NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|380714668|ref|NP_001244128|]
View 

glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 2 [Homo sapiens]

Protein Classification

glycerol-3-phosphate dehydrogenase family protein( domain architecture ID 11496765)

glycerol-3-phosphate dehydrogenase family protein is similar to human L-alpha-glycerol-3-phosphate dehydrogenase 1 (GPD1), which catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 5-319 1.68e-174

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


:

Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 486.85  E-value: 1.68e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668    5 KVCIVGSGNWGSAIAKIVGGNAAQLAQ-FDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNV---------- 73
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPElFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLvavpdlveaa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668   74 -------------FIGKICDQLKGHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCE 140
Cdd:TIGR03376  81 kgadilvfviphqFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  141 TTIGCKDPAQ----GQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFA 216
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  217 KLFC-SGPVSsaTFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGPETARELYSILQHKGLVDK 295
Cdd:TIGR03376 241 RMFFpTGEVT--FTFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDE 318

                         330       340
                  ....*....|....*....|....
gi 380714668  296 FPLFMAVYKVCYEGQPVGEFIHCL 319
Cdd:TIGR03376 319 FPLFEAVYQILYEGLPPKKLPECL 342
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 5-319 1.68e-174

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 486.85  E-value: 1.68e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668    5 KVCIVGSGNWGSAIAKIVGGNAAQLAQ-FDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNV---------- 73
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPElFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLvavpdlveaa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668   74 -------------FIGKICDQLKGHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCE 140
Cdd:TIGR03376  81 kgadilvfviphqFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  141 TTIGCKDPAQ----GQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFA 216
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  217 KLFC-SGPVSsaTFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGPETARELYSILQHKGLVDK 295
Cdd:TIGR03376 241 RMFFpTGEVT--FTFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDE 318

                         330       340
                  ....*....|....*....|....
gi 380714668  296 FPLFMAVYKVCYEGQPVGEFIHCL 319
Cdd:TIGR03376 319 FPLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 1-321 1.76e-137

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 394.00  E-value: 1.76e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668   1 MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNV------- 73
Cdd:PTZ00345   9 CGPLKVSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIvavsdlk 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  74 ----------------FIGKICDQLK--GHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVAD 135
Cdd:PTZ00345  89 eavedadllifviphqFLESVLSQIKenNNLKKHARAISLTKGIIVENGKPVLCSDVIEEELGIPCCALSGANVANDVAR 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668 136 EKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAF 215
Cdd:PTZ00345 169 EEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLF 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668 216 AKLFCSGpVSSATFLESCGVADLITTCYGGRNRKVAEAFARTG--KSIEQLEKELLNGQKLQGPETARELYSILQHKGLV 293
Cdd:PTZ00345 249 GKIFFPN-VMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDLK 327

                        330       340
                 ....*....|....*....|....*...
gi 380714668 294 DKFPLFMAVYKVCYEGQPVGEFIHCLQN 321
Cdd:PTZ00345 328 KEFPLFTVTYKIAFEGADPSSLIDVLST 355
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 4-314 9.27e-82

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 250.72  E-value: 9.27e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668   4 KKVCIVGSGNWGSAIAKIVGGNAAQlaqfdprVTMWVFEEDIggkklTEIINTQHENVKYLPGHKLPPNV---------- 73
Cdd:COG0240    1 MKIAVLGAGSWGTALAKVLARNGHE-------VTLWGRDPEV-----AEEINETRENPRYLPGVKLPENLratsdleeal 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  74 -------------FIGKICDQLKGHLKANATGISLIKGVDegPNGLKLISEVIGERLG--IPMSVLMGANIASEVADEKF 138
Cdd:COG0240   69 agadlvllavpsqALREVLEQLAPLLPPGAPVVSATKGIE--PGTGLLMSEVIAEELPgaLRIAVLSGPSFAEEVARGLP 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668 139 CETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKL 218
Cdd:COG0240  147 TAVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVA 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668 219 FCSGPvssATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQLEKELlnGQKLQGPETARELYSILQHKGlVDkF 296
Cdd:COG0240  227 LGARP---ETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYELAEKLG-VE-M 298

