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Conserved domains on  [gi|373838817|ref|NP_001243290|]
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voltage-dependent T-type calcium channel subunit alpha-1G isoform 29 [Homo sapiens]

Protein Classification

ion transporter( domain architecture ID 11997982)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium across cell membranes

CATH:  1.10.287.70
PubMed:  15816170
TCDB:  1.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-968 6.82e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 223.68  E-value: 6.82e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817   742 SKYFGRGIMIAILVNTLSMGIEYHEQPEE-LTNALEISNIVFTSLFALEMLLKLLVYGPFG-YIKNPYNIFDGVIVVISV 819
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817   820 WEIV---GQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD 896
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 373838817   897 GDtlPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS-WAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Cdd:pfam00520  161 PD--NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1572-1813 5.19e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 180.93  E-value: 5.19e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1572 SHYLDLFITGVIGLNVVTMAMEHYQQPQ-ILDEALKICNYIFTVIFVLESVFKLVAFGF-RRFFQDRWNQLDLAIVLLSI 1649
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1650 MGITLEEIEvnaslpiNPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1729
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1730 lecDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDqestcynTVISPIYFVSFVLTAQFVLVNVVI 1809
Cdd:pfam00520  154 ---KLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------EFWAYIYFVSFIILGGFLLLNLFI 223

                   ....
gi 373838817  1810 AVLM 1813
Cdd:pfam00520  224 AVII 227
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
80-406 2.81e-43

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 158.58  E-value: 2.81e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817    80 NPWFERISMLVILLNCVTLGMFRPCEDiacDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIfgKKCYLGDTWNRLDFFI 159
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP---EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGF--KKRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817   160 VIAGMLEYSLDLQN--VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCffvffifgivgvqLWAGLL 237
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLL-------------LLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817   238 rnrcflpenFSLplsvdleryyqtenedespficsqpreNGMrscrsvptlrgdggggppcgldyeaynsssnttcvnwn 317
Cdd:pfam00520  143 ---------FAI---------------------------IGY-------------------------------------- 148
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817   318 QYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Cdd:pfam00520  149 QLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFIAVIID 228
                          330
                   ....*....|
gi 373838817   397 QFSETKQRES 406
Cdd:pfam00520  229 NFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1275-1520 2.00e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 156.27  E-value: 2.00e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1275 HKMFDHVVLVIIFLNCITIAMERPKIdPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFgeqAYLRSSWNVLDGLLV 1354
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQ-PEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1355 LISVIDILVSMVSdsgtkILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
Cdd:pfam00520   77 LPSLISLVLSSVG-----SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLF 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1435 KGKFFVCQGEDTRNitnksdcaeasyrwvrhkYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQ---------- 1504
Cdd:pfam00520  152 GGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAyiyfvsfiil 213
                          250       260
                   ....*....|....*....|....
gi 373838817  1505 --------FVGVVVENFHKCRQHQ 1520
Cdd:pfam00520  214 ggflllnlFIAVIIDNFQELTERT 237
PHA03247 super family cl33720
large tegument protein UL36; Provisional
1842-2225 1.62e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 1842 PQPHSPLGspflwPGVEGPDSPDSPKPGALHPAAHARSASHfslehPTMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSY 1921
Cdd:PHA03247 2593 PQSARPRA-----PVDDRGDPRGPAPPSPLPPDTHAPDPPP-----PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS 2662
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 1922 MCRHGSTAEGPLGH----RGWGLPKAQS--GSVLSVHSQPADTsyilQLPKDAPHLLQP------------HSAPTWGTI 1983
Cdd:PHA03247 2663 RPRRARRLGRAAQAssppQRPRRRAARPtvGSLTSLADPPPPP----PTPEPAPHALVSatplppgpaaarQASPALPAA 2738
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 1984 PKLPPPGRSPLAQRPLRRQAAIRTDSldvqGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPP 2063
Cdd:PHA03247 2739 PAPPAVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAP 2814
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 2064 APCPGPEPNWGKGPPETRSSLEldtelswiSGDLLPPGgqeepPSPRDLKKCYSV-EAQSCQRRPTSWLDEQRRHSIAVS 2142
Cdd:PHA03247 2815 AAALPPAASPAGPLPPPTSAQP--------TAPPPPPG-----PPPPSLPLGGSVaPGGDVRRRPPSRSPAAKPAAPARP 2881
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 2143 CLDSGSQPHLgtDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMA 2222
Cdd:PHA03247 2882 PVRRLARPAV--SRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAV 2959

