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Conserved domains on  [gi|374253783|ref|NP_001243371|]
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proline-rich transmembrane protein 2 isoform 2 [Homo sapiens]

Protein Classification

CD225/dispanin family protein( domain architecture ID 10517436)

CD225/dispanin family protein similar to Homo sapiens tumor suppressor candidate 5 (TUSC5), which may be involved in fat metabolism, and synapse differentiation-inducing gene protein 1 (SynDIG1), which may regulate AMPA receptor content at nascent synapses and have a role in postsynaptic development and maturation. CD225 is an interferon-inducible transmembrane protein associated with interferon induced cell growth suppression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD225 pfam04505
Interferon-induced transmembrane protein; This family includes the human leukocyte antigen ...
 264-330 2.83e-28

Interferon-induced transmembrane protein; This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.


:

Pssm-ID: 461336  Cd Length: 68  Bit Score: 105.66  E-value: 2.83e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 374253783  264 KPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIA 330
Cdd:pfam04505   1 PPPDYLVWSIFSTLCCCLPLGIVAIVYSVKVRDRKAAGDYEGAQRASRTAKCLNIIALVLGLVVIIL 67
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 25-216 9.80e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 9.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783   25 PGHSEAETGPPQVLAGVPDQPEAPQPGPNTtAAPVDSGPKAGLAPETTETPA------GASETAQATDLSLSPGGESKAN 98
Cdd:PHA03247 2787 AVASLSESRESLPSPWDPADPPAAVLAPAA-ALPPAASPAGPLPPPTSAQPTapppppGPPPPSLPLGGSVAPGGDVRRR 2865

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783   99 CSPEDPCQE--TVSKPEVSKEATADQGSRLESAAPPEPAPE------PAPQPDPRPDSQPTPKPALQPELPTQEDPTPEI 170
Cdd:PHA03247 2866 PPSRSPAAKpaAPARPPVRRLARPAVSRSTESFALPPDQPErppqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP 2945

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 374253783  171 LSESVGEKQENGAVVPLQAGDGEEG--PAPEPHSPPSKKSPPANGAPP 216
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQPWLGALVPGrvAVPRFRVPQPAPSREAPASST 2993
 
Name Accession Description Interval E-value
CD225 pfam04505
Interferon-induced transmembrane protein; This family includes the human leukocyte antigen ...
 264-330 2.83e-28

Interferon-induced transmembrane protein; This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.


Pssm-ID: 461336  Cd Length: 68  Bit Score: 105.66  E-value: 2.83e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 374253783  264 KPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIA 330
Cdd:pfam04505   1 PPPDYLVWSIFSTLCCCLPLGIVAIVYSVKVRDRKAAGDYEGAQRASRTAKCLNIIALVLGLVVIIL 67
PHA03247 PHA03247
large tegument protein UL36; Provisional
 25-216 9.80e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 9.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783   25 PGHSEAETGPPQVLAGVPDQPEAPQPGPNTtAAPVDSGPKAGLAPETTETPA------GASETAQATDLSLSPGGESKAN 98
Cdd:PHA03247 2787 AVASLSESRESLPSPWDPADPPAAVLAPAA-ALPPAASPAGPLPPPTSAQPTapppppGPPPPSLPLGGSVAPGGDVRRR 2865

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783   99 CSPEDPCQE--TVSKPEVSKEATADQGSRLESAAPPEPAPE------PAPQPDPRPDSQPTPKPALQPELPTQEDPTPEI 170
Cdd:PHA03247 2866 PPSRSPAAKpaAPARPPVRRLARPAVSRSTESFALPPDQPErppqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP 2945

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 374253783  171 LSESVGEKQENGAVVPLQAGDGEEG--PAPEPHSPPSKKSPPANGAPP 216
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQPWLGALVPGrvAVPRFRVPQPAPSREAPASST 2993
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 16-212 2.65e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.90  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783   16 ESPKVPGEGPGHSEAETGPPQVLAGVPDQPEAPqpgpNTTAAPVDSGPKAGLAPETTETPAGASETAQATDLSLSP---G 92
Cdd:pfam05109 423 KAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVP----TNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPrdnG 498

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783   93 GESKAncspedpcQETVSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQ-PTPKPALQPELPTQEDPTPEIL 171
Cdd:pfam05109 499 TESKA--------PDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAvTTPTPNATSPTPAVTTPTPNAT 570

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 374253783  172 SESVGEKQENGAVVPlqagdgeegPAPEPHSPP-SKKSPPAN 212
Cdd:pfam05109 571 IPTLGKTSPTSAVTT---------PTPNATSPTvGETSPQAN 603
 
Name Accession Description Interval E-value
CD225 pfam04505
Interferon-induced transmembrane protein; This family includes the human leukocyte antigen ...
 264-330 2.83e-28

Interferon-induced transmembrane protein; This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.