                        330
                 ....*....|....*...
gi 380714668 297 PLFMAVYKVCYEGQPVGE 314
Cdd:COG0240  299 PITEAVYAVLYEGKSPRE 316
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 171-316 9.94e-64

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 198.00  E-value: 9.94e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  171 VDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGPvssATFLESCGVADLITTCYGG--RNR 248
Cdd:pfam07479   2 VIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKP---ETFFGLAGLGDLIVTCTSGlsRNR 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 380714668  249 KVAEAFARtGKSIEQLEKELlnGQKLQGPETARELYSILQHKGLvdKFPLFMAVYKVCYEGQPVGEFI 316
Cdd:pfam07479  79 RFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYEGKSPEEAL 141
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 5-319 1.68e-174

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 486.85  E-value: 1.68e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668    5 KVCIVGSGNWGSAIAKIVGGNAAQLAQ-FDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNV---------- 73
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPElFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLvavpdlveaa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668   74 -------------FIGKICDQLKGHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCE 140
Cdd:TIGR03376  81 kgadilvfviphqFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  141 TTIGCKDPAQ----GQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFA 216
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  217 KLFC-SGPVSsaTFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGPETARELYSILQHKGLVDK 295
Cdd:TIGR03376 241 RMFFpTGEVT--FTFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDE 318

                         330       340
                  ....*....|....*....|....
gi 380714668  296 FPLFMAVYKVCYEGQPVGEFIHCL 319
Cdd:TIGR03376 319 FPLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 1-321 1.76e-137

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 394.00  E-value: 1.76e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668   1 MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNV------- 73
Cdd:PTZ00345   9 CGPLKVSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIvavsdlk 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  74 ----------------FIGKICDQLK--GHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVAD 135
Cdd:PTZ00345  89 eavedadllifviphqFLESVLSQIKenNNLKKHARAISLTKGIIVENGKPVLCSDVIEEELGIPCCALSGANVANDVAR 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668 136 EKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAF 215
Cdd:PTZ00345 169 EEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLF 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668 216 AKLFCSGpVSSATFLESCGVADLITTCYGGRNRKVAEAFARTG--KSIEQLEKELLNGQKLQGPETARELYSILQHKGLV 293
Cdd:PTZ00345 249 GKIFFPN-VMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDLK 327

                        330       340
                 ....*....|....*....|....*...
gi 380714668 294 DKFPLFMAVYKVCYEGQPVGEFIHCLQN 321
Cdd:PTZ00345 328 KEFPLFTVTYKIAFEGADPSSLIDVLST 355
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 4-314 9.27e-82

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 250.72  E-value: 9.27e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668   4 KKVCIVGSGNWGSAIAKIVGGNAAQlaqfdprVTMWVFEEDIggkklTEIINTQHENVKYLPGHKLPPNV---------- 73
Cdd:COG0240    1 MKIAVLGAGSWGTALAKVLARNGHE-------VTLWGRDPEV-----AEEINETRENPRYLPGVKLPENLratsdleeal 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  74 -------------FIGKICDQLKGHLKANATGISLIKGVDegPNGLKLISEVIGERLG--IPMSVLMGANIASEVADEKF 138
Cdd:COG0240   69 agadlvllavpsqALREVLEQLAPLLPPGAPVVSATKGIE--PGTGLLMSEVIAEELPgaLRIAVLSGPSFAEEVARGLP 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668 139 CETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKL 218
Cdd:COG0240  147 TAVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVA 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668 219 FCSGPvssATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQLEKELlnGQKLQGPETARELYSILQHKGlVDkF 296
Cdd:COG0240  227 LGARP---ETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYELAEKLG-VE-M 298

                        330
                 ....*....|....*...
gi 380714668 297 PLFMAVYKVCYEGQPVGE 314
Cdd:COG0240  299 PITEAVYAVLYEGKSPRE 316
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
4-319 3.17e-72

