|
Name |
Accession |
Description |
Interval |
E-value |
| mito_nad_idh |
TIGR00175 |
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ... |
47-358 |
7.80e-169 |
|
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]
Pssm-ID: 272942 Cd Length: 333 Bit Score: 474.56 E-value: 7.80e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEkLEQVLSSMKENKVAIIGKIHTPMEyKGELA 126
Cdd:TIGR00175 2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKTEI-PDEAVESIKRNKVALKGPLETPIG-KGGHR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 127 SYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYAT 206
Cdd:TIGR00175 80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 207 KKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 286
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 385648280 287 GAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKI 358
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKN 311
|
|
| PLN00123 |
PLN00123 |
isocitrate dehydrogenase (NAD+) |
50-357 |
1.55e-121 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215065 Cd Length: 360 Bit Score: 355.33 E-value: 1.55e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 50 PVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHhlsEVQNmASEEKLEQVLSSMKENKVAIIGKIHTPMeyKGELASYD 129
Cdd:PLN00123 32 AVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERY---EVHG-DMKKVPEEVLESIRRNKVCLKGGLATPV--GGGVSSLN 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 130 MRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKG 209
Cdd:PLN00123 106 VQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNN 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 210 RGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAG 289
Cdd:PLN00123 186 RKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTG 265
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 385648280 290 VVPGESYSAEYAVFETGARH---PFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGK 357
Cdd:PLN00123 266 VMPGGNVGADHAVFEQGASAgnvGNEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGK 336
|
|
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
48-356 |
8.85e-100 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 299.23 E-value: 8.85e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 48 SFPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFQEH-----HLSEVQNMASEEkleqVLSSMKENKVAIIGKIHTP 118
Cdd:COG0473 1 TYKIAVLPGDGIGPEVVAAALKVLEAAAerfgLDFEFEEAdiggaAYDKTGTPLPDE----TLEALRKADAILLGAVGGP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 119 -MEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRH-----NNLDLVIIREQTEGEYSSLEHESARG----VIECLKI 188
Cdd:COG0473 77 kWDDGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 189 VTRAKSQRIAKFAFDYAtKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLV 268
Cdd:COG0473 157 YTRKGIERIARYAFELA-RKRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 269 MPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY-AVFEtgARH---PfaQAVGRNIANPTAMLLSASNMLRHLNLEYHSSM 344
Cdd:COG0473 236 TENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFE--PVHgsaP--DIAGKGIANPIATILSAAMMLRHLGEEEAADA 311
|
330
....*....|..
gi 385648280 345 IADAVKKVIKVG 356
Cdd:COG0473 312 IEAAVEKVLAEG 323
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
51-357 |
3.88e-87 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 267.24 E-value: 3.88e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 51 VTMLPGDGVGPELMHAVKEVFKAAAVPV----EFQEHHLSEVQNMASEEKL-EQVLSSMKENKVAIIGKIHTPMEYKGEL 125
Cdd:pfam00180 2 IAVLPGDGIGPEVMAAALKVLKAALEKAplefEFEERDVGGAAIDETGEPLpDETLEACKKADAVLLGAVGGPKWDPAGV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 126 ASYD--MRLRRKLDLFANVVHVKSLPG------YMTRHNNLDLVIIREQTEGEYSSLEHE---SARGVIECLKIVTRAKS 194
Cdd:pfam00180 82 RPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGikgSGNEVAVDTKLYSRDEI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 195 QRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYG 274
Cdd:pfam00180 162 ERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 275 NIIDNLAAGLVGGAGVVPGESYSA-EYAVFEtgARHPFAQAV-GRNIANPTAMLLSASNMLRH-LNLEYHSSMIADAVKK 351
Cdd:pfam00180 242 DILSDEASMLTGSLGLLPSASLGAnGFGIFE--PVHGSAPDIaGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLK 319
|
....*.
