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Conserved domains on  [gi|383792172|ref|NP_001244308|]
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SEC14-like protein 3 isoform 3 [Homo sapiens]

Protein Classification

SEC14 family lipid-binding protein( domain architecture ID 11271205)

SEC14 family lipid-binding protein contains a lipid-binding domain that is found in secretory proteins and in lipid regulated proteins; similar to Saccharomyces cerevisiae phosphatidylinositol transfer protein SFH5, a non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity

Gene Ontology:  GO:1902936|GO:0008289
PubMed:  12767229|17428729
SCOP:  4003560

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
17-186 2.28e-45

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


:

Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 152.07  E-value: 2.28e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383792172    17 PPEVIQKYMPGGLcGYDRDGCPVWYDIIGPLDPKgllfSVTKQDLLKTKMRDCERILHEcdlqtERLGKKIETIVMIFDC 96
Cdd:smart00516   1 ELELLKAYIPGGR-GYDKDGRPVLIERAGRFDLK----SVTLEELLRYLVYVLEKILQE-----EKKTGGIEGFTVIFDL 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383792172    97 EGLGLKHfwkPLVEVYQEFFGLLEENYPETLKFMLIVKATKLFPVGYNLMKPFLSEDTRRKIIVLGNNWKEGLLKLISPE 176
Cdd:smart00516  71 KGLSMSN---PDLSVLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDSKEELLEYIDKE 147
                          170
                   ....*....|
gi 383792172   177 ELPAQFGGTL 186
Cdd:smart00516 148 QLPEELGGTL 157
 
Name Accession Description Interval E-value
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
17-186 2.28e-45

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 152.07  E-value: 2.28e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383792172    17 PPEVIQKYMPGGLcGYDRDGCPVWYDIIGPLDPKgllfSVTKQDLLKTKMRDCERILHEcdlqtERLGKKIETIVMIFDC 96
Cdd:smart00516   1 ELELLKAYIPGGR-GYDKDGRPVLIERAGRFDLK----SVTLEELLRYLVYVLEKILQE-----EKKTGGIEGFTVIFDL 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383792172    97 EGLGLKHfwkPLVEVYQEFFGLLEENYPETLKFMLIVKATKLFPVGYNLMKPFLSEDTRRKIIVLGNNWKEGLLKLISPE 176
Cdd:smart00516  71 KGLSMSN---PDLSVLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDSKEELLEYIDKE 147
                          170
                   ....*....|
gi 383792172   177 ELPAQFGGTL 186
Cdd:smart00516 148 QLPEELGGTL 157
CRAL_TRIO pfam00650
CRAL/TRIO domain;
26-184 1.56e-35

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 126.22  E-value: 1.56e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383792172   26 PGGLCGYDRDGCPVWYDIIGPLDPKgllfSVTKQDLLKTKMRDCERILHECDlqterlGKKIETIVMIFDCEGLGLKHFW 105
Cdd:pfam00650   3 KVYLHGRDKEGRPVLYLRLGRHDPK----KSSEEELVRFLVLVLERALLLMP------EGQVEGLTVIIDLKGLSLSNMD 72
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 383792172  106 KPLVEVYQEFFGLLEENYPETLKFMLIVKATKLFPVGYNLMKPFLSEDTRRKIIVLGNNWKEGLLKLISPEELPAQFGG 184
Cdd:pfam00650  73 WWSISLLKKIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKNSNEEELEKYIPPEQLPKEYGG 151
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
18-185 2.79e-35

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 125.91  E-value: 2.79e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383792172  18 PEVIQKYM--PGGLCGYDRDGCPVWYDIIGPLDPKgllfSVTKQDLLKTKMRDCERILHECDLQTERlgkkietIVMIFD 95
Cdd:cd00170    1 LEELLELLggIGYLGGRDKEGRPVLVFRAGWDPPK----LLDLEELLRYLVYLLEKALRELEEQVEG-------FVVIID 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383792172  96 CEGLGLKHFWKPlvEVYQEFFGLLEENYPETLKFMLIVKATKLFPVGYNLMKPFLSEDTRRKIIVLGNNWKEgLLKLISP 175
Cdd:cd00170   70 LKGFSLSNLSDL--SLLKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLEE-LLEYIDP 146
                        170
                 ....*....|
gi 383792172 176 EELPAQFGGT 185
Cdd:cd00170  147 DQLPKELGGT 156
 