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 226.49  E-value: 3.17e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668   4 KKVCIVGSGNWGSAIAKIvggnaaqLAQFDPRVTMWVFEEDIggkklTEIINTQHENVKYLPGHKLPPNV---------- 73
Cdd:PRK00094   2 MKIAVLGAGSWGTALAIV-------LARNGHDVTLWARDPEQ-----AAEINADRENPRYLPGIKLPDNLrattdlaeal 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  74 -------------FIGKICDQLKGHLKANATGISLIKGVDEGPngLKLISEVIGERLG--IPMSVLMGANIASEVADEKF 138
Cdd:PRK00094  70 adadlilvavpsqALREVLKQLKPLLPPDAPIVWATKGIEPGT--GKLLSEVLEEELPdlAPIAVLSGPSFAKEVARGLP 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668 139 CETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKL 218
Cdd:PRK00094 148 TAVVIASTDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVA 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668 219 FCSGPvssATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQLEKELlnGQKLQGPETARELYSILQHKGLvdKF 296
Cdd:PRK00094 228 LGANP---ETFLGLAGLGDLVLTCTSplSRNRRFGLALGQ-GKSLEEALAEI--GMVAEGVRTAKAVYELAKKLGV--EM 299

                        330       340
                 ....*....|....*....|...
gi 380714668 297 PLFMAVYKVCYEGQPVGEFIHCL 319
Cdd:PRK00094 300 PITEAVYAVLYEGKDPREAVEDL 322
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 171-316 9.94e-64

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 198.00  E-value: 9.94e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  171 VDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGPvssATFLESCGVADLITTCYGG--RNR 248
Cdd:pfam07479   2 VIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKP---ETFFGLAGLGDLIVTCTSGlsRNR 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 380714668  249 KVAEAFARtGKSIEQLEKELlnGQKLQGPETARELYSILQHKGLvdKFPLFMAVYKVCYEGQPVGEFI 316
Cdd:pfam07479  79 RFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYEGKSPEEAL 141
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 5-149 3.80e-48

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 158.89  E-value: 3.80e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668    5 KVCIVGSGNWGSAIAKIVGGNAaqlaqfdPRVTMWVFEEDiggkkLTEIINTQHENVKYLPGHKLPPNV----------- 73
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADNG-------HEVRLWGRDEE-----LIEEINTTHENVRYLPGIKLPENLkattdlaealk 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668   74 ------------FIGKICDQLKGHLKANATGISLIKGVDEGpnGLKLISEVIGERLGI--PMSVLMGANIASEVADEKFC 139
Cdd:pfam01210  69 gadiivivvpsqALREVLKQLKGLLKPDAILVSLSKGIEPG--TLKLLSEVIEEELGIqpPIAVLSGPSHAEEVAQGLPT 146

                         170
                  ....*....|
gi 380714668  140 ETTIGCKDPA 149
Cdd:pfam01210 147 ATVIASKDEE 156
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 5-264 8.21e-39

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 140.30  E-value: 8.21e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668   5 KVCIVGSGNWGSAIAKIVGGNAAQLaqfdprvtMWVFEEDIggkklTEIINTQHENVKYLP-GHKLPPN----------- 72
Cdd:PRK12439   9 KVVVLGGGSWGTTVASICARRGPTL--------QWVRSAET-----ADDINDNHRNSRYLGnDVVLSDTlrattdfaeaa 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  73 -----VFIG-------KICDQLKGHLKANATGISLIKGVDEGPNglKLISEVIGERL-GIPMSVLMGANIASEVADEKFC 139
Cdd:PRK12439  76 ncadvVVMGvpshgfrGVLTELAKELRPWVPVVSLVKGLEQGTN--MRMSQIIEEVLpGHPAGILAGPNIAREVAEGYAA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668 140 ETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMiafAKLF 219
Cdd:PRK12439 154 AAVLAMPDQHLATRLSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIARALREM---TKLG 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 380714668 220 CSGPVSSATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQL 264
Cdd:PRK12439 231 VAMGGNPETFAGLAGMGDLIVTCTSqrSRNRHVGEQLGA-GKPIDEI 276
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 2-324 3.09e-38

