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Conserved domains on  [gi|374253774|ref|NP_001243367|]
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CDK5 and ABL1 enzyme substrate 1 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CABLES1 cd20602
cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called ...
 175-306 3.54e-94

cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES1 contains one cyclin box. The cyclin box is a protein binding domain.


:

Pssm-ID: 410305  Cd Length: 132  Bit Score: 274.61  E-value: 3.54e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253774 175 FKEKFPHIKLTLSKIRSLKREMRKLAQEDCGLEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHE 254
Cdd:cd20602    1 FKEKFPHIKLTLSKIRSLKREMRKLAQEECGYEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 374253774 255 VKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLVQSS 306
Cdd:cd20602   81 VKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLVQNS 132
 
Name Accession Description Interval E-value
CYCLIN_CABLES1 cd20602
cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called ...
 175-306 3.54e-94

cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410305  Cd Length: 132  Bit Score: 274.61  E-value: 3.54e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253774 175 FKEKFPHIKLTLSKIRSLKREMRKLAQEDCGLEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHE 254
Cdd:cd20602    1 FKEKFPHIKLTLSKIRSLKREMRKLAQEECGYEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 374253774 255 VKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLVQSS 306
Cdd:cd20602   81 VKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLVQNS 132
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 180-291 1.79e-03

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 39.33  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253774 180 PHIKLTLSKIRSLKreMRKLAQEDC---GLEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHEVK 256
Cdd:COG5333   34 PELTLEKELNLVIY--YLKLIMDLCtrlNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPRDISIE 111

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 374253774 257 HLI--DKLEEKFRLNRRELIAFEFPVLVALEFALHLP 291
Cdd:COG5333  112 SFEarDLWSEEPKSSRERILEYEFELLEALDFDLHVH 148
 
Name Accession Description Interval E-value
CYCLIN_CABLES1 cd20602
cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called ...
 175-306 3.54e-94

cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410305  Cd Length: 132  Bit Score: 274.61  E-value: 3.54e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253774 175 FKEKFPHIKLTLSKIRSLKREMRKLAQEDCGLEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHE 254
Cdd:cd20602    1 FKEKFPHIKLTLSKIRSLKREMRKLAQEECGYEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 374253774 255 VKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLVQSS 306
Cdd:cd20602   81 VKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLVQNS 132
CYCLIN_CABLES2 cd20603
cyclin box found in CDK5 and ABL1 enzyme substrate 2 (CABLES2); CABLES2, also called ...
 184-304 2.50e-72

cyclin box found in CDK5 and ABL1 enzyme substrate 2 (CABLES2); CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. CABLES2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410306  Cd Length: 121  Bit Score: 218.60  E-value: 2.50e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253774 184 LTLSKIRSLKREMRKLAqEDCGLEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHEVKHLIDKLE 263
Cdd:cd20603    1 LTLSKIRSLKREMRNVA-EECNLEPVTVAMAYVYFEKLVLQGKLNKQNRKLCAGACVLLAAKISSDLKKHEVKHLIDKLE 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 374253774 264 EKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLVQ 304
Cdd:cd20603   80 ERFRLNRRELISFEFTVLVALELALYLPENQVLPHYRRLTQ 120
CYCLIN_CABLES cd20556
cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes ...
 184-302 2.65e-68

cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes CABLES1 and CABLES2. CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. Both, CABLES1 and CABLES2, contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410259  Cd Length: 119  Bit Score: 208.19  E-value: 2.65e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253774 184 LTLSKIRSLKREMRKLAQEDCGLEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHEVKHLIDKLE 263
Cdd:cd20556    1 LTLSKLRSLKREMLKIALKLCGLDVSTVALAYVYFEKLVLKGLVNKSNRKLIAGACLLLAAKFNDDVKKEDLKSLLEEIE 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 374253774 264 EKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRL 302
Cdd:cd20556   81 DVFRLTRKELIAFEFPVLVALEFSLHVPDEEILPHLQRL 119
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 191-277 1.39e-07

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 48.18  E-value: 1.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253774 191 SLKREMRKLAQEdCGLEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIgsdlkkHEVKHLIDKLEEKFRLNR 270
Cdd:cd00043    1 KAVDFIRRLCSK-LGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKL------EELPRTLKEIAKVSGVSE 73


                 ....*..
gi 374253774 271 RELIAFE 277
Cdd:cd00043   74 KELRKAE 80
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 180-291 1.79e-03

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 39.33  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253774 180 PHIKLTLSKIRSLKreMRKLAQEDC---GLEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHEVK 256
Cdd:COG5333   34 PELTLEKELNLVIY--YLKLIMDLCtrlNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPRDISIE 111

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 374253774 257 HLI--DKLEEKFRLNRRELIAFEFPVLVALEFALHLP 291
Cdd:COG5333  112 SFEarDLWSEEPKSSRERILEYEFELLEALDFDLHVH 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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