGKAFSSSS 179
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371873395 180 VFLQHQRFH-----TGEKLYEC--NECWKTFSCSSSFTVHQRMHTGEKPYECK--ECGKRLSSNTALTQHQRIHTGEKPF 250
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                 ..
gi 371873395 251 EC 252
Cdd:COG5048  448 LC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
236-261 9.94e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 9.94e-05
                          10        20
                  ....*....|....*....|....*.
gi 371873395  236 ALTQHQRIHTGEKPFECKECGKAFNQ 261
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
265-288 1.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|....
gi 371873395  265 LIQHQRVHTGEKPYECKVCGKTFS 288
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
108-252 7.52e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 7.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371873395 108 KSFECKECGKYFRYNSLLIRHQ--IIHTGK--KPFKCKE--CGKGLSSDTALIQHQRIHTGEKPYECK--ECGKAFSSSS 179
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371873395 180 VFLQHQRFH-----TGEKLYEC--NECWKTFSCSSSFTVHQRMHTGEKPYECK--ECGKRLSSNTALTQHQRIHTGEKPF 250
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                 ..
gi 371873395 251 EC 252
Cdd:COG5048  448 LC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
236-261 9.94e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 9.94e-05
                          10        20
                  ....*....|....*....|....*.
gi 371873395  236 ALTQHQRIHTGEKPFECKECGKAFNQ 261
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-240 1.21e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371873395  64 SVSTQLTTNQTNPSGQI-SYECGQCGRYFIQMADFHRHEKC--HTGE--KSFECKE--CGKYFRYNSLLIRHQIIHTGKK 136
Cdd:COG5048  271 QSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371873395 137 PFKCKEC-------GKGLSSDTALIQHQRIHTGEKPYEC--KECGKAFSSSSVFLQHQRFHTGEKLYECN--ECWKTFSC 205
Cdd:COG5048  351 PAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 371873395 206 SSSFTVHQRMHTGEKPYECkeCGKRLSSNTALTQH 240
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
152-177 1.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.46e-04
                          10        20
                  ....*....|....*....|....*.
gi 371873395  152 ALIQHQRIHTGEKPYECKECGKAFSS 177
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
175-262 6.35e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 6.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371873395 175 FSSSSVFLQ-HQRFHTGE----KLYECNECWKTFSCSSSFTVHQRMHTGEKPYEC--KECGKRLSSNTALTQHQRIHTGE 247
Cdd:COG5048   10 SSNNSVLSStPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNN 89

                         90
                 ....*....|....*
gi 371873395 248 KPFECKECGKAFNQK 262
Cdd:COG5048   90 PSDLNSKSLPLSNSK 104
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-272 1.17e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371873395 192 KLYECNECWKTFSCSSSFTVHQRM--HTGE--KPYECKE--CGKRLSSNTALTQHQRIHTGEKPFECK--ECGKAFNQKI 263
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367


                 ....*....
gi 371873395 264 TLIQHQRVH 272
Cdd:COG5048  368 NNEPPQSLQ 376
zf-H2C2_2 pfam13465
Zinc-finger double domain;
265-288 1.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|....
gi 371873395  265 LIQHQRVHTGEKPYECKVCGKTFS 288
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 162-240 3.47e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 3.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371873395 162 GEKPYECK--ECGKAFSSSSvFLQHQRFHtgeklyecNECWKTFSCSSSFTVHQRMHTGEKPYECKECGKRLSSNTALTQ 239
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQN-GLKYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 371873395 240 H 240
Cdd:COG5189  417 H 417
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
71-288 4.61e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 4.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371873395  71 TNQTNPSGQISYECGQCGRYFIQMADFHRHEKCHTGEKSFECKECGKYFRYNSLLIRHQIIHTG-------KKPFKCKEC 143
Cdd:COG5048  216 SDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQC 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371873395 144 GKGLSSDTALIQHQR--IHTGE--KPYECKE--CGKAFSSSSVFLQHQRFHTGEKLYECnecwKTFSCSSSFTV------ 211
Cdd:COG5048  296 NISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE----KLLNSSSKFSPllnnep 371

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371873395 212 --HQRMHTGEKPYECKECGKRLSSNTALTQH----QRIHT---GEKPFECKECGKAFNQKITLIQHQRVHTGEKPYECKV 282
Cdd:COG5048  372 pqSLQQYKDLKNDKKSETLSNSCIRNFKRDSnlslHIITHlsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSI 451


                 ....*.
gi 371873395 283 CGKTFS 288
Cdd:COG5048  452 LKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
99-121 9.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.11  E-value: 9.64e-03
                          10        20
                  ....*....|....*....|...
gi 371873395   99 RHEKCHTGEKSFECKECGKYFRY 121
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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