Pssm-ID: 461336  Cd Length: 68  Bit Score: 105.66  E-value: 2.83e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 374253783  264 KPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIA 330
Cdd:pfam04505   1 PPPDYLVWSIFSTLCCCLPLGIVAIVYSVKVRDRKAAGDYEGAQRASRTAKCLNIIALVLGLVVIIL 67
PHA03247 PHA03247
large tegument protein UL36; Provisional
 25-216 9.80e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 9.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783   25 PGHSEAETGPPQVLAGVPDQPEAPQPGPNTtAAPVDSGPKAGLAPETTETPA------GASETAQATDLSLSPGGESKAN 98
Cdd:PHA03247 2787 AVASLSESRESLPSPWDPADPPAAVLAPAA-ALPPAASPAGPLPPPTSAQPTapppppGPPPPSLPLGGSVAPGGDVRRR 2865

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783   99 CSPEDPCQE--TVSKPEVSKEATADQGSRLESAAPPEPAPE------PAPQPDPRPDSQPTPKPALQPELPTQEDPTPEI 170
Cdd:PHA03247 2866 PPSRSPAAKpaAPARPPVRRLARPAVSRSTESFALPPDQPErppqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP 2945

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 374253783  171 LSESVGEKQENGAVVPLQAGDGEEG--PAPEPHSPPSKKSPPANGAPP 216
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQPWLGALVPGrvAVPRFRVPQPAPSREAPASST 2993
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 29-218 1.49e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783  29 EAETGPPQVLAGVPDQPEAPQPGPNTTAAPvdsgPKAGLAPETTETPAGASETAQatdlslsPGGESKANCSPEDPCQET 108
Cdd:PRK07764 585 EAVVGPAPGAAGGEGPPAPASSGPPEEAAR----PAAPAAPAAPAAPAPAGAAAA-------PAEASAAPAPGVAAPEHH 653

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783 109 VSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQPTPKPALQPELPTQEDPTPEILSESVGEKQENGAVVPLQ 188
Cdd:PRK07764 654 PKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSP 733

                        170       180       190
                 ....*....|....*....|....*....|
gi 374253783 189 AGDGEEGPAPEPHSPPSKKSPPANGAPPRV 218
Cdd:PRK07764 734 AADDPVPLPPEPDDPPDPAGAPAQPPPPPA 763
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 20-216 7.70e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 7.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783  20 VPGEGPGHSEAETGPPQVLAGVPDQPE-APQPGPNTTAAPVDSGPKAGLAPETTETPAGASETAQATDLSLSPGGESKAN 98
Cdd:PRK07764 588 VGPAPGAAGGEGPPAPASSGPPEEAARpAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGD 667

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783  99 CSPEDPCQETVSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQPTPKPALQPELPTQEDPTPEILSESVGEK 178
Cdd:PRK07764 668 GWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDD 747

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 374253783 179 QENGAVVPLQAGDGEEGPAPEPHSPPSKKSPPANGAPP 216
Cdd:PRK07764 748 PPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEM 785
PHA03247 PHA03247
large tegument protein UL36; Provisional
 20-247 1.81e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783   20 VPGEGPGHSEAETGPPQVLAGVPDQPEAPQPG-PNTTAAPVDSGPKAGLA----------PETTETPAGASETAQATDLS 88
Cdd:PHA03247  254 APAPPPVVGEGADRAPETARGATGPPPPPEAAaPNGAAAPPDGVWGAALAgaplalpappDPPPPAPAGDAEEEDDEDGA 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783   89 L---SPGGESKANCS------------PEDPCQETVSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQPTPK 153
Cdd:PHA03247  334 MevvSPLPRPRQHYPlgfpkrrrptwtPPSSLEDLSAGRHHPKRASLPTRKRRSARHAATPFARGPGGDDQTRPAAPVPA 413

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783  154 PAlqpelptqedPTPEILSESVGEKQENGAVVPLQAGDGEEGPAPEPH-SPPSKKSPPANGAPPRVLQQLVEEDRMRRAH 232
Cdd:PHA03247  414 SV----------PTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPErQPPAPATEPAPDDPDDATRKALDALRERRPP 483