                  ...
gi 373838817 2223 ASP 2225
Cdd:PHA03247 2960 PQP 2962
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-968 6.82e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 223.68  E-value: 6.82e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817   742 SKYFGRGIMIAILVNTLSMGIEYHEQPEE-LTNALEISNIVFTSLFALEMLLKLLVYGPFG-YIKNPYNIFDGVIVVISV 819
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817   820 WEIV---GQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD 896
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 373838817   897 GDtlPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS-WAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Cdd:pfam00520  161 PD--NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1572-1813 5.19e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 180.93  E-value: 5.19e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1572 SHYLDLFITGVIGLNVVTMAMEHYQQPQ-ILDEALKICNYIFTVIFVLESVFKLVAFGF-RRFFQDRWNQLDLAIVLLSI 1649
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1650 MGITLEEIEvnaslpiNPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1729
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1730 lecDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDqestcynTVISPIYFVSFVLTAQFVLVNVVI 1809
Cdd:pfam00520  154 ---KLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------EFWAYIYFVSFIILGGFLLLNLFI 223

                   ....
gi 373838817  1810 AVLM 1813
Cdd:pfam00520  224 AVII 227
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
80-406 2.81e-43

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 158.58  E-value: 2.81e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817    80 NPWFERISMLVILLNCVTLGMFRPCEDiacDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIfgKKCYLGDTWNRLDFFI 159
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP---EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGF--KKRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817   160 VIAGMLEYSLDLQN--VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCffvffifgivgvqLWAGLL 237
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLL-------------LLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817   238 rnrcflpenFSLplsvdleryyqtenedespficsqpreNGMrscrsvptlrgdggggppcgldyeaynsssnttcvnwn 317
Cdd:pfam00520  143 ---------FAI---------------------------IGY-------------------------------------- 148
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817   318 QYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Cdd:pfam00520  149 QLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFIAVIID 228
                          330
                   ....*....|
gi 373838817   397 QFSETKQRES 406
Cdd:pfam00520  229 NFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1275-1520 2.00e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 156.27  E-value: 2.00e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1275 HKMFDHVVLVIIFLNCITIAMERPKIdPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFgeqAYLRSSWNVLDGLLV 1354
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQ-PEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1355 LISVIDILVSMVSdsgtkILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
Cdd:pfam00520   77 LPSLISLVLSSVG-----SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLF 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1435 KGKFFVCQGEDTRNitnksdcaeasyrwvrhkYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQ---------- 1504
Cdd:pfam00520  152 GGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAyiyfvsfiil 213
                          250       260
                   ....*....|....*....|....
gi 373838817  1505 --------FVGVVVENFHKCRQHQ 1520
Cdd:pfam00520  214 ggflllnlFIAVIIDNFQELTERT 237
PHA03247 PHA03247
large tegument protein UL36; Provisional
1842-2225 1.62e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 1842 PQPHSPLGspflwPGVEGPDSPDSPKPGALHPAAHARSASHfslehPTMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSY 1921
Cdd:PHA03247 2593 PQSARPRA-----PVDDRGDPRGPAPPSPLPPDTHAPDPPP-----PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS 2662
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 1922 MCRHGSTAEGPLGH----RGWGLPKAQS--GSVLSVHSQPADTsyilQLPKDAPHLLQP------------HSAPTWGTI 1983
Cdd:PHA03247 2663 RPRRARRLGRAAQAssppQRPRRRAARPtvGSLTSLADPPPPP----PTPEPAPHALVSatplppgpaaarQASPALPAA 2738
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 1984 PKLPPPGRSPLAQRPLRRQAAIRTDSldvqGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPP 2063
Cdd:PHA03247 2739 PAPPAVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAP 2814
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 2064 APCPGPEPNWGKGPPETRSSLEldtelswiSGDLLPPGgqeepPSPRDLKKCYSV-EAQSCQRRPTSWLDEQRRHSIAVS 2142
Cdd:PHA03247 2815 AAALPPAASPAGPLPPPTSAQP--------TAPPPPPG-----PPPPSLPLGGSVaPGGDVRRRPPSRSPAAKPAAPARP 2881
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 2143 CLDSGSQPHLgtDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMA 2222
Cdd:PHA03247 2882 PVRRLARPAV--SRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAV 2959

