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Conserved domains on  [gi|384081577|ref|NP_001244893|]
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biorientation of chromosomes in cell division protein 1-like 2 [Homo sapiens]

Protein Classification

BOD1/SHG1 domain-containing protein( domain architecture ID 10525142)

BOD1/SHG1 domain-containing protein similar to biorientation of chromosomes in cell division 1 (BOD1) which corrects aberrant syntelic attachments in mitotic spindles and is required for proper chromosome biorientation, and to yeast Shg1p which is a component of the COMPASS (complex proteins associated with Set1p) complex which methylates lysine 4 on histone H3 and controls the silencing of telomeric regions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COMPASS-Shg1 pfam05205
COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of ...
 42-135 2.04e-27

COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.


:

Pssm-ID: 461586 [Multi-domain]  Cd Length: 100  Bit Score: 98.81  E-value: 2.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384081577   42 IVGQLKSRGLFDSFRRDCKADVDTKPAYQNLSQKADNFVSTHLDKQEwNPPAND-NQLHDGLRQSVVQSG---RSEAGVD 117
Cdd:pfam05205   2 LVHEFKKKGGFDKLRKDILADFDTSDAYQNLLQRLEEIVESEVERDP-SLLSKNrGKAAALIEGAIDRSDvykKAEAGVD 80

                          90       100
                  ....*....|....*....|
gi 384081577  118 RISSQVV--DPKLNHIFRPQ 135
Cdd:pfam05205  81 RLIDQVLdiEPKIREIRRPE 100
 
Name Accession Description Interval E-value
COMPASS-Shg1 pfam05205
COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of ...
 42-135 2.04e-27

COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.


Pssm-ID: 461586 [Multi-domain]  Cd Length: 100  Bit Score: 98.81  E-value: 2.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384081577   42 IVGQLKSRGLFDSFRRDCKADVDTKPAYQNLSQKADNFVSTHLDKQEwNPPAND-NQLHDGLRQSVVQSG---RSEAGVD 117
Cdd:pfam05205   2 LVHEFKKKGGFDKLRKDILADFDTSDAYQNLLQRLEEIVESEVERDP-SLLSKNrGKAAALIEGAIDRSDvykKAEAGVD 80

                          90       100
                  ....*....|....*....|
gi 384081577  118 RISSQVV--DPKLNHIFRPQ 135
Cdd:pfam05205  81 RLIDQVLdiEPKIREIRRPE 100
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
 99-165 8.35e-03

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 36.00  E-value: 8.35e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 384081577  99 HDG--LRQSVVqsgRSEAGVDRISSQvvdpkLNHIFRPQIEQIIHEFLVAQKEAAVPALPPEPEGQDPP 165
Cdd:cd13395  172 HDGyvLQKAIV---RSPLGGDFLTDQ-----LLKLLESKNIEIIPRYMIKSKEPVEGGAPAKYTKKDLP 232
 
Name Accession Description Interval E-value
COMPASS-Shg1 pfam05205
COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of ...
 42-135 2.04e-27

COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.


Pssm-ID: 461586 [Multi-domain]  Cd Length: 100  Bit Score: 98.81  E-value: 2.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384081577   42 IVGQLKSRGLFDSFRRDCKADVDTKPAYQNLSQKADNFVSTHLDKQEwNPPAND-NQLHDGLRQSVVQSG---RSEAGVD 117
Cdd:pfam05205   2 LVHEFKKKGGFDKLRKDILADFDTSDAYQNLLQRLEEIVESEVERDP-SLLSKNrGKAAALIEGAIDRSDvykKAEAGVD 80

                          90       100
                  ....*....|....*....|
gi 384081577  118 RISSQVV--DPKLNHIFRPQ 135
Cdd:pfam05205  81 RLIDQVLdiEPKIREIRRPE 100
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
 99-165 8.35e-03

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 36.00  E-value: 8.35e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 384081577  99 HDG--LRQSVVqsgRSEAGVDRISSQvvdpkLNHIFRPQIEQIIHEFLVAQKEAAVPALPPEPEGQDPP 165
Cdd:cd13395  172 HDGyvLQKAIV---RSPLGGDFLTDQ-----LLKLLESKNIEIIPRYMIKSKEPVEGGAPAKYTKKDLP 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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