                         250
                  ....*....|....*
gi 374253783  233 SGHPGSPRGSLSRHP 247
Cdd:PHA03247  484 EPPGADLAELLGRHP 498
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 16-212 2.65e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.90  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783   16 ESPKVPGEGPGHSEAETGPPQVLAGVPDQPEAPqpgpNTTAAPVDSGPKAGLAPETTETPAGASETAQATDLSLSP---G 92
Cdd:pfam05109 423 KAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVP----TNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPrdnG 498

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783   93 GESKAncspedpcQETVSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQ-PTPKPALQPELPTQEDPTPEIL 171
Cdd:pfam05109 499 TESKA--------PDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAvTTPTPNATSPTPAVTTPTPNAT 570

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 374253783  172 SESVGEKQENGAVVPlqagdgeegPAPEPHSPP-SKKSPPAN 212
Cdd:pfam05109 571 IPTLGKTSPTSAVTT---------PTPNATSPTvGETSPQAN 603
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
25-239 4.63e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.09  E-value: 4.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783  25 PGHSEAETGPPQVLAG-VPDQPEAPQPGPNTTAAPVDSGPKAGLAPEttetPAGASETAQATDLSLSPGGESKANCSPED 103
Cdd:PRK12323 365 PGQSGGGAGPATAAAApVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA----AAAAARAVAAAPARRSPAPEALAAARQAS 440

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783 104 PCQETVSKPEVSKEATADQGSrlESAAPPEPAPEPAPQPDPRPDSQPTPKPALQPELPTQEDPTPEILSESVGEKQENGA 183
Cdd:PRK12323 441 ARGPGGAPAPAPAPAAAPAAA--ARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAP 518

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 374253783 184 VVPLQAGDGEEGPAPEPHSPPSKKSPPANGAPPRVLQQLVEEDRMRRAHSGHPGSP 239
Cdd:PRK12323 519 AGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLP 574
PRK13700 PRK13700
conjugal transfer protein TraD; Provisional
 1-80 6.18e-03

conjugal transfer protein TraD; Provisional


Pssm-ID: 184256 [Multi-domain]  Cd Length: 732  Bit Score: 38.79  E-value: 6.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783   1 MAASSSEISEMKGVEEsPKVPGEGPGHSEAETGPPQvLAGVPDQPEAPQPgPNTTAAPVDSGPKAGLAPettETPAGASE 80
Cdd:PRK13700 589 LAAREAEGRQMASLFE-PDVPEVASGEDVTQAEQPQ-QPQQPQQPQQPQQ-PQQPVSPVINDKKSDAGV---NVPAGGIE 662
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 17-125 6.66e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.81  E-value: 6.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783  17 SPKVPGEGPGHSEAETGPPQVLAGVPDQPEAPQPGPNTTAAPVDSGPKAGLAPETTETPAGASETAQATDLSLSPGGESK 96
Cdd:PRK07764 404 AAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPA 483

                         90       100
                 ....*....|....*....|....*....
gi 374253783  97 ANCSPEDPcqetvSKPEVSKEATADQGSR 125
Cdd:PRK07764 484 PPAAPAPA-----AAPAAPAAPAAPAGAD 507
PHA03247 PHA03247
large tegument protein UL36; Provisional
 3-256 9.26e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.38  E-value: 9.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783    3 ASSSEISEMKGVEESPKVPGEGPGHSEAetgPPQV-------LAGVPDQPEAPQPGPNTTAAPVDSGPKAGLA-PETTET 74
Cdd:PHA03247 2630 SPSPAANEPDPHPPPTVPPPERPRDDPA---PGRVsrprrarRLGRAAQASSPPQRPRRRAARPTVGSLTSLAdPPPPPP 2706

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783   75 PAGASETAQATDLSLSPGGESKANCSPEDPCqeTVSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQP--TP 152
Cdd:PHA03247 2707 TPEPAPHALVSATPLPPGPAAARQASPALPA--APAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPrrLT 2784

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253783  153 KPALQPELPTQED-PTPEILSESVGEKQENGAVVPLQAGDGEEGPAPEPHSPPSKKSPPANGAPPRVLQQLVEE--DRMR 229
Cdd:PHA03247 2785 RPAVASLSESRESlPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggDVRR 2864

                         250       260
                  ....*....|....*....|....*..
gi 374253783  230 RAHSGHPGSPRGSLSRHPSSQLAGPGV 256
Cdd:PHA03247 2865 RPPSRSPAAKPAAPARPPVRRLARPAV 2891
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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