gi 385648280 352 VIKVGK 357
Cdd:pfam00180 320 VLESGI 325
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| mito_nad_idh |
TIGR00175 |
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ... |
47-358 |
7.80e-169 |
|
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]
Pssm-ID: 272942 Cd Length: 333 Bit Score: 474.56 E-value: 7.80e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEkLEQVLSSMKENKVAIIGKIHTPMEyKGELA 126
Cdd:TIGR00175 2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKTEI-PDEAVESIKRNKVALKGPLETPIG-KGGHR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 127 SYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYAT 206
Cdd:TIGR00175 80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 207 KKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 286
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 385648280 287 GAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKI 358
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKN 311
|
|
| PLN00123 |
PLN00123 |
isocitrate dehydrogenase (NAD+) |
50-357 |
1.55e-121 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215065 Cd Length: 360 Bit Score: 355.33 E-value: 1.55e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 50 PVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHhlsEVQNmASEEKLEQVLSSMKENKVAIIGKIHTPMeyKGELASYD 129
Cdd:PLN00123 32 AVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERY---EVHG-DMKKVPEEVLESIRRNKVCLKGGLATPV--GGGVSSLN 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 130 MRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKG 209
Cdd:PLN00123 106 VQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNN 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 210 RGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAG 289
Cdd:PLN00123 186 RKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTG 265
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 385648280 290 VVPGESYSAEYAVFETGARH---PFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGK 357
Cdd:PLN00123 266 VMPGGNVGADHAVFEQGASAgnvGNEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGK 336
|
|
| PLN00118 |
PLN00118 |
isocitrate dehydrogenase (NAD+) |
47-361 |
1.57e-116 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215062 Cd Length: 372 Bit Score: 343.01 E-value: 1.57e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSE-----VQNMASEEKLEqvlsSMKENKVAIIGKIHTPMEy 121
Cdd:PLN00118 40 TPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVGTtvdprTGSFLTWESLE----SVRRNKVGLKGPMATPIG- 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 122 KGElASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFA 201
Cdd:PLN00118 115 KGH-RSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGEYSGLEHQVVRGVVESLKIITRQASLRVAEYA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 202 FDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLA 281
Cdd:PLN00118 194 FHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLC 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 282 AGLVGGAGVVP-GESYSAEYAVFEtgARHPFAQAV-GRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKIP 359
Cdd:PLN00118 274 AGLIGGLGLTPsCNIGENGLALAE--AVHGSAPDIaGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNAILNTIAEGKYR 351
|
..
gi 385648280 360 SA 361
Cdd:PLN00118 352 TA 353
|
|
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
48-356 |
8.85e-100 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 299.23 E-value: 8.85e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 48 SFPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFQEH-----HLSEVQNMASEEkleqVLSSMKENKVAIIGKIHTP 118
Cdd:COG0473 1 TYKIAVLPGDGIGPEVVAAALKVLEAAAerfgLDFEFEEAdiggaAYDKTGTPLPDE----TLEALRKADAILLGAVGGP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 119 -MEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRH-----NNLDLVIIREQTEGEYSSLEHESARG----VIECLKI 188
Cdd:COG0473 77 kWDDGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 189 VTRAKSQRIAKFAFDYAtKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLV 268
Cdd:COG0473 157 YTRKGIERIARYAFELA-RKRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 269 MPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY-AVFEtgARH---PfaQAVGRNIANPTAMLLSASNMLRHLNLEYHSSM 344
Cdd:COG0473 236 TENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFE--PVHgsaP--DIAGKGIANPIATILSAAMMLRHLGEEEAADA 311
|
330
....*....|..