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 138.47  E-value: 3.09e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668   2 ASKKVCIVGSGNWGSAIAKivggNAAQLAQfdpRVTMWVFEEDiggkkLTEIINTQHENVKYLPGHKLPPNVFI------ 75
Cdd:PRK14618   3 HGMRVAVLGAGAWGTALAV----LAASKGV---PVRLWARRPE-----FAAALAAERENREYLPGVALPAELYPtadpee 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  76 -------------GKICDQLKGHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETT 142
Cdd:PRK14618  71 alagadfavvavpSKALRETLAGLPRALGYVSCAKGLAPDGGRLSELARVLEFLTQARVAVLSGPNHAEEIARFLPAATV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668 143 IGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKlfcSG 222
Cdd:PRK14618 151 VASPEPGLARRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITRGLREMVRFGV---AL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668 223 PVSSATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQLEKEllnGQKLQGPETARELYSILQHKGlVDkFPLFM 300
Cdd:PRK14618 228 GAEEATFYGLSGLGDLIATATSphSRNRAAGEAIVR-GVDREHLEAG---GKVVEGLYTVKALDAWAKAHG-HD-LPIVE 301

                        330       340
                 ....*....|....*....|....*
gi 380714668 301 AVYKVCYEG-QPVGEFIHCLQNHPE 324
Cdd:PRK14618 302 AVARVARGGwDPLAGLRSLMGREAK 326
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 5-316 5.07e-32

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 121.86  E-value: 5.07e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668   5 KVCIVGSGNWGSAIAKIVGGNAAQlaqfdprVTMWVFEEDIggkklTEIINTQHENVKYLPGHKLPPNVFIG-------- 76
Cdd:PRK14620   2 KISILGAGSFGTAIAIALSSKKIS-------VNLWGRNHTT-----FESINTKRKNLKYLPTCHLPDNISVKsaidevls 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  77 ----------------KICDQLKG-HLKANATGISLIKGVDEgpNGLKLISEVIGERL-GIPMSVLMGANIASEVADEKF 138
Cdd:PRK14620  70 dnatciilavptqqlrTICQQLQDcHLKKNTPILICSKGIEK--SSLKFPSEIVNEILpNNPIAILSGPSFAKEIAEKLP 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668 139 CETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAF--A 216
Cdd:PRK14620 148 CSIVLAGQNETLGSSLISKLSNENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVITKGMNEIKTLysA 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668 217 KlfcSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFA-RTGKSIEQLEKEllNGQKLQGPETARELYSILqhKGLVDK 295
Cdd:PRK14620 228 K---NGSIDLNTLIGPSCLGDLILTCTTLHSRNMSFGFKiGNGFNINQILSE--GKSVIEGFSTVKPLISLA--KKLNIE 300

                        330       340
                 ....*....|....*....|.
gi 380714668 296 FPLFMAVYKVCYEGQPVGEFI 316
Cdd:PRK14620 301 LPICESIYNLLYENISLEKTI 321
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-305 1.95e-26

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 106.22  E-value: 1.95e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668   1 MASKKVCIVGSGNWGSAIAKIVGGNaaqlaqfDPRVTMWVFEediGGKKLTEIINTQHENVKYLPGHKLPPnvfigkICD 80
Cdd:PRK14619   2 TQPKTIAILGAGAWGSTLAGLASAN-------GHRVRVWSRR---SGLSLAAVLADADVIVSAVSMKGVRP------VAE 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668  81 QLKG-HLKANATGISLIKGVDegPNGLKLISEVIGERLGI-PMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKELM 158
Cdd:PRK14619  66 QVQAlNLPPETIIVTATKGLD--PETTRTPSQIWQAAFPNhPVVVLSGPNLSKEIQQGLPAATVVASRDLAAAETVQQIF 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380714668 159 QTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGPvssATFLESCGVADL 238
Cdd:PRK14619 144 SSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTRALPEMIRVGTHLGAQT---ETFYGLSGLGDL 220

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 380714668 239 ITTCYG--GRNRKVAEAFARtGKSIEQLEKELlnGQKLQGPETARELYSILQHKGLVdkFPLFMAVYKV 305
Cdd:PRK14619 221 LATCTSplSRNYQVGYGLAQ-GKSLEQILAEL--EGTAEGVNTANVLVQLAQQQNIA--VPITEQVYRL 284
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 233-302 1.10e-06

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 45.18  E-value: 1.10e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 380714668  233 CGVADLITTCYGG--RNRKVAEAFARtGKSIEqlekELLNGQKLQGPETARELYSILQHKGLVDkFPLFMAV 302
Cdd:pfam20618   1 AGLGDLVLTCTSDlsRNRTFGLLLGK-GMTLA----EAGNGQVAEGVRTAKAVAAILARAHNVE-MPILEAV 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH