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Conserved domains on  [gi|378786683|ref|NP_001243770|]
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CMRF35-like molecule 8 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SIT super family cl21173
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 86-160 5.36e-08

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


The actual alignment was detected with superfamily member pfam15330:

Pssm-ID: 464650  Cd Length: 114  Bit Score: 48.92  E-value: 5.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378786683   86 LAWRMFQKWIKAGDHSELSQNPKQAATQ---SELHYANLELLMW-----PLQEK-------PAPPREVEVEYSTVAS-PR 149
Cdd:pfam15330  20 LAWRMMKRQKKAAGYSPEQVIPREYYLQpieGDLCYANLTLQQTgtspgSSDEKayeqmssSAQRSQNEVEYVTMAPfPR 99

                          90
                  ....*....|.
gi 378786683  150 EELHYASVVFD 160
Cdd:pfam15330 100 EEISYASLSLD 110
 
Name Accession Description Interval E-value
SIT pfam15330
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 86-160 5.36e-08

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


Pssm-ID: 464650  Cd Length: 114  Bit Score: 48.92  E-value: 5.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378786683   86 LAWRMFQKWIKAGDHSELSQNPKQAATQ---SELHYANLELLMW-----PLQEK-------PAPPREVEVEYSTVAS-PR 149
Cdd:pfam15330  20 LAWRMMKRQKKAAGYSPEQVIPREYYLQpieGDLCYANLTLQQTgtspgSSDEKayeqmssSAQRSQNEVEYVTMAPfPR 99

                          90
                  ....*....|.
gi 378786683  150 EELHYASVVFD 160
Cdd:pfam15330 100 EEISYASLSLD 110
 
Name Accession Description Interval E-value
SIT pfam15330
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 86-160 5.36e-08

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


Pssm-ID: 464650  Cd Length: 114  Bit Score: 48.92  E-value: 5.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378786683   86 LAWRMFQKWIKAGDHSELSQNPKQAATQ---SELHYANLELLMW-----PLQEK-------PAPPREVEVEYSTVAS-PR 149
Cdd:pfam15330  20 LAWRMMKRQKKAAGYSPEQVIPREYYLQpieGDLCYANLTLQQTgtspgSSDEKayeqmssSAQRSQNEVEYVTMAPfPR 99

                          90
                  ....*....|.
gi 378786683  150 EELHYASVVFD 160
Cdd:pfam15330 100 EEISYASLSLD 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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