gi 385648280 345 IADAVKKVIKVG 356
Cdd:COG0473 312 IEAAVEKVLAEG 323
|
|
| PRK08997 |
PRK08997 |
isocitrate dehydrogenase; Provisional |
51-356 |
9.69e-95 |
|
isocitrate dehydrogenase; Provisional
Pssm-ID: 181606 Cd Length: 334 Bit Score: 286.23 E-value: 9.69e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFQehhLSEVQNMASEEKLE----QVLSSMKENKVAIIGKIHTPMeykGE-L 125
Cdd:PRK08997 5 ITVIPGDGIGPSIIDATLKILDKLGCDFEYE---FADAGLTALEKHGEllpqRTLDLIEKNKIALKGPLTTPV---GEgF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 126 ASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHE-SARG-VIECLKIVTRAKSQRIAKFAFD 203
Cdd:PRK08997 79 TSINVTLRKKFDLYANVRPVLSFPGTKARYDNIDIITVRENTEGMYSGEGQTvSEDGeTAEATSIITRKGAERIVRFAYE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 204 YATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAG 283
Cdd:PRK08997 159 LARKEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAG 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 385648280 284 LVGGAGVVPGESYSAEYAVFEtgARHPFAQAV-GRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVG 356
Cdd:PRK08997 239 LVGGLGMAPGANIGRDAAIFE--AVHGSAPDIaGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAG 310
|
|
| PRK09222 |
PRK09222 |
NADP-dependent isocitrate dehydrogenase; |
47-356 |
1.60e-87 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236416 [Multi-domain] Cd Length: 482 Bit Score: 272.53 E-value: 1.60e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVE----------FQEHHLSEVqnmaSEEKLEqvlsSMKENKVAIIGKIH 116
Cdd:PRK09222 3 EKTPITVAYGDGIGPEIMEAVLKILEAAGAPLEietieigekvYKKGWTSGI----SPSAWE----SIRRTKVLLKAPIT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 117 TPME--YKgelaSYDMRLRRKLDLFANVVHVKSL-PGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAK 193
Cdd:PRK09222 75 TPQGggYK----SLNVTLRKTLGLYANVRPCVSYhPFVETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLISRPG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 194 SQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLY 273
Cdd:PRK09222 151 SEKIIRYAFEYARANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLY 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 274 GNIIDNLAAGLVGGAGVVPGESYSAEYAVFEtgARHPFAQAV-GRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKV 352
Cdd:PRK09222 231 GDILSDIAAEISGSVGLAGSANIGEEYAMFE--AVHGSAPDIaGKNIANPSGLLNAAVMMLVHIGQFDIAELIENAWLKT 308
|
....
gi 385648280 353 IKVG 356
Cdd:PRK09222 309 LEDG 312
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
51-357 |
3.88e-87 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 267.24 E-value: 3.88e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 51 VTMLPGDGVGPELMHAVKEVFKAAAVPV----EFQEHHLSEVQNMASEEKL-EQVLSSMKENKVAIIGKIHTPMEYKGEL 125
Cdd:pfam00180 2 IAVLPGDGIGPEVMAAALKVLKAALEKAplefEFEERDVGGAAIDETGEPLpDETLEACKKADAVLLGAVGGPKWDPAGV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 126 ASYD--MRLRRKLDLFANVVHVKSLPG------YMTRHNNLDLVIIREQTEGEYSSLEHE---SARGVIECLKIVTRAKS 194
Cdd:pfam00180 82 RPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGikgSGNEVAVDTKLYSRDEI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 195 QRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYG 274
Cdd:pfam00180 162 ERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 275 NIIDNLAAGLVGGAGVVPGESYSA-EYAVFEtgARHPFAQAV-GRNIANPTAMLLSASNMLRH-LNLEYHSSMIADAVKK 351
Cdd:pfam00180 242 DILSDEASMLTGSLGLLPSASLGAnGFGIFE--PVHGSAPDIaGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLK 319
|
....*.