                  ...
gi 373838817 2223 ASP 2225
Cdd:PHA03247 2960 PQP 2962
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
1842-2242 4.72e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.00  E-value: 4.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1842 PQPHSPLgSPFLWPGVEGPDSPDSPKPGALH----PAAHARSASHFSLEHPT-MQPHP-------TELPGPDLLTVRKSG 1909
Cdd:pfam03154  243 PSPHPPL-QPMTQPPPPSQVSPQPLPQPSLHgqmpPMPHSLQTGPSHMQHPVpPQPFPltpqssqSQVPPGPSPAAPGQS 321
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1910 VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPkaqsgsvlsvHSQPADTSYILQLPKDAPHLLQPH-SAPTWGTIP-KLP 1987
Cdd:pfam03154  322 QQRIHTPPSQSQLQSQQPPREQPLPPAPLSMP----------HIKPPPTTPIPQLPNPQSHKHPPHlSGPSPFQMNsNLP 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1988 PPgrsPlAQRPLrrqaairtdsldvqglgsredllAEVSGPSPPlaraysfwgqsstqaqqhsrshskiSKHmtppapcp 2067
Cdd:pfam03154  392 PP---P-ALKPL-----------------------SSLSTHHPP-------------------------SAH-------- 411
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  2068 gpepnwgkgPPETRssleldtelswisgdlLPPGGQEEPPSPRD---LKKCYSVEAQSCQRRPTSWLdeqrrHSIAvscl 2144
Cdd:pfam03154  412 ---------PPPLQ----------------LMPQSQQLPPPPAQppvLTQSQSLPPPAASHPPTSGL-----HQVP---- 457
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  2145 dsgSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPR---------TPPSPGICLRRRAPsSDSKDPLAS 2215
Cdd:pfam03154  458 ---SQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSssgpvpaavSCPLPPVQIKEEAL-DEAEEPESP 533
                          410       420
                   ....*....|....*....|....*..
gi 373838817  2216 GPPDSmaaSPSPKKDVLSLSGLSSDPA 2242
Cdd:pfam03154  534 PPPPR---SPSPEPTVVNTPSHASQSA 557
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-968 6.82e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 223.68  E-value: 6.82e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817   742 SKYFGRGIMIAILVNTLSMGIEYHEQPEE-LTNALEISNIVFTSLFALEMLLKLLVYGPFG-YIKNPYNIFDGVIVVISV 819
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817   820 WEIV---GQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD 896
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 373838817   897 GDtlPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS-WAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Cdd:pfam00520  161 PD--NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1572-1813 5.19e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 180.93  E-value: 5.19e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1572 SHYLDLFITGVIGLNVVTMAMEHYQQPQ-ILDEALKICNYIFTVIFVLESVFKLVAFGF-RRFFQDRWNQLDLAIVLLSI 1649
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1650 MGITLEEIEvnaslpiNPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1729
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1730 lecDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDqestcynTVISPIYFVSFVLTAQFVLVNVVI 1809
Cdd:pfam00520  154 ---KLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------EFWAYIYFVSFIILGGFLLLNLFI 223

                   ....
gi 373838817  1810 AVLM 1813
Cdd:pfam00520  224 AVII 227
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
80-406 2.81e-43