Name Accession Description Interval E-value
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
17-186 2.28e-45

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 152.07  E-value: 2.28e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383792172    17 PPEVIQKYMPGGLcGYDRDGCPVWYDIIGPLDPKgllfSVTKQDLLKTKMRDCERILHEcdlqtERLGKKIETIVMIFDC 96
Cdd:smart00516   1 ELELLKAYIPGGR-GYDKDGRPVLIERAGRFDLK----SVTLEELLRYLVYVLEKILQE-----EKKTGGIEGFTVIFDL 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383792172    97 EGLGLKHfwkPLVEVYQEFFGLLEENYPETLKFMLIVKATKLFPVGYNLMKPFLSEDTRRKIIVLGNNWKEGLLKLISPE 176
Cdd:smart00516  71 KGLSMSN---PDLSVLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDSKEELLEYIDKE 147
                          170
                   ....*....|
gi 383792172   177 ELPAQFGGTL 186
Cdd:smart00516 148 QLPEELGGTL 157
CRAL_TRIO pfam00650
CRAL/TRIO domain;
26-184 1.56e-35

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 126.22  E-value: 1.56e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383792172   26 PGGLCGYDRDGCPVWYDIIGPLDPKgllfSVTKQDLLKTKMRDCERILHECDlqterlGKKIETIVMIFDCEGLGLKHFW 105
Cdd:pfam00650   3 KVYLHGRDKEGRPVLYLRLGRHDPK----KSSEEELVRFLVLVLERALLLMP------EGQVEGLTVIIDLKGLSLSNMD 72
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 383792172  106 KPLVEVYQEFFGLLEENYPETLKFMLIVKATKLFPVGYNLMKPFLSEDTRRKIIVLGNNWKEGLLKLISPEELPAQFGG 184
Cdd:pfam00650  73 WWSISLLKKIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKNSNEEELEKYIPPEQLPKEYGG 151
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
18-185 2.79e-35

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 125.91  E-value: 2.79e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383792172  18 PEVIQKYM--PGGLCGYDRDGCPVWYDIIGPLDPKgllfSVTKQDLLKTKMRDCERILHECDLQTERlgkkietIVMIFD 95
Cdd:cd00170    1 LEELLELLggIGYLGGRDKEGRPVLVFRAGWDPPK----LLDLEELLRYLVYLLEKALRELEEQVEG-------FVVIID 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383792172  96 CEGLGLKHFWKPlvEVYQEFFGLLEENYPETLKFMLIVKATKLFPVGYNLMKPFLSEDTRRKIIVLGNNWKEgLLKLISP 175
Cdd:cd00170   70 LKGFSLSNLSDL--SLLKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLEE-LLEYIDP 146
                        170
                 ....*....|
gi 383792172 176 EELPAQFGGT 185
Cdd:cd00170  147 DQLPKELGGT 156
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
90-186 8.35e-05

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 41.93  E-value: 8.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383792172   90 IVMIFDCEGLGLKHFwkPLVEVYQEFFGLLEENYPETLKFMLIVKAT----KLFPVgynLMKPFLSEDTRRKIIVLGNnw 165
Cdd:pfam13716  42 FVVVVDHTGVTSENF--PSLSFLKKAYDLLPRAFKKNLKAVYVVHPStflrTFLKT---LGSLLGSKKLRKKVHYVSS-- 114
                          90       100
                  ....*....|....*....|.
gi 383792172  166 KEGLLKLISPEELPAQFGGTL 186
Cdd:pfam13716 115 LSELWEGIDREQLPTELPGVL 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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