gi 385648280 352 VIKVGK 357
Cdd:pfam00180 320 VLESGI 325
|
|
| PRK14025 |
PRK14025 |
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional |
51-357 |
5.12e-80 |
|
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
Pssm-ID: 184462 Cd Length: 330 Bit Score: 248.51 E-value: 5.12e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFqehhlseVQNMASEEKLEQVLSSMKENKVAIIGKIH-TPMEYKGELA-SY 128
Cdd:PRK14025 4 ICVIEGDGIGKEVVPAALHVLEATGLPFEF-------VYAEAGDEVFEKTGKALPEETIEAAKEADaVLFGAAGETAaDV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 129 DMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKK 208
Cdd:PRK14025 77 IVKLRRILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASERIFRFAFEMAKRR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 209 ----GRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGL 284
Cdd:PRK14025 157 kkmgKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGL 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 385648280 285 VGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGK 357
Cdd:PRK14025 237 VGGLGLAPSANIGDKYGLFE--PVHGSApDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGL 308
|
|
| PRK00772 |
PRK00772 |
3-isopropylmalate dehydrogenase; Provisional |
51-356 |
1.04e-55 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 234832 Cd Length: 358 Bit Score: 186.46 E-value: 1.04e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 51 VTMLPGDGVGPELMHAVKEVFKAAA----VPVEFQEHHLS-----EVQNMASEEKLEQVLSSMkenkvAII-GKIHTPme 120
Cdd:PRK00772 5 IAVLPGDGIGPEVMAEAVKVLDAVAekfgFDFEFEEALVGgaaidAHGVPLPEETLEACRAAD-----AVLlGAVGGP-- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 121 yKGELASYDMR-------LRRKLDLFANVVHVKSLPGYMT-------RHNNLDLVIIREQTEGEYS------SLEHESAR 180
Cdd:PRK00772 78 -KWDNLPPDVRpergllaLRKELGLFANLRPAKLYPGLADasplkpeIVAGLDILIVRELTGGIYFgeprgrEGLGGEER 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 181 GVIEClkIVTRAKSQRIAKFAFDYAtKKGRGKVTAVHKANIMKlGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQN 260
Cdd:PRK00772 157 AFDTM--VYTREEIERIARVAFELA-RKRRKKVTSVDKANVLE-SSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 261 PYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAE-YAVFETGarHPFA-QAVGRNIANPTAMLLSASNMLRH-LN 337
Cdd:PRK00772 233 PKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESgPGLYEPI--HGSApDIAGKGIANPIATILSAAMMLRYsLG 310
|
330
....*....|....*....
gi 385648280 338 LEYHSSMIADAVKKVIKVG 356
Cdd:PRK00772 311 LEEAADAIEAAVEKVLAQG 329
|
|
| leuB |
TIGR00169 |
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ... |
51-359 |
3.43e-49 |
|
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 272939 Cd Length: 346 Bit Score: 169.12 E-value: 3.43e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 51 VTMLPGDGVGPELMHAVKEVFKAAA----VPVEFQEHHLSEVQNMASEEKL-EQVLSSMKENKVAIIGKI------HTPM 119
Cdd:TIGR00169 2 IAVLPGDGIGPEVMAQALKVLKAVAerfgLKFEFEEHLIGGAAIDATGQPLpEETLKGCKEADAVLLGAVggpkwdNLPR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 120 EYKGELASydMRLRRKLDLFANVVHVKSLPGYMTRH-------NNLDLVIIREQTEGEY--SSLEHESARGVIECLKiVT 190
Cdd:TIGR00169 82 DQRPEQGL--LKLRKSLDLFANLRPAKVFPGLEDLSplkeeiaKGVDFVVVRELTGGIYfgEPKGREGEGEAWDTEV-YT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 191 RAKSQRIAKFAFDYATKKgRGKVTAVHKANIMKLGDgLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMP 270
Cdd:TIGR00169 159 VPEIERIARVAFEMARKR-RKKVTSVDKANVLESSR-LWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 271 NLYGNIIDNLAAGLVGGAGVVPGESYSAE-YAVFE-TGARHPfaQAVGRNIANPTAMLLSASNMLRH-LNLEYHSSMIAD 347
Cdd:TIGR00169 237 NLFGDILSDEASVITGSLGMLPSASLGSDgFGLFEpVHGSAP--DIAGKGIANPIAQILSAAMLLRYsFNLEEAADAIEA 314
|
330
....*....|..
gi 385648280 348 AVKKVIKVGKIP 359
Cdd:TIGR00169 315 AVKKVLAEGYRT 326
|
|
| PRK03437 |
PRK03437 |
3-isopropylmalate dehydrogenase; Provisional |
53-353 |
5.88e-44 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 179579 Cd Length: 344 Bit Score: 155.08 E-value: 5.88e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 53 MLPGDGVGPELMH-AVKeVFKAAA---VPVEFQEHHLSEVQNMASEEKL-EQVLSSMKENKVAIIGKIHTP------MEy 121
Cdd:PRK03437 9 VIPGDGIGPEVVAeALK-VLDAVAaggPGVETTEYDLGARRYLRTGETLpDSVLAELRQHDAILLGAIGDPsvpsgvLE- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 122 KGELasydMRLRRKLDLFANVVHVKSLPGYMTRHNN---LDLVIIREQTEGEYSS--------LEHESARGVieclKIVT 190
Cdd:PRK03437 87 RGLL----LKLRFALDHYVNLRPSKLYPGVTSPLAGpgdIDFVVVREGTEGPYTGnggalrvgTPHEVATEV----SVNT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 191 RAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMP 270
Cdd:PRK03437 159 AFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVIVTD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 271 NLYGNIIDNLAAGLVGGAGVVPGESYSAEYA---VFE-TGARHPfaQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIA 346
Cdd:PRK03437 239 NLFGDIITDLAAAVTGGIGLAASGNINPTGTnpsMFEpVHGSAP--DIAGQGIADPTAAILSVALLLDHLGEEDAAARIE 316
|
....*..
gi 385648280 347 DAVKKVI 353
Cdd:PRK03437 317 AAVEADL 323
|
|
| PRK06451 |
PRK06451 |
NADP-dependent isocitrate dehydrogenase; |
56-366 |
7.86e-40 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 235803 Cd Length: 412 Bit Score: 145.74 E-value: 7.86e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 56 GDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASE--EKL------EQVLSSMKENKVAIIGKIHTPMEyKGeLAS 127
Cdd:PRK06451 31 GDGIGPEITHAAMKVINKAVEKAYGSDREIKWVEVLAGDkaEKLtgnrfpKESEELIEKYRVLLKGPLETPIG-KG-WKS 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 128 YDMRLRRKLDLFANVVHVKSLPGY---MTRHNNLDLVIIREQTEGEYSSLEH----ESARGVIECL-------------- 186
Cdd:PRK06451 109 INVAIRLMLDLYANIRPVKYIPGIespLKNPEKIDLIIFRENTDDLYRGIEYpydsEEAKKIRDFLrkelgveveddtgi 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 187 --KIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCC---------------EEVAELYP------KI 243
Cdd:PRK06451 189 giKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAyevalkefrdyvvteEEVTKNYNgvppsgKV 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 244 KFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGRNIANP 322
Cdd:PRK06451 269 IINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFE--AIHGTApKYAGKNVANP 346
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 385648280 323 TAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKIPSAVPSFL 366
Cdd:PRK06451 347 TGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKKVTQDLARFM 390
|
|
| PRK08194 |
PRK08194 |
tartrate dehydrogenase; Provisional |
49-356 |
1.28e-37 |
|
tartrate dehydrogenase; Provisional
Pssm-ID: 181281 Cd Length: 352 Bit Score: 138.70 E-value: 1.28e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 49 FPVTMLPGDGVGPELMHAVKEVFKAAA-----VPVEFQEHHLS-----EVQNMASEEKLEQvlssMKENKVAIIGKIHTP 118
Cdd:PRK08194 4 FKIAVIPGDGVGKEVVPAAVRVLKAVAevhggLKFEFTEFPWSceyylEHGEMMPEDGLEQ----LKQFDAIFLGAVGNP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 119 MEYKGELASYDM--RLRRKLDLFANVVHVKSLPGY---MTRHNNLDLVIIREQTEGEYSSLEHESARGVIECL---KIVT 190
Cdd:PRK08194 80 KLVPDHISLWGLliKIRREFEQVINIRPAKQLRGIkspLANPKDFDLLVVRENSEGEYSEVGGRIHRGEDEIAiqnAVFT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 191 RAKSQRIAKFAFDYATKKgRGKVTAVHKAN----IMKLGDGLFlqccEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDV 266
Cdd:PRK08194 160 RKGTERAMRYAFELAAKR-RKHVTSATKSNgivhSMPFWDEVF----QEVGKDYPEIETDSQHIDALAAFFVTRPEEFDV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 267 LVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAE--Y-AVFEtgARHPFA-QAVGRNIANPTAMLLSASNMLRHLNLEYHS 342
Cdd:PRK08194 235 IVASNLFGDILTDIGAAIMGSIGIAPAANINVNgkYpSMFE--PVHGSApDIAGKGIANPIGQIWTAKLMLDHFGEEELG 312
|
330
....*....|....
gi 385648280 343 SMIADAVKKVIKVG 356
Cdd:PRK08194 313 SHLLDVIEDVTEDG 326
|
|
| PRK07006 |
PRK07006 |
isocitrate dehydrogenase; Reviewed |
56-354 |
1.07e-35 |
|
isocitrate dehydrogenase; Reviewed
Pssm-ID: 180792 Cd Length: 409 Bit Score: 134.80 E-value: 1.07e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 56 GDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKL----------EQVLSSMKENKVAIIGKIHTPMeyKGEL 125
Cdd:PRK07006 27 GDGIGPDITPAMLKVVDAAVEKAYKGERKISWMEIYAGEKATkvygedvwlpEETLDLIREYRVAIKGPLTTPV--GGGI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 126 ASYDMRLRRKLDLFA---NVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHES----ARGVIECL------------ 186
Cdd:PRK07006 105 RSLNVALRQELDLYVclrPVRYFKGVPSPVKRPEDTDMVIFRENSEDIYAGIEWKAgsaeAKKVIKFLqeemgvkkirfp 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 187 -------KIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAEL-----------YPKIK---- 244
Cdd:PRK07006 185 etsgigiKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAEEefgdelidggpWDKIKnpet 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 245 -----FETMIIDNCCMQLVQNPYQFDVLVMPNLYGNII-DNLAAGlVGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGR 317
Cdd:PRK07006 265 gkeiiVKDSIADAFLQQILLRPAEYDVIATMNLNGDYIsDALAAQ-VGGIGIAPGANINDGHAIFE--ATHGTApKYAGL 341
|
330 340 350
....*....|....*....|....*....|....*..
gi 385648280 318 NIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIK 354
Cdd:PRK07006 342 DKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIA 378
|
|
| Icd |
COG0538 |
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ... |
56-357 |
1.58e-35 |
|
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304 Cd Length: 409 Bit Score: 134.08 E-value: 1.58e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 56 GDGVGPELMHAVKEVFKAA-------AVPVEFQEHHLSEvqnMASEEKLEQV----LSSMKENKVAIIGKIHTPMEykGE 124
Cdd:COG0538 26 GDGIGPEITRAIWKVIDAAvekayggKRDIEWKEVDAGE---KARDETGDWLpdetAEAIKEYGVGIKGPLTTPVG--GG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 125 LASYDMRLRRKLDLFAN---VVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHES----ARGVIECL----------- 186
Cdd:COG0538 101 WRSLNVTIRQILDLYVCrrpVRYFKGVPSPVKHPEKVDIVIFRENTEDIYAGIEWKAgspeALKLIFFLedemgvtvirf 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 187 --------KIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAE--------------LYP--- 241
Cdd:COG0538 181 pedsgigiKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAEeefgdkfitegpweKYKgpk 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 242 ---KIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGE--SYSAeYAVFE----TGARHpfa 312
Cdd:COG0538 261 pagKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGAniGDDG-GAEFEathgTAPKY--- 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 385648280 313 qaVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGK 357
Cdd:COG0538 337 --AGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGK 379
|
|
| PLN02329 |
PLN02329 |
3-isopropylmalate dehydrogenase |
45-356 |
4.72e-29 |
|
3-isopropylmalate dehydrogenase
Pssm-ID: 215188 Cd Length: 409 Bit Score: 116.33 E-value: 4.72e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 45 VEGSFPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFQEHHLSEVQ-NMASEEKLEQVLSSMKENKVAIIGKIHTpm 119
Cdd:PLN02329 43 GKKRYNIALLPGDGIGPEVISVAKNVLQKAGslegLEFDFQEMPVGGAAlDLVGVPLPEETFTAAKQSDAILLGAIGG-- 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 120 eYKGELASYDMR-------LRRKLDLFANVVHVKSLPGYMTRHN-------NLDLVIIREQTEGEYSSLE-----HESAR 180
Cdd:PLN02329 121 -YKWDKNEKHLRpemalfyLRRDLKVFANLRPATVLPQLVDASTlkkevaeGVDMMIVRELTGGIYFGEPrgitiNENGE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 181 GVIECLKIVTRAKSQRIAKFAFDYATKKgRGKVTAVHKANIMKlGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQN 260
Cdd:PLN02329 200 EVGVSTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLD-ASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRD 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 261 PYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRH-LNLE 339
Cdd:PLN02329 278 PKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEE 357
|
330
....*....|....*..
gi 385648280 340 YHSSMIADAVKKVIKVG 356
Cdd:PLN02329 358 KAAKRIEDAVVDALNKG 374
|
|
| PRK07362 |
PRK07362 |
NADP-dependent isocitrate dehydrogenase; |
56-358 |
8.82e-18 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 180944 Cd Length: 474 Bit Score: 84.38 E-value: 8.82e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 56 GDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKL----------EQVLSSMKENKVAIIGKIHTPMeyKGEL 125
Cdd:PRK07362 36 GDGTGVDIWPATQKVLDAAVAKAYGGERKINWFKVYAGDEACdlygtyqylpEDTLEAIREYGVAIKGPLTTPI--GGGI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 126 ASYDMRLRRKLDLFANVVHVKSLPGYMTRHNN---LDLVIIREQTEGEYSSLEHES----ARGVIECL------------ 186
Cdd:PRK07362 114 RSLNVALRQIFDLYSCVRPCRYYAGTPSPHKNpekLDVIVYRENTEDIYMGIEWEAgdeiGDKLIKHLneevipaspelg 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 187 ------------KIVTRAKSQRIAKFAFDYATK--KGRGKVTAVHKANIMKLGDGLF----------------------- 229
Cdd:PRK07362 194 krqiplgsgigiKPVSKTGSQRHIRRAIEHALRlpGDKRHVTLVHKGNIMKYTEGAFrdwgyelattefrdecvteresw 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 230 --------------------------------LQCCEEVAELYPKI-------KFETMII------DNCCMQLVQNPYQF 264
Cdd:PRK07362 274 ilsnkeknpnisiednarmiepgydsltpekkAAICAEVKEVLDSIwsshgngKWKEKVLvddriaDSIFQQIQTRPQEY 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385648280 265 DVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGRNIANPTAMLLSASNMLRHLNLEYHSS 343
Cdd:PRK07362 354 SILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFE--ATHGTApKHAGLDRINPGSVILSGVMMLEYLGWQEAAD 431
|
410
....*....|....*
gi 385648280 344 MIADAVKKVIKVGKI 358
Cdd:PRK07362 432 LITKGLSAAIANKQV 446
|
|
|