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 158.58  E-value: 2.81e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817    80 NPWFERISMLVILLNCVTLGMFRPCEDiacDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIfgKKCYLGDTWNRLDFFI 159
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP---EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGF--KKRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817   160 VIAGMLEYSLDLQN--VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCffvffifgivgvqLWAGLL 237
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLL-------------LLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817   238 rnrcflpenFSLplsvdleryyqtenedespficsqpreNGMrscrsvptlrgdggggppcgldyeaynsssnttcvnwn 317
Cdd:pfam00520  143 ---------FAI---------------------------IGY-------------------------------------- 148
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817   318 QYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Cdd:pfam00520  149 QLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFIAVIID 228
                          330
                   ....*....|
gi 373838817   397 QFSETKQRES 406
Cdd:pfam00520  229 NFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1275-1520 2.00e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 156.27  E-value: 2.00e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1275 HKMFDHVVLVIIFLNCITIAMERPKIdPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFgeqAYLRSSWNVLDGLLV 1354
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQ-PEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1355 LISVIDILVSMVSdsgtkILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
Cdd:pfam00520   77 LPSLISLVLSSVG-----SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLF 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1435 KGKFFVCQGEDTRNitnksdcaeasyrwvrhkYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQ---------- 1504
Cdd:pfam00520  152 GGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAyiyfvsfiil 213
                          250       260
                   ....*....|....*....|....
gi 373838817  1505 --------FVGVVVENFHKCRQHQ 1520
Cdd:pfam00520  214 ggflllnlFIAVIIDNFQELTERT 237
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1607-1818 9.89e-08

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 54.98  E-value: 9.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1607 ICNYIFTVIFVLESVFKLVAFGfRRFFQDRWNQLDLAIVLLSIMGITL---EEIEVNA---SLPINP------------- 1667
Cdd:pfam08016   15 IVFVVFFLYFVVEEILKIRKHR-PSYLRSVWNLLDLAIVILSVVLIVLniyRDFLADRlikSVEASPvtfidfdrvaqld 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1668 TIIRIMR----VLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGdlecdeTHpceglgr 1743
Cdd:pfam08016   94 NLYRIILaflvFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG------TQ------- 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 373838817  1744 HATFRNFGMAFLTLFRVSTGD-NWNGIMKDtlrdcdqestcyNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEE 1818
Cdd:pfam08016  161 APNFSNFVKSILTLFRTILGDfGYNEIFSG------------NRVLGPLLFLTFVFLVIFILLNLFLAIINDSYVE 224
PHA03247 PHA03247
large tegument protein UL36; Provisional
1842-2225 1.62e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 1842 PQPHSPLGspflwPGVEGPDSPDSPKPGALHPAAHARSASHfslehPTMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSY 1921
Cdd:PHA03247 2593 PQSARPRA-----PVDDRGDPRGPAPPSPLPPDTHAPDPPP-----PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS 2662
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 1922 MCRHGSTAEGPLGH----RGWGLPKAQS--GSVLSVHSQPADTsyilQLPKDAPHLLQP------------HSAPTWGTI 1983
Cdd:PHA03247 2663 RPRRARRLGRAAQAssppQRPRRRAARPtvGSLTSLADPPPPP----PTPEPAPHALVSatplppgpaaarQASPALPAA 2738
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 1984 PKLPPPGRSPLAQRPLRRQAAIRTDSldvqGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPP 2063
Cdd:PHA03247 2739 PAPPAVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAP 2814
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 2064 APCPGPEPNWGKGPPETRSSLEldtelswiSGDLLPPGgqeepPSPRDLKKCYSV-EAQSCQRRPTSWLDEQRRHSIAVS 2142
Cdd:PHA03247 2815 AAALPPAASPAGPLPPPTSAQP--------TAPPPPPG-----PPPPSLPLGGSVaPGGDVRRRPPSRSPAAKPAAPARP 2881
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 2143 CLDSGSQPHLgtDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMA 2222
Cdd:PHA03247 2882 PVRRLARPAV--SRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAV 2959

                  ...
gi 373838817 2223 ASP 2225
Cdd:PHA03247 2960 PQP 2962
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
1842-2242 4.72e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.00  E-value: 4.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1842 PQPHSPLgSPFLWPGVEGPDSPDSPKPGALH----PAAHARSASHFSLEHPT-MQPHP-------TELPGPDLLTVRKSG 1909
Cdd:pfam03154  243 PSPHPPL-QPMTQPPPPSQVSPQPLPQPSLHgqmpPMPHSLQTGPSHMQHPVpPQPFPltpqssqSQVPPGPSPAAPGQS 321
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1910 VSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPkaqsgsvlsvHSQPADTSYILQLPKDAPHLLQPH-SAPTWGTIP-KLP 1987
Cdd:pfam03154  322 QQRIHTPPSQSQLQSQQPPREQPLPPAPLSMP----------HIKPPPTTPIPQLPNPQSHKHPPHlSGPSPFQMNsNLP 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  1988 PPgrsPlAQRPLrrqaairtdsldvqglgsredllAEVSGPSPPlaraysfwgqsstqaqqhsrshskiSKHmtppapcp 2067
Cdd:pfam03154  392 PP---P-ALKPL-----------------------SSLSTHHPP-------------------------SAH-------- 411
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  2068 gpepnwgkgPPETRssleldtelswisgdlLPPGGQEEPPSPRD---LKKCYSVEAQSCQRRPTSWLdeqrrHSIAvscl 2144
Cdd:pfam03154  412 ---------PPPLQ----------------LMPQSQQLPPPPAQppvLTQSQSLPPPAASHPPTSGL-----HQVP---- 457
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817  2145 dsgSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPR---------TPPSPGICLRRRAPsSDSKDPLAS 2215
Cdd:pfam03154  458 ---SQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSssgpvpaavSCPLPPVQIKEEAL-DEAEEPESP 533
                          410       420
                   ....*....|....*....|....*..
gi 373838817  2216 GPPDSmaaSPSPKKDVLSLSGLSSDPA 2242
Cdd:pfam03154  534 PPPPR---SPSPEPTVVNTPSHASQSA 557
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
1860-2246 4.94e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.01  E-value: 4.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 1860 PDSPDSPKPGALHPAAHARSASHFSLEHPTM---QPHPTELPGPDLLTvRKSGVSRT-------HSLPNDSYMCRHGSTA 1929
Cdd:PHA03307   65 FEPPTGPPPGPGTEAPANESRSTPTWSLSTLapaSPAREGSPTPPGPS-SPDPPPPTpppasppPSPAPDLSEMLRPVGS 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 1930 EGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPtwgtIPKLPPPGRSPLAQRPLRRQAAIRTDS 2009
Cdd:PHA03307  144 PGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAE----PPPSTPPAAASPRPPRRSSPISASASS 219
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 2010 LDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEpnwGKGPPETRSSlelDTE 2089
Cdd:PHA03307  220 PAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSS---RPGPASSSSS---PRE 293
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817 2090 LSwisGDLLP--PGGQEEPPSPRdlkkcySVEAQScqRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGP 2167
Cdd:PHA03307  294 RS---PSPSPssPGSGPAPSSPR------ASSSSS--SSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADP 362
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 373838817 2168 GSRPKKklSPPSitidPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2246
Cdd:PHA03307  363 SSPRKR--PRPS----RAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTP 435
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
838-967 2.60e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 41.49  E-value: 2.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838817   838 LMRVLKLVRFlpalQRQLVVLMKTM----DNVATFCMLLMLFIFIFSILGMHLFGCKFAserdgdtlpdrkNFDSLLWAI 913
Cdd:pfam08016  108 WLKLFKVLRF----NKTMSLFTKTLsrawKDLAGFALMFVIFFFAYAQFGYLLFGTQAP------------NFSNFVKSI 171
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 373838817   914 VTVFQILtqedWNKVLYNGMASTSSW-AALYFIALMTFGNYVLFNLLVAILVEGF 967
Cdd:pfam08016  172 LTLFRTI----LGDFGYNEIFSGNRVlGPLLFLTFVFLVIFILLNLFLAIINDSY 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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